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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： YAN-NAN LI YUN-HONG XIU YAN-JUN TANG JING-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI CHENG-HAO JIN department of biochemistry and molecular biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis center Daqing Oilfield General HospitalDaqingChina department of food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina department of molecular biology Chifeng UniversityChifengChina National Coarse Cereals Engineering research center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

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The application of omics technologies for understanding tropical plants-based bioactive compounds in ruminants:a review

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1376-1390页

作者： Metha Wanapat Gamonmas Dagaew Sukruthai Sommai Maharach Matra Chaichana Suriyapha Rittikeard Prachumchai Uswatun Muslykhah Srisan Phupaboon Tropical Feed Resources research and Development center(TROFREC) Department of Animal ScienceFaculty of AgricultureKhon Kaen UniversityKhon Kaen 40002Thailand department of Animal Science Faculty of Agricultural TechnologyUniversity of Technology ThanyaburiRajamangala Pathum Thani 12130Thailand

Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bioactive components of food is the crucial scientific objective of nutritional research. The complex relationship between metabolism and nutrition could be investigated with cutting-edge "omics" and bioinformatics techniques. This review paper provides an overview of the use of omics technologies in nutritional research, with a particular emphasis on the new applications of transcriptomics, proteomics, metabolomics, and genomes in functional and biological activity research on ruminant livestock and products in the tropical regions. A wealth of knowledge has been uncovered regarding the regulation and use of numerous physiological and pathological processes by gene, m RNA, protein, and metabolite expressions under various physiological situations and guidelines. In particular, the components of meat and milk were assessed using omics research utilizing the various methods of transcriptomics, proteomics, metabolomics, and genomes. The goal of this review is to use omics technologies—which have been steadily gaining popularity as technological tools—to develop new nutritional, genetic, and leadership strategies to improve animal products and their quality control. We also present an overview of the new applications of omics technologies in cattle production and employ nutriomics and foodomics technologies to investigate the microbes in the rumen ecology. Thus, the application of state-of-the-art omics technology may aid in our understanding of how species and/or breeds adapt, and the sustainability of tropical animal production, in the long run, is becoming increasingly important as a means of mitigating the consequences of climate change.

关键词： Animal nutrition Animal production Cutting-edge molecular markers Ruminants

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Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade Pereira Lucas Moraes Berneira Claudio Martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice Luehring Giongo Rodrigo de Almeida Vaucher center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

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Review on marine collagen peptides induce cancer cell apoptosis,necrosis,and autophagy by reducing oxidized free radicals

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BIOCELL 2023年第5期47卷 965-975页

作者： YINGHUA LUO YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO WENSHUANG HOU JIAN LIU YUHE CUI TING XU CHENGHAO JIN department of Grass Science College of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing163319China department of biochemistry and molecular biology College of Life Science and TechnologyHeilongjiang Bayi Agricultural UniversityDaqing163319China National Coarse Cereals Engineering research center Daqing163319China

Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or *** have a range of structures and biological activities and are widely present in marine *** also have a small molecular weight,are easily modified,and absorbed by the *** properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging *** of specific molecular weights have significant anti-tumor activity and no toxic side ***,MCPs have the potential use as anti-cancer adjuvant *** radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well *** this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice.

关键词： Marine Collagen Peptides(MCPs) Antioxidant Anti-tumor Apoptosis Necrosis Autophagy

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Plant and animal positive-sense single-stranded RNA viruses encode small proteins important for viral infection in their negative-sense strand

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molecular Plant 2023年第11期16卷 1794-1810页

作者： Pan Gong Qingtang Shen Mingzhen Zhang Rui Qiao Jing Jiang Lili Su Siwen Zhao Shuai Fu Yu Ma Linhao Ge Yaqin Wang Rosa Lozano-Durán Aiming Wang Fangfang Li Xueping Zhou State Key Laboratory for biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina School of Basic Medical Sciences Fujian Medical UniversityFuzhouChina State Key Laboratory of Rice biology and Breeding Institute of BiotechnologyZhejiang UniversityHangzhouZhejiangChina University of the Chinese Academy of Sciences BeijingChina department of Plant biochemistry Center for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany London research and Development center Agriculture and Agri-Food CanadaLondonONCanada

Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for *** on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding ***,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry *** protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication *** rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant ***,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis *** addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small *** together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought.

