检索结果-南通市图书馆

High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of department of Orthopaedics&Traumatology and Innovative Orthopaedic biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic department Peking University Third HospitalBeijingChina department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy biomaterials Endochondral ossification

Unveiling the oral-gut connection:chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE^(−/−)Mice on a high-fat diet

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第3期16卷 515-527页

作者： Guowu Gan Shihan Lin Yufang Luo Yu Zeng Beibei Lu Ren Zhang Shuai Chen Huaxiang Lei Zhiyu Cai Xiaojing Huang Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral biomaterial&Stomatology Key Laboratory of Fujian College and University School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Institute of Stomatology&Research Center of Dental and Craniofacial Implants School and Hospital of StomatologyFujian Medical UniversityFuzhouChina department of Stomatology Fujian Medical University Union HospitalFuzhouChina

The aim of this study was to explore the impact of chronic apical periodontitis(CAP)on atherosclerosis in apoE^(−/−)mice fed high-fat diet(HFD).This investigation focused on the gut microbiota,metabolites,and intestinal barrier function to uncover potential links between oral health and cardiovascular disease(CVD).In this study,CAP was shown to exacerbate atherosclerosis in HFD-fed apoE^(−/−)mice,as evidenced by the increase in plaque size and volume in the aortic walls observed via Oil Red O staining.16S rRNA sequencing revealed significant alterations in the gut microbiota,with harmful bacterial species thriving while beneficial species *** profiling indicated disruptions in lipid metabolism and primary bile acid synthesis,leading to elevated levels of taurochenodeoxycholic acid(TCDCA),taurocholic acid(TCA),and tauroursodeoxycholic acid(TDCA).These metabolic shifts may contribute to atherosclerosis ***,impaired intestinal barrier function,characterized by reduced mucin expression and disrupted tight junction proteins,was *** increased intestinal permeability observed was positively correlated with the severity of atherosclerotic lesions,highlighting the importance of the intestinal barrier in cardiovascular *** conclusion,this research underscores the intricate interplay among oral health,gut microbiota composition,metabolite profiles,and CVD *** findings emphasize the importance of maintaining good oral hygiene as a potential preventive measure against cardiovascular issues,as well as the need for further investigations into the intricate mechanisms linking oral health,gut microbiota,and metabolic pathways in CVD development.

关键词： atherosclerosis metabolism impaired

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 281-299页

作者： Bitao Lu Enling Hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital ***,multiple hemostatic strategies are critical for treating large bleeding *** this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug *** aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug *** ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally *** novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

Prosthetic venous valves for chronic venous insufficiency:Advancements and future design directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicine in Novel Technology and Devices 2024年第1期21卷 10-22页

作者： Qiushuo Zong Jing Liu Yunfei Chen Yuanyuan Kong Yiping Dang Zhihong Wang department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Tianjin Key Laboratory of biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Institute of Transplant Medicine Nankai University School of MedicineTianjin300071China

With the serious aging population and lifestyle changes,chronic venous insufficiency accounts for approximately 25.95%of the population,which may lead to lower limb edema and leg heaviness,as well as severe infections of skin ulcers that can result in sepsis and necessitate *** treatment and other supportive measures can only slow the disease's progression but are unable to drastically reverse it;surgical interventions are rarely used due to the high risk of catastrophic postoperative *** one of the most promising minimally invasive therapies,percutaneous prosthetic valve replacement has emerged in light of this situation,providing novel alternatives for patients with deep venous valve *** reviewed the historical prosthetic venous valve designs,including their structure and materials,animal evaluation models,and assessment *** the basis of the findings from in vitro tests,animal studies,and clinical trials,we summarized the major challenges and potential solutions for the development of advanced prosthetic venous valves.

