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De novo Synthesis of Chiral 3,4-Dihydroquinazolines via One-Pot Enantioselective Ugi-Azide/Cyclization Sequences

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Chinese Journal of chemistry 2024年第18期42卷 2140-2146页

作者： Zu-Kui Xie Jun-Jun Ding Yi-Ming Ou Jun-Xiu Shi Meng-Lan Shen Chuan-Zhi Yao Hua-Jie Jiang Jie Yu department of Applied chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and Applicationand Anhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefeiAnhui 230036China

Background and Originality Content,3,4-Dihydroquinazoline frameworks have frequently been encountered in natural products and bioactive *** the past decades,these key structures prompted the development of creative pharmaceuticals owing to their prominent biological properties,including trypanothione reductase(TryR)inhibitor,Hepatitis B virus(HBV)inhibitive activities,anticancer activities,etc.(Scheme 1A).[1]Notably,the chirality of the C4 atom is crucial for drug *** example,the DPC-083 is a potent reverse transcriptase inhibitor for the treatment of HIV infection but the undesired enantiomers exhibit virtually no activity.[ia]Therefore,developing synthetic methods for innovative chiral 4-substituted 3,4-dihydroquinazolines is significant and essential for drug discovery.

关键词： Anionic stereogenic-at-cobalt(ll)complex De novo synthesis post-Ugi transformation One-pot sequence Asymmetric synthesis Multicomponentreactions

Seed Priming with Potassium Nitrate Can Enhance Salt Stress Tolerance in Maize

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1819-1838页

作者： Bushra Rehman Asma Zulfiqar Houneida Attia Rehana Sardar Muneera A.Saleh Khalid H.Alamer Ibtisam M.Alsudays Faisal Mehmood Qamar uz Zaman Institute of Botany University of the PunjabLahore54590Pakistan department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia department of Botany Emerson UniversityMultan60000Pakistan biological Sciences department Faculty of Science and ArtsKing Abdulaziz UniversityRabigh21911Saudi Arabia department of Biology College of ScienceQassim UniversityBurydah52571Saudi Arabia department of chemistry Sciences The University of LahoreLahore54590Pakistan department of Environmental Sciences The University of LahoreLahore54590Pakistan

Salinity is a major abiotic stress that hinders plant development and productivity and influences agricultural *** priming is a technique used to boost germination and seedling growth under abiotic stress.A pot experiment was conducted to evaluate the impact of seed priming with potassium nitrate(KNO_(3))at various levels(0%,0.50%,1.00%and 1.50%)under salt stress(0,75,100 mM NaCl)on two maize verities(MNH360 and 30T60)for the growth,development and metabolic attributes results revealed that in maize variety MNH360,KNO_(3)priming’s significantly enhanced growth parameters than in maize variety 30T60 under control and salt-stressed *** with KNO_(3)enhanced carotenoids and total chlorophyll in the 30T60 variety that protected the maize plants from salt ***,it was shown that priming with 1.00%KNO_(3)acts as safeguarded to protect them from oxidative damage by salt stress minimizing reactive oxygen species(ROS)formation through increased levels of malondialdehyde(MDA),catalase(CAT),peroxidase(POD),ascorbate peroxidase(APX),and total soluble *** findings of the present study confirm that the use of the KNO_(3)seed priming technique is a lowcost,environmentally friendly technique for mitigating adverse impacts of salt stress in maize crops by activating the antioxidant defense system and improving chlorophyll and osmolyte contents.

关键词： Salinity Zea mays antioxidant enzymes growth seedlings oxidative damage

Functional characterization of(E)-β-caryophyllene synthase from lima bean and its up-regulation by spider mites and alamethicin

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Journal of Integrative Agriculture 2017年第10期16卷 2231-2238页

作者： LI Feng-qi FU Ning-ning ZHOU Jing-jiang WANG Gui-rong Institute of Plant and Environment protection Beijing Academy of Agriculture and Forestry Sciences Institute of Plant protection Chinese Academy of Agricultural Sciences department of biological chemistry and crop protect Rothamsted Research

（E）-β-Caryophyllene is a sesquiterpene compound widely distributed in plants and functions in plant defence. However, little is known about the sequence and function of （E）-β-caryophyllene synthase in lima bean （Phaseolus lunatus）. Here, we report a new full-length cDNA （PICAHS） encoding （E）-β-caryophyllene synthase, a possible key enzyme of plant defence. The cDNA of PICAHS contains an open reading frame of 1 761 bp, encoding a protein of 586 amino acids with a predicted mass of 67.95 kDa. The deduced amino acid sequence shows 52% identity with sesquiterpene synthase MtCAHS of Med- icago truncatula. Based on phylogenetic analysis, PICAHS is classified as the terpene synthases （TPS）-a subfamily. The recombinant enzyme, expressed in Escherichia coil, catalysed the formation of a major product （E）-β-caryophyllene （82%） and a minor product a-humulene （18%） from farnesyl dJphosphate. Real-time quantitative PCR （qRT-PCR） analysis found that the PICAHS transcript was significantly up-regulated in leaves after treatment with spider mites and alamethicin （ALA）, suggesting its ecological function in plant defence.

