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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina department of biomedical engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei Yin Liting Yin Shiyuan Qu Fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic engineering Xidian UniversityXi’an 710071People’s Republic of China department of Aerospace and Mechanical engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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Smart Gas Sensors:Recent Developments and Future Prospective

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Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang Zong Shufang Wu Yuehong Yang Qiuju Li Tian Tao Shun Mao College of Environmental Science and engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

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具有抗炎抗氧化作用的可注射壳聚糖微球用于缓解椎间盘退变（英文）

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Science China Materials 2025年

作者：黄林王挽涛刘磊马文政范景皓周丹赵磊郑召民刘洪梅吴德成 Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical Engineering Southern University of Science and Technology department of Spine Surgery The First Affiliated Hospital Pain Research Center Sun Yat-sen University

由于椎间盘（IVD）特殊缺血性的组织结构,治疗椎间盘退变是一项巨大的挑战.椎间盘退变的治疗是一个复杂的过程,包括调节细胞炎症因子和氧化应力,恢复髓核细胞活性,并重建椎间盘生物力学功能.在此,我们构建了一种MnO2纳米酶和celecoxib...

由于椎间盘（IVD）特殊缺血性的组织结构,治疗椎间盘退变是一项巨大的挑战.椎间盘退变的治疗是一个复杂的过程,包括调节细胞炎症因子和氧化应力,恢复髓核细胞活性,并重建椎间盘生物力学功能.在此,我们构建了一种MnO2纳米酶和celecoxib药物胶束共同负载的可注射壳聚糖微球（CS-MnO2@PC）.体外细胞实验证明,这种复合微球具有较好的自由基清除、缓解细胞氧化应力、降低髓核细胞中炎症因子的表达等功能.体内实验进一步表明,该混合载体可以维持纤维环（AF）组织的板层结构和髓核（NP）组织的水合状态,这已通过影像学和组织切片学评估得以证实.这种纳米酶和药物胶束共同负载的可注射壳聚糖微球为治疗椎间盘退变提供了一种有效策略.

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Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.Robert Singh Gyanendra Prasad Joshi Woong Cho School of Computing Sastra Deemed to be UniversityThanjavur613401India department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India department of AI and Software engineering Kangwon National UniversitySamcheok25913Republic of Korea department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of biomedical engineering of southern Medical university(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

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Model Reference Adaptive Control for Networked Distributed Systems with Strong Interconnections and Communication Delays

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Journal of Systems Science & Complexity 2018年第1期31卷 38-68页

作者： LYMPEROPOULOS Georgios IOANNOU Petros department of Electrical engineering University of Southern California

In recent years, networked distributed control systems（NDCS） have received research attention. Two of the main challenges that such systems face are possible delays in the communication network and the effect of strong interconnections between agents. This paper considers an NDCS that has delays in the communication network, as well as strong interconnections between its agents. The control objective is to make each agent track efficiently a reference model by attenuating the effect of strong interconnections via feedback based on the delayed information. First, the authors assume that each agent knows its own dynamics, as well as the interconnection parameters, but receives information about the states of its neighbors with some communication delay. The authors propose a distributed control scheme and prove that if the interconnections can be weakened and if the communication delays are small enough, then the proposed scheme guarantees that the tracking error of each agent is bounded with a bound that depends on the size of the weakened interconnections and delays, and reduces to zero as these uncertainties reduce to zero. The authors then consider a more realistic situation where the interconnections between agents are unknown despite the cooperation and sharing of state information. For this case the authors propose a distributed adaptive control scheme and prove that the proposed scheme guarantees that the tracking errors are bounded and small in the mean square sense with respect to the size of the weakened interconnections and delays, provided the weakened interconnections and time delays are small enough. The authors then consider the case that each agent knows neither its dynamics nor the interconnection matrices. For this case the authors propose a distributed adaptive control scheme and prove that the proposed scheme guarantees that the tracking errors are bounded and small in the mean square sense provided the weakened interconnections and time delays are

关键词： Adaptive control network distributed control delay systems

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Synthesis,Characterizations and Applications of Cadmium Chalcogenide Nanowires:A Review

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Journal of Materials Science & Technology 2015年第6期31卷 556-572页

作者： Liubing Huang Jia Grace Lu department of Physics and department of Electrical engineering University of Southern California

Cadmium chalcogenide nanowires have demonstrated superior electrical and optical properties,and have emerged as prominent building blocks for nanoscale electronic and optoelectronic *** addition to the effort devoted to advance techniques of fabricating high quality nanowires,much has been endeavored to elucidate their unique physical properties for better design and development of functional devices with low power consumption and high ***,this article provides a comprehensive review of the forefront research on cadmium chalcogenide nanowires,ranging from material synthesis,property characterizations,and device applications.

