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Protein extract of kenaf seed exhibits anticoagulant,antiplatelet and antioxidant activities

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 47-58页

作者： Sujatha M.Hanumegowda Chandramma Srinivasa Ashwini Shivaiah Manjula M.Venkatappa Ramesha Hanumanthappa Rajesh Rangappa Ramesh K.Laxmaiah Sathisha J.Gonchigar Devaraja Sannaningaiah department of biochemistry Jnansahydri Kuvempu UniversityShankarghatta-577451ShivamoggaKarnatakaIndia department of Studies and research in biochemistry and centre for Bioscience and Innovation Tumkur UniversityTumkurKarnatakaIndia Liveon Biolabs Private Limited Tumkur-572106India department of Food Science and Nutrition Maharani's Science College for WomenMysoreIndia

Objective:To explore the anticoagulant,antiplatelet and antioxidant activities of protein extract of kenaf seed(PEKS).Methods:Sodium dodecyl sulphate polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography techniques were employed for protein *** activity of PEKS was assessed using 1,1-diphenyl-2-picrylhydrazyl(DPPH)*** protective effect of PEKS on sodium nitrite(NaNO2)induced oxidative stress was evaluated using the in vitro red blood cell model,while the effect of PEKS on diclofenacinduced oxidative stress was examined in vivo in ***-rich plasma and platelet-poor plasma were used for anticoagulant and antiplatelet activities of ***:PEKS revealed similar protein bands on SDS-PAGE under reduced and non-reduced *** acidic proteins were present in native *** showed antioxidant properties by scavenging DPPH with an IC50 of 24.58μ*** exhibited a protective effect on NaNO2 induced oxidative stress in red blood cells by restoring the activity of stress *** addition,PEKS alleviated diclofenac-induced tissue damage of the liver,kidney,and small *** showed an anticoagulant effect in both in vivo and in vitro experiments by enhancing normal clotting *** did not affect prothrombin time but increase activated partial thromboplastin ***,PEKS inhibited adenosine diphosphate and epinephrine-induced platelet ***:PEKS protects tissues from oxidative stress and exhibits antithrombotic activity.

关键词： Protein Extract Kenaf seed Oxidative stress Antioxidant Anticoagulant Antiplatelet

Seasonal dynamics of foliar antioxidative enzymes and total anthocyanins in natural populations of Iris pumila L.

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Journal of Plant Ecology 2010年第1期3卷 59-69页

作者： Ana Vuleta Sanja Manitasevic Jovanovic Darka Seslija Branka Tucic department of Evolutionary Biology Sinisa Stankovic Institute for Biological ResearchBelgradeSerbia department of biochemistry Sinisa Stankovic Institute for Biological ResearchBelgradeSerbia

Aims Plants in their natural habitats frequently cope with a multitude of abiotic stresses,such as high light intensity,extreme temperatures and water deficit,which often co-occur during periods of drought,especially in semi-arid and arid *** of plants to stressful environmental conditions usually induce overproduction of reactive oxygen species(ROS)that,as highly toxic derivatives of O_(2),can assault all cell macromolecules,leading to the disruption of cellular homeostasis and,consequently,the uncoupling of major metabolic processes,the photosynthesis and *** order to minimize ROS-mediated cellular damage,plants have evolved highly efficient antioxidative defense systems that include both enzymatic and non-enzymatic *** abiotic stress can also operate as a strong evolutionary force that shapes adaptations in natural plant populations,the aim of this study was to examine the seasonal variation patterns of two distinct antioxidative systems,ROS-scavenging enzymes and anthocyanin pigments,in the leaf tissue of a steppe plant,Iris pumila,as expressed under contrasting light conditions that the species regularly experiences in the *** We selected two natural populations of *** inhabiting the alternative radiation environments in the Deliblato Sands,a sunexposed dune site and a woodland *** specific activity of three antioxidative enzymes,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD)and the content of total anthocyanins were examined in leaves of *** plants collected from each of the 31 Iris clones(17 in the exposed population and 14 in the shaded population)once during each of the three seasons,spring,summer and autumn in ***,a fully expanded leaf was cut from each clonal plant between 15:00 and 16:00 h,immediately frozen in liquid nitrogen and stored at-70℃until *** Findings Generally,all three antioxidative enzymes were up-regulated in summer-harvested

