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Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： Xin Lin Xin Lu Yun-He Zhao Yi-Bei Wang Ru-Ge Niu Xiao-Hu Chen department of cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CiN).Methods:CiN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CiN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CiN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CiN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of Geriatric cardiology 2024年第4期21卷 421-430页

作者： Jing TAN Jin Si Ke-Ling XiAO Ying-Hua ZHANG Qi HUA Jing Li department of cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMi) are *** We analyzed 2313 patients admitted for acute STEMi between October 2013 and December 2020. in-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(ith the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% Ci: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% Ci: 0.651–0.754, Pitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction

Sodium glucose cotransporter 2 inhibitors in the management of heart failure:Veni,Vidi,and Vici

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World Journal of cardiology 2024年第10期16卷 550-563页

作者： Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek Singh Rishi Sethi department of cardiology King Georg’s Medical UniversityLucknow 226003Uttar PradeshIndia

Heart failure(HF)is a chronic disease associated with high morbidity and mortality ***-angiotensin-aldosterone system blockers(including angiotensin receptor/neprilysin inhibitors),beta-blockers,and mineralocorticoid receptor blockers remain the mainstay of pharmacotherapy for HF with reduced ejection fraction(HFrEF).However,despite the use of guideline-directed medical therapy,the mortality from HFrEF remains *** with preserved ejection fraction(HFpEF)comprises approximately half of the total incident HF cases;however,unlike HFrEF,there are no proven therapies for this *** glucose cotransporter-2 inhibitors(SGLT-2is)represent a new class of pharmacological agents approved for diabetes mellitus(DM)that inhibit SGLT-2 receptors in the kidney.A serendipitous finding from seminal trials of SGLT-2is in DM was the significant improvement in renal and cardiovascular(CV)*** importantly,the improvement in HF hospitalization(HHF)in the CV outcomes trials of SGLT-2is was *** mechanisms have been proposed for the pleiotropic effects of SGLT-2is beyond their glycemic ***,as patients with HF were not included in any of these trials,it can be considered as a primary ***,two landmark studies of SGLT-2is in patients with HFrEF,namely,an empagliflozin outcome trial in patients with chronic HF and a reduced ejection fraction(EMPEROR-Reduced)and dapagliflozin and prevention of adverse outcomes in HF(DAPA-HF),demonstrated significant improvement in HHF and CV mortality regardless of the presence of *** impressive results pitchforked these drugs as class i indications in patients with HFrEF across major ***,empagliflozin outcome trial in patients with chronic HF with preserved ejection fraction(EMPEROR-Preserved)and dapagliflozin evaluation to improve the lives of patients with preserved ejection fraction HF(DELiVER)trials successively confirmed that SGLT-2is also benefit patients w

关键词： Heart failure with preserved ejection fraction Gliflozins Diuresis Natriuresis N terminal-pro brain natriuretic peptide Heart failure hospitalization

Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

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Congenital Heart Disease 2024年第3期19卷 325-339页

作者： Wenjie Dong Zhibin Hong Aqian Wang Kaiyu Jiang Hai Zhu Fu zhang Zhaoxia Guo Hongling Su Yunshan Cao department of cardiology The First People’s Hospital of TianshuiTianshui741000China department of cardiology Pulmonary Vascular Disease CenterGansu Provincial HospitalLanzhou730000China Heart Lung and Vessels CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Current guidelines for managing pulmonary arterial hypertension(PAH)recommend a risk strati-fication ***,the applicability and accuracy of these strategies for PAH associated with congenital heart disease(PAH-CHD)require further *** study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year ***,new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD ***:This retrospective study included 126 PAH-CHD *** and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s exact ***-dent risk factors were identified using ordered logistic regression,while Kaplan-Meier and Cox proportional hazards regression analyses evaluated their impact on all-cause mortality.A new stratification model for the PAH-CHD population was constructed based on these ***:Significant survival differences across stratified risk groups were observed(pidating the effectiveness of the simplified risk stratification method in PAH-CHD *** activity was a strong independent predictor of adverse outcomes of PAH-CHD patients(Hazard ratio 0.95,pindex 0.70).A model combining N-terminal pro-brain natriuretic peptide,prothrombin activity,albumin,and right atrial area achieved an area under the curve of 0.89 and a C-index of ***:The simplified risk stratification method is applicable to PAH-CHD *** activity is a strong independent predictor of adverse outcomes.A comprehensive risk stratification approach,incorporating both established and novel biomarkers,enhances accessibility and offers predictive efficacy during follow-up for PAH-CHD patients,comparable to established models.

关键词： Pulmonary hypertension pulmonary arterial hypertension congenital heart disease risk stratification

How to manage the malposition of deep vein catheterization into the artery?