关键词： plant defence terpene synthases (E)--caryophyllene lima bean

Phosphatidylcholine protects against the hepatotoxicity of acrylamide via maintaining metabolic homeostasis of glutathione and glycerophospholipid

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Food Science and Human Wellness 2024年

作者： Yaoran Li Wei Jia Yiju Zhang Yong Wu Li Zhu Jingjing Jiao Yu Zhang department of Gastroenterology， the First Affiliated Hospital， Zhejiang University School of Medicine，Zhejiang Key Laboratory for Agro-Food Processing， College of Biosystems Engineering and Food Science， Zhejiang University department of Gastroenterology， the First Affiliated Hospital， Zhejiang University School of Medicine， Zhejiang Key Laboratory for Agro-Food Processing， College of Biosystems Engineering and Food Science， Zhejiang University College of Food Science and Technology， Yunnan Agricultural University College of chemistry and Life Sciences， Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticultural biological Resources， Chengdu Normal University department of Nutrition， School of Public Health， department of Clinical Nutrition of Affiliated Second Hospital， Zhejiang University School of Medicine

Acrylamide is classified as a Class 2A carcinogen and mainly metabolized to produce hepatotoxicity. Phosphatidylcholine is thought to protect the liver from damage， but the protective role of phosphatidylcholine on acrylamide-exposed metabolic disorders remains unclear. We investigated protective effect of phosphatidylcholine on the hepatic metabolism in rats exposed to acrylamide using metabolomics and molecular biology approaches. Overall， 32 endogenous effect biomarkers and 4 exposure biomarkers were identified as differential signature metabolites responsible for acrylamide exposure and phosphatidylcholine protection. Acrylamide exposure interferes with glutathione metabolism by consuming antioxidant glutathione， cysteine and L-ascorbic acid， and disrupts lipid and carbohydrate metabolism through reducing carnitine content and increasing lipid peroxidation. The phosphatidylcholine treatment reduces the expression of cytochrome P450 2E1， alleviates the oxidative stress and inflammation of the liver， and stabilizes the content of glutathione， and thus alleviates the disorder of glutathione. Meanwhile， phosphatidylcholine shifted acrylamide-induced phosphatidylcholine into lysophosphatidylcholine to storage from lysophosphatidylcholine to diacylglycerol， thereby maintaining metabolic homeostasis of glycerophospholipid. The results suggested that phosphatidylcholine supplementation alleviate the disorder of glutathione and lipid metabolism caused by acrylamide exposure， but not significantly change the levels of mercapturic acid adducts of acrylamide， providing the evidence for phosphatidylcholine protection against acrylamide-induced liver injury.

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TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water

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Journal of Environmental Sciences 2017年第8期29卷 208-216页

作者： Michael J.Plewa Elizabeth D.Wagner Susan D.Richardson Safe Global Water Institute and the Department of Crop Sciences University of Illinois at Urbana-Champaign department of chemistry and Biochemistry University of South Carolina

The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products（DBPs）. Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the *** a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects. In this study, we combine analytical chemical and biological data to resolve the forcing agents associated with mammalian cell cytotoxicity of drinking water samples from three cities. These data suggest that the trihalomethanes（THMs） and haloacetic acids may be a small component of the overall cytotoxicity of the organic material isolated from disinfected drinking water. Chemical classes of nitrogen-containing DBPs, such as the haloacetonitriles and haloacetamides, appear to be the major forcing agents of toxicity in these samples. These findings may have important implications for the design of epidemiological studies that primarily rely on the levels of THMs to define DBP exposure among populations. The TIC-Tox approach constitutes a beginning step in the process of identifying the forcing agents of toxicity in disinfected water.