关键词： SOD CAT POD anthocyanins seasonal variation

Dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) alleviates oxidative stress in experimental myocardial infarction

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Food Science and Human Wellness 2017年第2期6卷 77-87页

作者： P.Mukthamba K.Srinivasan department of biochemistry and Nutrition CSIR–Central Food Technological Research InstituteMysore 570020India

Soluble fiber-rich fenugreek seeds(Trigonella foenum-graecum)and garlic(Allium sativum)are understood to exert cholesterol-lowering and antioxidant *** cardioprotective influence of a combination of fenugreek seeds and garlic by their antioxidant influence was evaluated in hypercholesterolemic rats administered *** rats were maintained on high-cholesterol diet for 8 weeks along with dietary interventions of fenugreek(10%),garlic(2%)and their *** infarction was induced with isoproterenol *** circulatory troponin,disturbed activities of cardiac ATPases,increased serum iron and decreased ceruloplasmin confirmed myocardial *** lipid peroxides accompanied with reduced antioxidant molecules caused by isoproterenol and altered activities of antioxidant enzymes in serum and heart in induced myocardial necrosis were countered by dietary fenugreek,garlic,and fenugreek+*** fenugreek seeds and garlic ameliorated isoproterenol-induced compromised antioxidant status,the cardioprotective effect being higher by the combination of fenugreek seeds and garlic.

关键词： Fenugreek seeds Garlic High cholesterol diet Isoproterenol Myocardial infarction Oxidative stress

Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

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research 2023年第4期2023卷 131-144页

作者： LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology Laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of biochemistry Biological Research CentreSzegedHungary department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(LNP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

Investigation of genome instability in patients with non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2013年第32期19卷 5295-5301页

作者： Ahmet Karaman Hamiyet Donmez-Altuntas Nazmiye Bitgen Zuhal Hamurcu Arzu Oguz Cigdem Karakukcu department of Gastroenterology Kayseri Education and Research Hospital department of Medical Biology Medical SchoolErciyes University department of Medical Oncology Kayseri Education and Research Hospital department of Clinical biochemistry Kayseri Education and Research Hospital

AIM:To evaluate the occurrence of micronucleus(MN),nucleoplasmic bridges(NPBs)and nuclear buds(NBUDs)in the mitogen-stimulated lymphocytes of patients with non-alcoholic steatohepatitis(NASH).METHODS:The study was performed in 25(9 females,16 males)patients newly diagnosed with NASH,and 25healthy subjects of similar ages and genders were used as a control *** of the controls was known to be receiving any drugs for medical or other reasons or using *** was further excluded by abdominal ultrasound imaging in the control *** numbers of MN,NPBs and NBUDs scored in binucleated(BN)cells were obtained from the mitogen-stimulated lymphocytes of patients and control *** comparisons of the numbers of BN cells with MN,NPBs and NBUDs and ages between the patients with NASH and control subjects were ***:The mean ages of the patients and the control group were 41.92±13.33 and 41.80±13.09 years(P>0.05),*** values of the mean body mass index(BMI),HOMA-IR,hemoglobin,creatinin,aspartate aminotransferase,alanine aminotransferase,triglyceride,high density lipoprotein,and low density lipoprotein were 31.19±4.62 kg/m2vs 25.07±4.14 kg/m2,6.71±4.68 vs 1.40±0.53,14.73±1.49 g/dL vs 14.64±1.30 g/dL,0.74±0.15 mg/dL vs 0.80±0.13 mg/dL,56.08±29.11 U/L vs 16.88±3.33 U/L,92.2±41.43U/L vs 15.88±5.88 U/L,219.21±141.68 mg/dL vs102.56±57.98 mg/dL,16.37±9.65 mg/dL vs 48.72±15.31 mg/dL,and 136.75±30.14 mg/dL vs 114.63±34.13 mg/dL in the patients and control groups,*** total numbers and frequencies of BN cells with MN,NPBs and NBUDs,which were scored using the CBMN cytome assay on PHA-stimulated lymphocytes,were evaluated in the patients with NASH and control *** found significantly higher numbers of MN,NPBs and NBUDs in the BN cells of patients with NASH than in those of the control subjects(21.60±9.32vs 6.88±3.91;29.28±13.31 vs 7.84±3.96;15.60±5.55 vs 4.20±1.63,respectively,P<0.0001).CONCLUSION:The increased

