检索结果-南通市图书馆

Feeding the vasculature with cruciferous vegetables:a secret for organ protection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 828-830页

作者： Priya Veluswamy Jens Wippermann Max Wacker Heart surgery research Department of Cardiothoracic SurgeryOtto-von-Guericke University HospitalMagdeburgGermany

Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hydrocarbon receptor(AHr)/dietary-ligand axis,in enteric and pulmonary vasculature to emphasize tolerance induction and vessel integrity during homeostasis,sterile inflammation and *** studies spectacularly highlight the significance of endothelium in orchestrating tissue tolerance by demonstrating the multifaceted activities of endothelial-expressed AHr that protects the vasculature to maintain organ homeostasis.

关键词： maintain sterile homeostasis

Editorial: Welcome Message from Editor-in-Chief, Xuming Mo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2024年第1期19卷 1-3页

作者： Xuming Mo department of cardiothoracic surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China

1 Introduction The release of the most recent volume of Congenital Heart Disease(CHD)(Issue 19,Volume 1,2024)coincides with my assumption of the role of Co-Editor-In-Chief for CHD.I would like to express my appreciation to CHD for providing me with the opportunity to use the Editorial page.I took on this responsibility on November 18,2023.I would like to take this opportunity to share reflections and convey my *** in 2006,CHD stands as the pioneering professional periodical exclusively dedicated to the exploration and treatment of congenital cardiac abnormalities across all age *** paramount goal is to elevate the scholarly and educational dimension of CHD,driven by an unwavering commitment to provide optimal,holistic cardiac care to patients spanning infancy to *** commitment remains steadfast,with a focus on community service,research,and education quality,regardless of the patient’s financial situation.

关键词： cardiac education release

Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 170-180页

作者： Hao Zhang Kun Zhu Xue-Feng Zhang Yi-Hui Ding Bing Zhu Wen Meng Qing-Song Ding Fan Zhang department of Emergency Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006ZhejiangChina department of cardiothoracic surgery The Third Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161000HeilongjiangChina department of cardiothoracic surgery The Affiliated Heilongjiang Provincial Hospital of Harbin Institute of TechnologyHarbin 150036HeilongjiangChina

Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying ***:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as ***,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic ***:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell *** also targeted PTP1B and lowered PTP1B ***,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD ***:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.

关键词： Pachymic acid Lung adenocarcinoma Protein tyrosine phosphatase 1B Wnt/β-catenin signaling pathway Metastasis Angiogenesis Autophagy

Effect of programmed comprehensive nursing on delirium incidence in intensive care unit children following severe cardiac surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第9期14卷 1301-1307页

作者： Qiu-Yue Wang Xiang Wang Ming-Xiong Li department of cardiothoracic surgery Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGrOUND Programmed comprehensive nursing was adopted for intensive care unit(ICU)children following severe cardiac surgery to improve respiratory function and delirium *** To explore how programmed comprehensive nursing impacts respiratory func-tion and delirium incidence in ICU children post cardiac *** Between January 2022 and January 2024,180 pediatric patients from the Chil-dren’s Hospital of Nanjing were admitted to the ICU after cardiac surgery and randomly *** control group comprised 90 patients and received routine nursing *** observation group comprised 90 patients and received program-med comprehensive *** groups received continuous nursing care until *** respiratory function,incidence of delirium,and clinical outcomes were *** memory state and sleep quality of both groups were *** The incidence of delirium was 5.56%in the observation group when admitted to ICU,which was lower than that in the control group(20.00%;Prvation group demonstrated higher peak expiratory flow rate,respiratory frequency,deep breathing volume,and tidal volume in the ICU compared with the control ***,the observation group showed higher sleep depth,sleep latency,night awakening,return to sleep,and sleep quality com-pared with the control group(Programmed comprehensive nursing in ICU patients following severe cardiac surgery can reduce the impact on respiratory function,improve sleep quality,and alleviate postoperative delirium,showing significant promise for clinical application.

关键词： Programmed comprehensive nursing Intensive care unit Cardiac surgery respiratory function Delirium

IL13rA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology research 2024年第9期32卷 1453-1465页

作者： ZIYONG LIU TAO MA JINFANG LI WEI rEN ZHIXIN ZHANG department of cardiothoracic surgery 970th Hospital of the People’s Liberation ArmyWeihai264209China department of Cardiac Ultrasound Weihai Municipal HospitalWeihai264200China

Background:Interleukin 13 receptor subunit alpha 2(IL13rA2)plays an essential role in the progression of many ***,the role of IL13rA2 in infantile haemangioma(IH)is still *** and Methods:IL13rA2 expression in IH tissues was analyzed using western blot,qrT-PCr,and *** role of IL13rA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13rA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western ***:IL13rA2 expression was upregulated in IH ***13rA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis ***,IL13rA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of ***:These findings revealed that targeting IL13rA2 is a potential therapeutic approach for IH.

