检索结果-南通市图书馆

Journal of Genetics and Genomics 2016年第4期43卷 179-186页

作者： Dongyu Jia Jamal Bryant Allison Jevitt Gabriel Calvin Wu-Min Deng department of biological science Florida State University

Metazoan development requires coordination of signaling pathways to regulate patterns of gene *** Drosophila,the wing imaginal disc provides an excellent model for the study of how signaling pathways interact to regulate pattern *** determination of the dorsal-ventral（DV） boundary of the wing disc depends on the Notch pathway,which is activated along the DV boundary and induces the expression of the homeobox transcription factor,***,we show that Broad（Br）,a zinc-finger transcription factor,is also involved in regulating Cut expression in the DV boundary ***,Br expression is not regulated by Notch signaling in wing discs,while ecdysone signaling is the upstream signal that induces Br for Cut ***,we find that the ecdysone-Br cascade upregulates cut-lacZ expression,a reporter containing a 2.7 kb cut enhancer region,implying that ecdysone signaling,similar to Notch,regulates cut at the transcriptional ***,our findings reveal that the Notch and ecdysone signaling pathways synergistically regulate Cut expression for proper DV boundary formation in the wing ***,we show br promotes Delta,a Notch ligand,near the DV boundary to suppress aberrant high Notch activity,indicating further interaction between the two pathways for DV patterning of the wing disc.

关键词： Ecdysone Notch Broad Cut Drosophila Wing disc Dorsal-ventral boundary

Passive activity enhances residual control ability in patients with complete spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The state Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

Zika virus and neural developmental defects: building a case for a cause

在线全文

学校读者我要写书评

暂无评论

science China(Life sciences) 2016年第5期59卷 536-538页

作者： Sarah C Ogden Christy Hammack Hengli Tang department of biological science Florida State University

Zika virus （ZIKV）, a little-known .flavivirus until a few months ago, is currently at the forefront of public health concerns worldwide because of its suspected role in causing microcephaly and other developmental defects in fetuses of infected mothers. On February 1, 2016, the World Health Organization declared a Public Health Emergency of Inter- national Concern （PHEIC） for ZIKV. Discovered more than half a century ago in Uganda,

关键词：神经发育病毒缺陷事业世界卫生组织健康问题公共卫生乌干达

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2015年第2期30卷 130-145页

作者： Denis Avey Brittany Brewers Fanxiu Zhu department of biological science florida state university Tallahassee 32306 USA

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.

关键词： Kaposi’s sarcoma-associated herpesvirus(KSHV) Kaposi’s sarcoma epigenetic epigenome herpesvirus oncovirus chromatin

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第2期9卷 261-270页

作者： Danyu Kong Yueling Hao Hongchang Cui department of biological science Florida State University Tallahassee FL 32306 USA

Sugars promote lateral root formation at low levels but become inhibitory at high C/N or C/P ratios. How sugars suppress lateral root formation is unclear, however. Here we report that WOX7, a member of the WUSCHEL related homeobox （WOX） family transcription factors, inhibits lateral root development in a sugar-dependent manner. The number of lateral root primordia increased in wox7 mutants but decreased in plants over-expressing WOX7o Plants expressing the WOX7-VP16 fusion protein produced even more lateral roots than wox7, suggesting that WOX7 acts as a transcriptional repressor in lateral root develop- ment. WOX7 is expressed at all stages of lateral root development, but it is primarily involved in lateral root initiation. Consistent with this, the wox7 mutant had a higher mitotic activity only at early stages of lateral root development. Further studies suggest that WOX7 regulates lateral root development through direct repression of cell cycle genes, particularly CYCD6;1. WOX7 expression was enhanced by sugar, reduced by auxin, but did not respond to salt and mannitoh In the wox7 mutant, the effect of sugar on lateral root formation was mitigated. These results together suggest that WOX7 plays an important role in coupling the lateral root development program and sugar status in plants.

关键词： WOX7, CYCD6 1, lateral root, sugar signaling, auxin, abiotic stress

Cell competition and its implications for development and cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2011年第10期38卷 483-495页

作者： Yoichiro Tamori department of biological science Florida State UniversityTallahasseeFL 32306-4370USA

Cell competition is a struggle for existence between cells in heterogeneous tissues of multicellular organisms. Loser cells, which die during cell competition, are normally viable when grown only with other loser cells, but when mixed with winner cells, they are at a growth disadvantage and undergo apoptosis. Intriguingly, several recent studies have revealed that cells bearing mutant tumor-suppressor genes, which show overgrowth and tumorigenesis in a homotypic situation, are frequently eliminated, through cell competition, from tissues in which they are surrounded by wild-type cells. Here, we focus on the regulation of cellular competitiveness and the mechanism of cell competition as inferred from two different categories of mutant cells：（1） slower-growing cells and （2） structurally defective cells. We also discuss the possible role of cell competition as an intrinsic homeostasis system through which normal cells sense and remove aberrant cells, such as precancerous cells, to maintain the integrity and normal development of tissues and organs.