关键词： Non-alcoholic steatohepatitis Micronucleus Nucleoplasmic bridges Nuclear buds

Author Correction:Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKa1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2023年第3期20卷 311-312页

作者： Junqiong Huang Scot Leary Jim Xiang cancer research Cluster Saskatchewan Cancer Agency Saskatoon SK Canada department of Oncology College of Medicine University of Saskatchewan Saskatoon SK Canada department of Blood Transfusion Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China department of biochemistry Microbiology and Immunology College of Medicine University of Saskatchewan Saskatoon SK Canada

In the version of this article initially published,unintended typographical errors in the original version of Fig.1B were made during manuscript *** revised Fig.1,including the correct Fig.1B,isshown below.

关键词： FOXO1 mTORC1 initially

Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1

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Frontiers in Biology 2016年第6期11卷 413-426页

作者： Pang-Kuo Lo Benjamin Wolfson Qun Zhou department of biochemistry and Molecular Biology Greenebaum Cancer Center University of Maryland School of Medicine BaltimoreMD 21201 USA

BACKGROUND： The majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs （lncRNAs） based on their transcript sizes larger than 200 nucleotides. Growing evidence has shown that lncRNAs are not junk transcripts and play regulatory roles in multiple aspects of biological processes. Dysregulation of lncRNA expression has also been linked to diseases, in particular cancer. Therefore, studies of lncRNAs have attracted significant interest in the field of medical research. Nuclear enriched abundant transcript 1 （NEAT1）, a nuclear lncRNA, has recently emerged as a key regulator involved in various cellular processes, physiological responses, developmental processes, and disease development and progression. OBJECTIVE： This review will summarize and discuss the most recent findings with regard to the roles of NEAT1 in the function of the nuclear paraspeckle, cellular pathways, and physiological responses and processes. Particularly, the most recently reported studies regarding the pathological roles of deregulated NEAT1 in cancer are highlighted in this review. METHODS： We performed a systematic literature search using the Pubmed search engine. Studies published over the past 8 years （between January 2009 and August 2016） were the sources of literature review. The following keywords were used：＂Nuclear enriched abundant transcript 1,＂＂NEATI,＂ and ＂paraspeckles.＂ RESULTS： The Pubmed search identified 34 articles related to the topic of the review. Among the identified literature, 13 articles report findings related to cellular functions of NEAT1 and eight articles are the investigations of physiological functions of NEAT1. The remaining 13 articles are studies of the roles of NEAT1 in cancers. CONCLUSION： Recent advances in NEAT1 studies reveal the multifimctional roles of NEAT1 in various biological processes, which are beyond its role in nuclear paraspeckles. Recent studies al

关键词： long non-coding RNAs (lncRNAs) nuclear enriched abundant transcript 1 (NEAT1) paraspeckles microRNAs(miRNAs) epigenetic regulation cancer

A review of tax avoidance in China

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China Journal of Accounting research 2020年第4期13卷 327-338页

作者： Tanya Y.H.Tang department of Accounting Goodman School of BusinessBrock UniversityCanada

This paper synthesizes the major empirical findings of the burgeoning tax avoidance research in China from the accounting,finance,and economics literature over the last 13 *** surveys the evidence in four main areas:(1)the mechanisms through which Chinese firms avoid income taxes;(2)the effects of government ownership and agency problem on tax avoidance;(3)tax avoidance and political connections;and(4)the roles of book-tax conformity,tax enforcement,and corporate *** also discusses the appropriateness of tax avoidance measures in the Chinese ***,it proposes important directions for future research.

关键词： Tax avoidance Government ownership Agency problems Corporate political activity Book-tax conformity China

Hepatobiliary Schistosomiasis

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Journal of Clinical and Translational Hepatology 2014年第3期2卷 212-216页

作者： Yehia Shaker Nervana Samy Esmat Ashour biochemistry department National Research CenterCairoEgypt

Schistosomiasis is an ancient parasitic disease that has afflicted Egyptians since the time of the *** disease is caused by lodged schistosome eggs in the host liver,evoking an immune response and leading in some patients to the development of hepatic granuloma and ***,we review the epidemiology,immunopathogenesis,and clinical profile of *** information may aid in the development of more efficacious treatments and improved disease prognosis.

关键词： Schistosomiasis Immunopathogenesis Hepatosplenic schistosomiasis Co-infection and complications Anti-schistosomal vaccine