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Disordered hyperuniformity and thermal transport in monolayer amorphous carbon

Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 145-152页

作者： Nianjie Liang Yuxi Wang Bai Song department of Energy and Resources Engineering Peking UniversityBeijing 100871China department of Advanced Manufacturing and robotics Peking UniversityBeijing 100871China

Disordered hyperuniformity(DHU)is a recently discovered novel state of amorphous systems characterized by strongly suppressed density fluctuations at large length scales as in crystalline materials,which offers great potential for achieving unusual mechanical,electronic,and photonic ***,despite the fundamental and technological importance of thermal transport in amorphous solids,the effect of DHU remains largely ***,we theoretically study thermal transport in a class of two-dimensional DHU materials—monolayer amorphous carbon(MAC).Beginning with a perfect graphene lattice,we continuously apply Stone-Wales transformations to generate a series of MAC models with varied degrees of disorder and defects,which are quantified through comprehensive structural analysis including the so-called hyperuniformity index(H),where a smaller H indicates a higher degree of ***,we conduct molecular dynamics simulations to obtain the thermal conductivity(κ).A significant correlation between the thermal transport behavior and degree of hyperuniformity is observed,with the room-temperatureκdecreasing from 26.3 to 5.3 W m^(-1)K^(-1)while H is tuned from 0.0004 to ***,two distinct transport regimes are identified,including a nearly-DHU regime at small H(<0.005)whereκdrops sharply and a non-DHU region at larger H whereκbecomes relatively ***-resolved analysis reveals longer lifetime and higher participation ratio for the heat carriers in nearly-DHU MAC,implying that the hidden long-range correlations could support extended modes that enhance *** work highlights the impact of DHU on the thermal properties of amorphous materials and represents a conceptual advancement that is worthy of future exploration.

关键词： disordered hyperuniformity thermal transport amorphous material two-dimensional monolayer amorphous carbon

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Concurrent generation and amplification of longitudinal and bending waves using defective phononic crystals

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 269-288页

作者： S.H.JO department of Mechanical Robotics and Energy Engineering Dongguk University

Defective phononic crystals (PnCs) have enabled spatial localization and quantitative amplification of elastic wave energy. Most previous research has focused on applications such as narrow-bandpass filters, ultrasonic sensors, and piezoelectric energy harvesters, typically operating under the assumption of an external elastic wave incidence. Recently, a novel approach that uses defective PnCs as ultrasonic actuators to generate amplified waves has emerged. However, the existing studies are limited to the generation of either longitudinal or bending waves, with no research addressing the concurrent generation of both. Hence, this paper proposes a straightforward methodology for the concurrent generation and amplification of both wave types utilizing defect modes at independent defect-band frequencies. Bimorph piezoelectric elements are attached to the defect, with each element connected to independent external voltage sources. By precisely adjusting the magnitude and temporal phase differences between the voltage sources, concurrently amplified wave generation is achieved. The paper highlights the advantages of the proposed analytical model. This model is both computationally timeefficient and accurate, in comparison with the COMSOL simulation results. For instance,in case studies, the analytical model reduces the computational time from one hour to mere seconds, while maintaining acceptable error rates of 1%in peak frequencies. This concurrent wave-generation methodology opens new avenues for applications in rotating machinery fault diagnosis, structural health monitoring, and medical imaging.

关键词： phononic crystal (PnC) defect concurrent generation piezoelectric ultrasonic actuator O328 O346

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-Jun Li department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA department of bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek W.Wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study bioengineering department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

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Chinese Chemical Letters 2025年第2期36卷 289-296页

作者： Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew K.Whittaker Bai Yang Quan Lin State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University department of Endocrinology Lequn Branch the First Hospital of Jilin University department of Urology the First Hospital of Jilin University Australian Institute for bioengineering and Nanotechnology the University of Queensland

Prostate cancer(PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase(ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregationinduced emission luminogens(AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve “intraoperative visual navigation”, showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关键词： AIE ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy Prostate cancer

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Best Linear Controllers for Decentralized Linear Quadratic Systems

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Journal of Systems Science & Complexity 2025年第01期 210-237页

作者： AFSHARI Mohammad MAHAJAN Aditya Institute for robotics and Intelligent Machines Georgia Institute of Technology department of Electrical and Computer Engineering McGill University

In this paper, the authors revisit decentralized control of linear quadratic(LQ) *** of imposing an assumption that the process and observation noises are Gaussian, the authors assume that the controllers are restricted to be linear. The authors show that the multiple decentralized control models, the form of the best linear controllers is identical to the optimal controllers obtained under the Gaussian noise assumption. The main contribution of the paper is the solution ***, optimal controllers for decentralized LQ systems are identified using dynamic programming, maximum principle, or spectral decomposition. The authors present an alternative approach which is based by combining elementary building blocks from linear systems, namely, completion of squares, state splitting, static reduction, orthogonal projection,(conditional) independence of state processes, and decentralized estimation.

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Research progress on piperidine-containing compounds as agrochemicals

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Chinese Chemical Letters 2025年第1期36卷 58-67页

作者： Wei Sun Anjing Liao Li Lei Xu Tang Ya Wang Jian Wu State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China

Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug *** flexibility increases the molecule’s capability to bind to the *** piperidine-containing compounds are distinguished by their remarkable activity,and are increasingly becoming a vital category of *** this review,the research progress of piperidines in the discovery of pesticides was updated according to their active *** structure-activity relationships(SARs),and mechanisms of action of piperidine-containing compounds were also *** article is meant to enable readers to quickly understand piperidines,while providing ideas for creating piperidines with novel structures and unique mechanisms of action.

