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Reliability, Accuracy, and Use Frequency of Evaluation Methods for Amount of Tongue Coating

Chinese Journal of Integrative medicine 2019年第5期25卷 378-385页

作者： Su-Ryun Kim Dong-Hyun Nam department of biofunctional medicine and diagnosis College of Korean MedicineSangji UniversityWonju 26339Republic of Korea

Objective: To classify the evaluation methods for amount of tongue coating(TC) and investigate their reliability, accuracy, and frequency of use. Methods: Articles published from 1985 to 2015 were searched for evaluation methods for the amount of TC in PubMed and the Cochrane Library. Only clinical researches were included except protocol articles. The methods were classi?ed according to their characteristics. Results: Finally,113 articles were selected. The evaluation method for the amount of TC from the articles was classi?ed into 4 types: intuitive, specificative, computerized, and weighing TC. The reliability in the intuitive and specificative methods(κ=0.33–0.92) showed varying levels among the studies. In general, the amount of TC calculated by the speci?cative method(Spearman's r=0.68–0.80) was more strongly related to the directly measured value than to the value estimated by the computerized method(Pearson's r=0.442). The number of articles published on this topic has increased consistently, and the speci?cative method was the most frequently used. Despite the higher reliability of the computerized method, it has not been widely used. Conclusions: The high prevalence of the speci?cative method would continue in clinical practice because of its convenience and accuracy. However,to establish higher reliability, the limitation of the subjectivity of the assessors should be overcome through calibration training. In the computerized method, novel algorithms are needed to obtain a higher accuracy so that it can help the practitioners con?dently estimate the amount of TC.

关键词： tongue coating evaluation methods reliability accuracy frequency

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Unveiling the intricacies:Insight into gastroesophageal reflux disease

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World Journal of Gastroenterology 2025年第1期31卷 24-41页

作者： Nilanka Wickramasinghe Niranga Manjuri Devanarayana department of Physiology Faculty of MedicineUniversity of ColomboColombo 00800Western ProvinceSri Lanka department of Physiology Faculty of MedicineUniversity of KelaniyaRagama 11010Western ProvinceSri Lanka

Gastroesophageal reflux disease(GERD)poses a substantial global health challenge,with prevalence rates exhibiting geographical *** its widespread recognition,the exact prevalence and associated risk factors remain *** article comprehensively analyzed the global burden of GERD,shedding light on its risk factors,underlying pathophysiological mechanisms,current diagnostic modalities,evolving management strategies tailored to diverse patient profiles,and complex determinants contributing to treatment failures.A deeper comprehension of GERD is achieved by dissecting these intricate facets,paving the way for enhanced clinical management and improved patient outcomes.

关键词： Gastroesophageal reflux disease Risk factors Pathophysiological mechanisms diagnosis Management

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Relationships between Pathological Patterns and Vocal Qualities Estimated by Acoustic Parameters

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Chinese Journal of Integrative medicine 2015年第5期21卷 346-354页

作者： Young-Jae Park Young-Bae Park department of diagnosis and biofunctional medicine College of Korean MedicineKyung Hee University department of diagnosis and biofunctional medicine Kyung Hee University Hospital at Gangdong

Objective： To examine whether vocal characteristics estimated by acoustic parameters were associated with phlegm, yin deficiency, or cold-heat patterns. Methods： A total of 75 college students （males：females = 53：22） aged 19-24 years were enrolled in this study. Each subject was asked to complete the phlegm pattern questionnaire （PPQ）, yin deficiency questionnaire （YDQ） and cold-heat questionnaire （CHQ）. For the acoustic analysis, each subject was asked to produce a sustained vowel sound （/a/） for 3 s to be used to calculate acoustic parameters. Then, habitual fundamental frequency （F0）, jitter, shimmer, F0 tremor, mean F0, standard deviation of F0, maximum F0, minimum F0, normalized noise energy, harmonic-to-noise ratio, signal-to-noise ratio, amplitude tremor, and power ratio were calculated using the Dr. Speech software. Finally, four hierarchical regression models with pattern questionnaire scores as dependent variables were formed to examine which factors among acoustic parameters, sex, and age were predictive of those pattern scores. Results： PPQ, YDQ, heat, and cold pattern scores all formed significant regression model equations and the adjusted R2 values were 0.281, 0.164, 0.156, and 0.170, respectively. There were aging effects in the PPQ and YDQ models （standardized β =0.199, 0.271, respectively）. Vocal tremor-related Fo tremor and vocal ringing-related power ratio parameters were associated with PPQ and YDQ scores. Gender was directly predictive of PPQ and indirectly moderated the relationship between power ratio and YDQ score. Vocal pitch- related habitual F0 and mean F0 were associated with heat and cold scores. These results indicate that the vocal qualities of phlegm- and yin deficiency-susceptible subjects tend to be ringing and less tremorous, and those of heat- and cold-susceptible subjects tend to be high-pitched. Conclusion： Our study results suggest that vocal characteristics estimated by acoustic parameters are partially predictive of phlegm,

关键词： Chinese medicine syndrome oriental medicine acoustic parameters

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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei Du department of Pathology and Laboratory medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Development and Validation of A Lao Juan(劳倦)Questionnaire

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Chinese Journal of Integrative medicine 2015年第7期21卷 500-506页