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Journal of Geriatric cardiology 2024年第6期21卷 682-685页

作者： Jun-Na SUN Hai DONG Peng CHEN Zi-Qi Li Li-You SUi Bin Qi Quan-Min JiNG department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina department of cardiology General Hospital of Northern Theater CommandShenyangChina

Central venous catheterization establishes temporary,efficient,and rapid use of deep venous access in patients,which provides high flow rate fluid perfusion,enables measurement of central venous pressure,and acts as an important reference for clinical ***,various complications such as pneumothorax,hemothorax,hematoma,and puncture failure can easily occur during the puncture and catheterization process.

关键词： process enable catheter

Soluble ST2:A Novel Biomarker for Diagnosis and Prognosis of Cardiovascular Disease

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当代医学科学（英文） 2024年第4期44卷 669-679页

作者： Yin FENG Li-qun HE department of cardiology Traditional Chinese and Western Medicine Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The increasing incidence of cardiovascular disease(CVD)is a significant global health concern,affecting millions of individuals each *** diagnosis of acute CVD poses a formidable challenge,as misdiagnosis can significantly decrease patient survival *** biomarkers have played a vital role in the diagnosis and prognosis of CVDs,but they can be influenced by various factors,such as age,sex,and renal *** ST2(sST2)is a novel biomarker that is closely associated with different *** low reference change value makes it suitable for continuous measurement,unaffected by age,kidney function,and other confounding factors,facilitating risk stratification of ***,the combination of sST2 with other biomarkers can enhance diagnostic accuracy and prognostic *** review aims to provide a comprehensive overview of sST2,focusing on its diagnostic and prognostic value as a myocardial marker for different types of CVDs and discussing the current limitations of sST2.

关键词： cardiovascular disease combined biomarker diagnosis and prognosis limitations soluble ST2

Double-chambered left ventricle with a thrombus in an asymptomatic patient:A case report

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World Journal of Clinical Cases 2024年第2期12卷 460-465页

作者： Narae Kim in-Ho Yang Hui-Jeong Hwang il-Suk Sohn department of Medicine Kyung Hee UniversitySeoul 02447South Korea department of cardiology Kyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND Double-chambered left ventricle(DCLV)is an extremely rare congenital disease in which the left ventricle(LV)is divided by abnormal muscle *** to its rarity,there is a lack of data on the disease,including its diagnosis,treatment,and ***,we report a case in which DCLV was diagnosed and followed *** SUMMARY A 45-year-old man presented to our hospital due to abnormal findings on an electrocardiogram recorded during a health *** had no specific cardiac symptoms,comorbidities or relevant past medical *** revealed that the LV was divided into two by muscle *** were no findings of ischemia on coronary angiography and coronary computed tomography angiography performed to exclude differential *** comprehensive analysis of the images,DCLV was *** it seemed to be asymptomatic DCLV,we decided the patient was to be observed without administering any ***,follow-up echocardiography revealed a thrombus in the accessory chamber(AC).Anticoagulant medication was initiated,the thrombus resolved,and the patient is currently undergoing follow-up without any specific *** Asymptomatic,uncomplicated DCLV was diagnosed through multimodal imaging;however,a thrombus in the AC occurred during the *** findings highlight that multimodal imaging is essential in diagnosing DCLV,and that anticoagulation is important in its management.

关键词： Double-chambered left ventricle Congenital heart disease Left ventricular aneurysm Echocardiography Coronary computed tomography angiography Contrast echocardiography Case report

Minimalistic approach to left atrial appendage occlusion guided by cardiac computed tomography angiography

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Journal of Geriatric cardiology 2024年第4期21卷 431-442页

作者： Xian-Sai MENG Qing-Song WANG Xin-Yan WANG Xu LU Yang MU Jing WANG Ting-Ting SONG Yun-Dai CHEN Tao CHEN Jun GUO Graduate School of Chinese PLA Medical College BeijingChina Senior department of cardiology the Sixth Med-ical CenterChinese PLA General HospitalBeijingChina

OBJECTiVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. in the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using *** A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P ital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months *** CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.

关键词： anesthesia matched approach

Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

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Journal of Geriatric cardiology 2024年第5期21卷 542-549页

作者： Qian Li Yue YU Ya-Qiong ZHOU Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian WANG Tao ZHENG department of Cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina department of cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(Mi),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(Pier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal Mi,and mortality in patients within the high tertile than those in the low and intermediate groups(all Pivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[Ci]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%Ci:1.56-6.52;P=0.001),Mi(HR=2.61;95%Ci:1.35-5.03;P=0.043)and mortality(HR=3.78;95%Ci:1.65-8.77;P=0.001).CONCLUSiON Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO.

关键词： patients coronary occlusion