关键词： Piperidine Agrochemicals Biological activity Structure-activity relationships Mechanism of action

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Acellular scaffold‑based approach for in situ genetic engineering of host T‑cells in solid tumor immunotherapy

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Military Medical Research 2025年第1期12卷 16-35页

作者： Hiren Y.Dandia Mamatha M.Pillai Deepak Sharma Meghna Suvarna Neha Dalal Ayush Madhok Arvind Ingle Shubhada V.Chiplunkar Sanjeev Galande Prakriti Tayalia department of Biosciences and bioengineering Indian Institute of Technology BombayPowaiMumbai 400076India Radiation Biology and Health Sciences Division Bhabha Atomic Research CentreMumbai 400085India Centre of Excellence in Epigenetics Department of BiologyIndian Institute of Science Education and ResearchPune 411008India Advanced Centre for Treatment Research and Education in Cancer(ACTREC)Tata Memorial CentreKhargharMumbai 410210India

Background:Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological ***,its application to solid tumors presents significant challenges due to the limited accessibility and *** delivery of tumor-specific T-cells using biomaterials has shown promise,however,procedures required for genetic modification and generation of a sufficient number of tumor-specific T-cells ex vivo remain major obstacles due to cost and time ***:Polyethylene glycol(PEG)-based three-dimensional(3D)scaffolds were developed and conjugated with positively charged poly-L-lysine(PLL)using carbamide chemistry for efficient loading of lentiviruses(LVs)carrying tumor antigen-specific T-cell receptors(TCRs).The physical and biological properties of the scaffold were extensively ***,the scaffold loaded with OVA-TCR LVs was implanted in B16F10 cells expressing ovalbumin(B16-OVA)tumor model to evaluate the anti-tumor response and the presence of transduced ***:Our findings demonstrate that the scaffolds do not induce any systemic inflammation upon subcutaneous implantation and effectively recruit T-cells to the *** B16-OVA melanoma tumor-bearing mice,the scaffolds efficiently transduce host T-cells with OVA-specific *** genetically modified T-cells exhibit homing capability towards the tumor and secondary lymphoid organs,resulting in a significant reduction of tumor size and systemic increase in anti-tumor *** cell profiling revealed a significantly high percentage of transduced T-cells and a notable reduction in suppressor immune cells within the tumors of mice implanted with these ***:Our scaffold-based T-cell therapy presents an innovative in situ localized approach for programming T-cells to target solid *** approach offers a viable alternative to in vitro manipulation of T-cells,circumventing the need for large-scale in vitro generat

关键词： Polyethylene glycol diacrylate Poly-L-lysine Lentiviruses T-cell therapy B16F10-OVA melanoma

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Recycling technologies of spent lithium-ion batteries and future directions:A review

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 271-295页

作者： Xue-song GAO Meng WU Guang-jin ZHAO Kun-hong GU Jia-jia WU Hong-bo ZENG Wen-qing QIN Jun-wei HAN School of Minerals Processing&bioengineering Central South UniversityChangsha 410083China department of Chemical and Materials Engineering University of AlbertaEdmonton T6G 1H9Canada Electric Power Research Institute Henan Electric Power CompanySTATE GRID Corporation of ChinaZhengzhou 450052China

Lithium-ion batteries(LIBs)are the most popular energy storage devices due to their high energy density,high operating voltage,and long cycle ***,green and effective recycling methods are needed because LIBs contain heavy metals such as Co,Ni,and Mn and organic compounds inside,which seriously threaten human health and the *** this work,we review the current status of spent LIB recycling,discuss the traditional pyrometallurgical and hydrometallurgical recovery processes,and summarize the existing short-process recovery technologies such as salt-assisted roasting,flotation processes,and direct ***,we analyze the problems and potential research prospects of the current recycling process,and point out that the multidisciplinary integration of recycling will become the mainstream technology for the development of spent LIBs.

关键词： spent lithium battery short-process recycling secondary resources pretreatment metal recovery

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DKP-SLAM:A Visual SLAM for Dynamic Indoor Scenes Based on Object Detection and Region Probability

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Computers, Materials & Continua 2025年第1期82卷 1329-1347页

作者： Menglin Yin Yong Qin Jiansheng Peng College of Automation Guangxi University of Science and TechnologyLiuzhou545000China department of Artificial Intelligence and Manufacturing Hechi UniversityHechi546300China Key Laboratory of AI and Information Processing Education Department of Guangxi Zhuang Autonomous RegionHechi546300China Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology School of Chemistry and BioengineeringHechi UniversityHechi546300China

In dynamic scenarios,visual simultaneous localization and mapping(SLAM)algorithms often incorrectly incorporate dynamic points during camera pose computation,leading to reduced accuracy and *** paper presents a dynamic SLAM algorithm that leverages object detection and regional dynamic ***,a parallel thread employs the YOLOX object detectionmodel to gather 2D semantic information and compensate for missed ***,an improved K-means++clustering algorithm clusters bounding box regions,adaptively determining the threshold for extracting dynamic object contours as dynamic points *** process divides the image into low dynamic,suspicious dynamic,and high dynamic *** the tracking thread,the dynamic point removal module assigns dynamic probability weights to the feature points in these *** with geometric methods,it detects and removes the dynamic *** final evaluation on the public TUM RGB-D dataset shows that the proposed dynamic SLAM algorithm surpasses most existing SLAM algorithms,providing better pose estimation accuracy and robustness in dynamic environments.

关键词： Visual SLAM dynamic scene YOLOX K-means++clustering dynamic probability

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