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Epilepsy associated tumors: Review article

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World Journal of Clinical Cases 2014年第11期2卷 623-641页

作者： Marco Giulioni Gianluca Marucci Matteo Martinoni Anna Federica Marliani Francesco Toni Fiorina Bartiromo Lilia Volpi Patrizia Riguzzi Francesca Bisulli Ilaria Naldi Roberto Michelucci Agostino Baruzzi Paolo Tinuper Guido Rubboli IRCCS Institute of Neurological sciences of Bologna Division of Neurosurgery Bellaria Hospital 40139 Bologna Italy department of biomedical and neuromotor sciences (dibinem) Section of Pathology "M.Malpighi" Bellaria Hospital University of Bologna 40139 Bologna Italy IRCCS Institute of Neurological sciences of Bologna Section of Neuroradiology Bellaria Hospital 40139 Bologna Italy department of Specialistic Diagnostic and Experimental Medicine (DIMES) Section of NeuroradiologyUniversity of Bologna 40139 Bologna Italy IRCCS Institute of Neurological sciences of Bologna Division of Neurology Bellaria Hospital 40139 Bologna Italy IRCCS Institute of Neurological sciences of Bologna Bellaria Hospital 40139 Bologna Italy department of biomedical and neuromotor sciences University of Bologna 40139 Bologna Italy Danish Epilepsy Centre Epilepsi hospitalet4293 Dianalund Denmark

Long-term epilepsy associated tumors(LEAT) represent a well known cause of focal epilepsies. Glioneuronaltumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly ariseing in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic networkwith complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.

关键词： Epilepsy Low grade tumors Long-term epilepsy associated tumors Glioneuronal tumors Ganglioglioma Dysembryoplastic neuroepithelial tumor Lesionectomy Epilepsy surgery

Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli Aude Simongiovanni Tristan Chalvon-Demersay Maddalena Zini Luciano Fusco Paolo Bosi Paolo Trevisi department of Agricultural and Food sciences University of Bologna40127 BolognaItaly department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance department of biomedical and neuromotor sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(P<0.05)in the sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(P<0.10)in the sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,Erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(P<0.05).Furthermore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(P<0.05)in the sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,P<0.10)at d 20 in the milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy

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四川生理科学杂志 2022年第5期44卷 897-897页

作者： Yao-Chung Liu From the department of Pathology Brigham and Women's Hospital (Y.-C.L. C. Gao Jun Liu J.Y. L. Chai) Harvard Stem Cell Institute Harvard Medical School (A.I.J. M.A.B. D.G.T.) and the Department of Medical Oncology Dana-Farber Cancer Institute (R.P.) - all in Boston the Division of Hematology Department of Medicine Taipei Veterans General Hospital (Y.-C.L.) and the Faculty of Medicine and the Program in Molecular Medicine Institute of Biopharmaceutical Sciences School of Life Science National Yang Ming Chiao Tung University (Y.-C.L. J.-H.L.) - both in Taipei Taiwan the Cancer science Institute of Singapore Singapore (J.K. Y.V.L. H.Y. M.A.B. D.G.T.) the department of Biomedicine and Prevention University of Rome Tor Vergata (E.F. G.F. L.V. C. Gurnari M.T.V.) and UniCamillus-Saint Camillus International University of Health Sciences (E.F.) Rome and Cellular Signaling Laboratory Department of Biomedical and Neuromotor Sciences University of Bologna (M.Y.F. L. Cocco) and IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" (C.F.) Bologna - all in Italy the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China (Z.X. Jinqin Liu H.H.) and the School of Medical sciences and Lowy Cancer Research Centre (J.A.I.T. J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U. J.E.P.) Faculty of Medicine University of New South Wales Sydney and the Department of Hematology Prince of Wales Hospital Randwick NSW (J.E.P.) - both in Australia.

Background:Although hypomethylating agents are currently used to treat patients with cancer,whether they can also reactivate and up-regulate oncogenes is not well ***:We examined the effect of hypomethylating agents on SALL4,a known oncogene that plays an important role in myelodysplastic syndrome and other *** bone marrow samples that were obtained from two cohorts of patients with myelodysplastic syndrome before and after treatment with a hypomethylating agent were used to explore the relationships among changes in SALL4 expression,treatment response,and clinical *** cell lines with low or undetectable SALL4 expression were used to study the relationship between SALL4 methylation and expression.A locus-specific demethylation technology,CRISPR-DNMT1-interacting RNA(CRISPR-DiR),was used to identify the CpG island that is critical for SALL4 expression.

关键词： SALL4 expression. patients