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Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan

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World Journal of Virology 2025年第1期14卷 73-82页

作者： Yumna Shahid Amna Subhan Butt Iqra Jamali Faisal Wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan department of Medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND For decades,hepatitis A virus(HAV)has been a leading cause of acute hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acute hepatitis due to HAV among *** To estimate frequency of HAV in acute viral hepatitis and compare characteristics in HAV and hepatitis E virus(HEV)*** This was a trend analysis conducted at Aga Khan university Hospital karachi(Sindh,Pakistan)from February 2024 to May *** aged 18 years and older diagnosed with acute viral hepatitis attributed to hepatotropic viruses in 2024 were *** compare the trend patients admitted with acute hepatitis during 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acute hepatitis due to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were found to have acute hepatitis during our study *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were found to have acute HEV ***,acute hepatitis B virus infection was identified in 3 patients(0.7%),whereas acute hepatitis C virus infection was found in 2(0.5%)cases of acute *** trends showed increasing occurrence of HAV infection among adults over last 5 *** patients with acute HAV were younger than patients with HEV(28 years±8 years vs 30 years±8 years;P<0.01).Higher levels of total bilirubin were seen in HEV infection,while higher levels of alanine transaminase were seen in HAV ***,a higher proportion of acute liver failure(ALF),coagulopathy,and mortality were observed in *** An increase in acute hepatitis A cases among adults shows less severity than hepatitis E,highlighting the need for better sanitation,hygiene,and adult hepatitis A vaccination programs.

关键词： Acute hepatitis Hepatitis A virus Hepatitis E virus Acute liver failure Hepatotropic virus Vaccination

Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan:A single center retrospective study

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World Journal of Clinical Cases 2025年第6期13卷 9-13页

作者： Masood Muhammad Karim Hafsa Shaikh Faisal Wasim Ismail department of Medicine The Aga Khan University HospitalKarachi 74800Pakistan department of General Surgery The Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venous thromboembolism(VTE)as compared to the general *** the exact pathogenesis is unclear,the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors,inflammatory cytokines,and reduction in anticoagulants leading to a prothrombotic *** To assess the prevalence,risk factors,management,and outcome of ulcerative colitis(UC)patients who develop *** This was a retrospective chart review done in The Gastroenterology department of The Aga Khan university *** was collected from medical records for all patients admitted with a diagnosis of UC from January 2012 to December *** Seventy-four patients fulfilled the inclusion *** mean±SD of age at presentation of all UC patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 *** and diabetes were the most common co-morbid seen among UC patients with a frequency of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed *** venous thrombosis was the most common thromboembolic phenomenon seen in 3(60%)*** the patients with UC and concomitant VTE were discharged home(5;100%).CONCLUSION The prevalence of VTE with UC in Pakistani patients corresponds with the international ***,multi-centric studies are required to further explore these results.

关键词： Deep venous thrombosis Inflammatory bowel disease Low-middle-income country Anticoagulation Protein C deficiency

Dexamethasone in coronavirus disease 2019 care:Dosage and utilization insights

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World Journal of Virology 2025年第1期14卷 1-4页

作者： Laiba Shamim Imshaal Musharaf Abdulqadir J Nashwan department of Clinical Medicine Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan department of Medicine Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan department of Nursing and Midwifery Research Hamad Medical CorporationDoha 3050Qatar

Coronavirus disease 2019(COVID-19)is a contagious disease caused by severe acute respiratory syndrome coronavirus *** was declared a global pandemic on March 11,2020,by the World Health *** excessive inflammatory response is a severe respiratory manifestation of COVID-19,which becomes predominant in later *** to its immunosuppressive and anti-inflammatory properties,dexamethasone is the first systemic glucocorticoid to treat severe COVID-19 *** editorial reviews the efficacy and safety of highdose vs low-dose dexamethasone in patients with *** indicate that using low-dose dexamethasone is beneficial and emphasize the need for additional research on the use of high-dose *** the study provides a robust evidence base,it is limited by the lack of long-term data,focus on specific outcomes and heterogeneity of the included *** research should focus on the long-term effects of dexamethasone and its impact across varying disease severities and patient populations to refine treatment strategies and improve patient care.