关键词： Prosthetic venous valves Interventional venous valves Deep venous valve insufficiency Deep venous valve reflux Valve leaflets Valve design

Thin layers of Fe doped ZnO deposited by spin-coating for electrolysis and photodetector applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年

作者： Dikra BOURAS Mamoun FELLAH Regis BARILLE Amjad IQBAL Hamadi FOUZIA Obrosov ALEKSEI Gamal A.EL-HITI Faculty of Science and Technology， University of Souk-Ahras Mechanical Engineering department， ABBES Laghrour University biomaterial， Synthesis and Tribology Research team， ABBES Laghrour-University MOLTECH-Anjou， Université d'Angers/UMR CNRS 6200 department of Materials Technologies， Faculty of Materials Engineering， Silesian University of Technology Matter science department， ABBES Laghrour University Brandenburg University of Technology Cottbus-Senftenberg department of Optometry， College of Applied Medical Sciences， King Saud University

ZnO is nowadays not only used as an additive for the copper and cement industry， but also in medicine and cosmetic industry as part of the substitute materials of choice for the field of new technologies such as renewable energy. This study aims to investigate the effect of iron concentration on the microstructural and structural properties of ZnO for Electrolysis and Photodetector Applications. The Thin layers of un-doped and doped ZnO with different percentages of Fe （2， 4， and 6 wt.%） were deposited by spin-coating on glass substrates. Sample characterization was done by X-ray diffraction （XRD）， Atomic force microscopy （AFM）， Scanning electron microscopy （SEM）， energy-dispersive X-ray spectroscopy （EDS）， UV-visible absorption spectra and X-ray photoelectron spectroscopy （XPS）. Structural measurements by XRD show that all the layers are polycrystalline with a hexagonal Wurtzite structure. Two new peaks were also discovered after the doping process （400） and （440） belonging to the Fe2O4crystal phase spectrum. Morphological analysis showed that the surface roughness values of ZnO layers ranged between 8 and 45 nm. XPS studies confirmed the presence of Fe in +3 states in ZnO layers. An average transmittance of 90% was measured by UV- in the wavelength range of 200-900 nm. The values of the energy gap （Eg） decreased with an increase in the concentration of Fe. AFM topography results confirmed that ZnO-based thin layers have a relatively uniform surface. The efficiency of these samples has been confirmed for their use in many electrical applications， including photodetectors and electrolysis of contaminated solutions.

关键词：

Characterization of Hydroxyapatite Extracted from Crab Shell Using the Hydrothermal Method with Varying Holding Times

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第6期12卷 1145-1163页

作者： Deni Fajar Fitriyana Rifky Ismail Athanasius Priharyoto Bayuseno Januar Parlaungan Siregar Tezara Cionita department of Mechanical Engineering Faculty of EngineeringDiponegoro UniversitySemarangJawa Tengah50275Indonesia department of Mechanical Engineering Faculty of EngineeringUniversitas Negeri SemarangGunung PatiSemarang50229Indonesia Center for Biomechanics BiomaterialBiomechatronicsand Biosignal Processing(CBIOM3s)Diponegoro UniversitySemarang50275Indonesia Automotive Engineering Center(AEC) Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)PahangMalaysia Faculty of Mechanical&Automotive Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahPekan26600Malaysia Faculty of Engineering and Quantity Surveying INTI International UniversityNilaiMalaysia

Hydroxyapatite(HA)is a bio ceramic commonly utilized in bone tissue engineering due to its bioactive and osteoconductive *** shells are usually disregarded as waste material despite their significant CaCO_(3) content,and have not been widely utilized in the synthesis of *** study aims to synthesize and analyze HA derived from crab shells using the hydrothermal method with different durations of holding *** study utilized precipitated calcium carbonate(PCC)derived from crab *** a hydrothermal reactor set at 160℃ and varying holding times of 14(HA_14),16(HA_16),and 18(HA_18)h,a PCC and(NH4)2HPO4 mixture was used to synthesize *** synthesis results were analyzed using scanning electron microscopy(SEM),fourier transform infrared spectroscopy(FTIR),and X-ray diffraction(XRD)*** study has accomplished the synthesis of HA from crab ***,the final product of synthesis still contained CaCO_(3) as an *** prolonged hydrothermal holding time of 14 to 18 h resulted in a reduction of impurities while increasing the percentage of crystal weight and crystallite size of *** CH_18 is the best-quality product generated in this *** specimen produced HA with the highest percentage of crystal weight and crystallite size compared to the other ***,specimen CH_18 exhibited the lowest concentration of *** Ca/P ratio in this specimen was also the closest to *** Ca/P ratio,crystallite size,and crystal weight percentage of this specimen are 1.54,19.06 nm,and 99.1%,respectively.