关键词： Cell competition Canalization Competition-dependent cell death Drosophila models Cellular proliferation Cellular growth Tumor-suppressor genes

Middle Cortex Formation in the Root： An Emerging Picture of Integrated Regulatory Mechanisms

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第6期9卷 771-773页

作者： Hongchang Cui department of biological science Florida State University Tanahassee FL 32306 USA

Located between the epidermis and endodermis, cortex is a major constituent of the ground tissue in plants. Cortex is initially derived from the same initial cell that gives rise to the endodermis, another cell type of ground tissue. Subsequently, the endodermis can divide repeatedly, producing multiple layers of cortex while maintaining a single layer of endodermis. This is the case in most plant species, but in the root of Arabidopsis thaliana there are generally only one or two cortex cell layers （Baum et al., 2002）. The second layer, called the middle cortex （MC）, is not produced until the seedling is 1 week old （Figure 1）. Although MC formation seems to be a very simple process of cell proliferation, studies in the past decade have shown that it is regulated by multiple genes and signaling pathways. Some signaling pathways even act in an unexpected manner. Thus, it is essential to understand the mechanisms underlying MC formation for a comprehensive understanding of the roles of various signaling pathways in plant growth and development.

关键词： major divide maintaining

NAC1 goes TOPLESS to manage cortex proliferation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第5期16卷 804-805页

作者： Hongchang Cui department of biological science Florida State UniversityTallahasseeFL 32306USA

Tissue proliferation is a fundamental process in plant growth and *** a relatively undifferentiated cell type,the cortex makes up the bulk of the ground tissue in most plant *** the root of Arabidopsis thaliana,however,the cortex has a limited ability to *** the apical meristem of young seedlings(within 1 week of seed germination),only one layer of the cortex is present;as the root matures,a second layer of the cortex starts to form in the elongation zone as a result of an asymmetric cell division of the endodermis,another cell type in the ground tissue(Cui and Benfey,2009a,Figure 1A).In the roots of rice and maize,the cortex/endodermis initial(CEI)undergoes multiple rounds of *** the innermost cell layer is differentiated into the endodermis;the outer layers of cells become the cortex by default.

关键词： species Figure default

Molecular genetics of cancer and tumorigenesis:Drosophila models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2011年第10期38卷 429-430页

作者： Wu-Min Deng department of biological science Florida State University Tallahassee FL 32306-4295 USA

Why do some cells not respond to normal control of cell division and become tumorous？ Which signals trigger some tumor cells to migrate and colonize other tissues？ What genetic factors are responsible for tumorigenesis and cancer development？ What environmental factors play a role in cancer formation and progression？ In how many ways can our bodies prevent and restrict the growth of cancerous cells？ How can we identify and deliver effective drugs to fight cancer？ In the fight against cancer, which kills more people than any other disease, these and other questions have long interested researchers from a diverse range of fields. To answer these questions and to fight cancer more effectively,

关键词： Molecular genetics cancer and tumorigenesis Drosophila

G-Quadruplex(G4) Motifs in the Maize(Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status,Hypoxia,Low Sugar,and Nutrient Deprivation

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2014年第12期41卷 627-647页

作者： Carson M.Andorf Mykhailo Kopylov Drena Dobbs Karen E.Koch M.Elizabeth Stroupe Carolyn J.Lawrence Hank W.Bass USDA-ARS Corn Insects and Crop Genetics Research Unit Iowa State University department of Computer science Iowa State University Institute of Molecular Biophysics Florida State University department of Genetics Development and Cell BiologyIowa State University Plant Molecular and Cellular Biology Program Horticultural Sciences DepartmentGenetics InstituteUniversity of Florida department of biological science Florida State University department of Agronomy Iowa State University

The G-quadruplex （G4） elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix. This （34 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA. The reversibility and structural diversity of G4s make them highly versatile genetic structures, as demonstrated by their roles in various functions including telomere metabolism, genome maintenance, immunoglobulin gene diversification, transcription, and translation. Sequence motifs capable of forming G4 DNA are typically located in telomere repeat DNA and other non-telomeric genomic loci. To investigate their potential roles in a large-genome model plant species, we computationaily identified 149,988 non-telomeric G4 motifs in maize （Zea mays L., B73 AGPv2）, 29% of which were in non-repetitive genomic regions. G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand, one in the 5~ UTR and the other at the 5~ end of the first intron. Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures in vitro. The G4 motifs were prevalent in key regulatory genes associated with hypoxia （group VII ERFs）, oxidative stress （D J-1/GATasel）, and energy status （AMPK/ SnRK） pathways. They also showed statistical enrichment for genes in metabolic pathways that function in glycolysis, sugar degradation, inositol metabolism, and base excision repair. Collectively, the maize G4 motifs may represent conditional regulatory elements that can aid in energy status gene responses. Such a network of elements could provide a mechanistic basis for linking energy status signals to gene regulation in maize, a model genetic system and major world crop species for feed, food, and fuel.

关键词： Maize G-quadruplex G4 Hypoxia Sucrose synthase