关键词： positive-sense single-stranded RNA viruses small proteins negative-sense RNA turnip mosaic virus severe acute respiratory syndrome coronavirus 2

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Conventional Breeding and molecular Markers for Blast Disease Resistance in Rice (Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2023年第3期92卷 725-746页

作者： Adel A.Rezk Mohamed M.El-Malky Hossam S.El-Beltagi Mohammed Al-daej Kotb AAttia agricultural Biotechnology department College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Plant Pathology research Institute Agriculture Research CenterGiza12619Egypt Rice research and Training center SakhaField Crops Research InstituteAgricultural Research CenterKafr El-Sheikh33717Egypt biochemistry department Faculty of AgricultureCairo UniversityGiza12613Egypt center of Excellence in Biotechnology research King Saud UniversityRiyadh11451Saudi Arabia Rice Biotechnology Laboratory Rice Research DepartmentField Crops Research InstituteARCKafr EL-Sheikh33717Egypt

Monogenic lines,which carried 23 genes for blast resistance were tested and used donors to transfer resistance genes by crossing *** results under blast nursery revealed that 9 genes from 23 genes were susceptible to highly susceptible under the three locations(Sakha,Gemmeza,and Zarzoura in Egypt);Pia,Pik,Pik-p,Piz-t,Pita,Pi b,Pi,Pi 19 and Pi ***,the genes Pii,Pik-s,Pik-h,Pi z,Piz-5,Pi sh,Pi 3,Pi 1,Pi 5,Pi 7,Pi 9,Pi 12,Pikm and Pita-2 were highly resistant at the same *** analysis confirmed the results,which divided into two groups;the first one included all the susceptible genes,while the second one included the resistance *** the greenhouse test,the reaction pattern of five races produced 100%resistance under artificial inoculation with eight genes showing complete resistance to all *** completely resistant genes:Pii,Pik-s,Piz,Piz-5(=bi2)(t),Pita(=Pi4)(t),Pita,Pi b and Pi1 as well as clustering analysis confirmed the *** the F1 crosses,the results showed all the 25 crosses were resistant for leaf blast disease under field ***,the results in F2 population showed seven crosses with segregation ratio of 15(R):1(S),two cross gave segregated ratio of 3 R:1 S and one gave 13:*** the identification of blast resistance genes in the parental lines,the marker K3959,linked to Pik-s gene and the variety IRBLKS-F5 carry this gene,which was from the monogenic *** results showed that four genotypes;Sakha 105,Sakha 103,Sakha 106 and IRBLKS-F5 were carrying Pik-s gene,while was absent in the Sakha 101,Sakha 104,IRBL5-M,IRBL9-W,IRBLTACP1 and IRBL9-W(R)*** for Pi 5 gene,the results showed that it was present in Sakha 103 and Sakha 104 varieties and absent in the rest of the *** addition,Pita-Pita-2 gene was found in the three Egyptian genotypes(Sakha 105,Sakha 101 and Sakha 104)plus IRBLTACP1 *** F2 generation,six populations were used to study the inheritance of blast resistance and s

关键词： Biotechnology tools clustering analysis monogenic lines resistance genes breeding Oryza sativa L.

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Testing the polar auxin transport model with a selective plasma membrane H^(+)-ATPase inhibitor

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Journal of Integrative Plant biology 2022年第6期64卷 1229-1245页

作者： Yongqing Yang Xiaohui Liu Wei Guo Wei Liu Wei Shao Jun Zhao Junhong Li Qing Dong Liang Ma Qun He Yingzhang Li Jianyong Han Xiaoguang Lei State Key Laboratory of Plant Physiology and biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Beijing National Laboratory for molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringSynthetic and Functional Biomolecules Centerand Peking‐Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Institute of food Science and Technology Chinese Academy of Agricultural SciencesBeijing 100193China department of Dermatology Peking University First HospitalBeijing 100034China Iomics Biosciences Inc. Beijing 100102China College of Biological Sciences China Agricultural UniversityBeijing 100193China

Auxin is unique among plant hormones in that its function requires polarized transport across plant cells.A chemiosmotic model was proposed to explain how polar auxin transport is derived by the H^(+)gradient across the plasma membrane(PM)established by PM H^(+)-adenosine triphosphatases(ATPases).However,a classical genetic approach by mutations in PM H^(+)-ATPase members did not result in the ablation of polar auxin distribution,possibly due to functional redundancy in this gene *** confirm the crucial role of PM H^(+)-ATPases in the polar auxin transport model,we employed a chemical genetic *** a chemical screen,we identified protonstatin-1(PS-1),a selective small-molecule inhibitor of PM H^(+)-ATPase activity that inhibits auxin *** with transgenic plants and yeast strains showed that the activity of PM H^(+)-ATPases affects auxin uptake as well as acropetal and basipetal polar auxin *** propose that PS-1 can be used as a tool to interrogate the function of PM H^(+)-*** results support the chemiosmotic model in which PM H^(+)-ATPase itself plays a fundamental role in polar auxin transport.

关键词： Arabidopsis auxin transport inhibitor plasma membrane H^(+)-ATPase

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The Genetic and Biochemical Mechanisms Underlying Cereal Seed Dormancy

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1203-1214页

作者： Sasa Jing Yuan Tian Heng Zhang John THancock Ying Zhu Ping Li Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-products Research Center for Crop Molecular Breeding at Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural ScienceHangzhou310021China department of Applied Sciences University of the West of EnglandBristolBS161QYUK

The crop seeds have been a staple food for humans,and seed yield is important for sustaining agriculture development and enhancing human adaptability to food *** phenomenon of pre-harvest sprouting(PHS),caused by seed dormancy deficiency,and the phenomenon of low seedling emergence caused by seed deep dormancy,will lead to a reduction in agricultural ***,it is particularly important to understand the regulation mechanisms of seed *** are many studies on the regulation of seed dormancy in rice,but there are few studies on the regulation of seed dormancy in other crops,and the research on its mechanism is not thorough *** this paper,we comprehensively summarize the regulation mechanisms of cereal seed dormancy,including rice,barley and wheat,discussing the integral mechanism of seed *** information should provide new insights for developing versatile cultivated lines to improve crop yield and economic benefits.