关键词： Hydroxyapatite crab shells CaCO_(3) hydrothermal holding time

CELL ADHESION AND SURFACE PROPERTIES OF POLYSTYRENE SURFACES GRAFTED WITH POLY(N-ISOPROPYLACRYLAMIDE)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2013年第11期31卷 1509-1518页

作者： Esmaeil Biazar Mohammad Taghi Khorasani Morteza Daliri Joupari department of Biomedical Engineering Science and Research BranchIslamic Azad University biomaterial department of Iran Polymer and Petrochemical Institute National Research Center for Genetic Engineering and Biotechnology

Cell adhesion plays a key role in various aspects of biological and medical sciences. In this study, poly（N- isopropylacrylamide）（PNIPAM） was grafted on polystyrene surfaces using different solvents under UV radiation. Moreover, the relation between surface roughness and cell adhesion were evaluated by gravimetric, SEM, AFM, contact angle measurement and cellular analyses. The gravimetric analysis clearly indicated an increase in the grafting by adding 10% methanol to water. The study of surface topography by AFM images showed an increase in the surface roughness and as a result of which, a decrease in wettablity was observed. At 37 ~C, epithelial ceils were well attached and proliferated on the grafted surfaces, while these cells were spontaneously detached below 32 ℃ in the absence of any enzymes. Moreover, MTT assay and SEM images indicated good cell viability and an increase in cell adhesion caused by the roughness increase. The results of this study reveal the great potential of PNIPAM-grafted polystyrene for being used in the biomedical fields such as drug delivery systems, tissue engineering and cell separation.

关键词： Grafting Solvent effect PNIPAM Cell adhesion Surface roughness.

Comparative study of chitosan/fibroin–hydroxyapatite and collagen membranes for guided bone regeneration in rat calvarial defects: micro-computed tomography analysis

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2014年第2期6卷 87-93页

作者： Jae Min Song Sang Hun Shin Yong Deok Kim Jae Yeol Lee Young Jae Baek Sang Yong Yoon Hong Sung Kim department of Oral and Maxillofacial Surgery School of Dentistry Pusan National University Yangsan Korea department of biomaterial Science Pusan National University Miryang Korea

This study aimed to utilize micro-computed tomography （micro-CT） analysis to compare new bone formation in rat calvarial defects using chitosan/fibroin-hydroxyapatite （CFB-HAP） or collagen （Bio-Gide） membranes. Fifty-four （54） rats were studied. A circular bony defect （8 mm diameter） was formed in the centre of the calvaria using a trephine bur. The CFB-HAP membrane was prepared by thermally induced phase separation. In the experimental group （n= 18）, the CFB-HAP membrane was used to cover the bony defect, and in the control group （n= 18）, a resorbable collagen membrane （Bio-Gide） was used. In the negative control group （n= 18）, no membrane was used. In each group, six animals were euthanized at 2, 4 and 8 weeks after surgery. The specimens were then analysed using micro-CT. There were significant differences in bone volume （BV） and bone mineral density （BMD）（P〈O.05） between the negative control group and the membrane groups. However, there were no significant differences between the CFB-HAP group and the collagen group. We concluded that the CFB-HAP membrane has significant potential as a guided bone regeneration （GBR） membrane.

关键词： chitosan/fibroin-hydroxyapatite collagen membrane guided bone regeneration micro-computed tomography rat calva rial defect

Expert consensus on the diagnosis and therapy of endo-periodontal lesions

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第3期16卷 381-389页

作者： Bin Chen Yanan Zhu Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song Ge Jiang Lin Yaping Pan Yan Xu Yi Ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue Xuedong Zhou Fuhua Yan department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina department of Endodontics Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province&Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral biomaterial School and Hospital of StomatologyFujian Medical UniversityFuzhouChina department of Periodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina School and Hospital of Stomatology Zunyi Medical UniversityZunyiChina department of Stomatology Beijing TongRen HospitalCapital Medical UniversityBeijingChina department of Periodontics School and Hospital of StomatologyChina Medical UniversityShenyangChina department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Key Laboratory of Oral DiseasesNanjing Medical UniversityNanjingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Periodontics West China Hospital of StomatologySichuan UniversityChengduChina department of Periodontology School and Hospital of StomatologyShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases JinanJinanChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of periodontologySchool of StomatologyThe Fou

Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing *** etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical ***,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal *** compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

关键词： diagnosis periodontal lesions