关键词： Infantile haemangioma IL13rA2 Glycolysis Wnt/β-catenin pathway

Application of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in recurrent anastomotic tumors after surgery in digestive tract tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal surgery 2024年第8期16卷 2474-2483页

作者： Deng-Feng Ge Hao ren Zi-Chen Yang Shou-Xiang Zhao Zhen-Ting Cheng Da-Da Wu Bin Zhang department of cardiothoracic surgery Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina department of Gastrointestinal surgery Shanghai Sixth People’s HospitalShanghai 250063China

BACKGrOUND This study was to investigate the application value of whole-body dynamic ^(18)F-fluorodeoxyglucose(FDG)positron emission tomography/computed tomogra-phy(PET/CT)imaging in recurrent anastomotic tumors of digestive tract after gastric and esophageal cancer *** patients with gastric and esophageal cancer have a high risk of tumor recurrence,and traditional imaging methods have certain limitations in early detection of recurrent ***-body dynamic ^(18)F-FDG PET/CT imaging,due to its high sensitivity and specifi-city,can provide comprehensive information on tumor metabolic activity,which is expected to improve the early diagnosis rate of postoperative recurrent tumors,and provide an important reference for clinical treatment *** A retrospective analysis was performed on 53 patients with upper digestive tract tumors after operation and systemic dynamic ^(18)F-FDG PET/CT imaging indi-cating abnormal FDG uptake by anastomosis,including 29 cases of gastric cancer and 24 cases of esophageal *** to the follow-up results of gas-troscopy and other imaging examinations before and after PET/CT examination,the patients were divided into an anastomotic recurrence group and anastomotic inflammation *** multi-parameter analysis software was used to obtain the metabolic rate(MrFDG),volume of distribution maximum(DVmax)of anastomotic lesions,and Mrmean and DVmean of normal liver *** lesion/background ratio(LBr)was calculated by dividing the MrFDG and DVmax of the anastomotic lesion by the Mrmean and DVmean of the normal liver tissue,respectively,to obtain LBr-MrFDG and *** independent sample t test was used for statistical analysis,and a receiver operating characteristic curve was used to analyze the differential diagnostic efficacy of each parameter for anastomotic recurrence and *** The dynamic ^(18)F-FDG PET/CT imaging parameters MrFDG,DVmax,LBr-MrFDG,and LBr-DVmax of post

关键词： Gastric cancer Esophageal cancer Anastomosis Dynamic positron emission tomography Differential diagnosis Metabolic rate

Arterial Duct Stenting Versus Modified Blalock-Taussig Shunt in Patient with Ductal-Dependent Pulmonary Circulation: Systematic review & Meta-Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2024年第2期19卷 139-156页

作者： Ketut Putu Yasa Nyoman Satria Sadu Bhaskara Putu Febry Krisna Pertiwi department of cardiothoracic&Vascular surgery Prof.Dr.I.G.N.G Ngoerah General HospitalDenpasar80113Indonesia Faculty of Medicine Udayana UniversityDenpasar80232Indonesia

Objective:Patients with ductal-dependent pulmonary circulation require alternative bloodflow to provide and maintain adequate *** Blalock-Taussig Shunt(MBTS)has been the standard for providing such a ***,less invasive methods such as Arterial Duct(AD)stenting have been performed as *** study aims to compare the outcome of AD stenting and ***:Systematic research was performed in online databases using the PrISMA *** outcomes measured were 30-day mortality,com-plication,unplanned intervention,oxygen saturation,duration of hospital,and ICU length of *** compara-tive study provided with full text is *** outcome of each study was analyzed using a trandom effects model with relative risk and mean difference as the effect *** risk assessment was conducted using the New-castle-Ottawa *** analyses were performed using review Manager ***:A total of 11 studies with 3154 samples included in this *** is no significant difference in 30-day mortality between the two groups(p-value=0.10).However,there is significantly less complication(rr 0.53[0.35,0.82];p-value=0.004)and unplanned intervention(rr 0.59[0.38,0.92];p-value=0.02)in the AD stent *** of the Nakata index showed no significant difference(p-value=0.88).Post-operative oxygen saturation was measured signifi-cantly higher in the AD stenting(MD 1.80[0.85,2.74];p-value=0.0002).However,AD stent group shows sig-nificantly lower long-term oxygen saturation(MD-8.43[-14.38,-2.48];p-value=0.005).Both hospital and ICU length of stay was significantly shorter in the AD stent group(MD-8.30[-11.13,-5.48];p-valuerovides comparable outcomes relative to MBTS as it provides less complication and unplanned intervention and higher post-procedural O2 ***,MBTS proved its superiority in maintaining higher long-term oxygen saturation and still beca