关键词： Crops rice wheat barly dormancy germination ABA GA

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Effect of Glutathione and Storage Time on Rheological Properties of Per-proofed Frozen Dough

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食品科学 2006年第10期27卷 202-209页

作者： J Uriyapongson C L Goad P Rayas-Duarte Khon Kaen University Khon Kaen Thailand department of Statistics Oklahoma State University Stillwater OK 74078 USA department of biochemistry and molecular biology food and agricultural products research center OklahomaState University Stillwater OK 74078 USA

The effect of reduced glutathione (GSH) on fresh and pre-proofed frozen dough rheological properties were investigated using dynamic stress rheometry and small scale extensibility with the addition of three levels (80×10-6, 160× 10-6 and 240×10-6 GSH) and six storage times (0 and 1 day, 2, 4, 6 and 8 weeks). Three relaxation times (1, 13 and 26min) after loading the dough in the rheometer were used to determine storage (G’) and loss (G”) moduli. Correlations for G’ (r=0.678 and 0.622 at 0.05, and 10Hz, respectively) and G” (r=0.699, and 0.690 at 0.05, and 10Hz, respectively) were observed with the area under the extension curve at 26 min relaxation time. The addition of GSH to fresh dough reduced G’ (16.4% to 55.9%) and G” (13.7% to 52.2%). Freezing and frozen storage caused increase in G’ and G”. The addition of GSH reduced dough strength indicated by the reduction in maximum resistance to extension (Rmax) and the ratio of maximum resistance to extensibility (Rmax/E). The reduction in Rmax across all relaxation times ranged from 16.2% to 59.4%. An increase in dough extension (E) was observed with 240×10-6 GSH at all frozen storage and rest period times. Addition of GSH caused an increase of liquid phase (30.6% to 35.3%) in fresh dough and frozen dough (10.3% to 20.7%) after one day frozen storage. Negative correlations of water content in the solid phase with dough extensibility and area under the extensibility curve were found (r=-0.594 and-0.563, respectively, p<0.001). This suggests a loss of dough extensibility and strength as the water holding capacity of the dough components changes during frozen storage.

关键词： Effect of Glutathione and Storage Time on Rheological Properties of Per-proofed Frozen Dough GSH

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OsRLR4 binds to the OsAUX1 promoter to negatively regulate primary root development in rice

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Journal of Integrative Plant biology 2022年第1期64卷 118-134页

作者： Chendong Sun Dongming Li Zhenyu Gao Lei Gao Lianguang Shang Mei Wang Jiyue Qiao Shilin Ding Chuanyou Li Markus Geisler Dean Jiang Yanhua Qi Qian Qian Key Laboratory of Herbage&Endemic Crop biology of Ministry of Education Inner Mongolia Key Laboratory of Herbage&Endemic Crop BiotechnologySchool of Life SciencesInner Mongolia UniversityHohhot 010000China State Key Laboratory of Plant Physiology and biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China The Key Laboratory for Quality Improvement of agricultural products of Zhejiang Province College of Advanced Agricultural SciencesZhejiang Agriculture and Forestry UniversityLin'an Hangzhou 311300China State Key Laboratory of Rice biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 310006China College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenChina agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyThe Chinese Academy of SciencesBeijing 100101China department of biology University of FribourgFribourg CH-1700Switzerland

Root architecture is one of the most important agronomic traits that determines rice crop yield. The primary root(PR) absorbs mineral nutrients and provides mechanical support;however, the molecular mechanisms of PR elongation remain unclear in rice. Here, the two loss-of-function T-DNA insertion mutants of root length regulator 4(Os RLR4), osrlr4-1 and osrlr4-2 with longer PR, and three Os RLR4 overexpression lines, OE-Os RLR4-1/-2/-3 with shorter PR compared to the wild type/Hwayoung(WT/HY), were identified. Os RLR4 isone of five members of the PRAF subfamily of the regulator chromosome condensation1(RCC1) family. Phylogenetic analysis of Os RLR4 from wild and cultivated rice indicated that it is under selective sweeps, suggesting its potential role in domestication. Os RLR4 controls PR development by regulating auxin accumulation in the PR tip and thus the root apical meristem activity. A series of biochemical and genetic analyses demonstrated that Os RLR4 functions directly upstream of the auxin transporter Os AUX1. Moreover, Os RLR4 interacts with the TRITHORAX-like protein Os Trx1 to promote H3 K4 me3 deposition at the Os AUX1 promoter, thus altering its transcription level. This work provides insight into the cooperation of auxin and epigenetic modifications in regulating root architecture and provides a genetic resource for plant architecture breeding.

关键词： auxin transporter primary root development regulator chromosome condensation 1 rice root length regulator

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