作者： Kyu-Jin Yoon Young-Bae Park Young-Jae Park Min-Yong Kim department of diagnosis and biofunctional medicine College of Korean MedicineKyung Hee University department of diagnosis and biofunctional medicine Kyung Hee University Hospital at Gangdong Business School Kyung Hee University

Objectives： Lao Juan （LJ, 劳倦） is a syndrome described in Chinese medicine （CM） that manifests with fatigue, fever, spontaneous sweating, indigestion, work-induced pain, weakness of the limbs, and shortness of breath. The present study was conducted to examine the reliability and validity of a Lao Juan Questionnaire （LJQ）. Methods： A total of 151 outpatients and 73 normal subjects were asked to complete the LJQ. Seventy-three normal subjects were additionally asked to complete the Chalder Fatigue Scale （CFS）. Twelve clinicians determined whether the 151 outpatients exhibited LJ or not. The internal consistency and construct validity for the LJQ were estimated using data from the outpatient subjects. The CFS data were used to examine the concurrent validity of the LJQ. Total LJQ scores and the clinicians＇ diagnoses of the outpatients were used to perform receiver operating characteristics （ROC） curve analyses and to define an optimum cut-off score for the LJQ. Results： The 19-item LJQ had satisfactory internal consistency （α =0.828） and concurrent validity, with significant correlations between the LJQ and the CFS subscales. In the test of construct validity using principal component analysis, a total of six factors were extracted, and the overall variance explained by all factors was 59.5%. In ROC curve analyses, the sensitivity, specificity, and area under the curve were 76.0%, 59.2%, and 0.709, respectively. The optimum cut-off score was defined as six points. Conclusions： Our results suggest that the LJQ is a reliable and valid instrument for evaluating LJ.

关键词： Chinese medicine chronic fatigue syndrome Chinese medicine-pattern

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Cardiff acne disability index： cross-cultural translation in Korean and its relationship with clinical acne severity, pathological patterns, and general quality of life

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Journal of Traditional Chinese medicine 2017年第5期37卷 702-709页

作者： Kyeong-Han Kim Sang-Chul Lee Young-Bae Park Young-Jae Park department of Human Informatics of Korean medicine Interdisciplinary Programs Kyung Hee University Seoul02447 Korea department of Business Administration Korea Christian University Seoul07661 Korea department of biofunctional medicine and Diagnostics College of Korean MedicineKyung Hee University Seoul02447 Korea department of diagnosis and biofunctional medicine Kyung Hee University Hospital at Gangdong Seoul 05278 Korea

OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The CADI was culturally and lin-guistically translated into Korean via translation,back-translation, and face validity test process. Two hundred and fifty-four Korean adolescents were asked to complete the Korean version of the CADI(K-CADI), the Phlegm Pattern, the Cold-Heat Pattern, and the Korean version of the General Health Questionnaires. A clinician estimated acne severity for the adolescents, using the Korean Acne Grading System. Finally, reliability and validity of the K-CADI was examined, and the relationships between acne severity, Phlegm, Cold, and Heat patterns, and Qo L level were examined via pathway ***: The K-CADI had satisfactory internal consistency(α = 0.827). The examination of construct validity indicated that the K-CADI had one factor(explaining 59.6% of the total variance). Pathway analysis showed satisfactory model fit(normal fit index = 0.960 and comparative fit index = 0.983),and acne-related Qo L was determinant to Phlegm,Heat, and Cold patterns(0.13-0.27 of β), and Phlegm and Heat patterns lowered one's Qo L level(0.17-0.34 of β).CONCLUSION: The K-CADI is a valid and reliable instrument. Phlegm and Heat patterns should be managed when treating acne since they have a moderating effect on general Qo L aggravation.

关键词： Acne vulgaris Quality of life medicine East Asian Traditional Psychology adolescent Causality Cardiff acne disability index

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Ulcerative colitis and bullous pemphigoid:Direct association or a medication side effect:A case report

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World Journal of Clinical Cases 2025年第9期13卷 47-52页

作者： Gaelle-Christie Haddad Anthony El Dada Sergio Sbeih Tony Kazzi Karam Karam Louis A Chaptini department of Internal medicine University of BalamandBeirut 100Lebanon department of medicine GastroenterologyUniversity of BalamandBalamand 100Lebanon department of medicine Digestive DiseasesYale School of MedicineNew HavenCT 06510United States

BACKGROUND Bullous pemphigoid(BP)is an autoimmune blistering skin *** is associated with other autoimmune disorders and the use of certain *** describe a case of BP in a patient with ulcerative colitis(UC)treated with *** SUMMARY A 38-year-old male patient with UC and a history of multiple flares was maintained on mesalamine with good clinical *** year after starting mesalamine,he sought medical care following the onset of a severe itchy rash of several weeks’duration with a recent appearance of skin bullae.A biopsy of the skin revealed subepidermal blistering dermatitis with focal eosinophilic *** immunofluorescence studies revealed linear IgG and C3 immune reactant deposits at the dermoepidermal junction,consistent with the diagnosis of *** therapy alleviated his ***,tapering prednisone led to re-eruption of the *** BP should be considered when patients with UC develop skin *** BP is not one of the extraintestinal manifestations of UC,there may be an association between these two *** treatment with mesalamine or other therapeutic agents plays a role in the development of BP remains unclear.

关键词： Bullous pemphigoid Ulcerative colitis Autoimmune disorders Skin manifestations in inflammatory bowel diseases Mesalamine Case report

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

作者： Bridget Martinez Philip V.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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