关键词： Duct-dependent pulmonary circulation arterial duct stenting modified Blalock-Taussig shunt

Loss to Specialized Cardiology Follow-Up in Adults Living with Congenital Heart Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2024年第1期19卷 49-63页

作者： Cheryl Dickson Danielle Osborn David Baker Judith Fethney David S.Celermajer rachael Cordina department of Cardiology Royal Prince Alfred HospitalSydneyAustralia department of cardiothoracic surgery Westmead HospitalSydneyAustralia Susan Wakil School of Nursing and Midwifery The University of SydneySydneyAustralia Sydney Medical School The University of SydneySydneyAustralia

Background:Much has been written about the loss to follow-up in the transition between pediatric and adult Congenital Heart Disease(CHD)care *** less is understood about the loss to follow-up(LTF)after a successful *** is critical too,as patients lost to specialised care are more likely to experience mor-bidity and premature ***:To understand the prevalence and reasons for loss to follow-up(LTF)at a large Australian Adult Congenital Heart Disease(ACHD)***:Patients with moderate or highly complex CHD and gaps in care of>3 years(deﬁned as LTF)were identiﬁed from a comprehensive ACHD *** telephone interviews examined current care and barriers to clinic ***:Overall,407(22%)of ACHD patients(n=1842)were *** mean age at LTF was 31(SD 11.5)years and 54%were male;311(76%)were *** to adults seen regularly,lost patients were younger,with a greater socio-economic disadvantage,and had less complex CHD(pr all).We interviewed 59 patients(14%).The top 3 responses for care absences were“feeling well”(61%),losing track of time(36%),and not needing fol-low-up care(25%).Conclusions:A large proportion of the ACHD population becomes lost to specialised cardiac care,even after a successful *** Australian study reports younger age,moderate complexity defects,and socio-economic disadvantage as predictive of loss to *** study highlights the need for novel approaches to patient-centered service delivery even beyond the age of transition and resources to maintain patient engagement within the ACHD service.

关键词： Loss to follow-up follow-up adult congenital heart disease lapse in care gaps in care care gaps care continuity ACHD predictors

Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology research 2024年第5期32卷 965-981页

作者： ZHEN LIU LIANGWANG YANG ZHENGXING XIE HUI YU TIANYI GU DAOMING SHI NING CAI SHENGHUA ZHUO department of Neurosurgery Affiliated Hospital of Jiangsu UniversityZhenjiang212000China department of Neurosurgery First Affiliated Hospital of Hainan Medical UniversityHaikou570100China department of cardiothoracic surgery Affiliated Hospital of Jiangsu UniversityZhenjiang212000China department of General surgery Affiliated Hospital of Jiangsu UniversityZhenjiang212000China

Clinical data indicates that glioma patients have poor treatment outcomes and clinical *** role of olfactory signaling pathway-related genes(OSPrGs)in glioma has not been fully *** this study,we aimed to investigate the role and relationship between OSPrGs and *** and multivariate Cox regression analyses were performed to assess the relationship between OSPrGs and the overall survival of glioma based on public cohorts,and the target gene(G Protein Subunit Alpha L,GNAL)was *** association of GNAL expression with clinicopathological characteristics,gene mutation landscape,tumor immune microenvironment(TIME),deoxyribonucleic acid(DNA)methylation,and naris-occlusion controlled genes(NOCGs)was *** was used to evaluate GNAL level in *** analysis was conducted to evaluate the drug sensitivity,immunotherapy response,and functional enrichment of *** was an independent prognostic factor,and patients with low GNAL expression have a poor *** of GNAL was closely associated with clinicopathological characteristics,DNA methylation,and several immune-related *** infiltration analysis indicated that GNAL levels were negatively correlated with immune *** low-expression group showed efficacy with anti-PD-1 *** compounds with significantly different half-maximal inhibitory concentration(IC50)values between the GNAL high and low-expression groups were ***,its expression was associated with several immune cells,immune-related genes,and *** expression of GNAL is closely associated with clinicopathological characteristics,TIME,and the response to therapeutic interventions,highlighting its potential as a prognostic biomarker for glioma.

关键词： Glioma Olfaction GNAL Tumor immune microenvironment Immunotherapy/chemotherapy response