关键词： COVID-19 Severe acute respiratory syndrome Corticosteroid Dexamethasone Anti-inflammatory

Population structure,age and growth rates of conifer species and their relation to environmental variables at Malam Jabba,Swat District,Pakistan

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Journal of Forestry Research 2020年第2期31卷 429-441页

作者： Arsalan Muhammad Faheem Siddiqui Moinuddin Ahmed Syed Shahid Shaukat Alamdar Hussain department of botany University of KarachiKarachi 75270Pakistan Dr.Moinuddin Ahmed Laboratory of Plant Ecology and Dendrochronology Department of BotanyFederal Urdu UniversityKarachiPakistan Institute of Environmental Studies University of KarachiKarachiPakistan department of botany Karakoram International UniversityGilgitGilgit-BaltistanPakistan

This study focuses on age,growth rate and diameter distribution of pine forests in the Malam Jabba area,Swat District,*** core samples were taken from twenty *** smithiana was the oldest at 234 years with a 112-cm *** pindrow was 125 years with an 80-cm diameter while the oldest Pinus wallichiana was 122 years with 75-cm *** fastest overall growth rate of 1.5±0.1 year/cm was for *** on a west-facing aspect,while the slowest 5.8±2.6 year/cm growth was *** on an eastfacing *** and *** exhibited marked differences in growth rates over a 5-year *** highest growth was by *** from 1966 to *** showed less growth over the same years,such pattern simultaneously reverse from 1911 to *** relationship between diameter and age,diameter and growth rate and age and growth rate were *** and *** ages were correlated with diameter and growth *** age was positive correlated with ***,topographic and edaphic factors did not show significant correlations with growth rates,although some appreciable correlations were *** growth of *** was correlated with elevation while *** was correlated with maximum water retaining *** and age produced uneven size classes and many size gaps,which could be the result of anthropogenic disturbances.

关键词： Dendrochronology Environmental variables Conifer species Forest structure Age classes

Vegetation-environment relationships in the forests of Chitral district Hindukush range of Pakistan

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Journal of Forestry Research 2013年第2期24卷 205-216页

作者： Nasrullah Khan Syed Shahid Shaukat Moinuddin Ahmed Muhammad Faheem Siddiqui department of botany university of Malakand Dept. of botany University of Karachi Laboratory of Dendrochronology and Plant Ecology department of botany Federal Urdu University of Arts Science and Technology

We investigated the composition of plant communities to quantify their relationships with environmental parameters in the Chitral Hindukush range of Pakistan. We sampled tree vegetation using the Point Centered Quarter （PCQ） method while understory vegetation was sampled in 1.5-m circular quadrats. Cedrus deodara is the national symbol of Pakistan and was dominant in the sampled communities. Because environmental variables determine vegetation types, we analyzed and evaluated edaphic and topographic factors. DCA-Ordination showed the major gradient as an amalgam of elevation （p〈0.05） and slope （p〈0.01） as the topographic factors correlated with species distribution. Soil variables were the factors of environmental significance along DCA axes. However, among these factors, Mg2＋ , K ＋ and N2＋ contributed not more than 0.054% 0.20% and 0.073%, respectively, to variation along the first ordination axis. We conclude that the principal reason for weak or no correlation with many edaphic variables was the anthropogenic disturbance of vegetation. The understory vegetation was composed of perennial herbs in most communities and was most dense under the tree canopy. The understory vegetation strongly regulates tree seedling growth and regeneration patterns. We recommend further study of the understory vegetation using permanent plots to aid development of forest regeneration strategies.

关键词： environmental relationship multivariate analysis cluster analysis ordination anthropogenic factors forest, Hindukush range

Vegetation-environment relationship in conifer dominating forests of the mountainous range of Indus Kohistan in northern Pakistan

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Journal of Mountain Science 2020年第8期17卷 1989-2000页

作者： Adam KHAN Moinuddin AHMED Muhammad Faheem SIDDIQI Mohib SHAH Eduardo Soares CALIXTO Afsheen KHAN Paras SHAH Javed IQBAL Muhammad AZEEM department of botany University of BunerSwari 19290Pakistan Dr.Moinuddin Ahmed Research Laboratory of Dendrochronology and Plant Ecology department of botany FederalUrdu University of ArtsScience and Technology Gulshan-e-Iqbal campus KarachiKarachi 75300Pakistan department of botany university of karachi Karachi 75270Pakistan department of botany Abdul Wali Khan University MardanMardan 23200Pakistan department of Entomology University of Sao PauloRibeirao PretoRibeirao Preto 14040-900Brazil Dr.Abdul Ghaffar laboratory of Plant Pathology and Aerobiology Department of BotanyFederal Urdu University ofArtsScience and Technology Gulshan-e-Iqbal campus KarachiKarachi 75300Pakistan

Environmental variables play a crucial role in shaping vegetation structure,mainly in mountainous *** studies have attempted to identify the environment-vegetation relationship of Conifer Dominating Forests(CDF)***,due to differences in local climate and soil composition,different environmental drivers can be *** applying multivariate analysis techniques,this study investigated the vegetation-environment relationship of CDF of Indus Kohistan in northern *** results showed that CDF of Indus Kohistan are distributed in five distinct ecological groups,which are dominated by different trees and understory species.A total of 7 trees and 71 understory species were recorded from the sampling *** deodara was the leading species among four groups,having the highest importance value(IV),density and basal *** I was dominated by Pinus wallichiana with the second highest importance value,density and basal *** addition,elevation,slope,maximum water holding capacity(MWHC),soil moisture(SM),total organic matter(TOM),sodium,phosphorus and nickel showed highly significant influence on composition and distribution pattern of Indus Kohistan ***,this study shows a new evidence of vegetation-environment relationship,pointing out specific drivers of vegetation structure in CDF of Indus Kohistan region in northern Pakistan.

