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The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism

Genes & Diseases 2024年第4期11卷 220-233页

作者： Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong College of bioengineering Chongqing UniversityChongqing 400044China department of biomedical Materials Science College of Biomedical EngineeringArmy Medical University(Third Military Medical University)Chongqing 400038China State Key Laboratory of Trauma and Chemical Poisoning Army Medical University(Third Military Medical University)Chongqing 400038China

In recent years,researchers have become focused on the relationship between lipids and bone metabolism ***,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic *** has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone ***,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal *** lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards ***,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of ***,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism *** also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关键词： Bone homeostasis Cross-organ communication Lipid metabolism Osteoclast Osteoporosis

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Storing Freshwater Versus Storing Electricity in Power Systems with High Freshwater Electric Demand

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 323-333页

作者： Mubarak J.Al-Mubarak Antonio J.Conejo department of Electrical and Computer engineering The Ohio State UniversityColumbusOHUSA department of Electrical engineering Kuwait UniversityP.O.Box 5969Safat 13060Kuwait department of Integrated Systems engineering and the department of Electrical and Computer engineering The Ohio State UniversityColumbusOH 43210USA IEEE

We consider a power system whose electric demand pertaining to freshwater production is high(high freshwater electric demand),as in the Middle East,and investigate the tradeoff of storing freshwater in tanks versus storing electricity in batteries at the day-ahead operation *** storing freshwater and storing electricity increase the actual electric demand at valley hours and decrease it at peak hours,which is generally beneficial in term of cost and ***,to what extent?We analyze this question considering three power systems with different generation-mix configurations,i.e.,a thermal-dominated mix,a renewable-dominated one,and a fully renewable *** generation-mix configurations are inspired by how power systems may evolve in different countries in the Middle *** production uncertainty is compactly modeled using chance *** draw conclusions on how both storage facilities(freshwater and electricity)complement each other to render an optimal operation of the power system.

关键词： Power system operation freshwater production and transportation coordination day-ahead scheduling

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Origami multi-layer space shield for cylindrical space structure

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Chinese Journal of Aeronautics 2024年第10期37卷 294-312页

作者： Ji-Hun CHA Ji-Sub NOH Sarath Kumar SATHISH KUMAR Dohyeon JIN Dae-Young LEE Chun-Gon KIM department of Aerospace engineering Chosun UniversityGwangju 61452Republic of Korea department of Aerospace and Software engineering Gyeongsang National UniversityGyeongsangnam-do 52828Republic of Korea department of Aerospace engineering Seoul National UniversitySeoul 08826Republic of Korea department of Aerospace engineering KAISTDaejeon 34141Republic of Korea

The multidisciplinary space environment,encompassing orbital debris,cosmic radiation,and solar radiative heat,poses significant risks to spacecraft and astronauts,necessitating efficient and effective shielding solutions.A multi-layer shield with wide spacing has been proven to be an effective way to shield the spacecraft from space debris impact;however,due to the limited volume of the payload fairing,it was not feasible to apply a multi-layer shield to the spacecraft *** the origami design,the shield maintains a compact form during launch and subsequently expands in outer space to enhance *** geometric analysis,it has been confirmed that the deployable multi-layer space shield can occupy less space than conventional space shield structures while expanding into wider shield intervals and multiple *** hypervelocity impact experiments,it was confirmed that as the bumper spacing of the multi-layer space shield expands,its ballistic performance becomes superior to conventional space *** deployable multi-layer space shield can reduce not only hypervelocity impacts but also solar radiative heat using the same mechanism as multi-layer *** cosmic radiation dose analysis,it has been confirmed that the multi-layer space shield is effective in cosmic radiation shielding compared to conventional space structures.

关键词： Hybrid composite Origami Hypervelocity impact Space environment Space debris Cosmic radiation

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An asymmetrical multilevel inverter with minimum voltage stress and fewer components for photovoltaic renewable-energy system

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Clean Energy 2024年第1期8卷 1-22页

作者： Rabail Memon Mukhtiar Ahmed Mahar Abdul Sattar Larik Syed Asif Ali shah department of Electrical engineering Mehran University of Engineering and TechnologyJamshoroPakistan

