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Gut microbiome regulates inflammation and insulin resistance:a novel therapeutic target to improve insulin sensitivity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 825-827页

作者： Dilvin Semo Holger Reinecke Rinesh Godfrey Vascular Signalling Molecular CardiologyDepartment of Cardiology I-Coronary and Peripheral Vascular DiseaseHeart FailureUniversity Hospital Münster48149 MünsterGermany

in a recent study published in Nature,Takeuchi et *** a multiomics strategy in humans to provide compelling evidence that increased carbohydrate metabolism by the gut microbiota contributes to insulin resistance(iR).The authors uncovered a previously unknown link between elevated gut monosaccharides and host inflammatory cytokines and suggest potential intervention opportunities to combat iR by targeting specific gut microbial species.

关键词： metabolism inflammation al.

Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei YE department of cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina department of cardiology Clinical Medicine School of Nanjing UniversityNanjingChina department of cardiology Tianchang People’s HospitalTianchangChina department of cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTiVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(iVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NiH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCi) treatment guided by iVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete iVUS detection pre-and post-PCi and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NiH at SBO at the 1-year follow-up. if the correlation was confirmed, the cutoff value of the remodeling index(Ri) for predicting NiH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** in phase i: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the Ri cutoff value predicting percent NiH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. in phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P ignificantly higher in the several NR(s NR, defined as Ri ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NiH post-PCi for distal LMb lesions with a 2-stent strategy,and NR with Ri ≤ 0.85 is linked to percent NiH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

An unexpected cellular fountain of youth:platelets provide factors rejuvenating brain functions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 16-18页

作者： Harald F.Langer department of cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany German Centre for Cardiovascular Research(DZHK) Partner Site Heidelberg/MannheimMannheimGermany European Center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Cardiovascular systems biology Medical Clinic IUniversity Heart Center LübeckLübeckGermany

in a recent manuscript published in Nature,Schroer et *** that platelets and in particular platelet derived PF-4(CXCL4)are a novel factor,which can rejuvenate the mammalian neuronal system.1 These findings have the potential to trigger an entire new field of research opening new platelet-derived candidate effector molecules for supporting regeneration.

关键词： supporting platelets finding

The impact of being in the COViD-19 pandemic on in-hospital mortality of non-infected patients aged 80 years and older with ST-elevation myocardial ınfarction

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Journal of Geriatric cardiology 2024年第7期21卷 768-774页

作者： Mustafa Ebik Muhammet Gürdoğan UğurÖzkan department of cardiology Edirne SultanMurat State HospitalEdirneTurkey department of cardiology School of MedicineTrakya UniversityEdirneTurkey

The COViD-19 outbreak in late 2019 was declared a pandemic by the World Health Organization(WHO)on March 12,2020.[1]As of the latest WHO data,COViD-19 has caused over 770 million cases and nearly 7 million deaths worldwide.[2]Hospitalizations due to COViD-19 are correlated with advanced age.[3,4]According to re-ports,individuals over the age of 65 account for 80%of COViD-19-related deaths.[3,4]This is primar-ily due to the increased burden of comorbidity with age.

关键词： infected patients mortality

Oral fluoroquinolones and the risk of Achilles tendon rupture

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Journal of Sport and Health Science 2024年第6期13卷 749-750页

作者： Peter Vibe Rasmussen Jarl Emanuel Strange Anders Holt department of cardiology Herlev-Gentofte University HospitalCopenhagen 2730Denmark department of cardiology Bispebjerg-Frederiksberg University HospitalCopenhagen 2400Denmark department of cardiology Rigshospitalet University HospitalCopenhagen 2100Denmark

Dear editor,Fluoroquinolones(FQs)are a class of antibiotics used to treat bacterial infections,such as lower respiratory,gastrointestinal,and urinary tract *** to its broad-spectrum action and wide availability,it is ... 详细信息

关键词： prescribed spectrum action

is primary transcatheter aortic valve implantation the new normal?

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Journal of Geriatric cardiology 2024年第4期21卷 458-461页

作者： R.Anantharaman C.Sundar Kamal Kant Jena K.Arun department of cardiology Kauvery HospitalChennaiIndia

Degenerative calcific aortic valve stenosis(AS)is the most common valvular heart disease in elderly.^[1] it is well documented that symptomatic severe AS follows a malignant course leading to cardiogenic shock(CS).