关键词： Conifer forests Understory species Environmental variables Multivariate analysis Indus Kohistan Northern Pakistan

An Implementation of Haar Wavelet Based Method for Numerical Treatment of Time-fractional Schrdinger and Coupled Schrdinger Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 177-187页

作者： Najeeb Alam Khan Tooba Hameed the department of Mathematics University of Karachi

The objective of this paper is to solve the timefractional Schr¨odinger and coupled Schr¨odinger differential equations(TFSE) with appropriate initial conditions by using the Haar wavelet approximation. For the most part, this endeavor is made to enlarge the pertinence of the Haar wavelet method to solve a coupled system of time-fractional partial differential equations. As a general rule, piecewise constant approximation of a function at different resolutions is presentational characteristic of Haar wavelet method through which it converts the differential equation into the Sylvester equation that can be further simplified easily. Study of the TFSE is theoretical and experimental research and it also helps in the development of automation science,physics, and engineering as well. Illustratively, several test problems are discussed to draw an effective conclusion, supported by the graphical and tabulated results of included examples, to reveal the proficiency and adaptability of the method.

关键词： Fractional calculus Haar wavelets operational matrix wavelets

Composition,Structure and Regeneration Dynamics of Olea ferruginea Royle Forests from Hindukush Range of Pakistan

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Journal of Mountain Science 2015年第3期12卷 647-658页

作者： NASRULLAH Khan FAYAZ Ali KISHWAR Ali SHAHID Shaukat Laboratory of Plant Ecology department of botany university of Malakand department of Plant Sciences School of Biological SciencesUniversity of Reading Institute of Environmental Studies University of Karachi

Abstract＂ The abundance of Olea ferruginea in Malakand Division has been significantly reduced across its distribution range due to anthropogenic pressure in the recent past. A number of initiatives were taken for grafting this species to obtain better seeds for oil production, without the basic information on their ecology and management. To address this knowledge gap, we quantified the composition, structure and regeneration dynamics of Olea ferruginea forests in Malakand Division, Hindukush range of Pakistan. In the present study, five communities dominated by Oleaferruginea were identified using Ward＇s agglomerative cluster analysis. Total tree density ranged from 153-26o2 plants/ha, and basal area from 19.55 to 2353 m~ ha-1 with Olea having a relative density of 51% to 87% and basal area of 48% to 93%, respectively. The density of juveniles of the dominant and subordinate tree species were generally low which reflect their narrow distribution in the study area. Size-class distributions of O. ferruginea disclosed a bell-shaped pattern, indicating that forests were heavily exploited by local inhabitants in previous periods and recently by armed forces owing to security risks in the study area. The age （mean max. 300±34 years） and annual increment （3.2±1.2 years/cm） indicates that the species is long lived and generally slow growing among the different broad leaved species studied so far. However, the oldest trees can be found by the exploration of large diameter trees in the area. In addition, we found a stable linear relationship between the age and diameter （r2 = o.779）, indicating that diameter is a good predictor of age for this broad leaved species. In view of its relatively slow growth, longevity and positive ring-width characteristics O. ferruginea seems to be a suitable choice for dendroecological and dendrochronological studies in lesser Himalayan and Hindukush ranges of Pakistan. The results obtained from this study may help in understanding the composi

关键词： Oleaferruginea Species composition Ward's agglomerative cluster analysis Seedling Dendroecology

Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

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Traditional Medicine Research 2025年第2期10卷 30-36页

作者： Abdur Rauf Zuneera Akram Naveed Muhammad Najla AlMasoud Taghrid Saad Alomar Saima Naz Abdul Wadood Chandni Hayat Marcello Iriti department of Chemistry University of SwabiAmbar 23561Pakistan department of Pharmacology Faculty of Pharmaceutical SciencesBaqai Medical UniversityKarachi 74600Pakistan department of Pharmacy Abdul Wali Khan University MardanMardan 23200Pakistan department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia department of Biotechnology BKUC-Bacha Khan University CharsaddaCharsadda 24620Pakistan department of Biochemistry Abdul Wali Khan University MardanMardan 23200Pakistan department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20129Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) Firenze 50121Italy

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and *** study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia ***:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were *** docking studies were conducted using a molecular operating ***:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µ*** antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%*** docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/***:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

关键词： Pistacia chinensis Bunge antioxidant DPPH assay antilipoxygenase docking analysis