关键词： DBPs CHO cell cytotoxicity Toxicity Additivity

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China department of chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical chemistry South China Normal UniversityGuangzhouGuangdong 510006China department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Rising from the dead: the power of genome editing

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Science China(Life Sciences) 2023年第12期66卷 2949-2951页

作者： Hongyuan Zheng Junyao Zhao Daowen Wang Zheng Qing Fu State Key Laboratory of Wheat and Maize crop Science College of Agronomyand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450002China department of biological Sciences University of South CarolinaColumbia SC 29208USA

To protect themselves against diverse pathogens, plants have developed sophisticated defense mechanisms. Hypersensitive response or the rapid localized death of plant cells is a major defense strategy deployed by plan... 详细信息

关键词： dead genome

Influence of Microorganisms Effective against Basal Rot and on Agronomic Parameters of Onion [Allium cepa L. (Amaryllidaceae)]

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Journal of Agricultural chemistry and Environment 2024年第3期13卷 282-299页

作者： Henriette Doukahonon Guigui Bi Zaï Pacôme Zaouli Alain Serge Coulibaly Juliette Ky Dedi Training and Research Unit of Sciences of Nature Laboratory of Biology and Improvement of Plant Production Nangui Abrogoua University Abidjan Cte dIvoire department of Plant Biology Training and Research Unit (UFR) of Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire

Onions are a horticultural crop of great economic, dietary and medicinal importance, and are highly prized by the Ivorian population. However, production remains low, due to a number of constraints, including parasitic attacks. The most frequent is fusariosis caused by Fusarium sp., a pathogen that causes enormous damage to onion crops. Faced with these attacks, chemical control appears to be ineffective, with consequences for human health and the environment. This is why the search for effective alternative methods that respect the environment and human health is so necessary. It is in this context that this study was carried out, with the general aim of controlling fusarium wilt in onion crops, with a view to improving onion production in Ivory Coast through the use of effective microorganisms. The experimental set-up used for this purpose was a fisher block with complete randomization, comprising three replicates. A fungal spore concentration of 106 spore/mL of Fusarium sp., three doses (1%;2.5% and 5% v/v) of EM and one dose of a chemical fungicide (30 mL/16L) were tested on young onion plants. Each block consisted of nine sub-plots with nine treatments. Health parameters (incidence and severity) and agronomic parameters (growth and yield) were assessed. Microbiological analysis of the EM revealed the presence of nine morphotypes of Trichoderma sp., Aspergillus clavatus, Aspergillus flavus, Aspergillus sp., Penicillium sp., Rhizopus sp., lactic acid bacteria of the Bacillus family and the yeast Saccharomyces cerevisiae. Field experimentation showed that the 5% EM microbial solution reduced the incidence and severity of fusariosis compared with the chemical fungicide, and proved to be the best. This dose reduced yield losses by 7.14%, while improving onion growth and yield by over 5%. The results demonstrated the ability of the EM solution to effectively control the causal agent of basal rot in onion crops.

关键词： Basal Rot Effective Microorganisms (EM) Fusarium sp. Onion

Molecular and functional characterization of a candidate sex pheromone receptor OR1 in Spodoptera fitura

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Insect Science 2017年第4期24卷 543-558页

作者： Qin-Hui Zhang Zhong-Nan Wu Jing-Jiang Zhou Yong-Jun Du College of Life Sciences Sichuan University Chengdu 610065 China Institute of Health & Environmental Ecology Wenzhou Medical University Wenzhou Zhejiang 325035 China department of biological chemistry and crop protection Rothamsted Research BBSRC Harpenden Herts. AL5 2JQ UK

Olfaction is primarily mediated by highly specified olfactory receptors （ORs）. Here, we cloned and identified an olfactory receptor, named SlituOR1 （Genbank no. JN835269）, from Spodoptera litura and found evidence that it is a candidate pheromone receptor. It exhibited male-biased expression in the antennae, where it was localized at the base of sensilla trichoidea, the antennal sensilla mainly responsive to pheromones in moths. Conserved orthologues of this receptor, found among known pheromone receptors within the Lepidoptera, and SlituOR1 were placed among a clade of candidate pheromone re- ceptors in a phylogeny tree of insect OR gene sequences. SlituOR1 showed differential expression in S. litura populations attracted to traps baited with different ratios of the two sex pheromone components （9Z,11E）-tetradecadienyl acetate （Z9E11-14：OAc） and （9Z,12E）-tetradecadienyl acetate （Z9E12-14：OAc）. Knocking down of SlituOR1 by RNA interference reduced the electroantennogram （EAG） response to Z9E11-14：OAc, and this result is consistent with the field trapping experiment. We infer that variation in transcrip- tion levels of olfactory receptors may modulate sex pheromone perception in male moths and could provide some of the flexibility required to maintain the functionality of com- munication with females when a population is adapting to a new niche and reproductive isolation becomes an advantage.

关键词： electroantennogram (EAG) individual variation in situ hybridization ol-factory receptor (9Z, 11E)-tetradecadienyl acetate (9Z, 12E)-tetradecadienyl acetate RNAinterference