关键词： Cadmium chalcogenide Nanowire synthesis Electrical

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Electron-beam lithography for polymer bioMEMS with submicron features

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Microsystems & Nanoengineering 2016年第1期2卷 45-51页

作者： Kee Scholten Ellis Meng department of biomedical engineering University of Southern CaliforniaLos AngelesCA 90089-1111USA

We present a method for submicron fabrication of flexible,thin-film structures fully encapsulated in biocompatible polymer poly(chloro-p-xylylene)(Parylene C)that improves feature size and resolution by an order of magnitude compared with prior *** achieved critical dimensions as small as 250 nm by adapting electron beam lithography for use on vapor deposited Parylene-coated substrates and fabricated encapsulated metal structures,including conducting traces,serpentine resistors,and nano-patterned *** were probed electrically and mechanically demonstrating robust performance even under flexion or *** developed fabrication process for electron beam lithography on Parylene-coated substrates and characterization of the resulting structures are presented in addition to a discussion of the challenges of applying electron beam lithography to *** an application of the technique,a Parylene-based neural probe prototype was fabricated with 32 recording sites patterned along a 2 mm long shank,an electrode density surpassing any prior polymer probe.

关键词： electron beam lithography flexible electronics parylene C polymer MEMS

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=unctional interlayer of PVDF-HFP and carbon nanofiber for long-life lithium-sulfur batteries

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Nano Research 2018年第6期11卷 3340-3352页

作者： Anyi Zhang Xin Fang Chenfei Shen Yihang Liu In Gi Seo Yuqiang Ma Liang Chen Patrick Cottingham Chongwu Zhou Mork Family department of Chemicol engineering and Materials Science University of Southern California Los Angeles California 90089 USA Ming Hsieh department of Electrical engineering University of Southern California Los Angeles California 90089 USA department of Physics and Astronomy University of Southern California Los Angeles California 90089 USA department of Chemistry University of Southern California Los Angeles California 90089 USA

In the present work we develop a scalable and inexpensive design for lithium- sulfur （Li-S） batteries by capping a flexible gel polymer/carbon nanofiber （CNF） composite membrane onto a free-standing and binder-free CNF ＋ ni2s6 cathode, thus achieving a three-dimensional （3D） structural design. The CNF network is used as the current collector and S holder to overcome the insulating nature and volume expansion of S, while the composite membrane comprises a gel polymer poly（vinylidene fluoride-co-hexafluoropropylene）（PVDF-HFP）, and CNF additive is used as an interlayer to trap polysulfides and recycle the remaining S species, leading to a high specific capacity and long cycle life. This 3D structure enables excellent cyclability for 500 cycles at 0.5℃ with a small capacity decay of 0.092% per cycle. Furthermore, an outstanding cycle stability was also achieved at even higher current densities （1.0 to 2.0℃）, indicating its good potential for practical applications of Li-S batteries.

关键词： lithium-sulfur batteries poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP) gel polymer electrolyte carbon nanofiber conductive network

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Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer

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Visual Computing for Industry,Biomedicine,and Art 2018年第1期1卷 18-23页

作者： Yuqi Tang Wei Liu Yang Li Qifa Zhou Junjie Yao department of biomedical engineering Duke UniversityDurhamNC 27708USA department of Ophthalmology Department of Biomedical EngineeringUniversity of Southern CaliforniaLos AngelesCA 90089USA

Simultaneous photoacoustic and ultrasound(PAUS)imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of ***,the resolution for majority of the existing PAUS systems is on the order of 1 mm as the majority are designed for clinical use with low-frequency US *** we developed a concurrent PAUS microscopy that consists of optical-resolution photoacoustic microscopy(OR-PAM)and high-frequency US pulse-echo *** dual-modality system utilizes a novel coaxial dual-element ultrasonic transducer(DE-UST)and provides anatomical and functional information with complementary contrast mechanisms,achieving a spatial resolution of 7μm for PA imaging and 106μm for US *** performed phantom studies to validate the system’s *** vasculature of a mouse’s hind paw was imaged to demonstrate the potential of this hybrid system for biomedical applications.

关键词： Photoacoustic microscopy Ultrasound microscopy Concurrent imaging Coaxial dual-element ultrasonic transducer

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