关键词： aortic stenosis implantation

Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with in-stent Restenosis after Drug-coated Balloon Angioplasty

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Current Medical Science 2024年第3期44卷 561-567页

作者： Xiang-qi WU Long-bo Li Wei YOU Zhi-ming WU Lei ZHAO Zhi-hui WANG Pei-na MENG Bin LiU Fei YE department of cardiology Nanjing First HospitalNanjing Medical UniversityNanjing210006China department of cardiology The Second Hospital of Jilin UniversityJilin130000China

Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(iSR)by using drug-coated balloon(DCB)treatment after a long-term *** This was a retrospective study.A total of 186 patients who underwent DCB angioplasty for iSR in two hospitals from March 2014 to September 2019 were *** QFR of the entire target vessel was measured *** primary endpoint was TVF,including target vessel-cardiac death(TV-CD),target vessel-myocardial infarction(TV-Mi),and clinically driven-target vessel revascularization(CD-TVR).Results The follow-up time was 3.09±1.53 years,and 50 patients had *** QFR immediately after percutaneous coronary intervention(PCi)was significantly lower in the TVF group than in the no-TVF *** Cox regression analysis indicated that the QFR immediately after PCi was an excellent predictor for TVF after the long-term follow-up[hazard ratio(HR):5.15×10−5(6.13×10−8−0.043);Piver-operating characteristic(ROC)curve analysis demonstrated that the optimal cut-off value of the QFR immediately after PCi for predicting the long-term TVF was 0.925(area under the curve:0.886,95%confidence interval:0.834–0.938;sensitivity:83.40%,specificity:88.00;Pin addition,QFR≤0.925 post-PCi was strongly correlated with the TVF,including TV-Mi and CD-TVR(Pion The QFR immediately after PCi showed a high predictive value of TVF after a long-term follow-up in iSR patients who underwent DCB angioplasty.A lower QFR immediately after PCi was associated with a worse TVF outcome.

关键词： percutaneous coronary intervention in-stent restenosis target vessel failure quantitative flow ratio

Conquer coronary artery perforation with magic hands

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Journal of Geriatric cardiology 2024年第4期21卷 379-386页

作者： Yi-Lun ZOU Jian-Qiang Li Ding-Yu WANG Yong-Tai GONG Li SHENG Yue Li department of cardiology the First Affiliated Hospital of Harbin Medical UniversityHarbinChina

Coronary artery perforation(CAP) poses a significant challenge for interventional cardiologists. Management of CAP depends on the location and severity of the perforation. The conventional method for addressing the perforation of large vessels involves the placement of a covered stent, while the perforation of distal and collateral vessels is typically managed using coils, autologous skin, subcutaneous fat, microspheres, gelatin sponge, thrombin or other substances. However, the above techniques have certain limitations and are not applicable in all scenarios. Our team has developed a range of innovative strategies for effectively managing CAP. This article provides an insightful review of the various tips and tricks for the treatment of CAP.

关键词： coronary sponge perforation

Heterogeneous body compositions and all-cause mortality in acute coronary syndrome patients:a ten-year retrospective cohort study

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Journal of Geriatric cardiology 2024年第5期21卷 534-541页

作者： Guang-Zhi LiAO Lin BAi Yu-Yang YE Xue-Feng CHEN Xin-Ru HU Yong PENG department of cardiology West China HospitalSichuan UniversityChengduSichuanChina

BACKGROUND The association of different body components,including lean mass and body fat,with the risk of death in acute coronary syndrome(ACS)patients are *** We enrolled adults diagnosed with ACS at our center between January 2011 and December 2012 and obtained fol-low-up outcomes via telephone *** used restricted cubic splines(RCS)with the Cox proportional hazards model to analyze the associations between body mass index(BMi),predicted lean mass index(LMi),predicted body fat percentage(BF),and the value of LMi/BF with 10-year *** also examined the secondary outcome of death during *** During the maximum 10-year follow-up of 1398 patients,331 deaths(23.6%)occurred,and a U-shaped relationship was found between BMi and death risk(P_(nonlinearity)=0.03).After adjusting for age and history of diabetes,the overweight group(24≤BMiity(HR=0.53,95%Ci:0.29-0.99).Predicted LMi and LMi/BF had an inverse linear relationship with a 10-year death risk(P_(nonlinearity)=0.24 and P_(nonlinearity)=0.38,respectively),while an increase in BF was associ-ated with increased mortality(P_(nonlinearity)=0.64).During hospitalization,31 deaths(2.2%)were recorded,and the associations of the indicators with in-hospital mortality were consistent with the long-term outcome *** Our study provides new insight into the“obesity paradox”in ACS patients,highlighting the importance of considering body composition *** LMi and BF may serve as useful tools for assessing nutritional status and predicting the prognosis of ACS,based on their linear associations with all-cause mortality.

关键词： patients mortality coronary