The enhanced power quality provided by multilevel inverters(MLIs)has made them more appropriate for medium-and high-power applications,including photovoltaic ***,a prevalent limitation involves the necessity for numerous switches and increased voltage stress across these switches,consequently increasing the overall system *** address these challenges,a new 17-level asymmetrical MLI with fewer components and low voltage stress is proposed for the photovoltaic *** innovative MLI configuration has four direct current(DC)sources and 10 *** on the trinary sequence,the proposed topology uses photovoltaics with boost converters and fuzzy logic controllers as its DC *** equations are used to calculate cru-cial parameters for this proposed design,including total standing voltage per unit(TSVPU),cost function per level(CF/L),component count per level(CC/L)and voltage stress across the *** comparison is conducted by considering switches,DC sources,TSVPU,CF/L,gate driver circuits and CC/L with other existing MLI *** analysis is carried out under various conditions,encompassing different levels of irradiance,variable loads and modulation *** reduce the total harmonic distortion of the suggested topology,the phase opposition disposition approach has been *** suggested framework is simulated in MATLAB®/Simulink®.The results indicate that the proposed topology achieves a well-distributed stress profile across the switches and has CC/L of 1.23,TSVPU of 5 and CF/L of 4.58 and 5.76 with weight coefficients of 0.5 and 1.5,*** values are not-ably superior to those of existing MLI *** results demonstrate that the proposed topology maintains a consistent output at varying irradiance levels with FLCs and exhibits robust performance under variable loads and diverse modulation ***,the total harmonic distortion achieved with phase opposition disposi

关键词： asymmetrical multilevel inverter photovoltaic system renewable energy component count per level cost function per level total standing voltage per unit phase opposition disposition technique

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Stochastic Ranking Improved Teaching-Learning and Adaptive Grasshopper Optimization Algorithm-Based Clustering Scheme for Augmenting Network Lifetime in WSNs

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China Communications 2024年第9期21卷 159-178页

作者： N Tamilarasan SB Lenin P Mukunthan NC Sendhilkumar department of Electronics and Communications engineering Sri Indu College of Engineering and TechnologyHyderabadTelanganaIndia department of Electronics and Communications engineering Sri Manakula Vinayagar Engineering CollegePondicherryIndia

In Wireless Sensor Networks(WSNs),Clustering process is widely utilized for increasing the lifespan with sustained energy stability during data *** clustering protocols were devised for extending network lifetime,but most of them failed in handling the problem of fixed clustering,static rounds,and inadequate Cluster Head(CH)selection criteria which consumes more *** this paper,Stochastic Ranking Improved Teaching-Learning and Adaptive Grasshopper Optimization Algorithm(SRITL-AGOA)-based Clustering Scheme for energy stabilization and extending network *** SRITL-AGOA selected CH depending on the weightage of factors such as node mobility degree,neighbour's density distance to sink,single-hop or multihop communication and Residual Energy(RE)that directly influences the energy consumption of sensor *** specific,Grasshopper Optimization Algorithm(GOA)is improved through tangent-based nonlinear strategy for enhancing the ability of global *** the other hand,stochastic ranking and violation constraint handling strategies are embedded into Teaching-Learning-based Optimization Algorithm(TLOA)for improving its exploitation ***,SR and VCH improved TLOA is embedded into the exploitation phase of AGOA for selecting better CH by maintaining better balance amid exploration and *** results confirmed that the proposed SRITL-AGOA improved throughput by 21.86%,network stability by 18.94%,load balancing by 16.14%with minimized energy depletion by19.21%,compared to the competitive CH selection approaches.

关键词： Adaptive Grasshopper Optimization Algorithm(AGOA) Cluster Head(CH) network lifetime Teaching-Learning-based Optimization Algorithm(TLOA) Wireless Sensor Networks(WSNs)

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Mechanical performance of cold mix asphalt containing cup lump rubber as a sustainable bio-modifier

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Journal of Traffic and Transportation engineering(English Edition) 2024年第3期11卷 424-440页

作者： Syed Abdul Ghafar Muhammad Naqiuddin Mohd Warid Norhidayah Abdul Hassan Zulfiqar Ali Jattak Ashraf Abdalla Mohammed Radwan Faculty of Civil engineering Universiti Teknologi MalaysiaSkudai 81310Malaysia department of Civil engineering Balochistan University of Information TechnologyEngineering&Management SciencesQuettaPakistan department of Civil engineering Balochistan University of Engineering and TechnologyKhuzdarPakistan department of Civil engineering Faculty of EngineeringUniversity of TripoliTripoliLibya

The road construction industry aims to contribute to the protection of already compromised *** mix asphalt(CMA)is a measure initiated by the road industry to protect the environment and preserve *** having additional benefits,CMA has attracted little attention due to its inferior ***'s performance is enhanced using a sustainable binder bio-modifier,natural cup lump rubber(CLR)is one of *** study evaluated the tensile properties,rutting,moisture susceptibility,and adhesion properties of CLR-modified CMA(CMA-CR).The tensile property was enhanced by 26%due to CLR ***-CR had excellent rutting resistance of less than 2 mm rut depth at 10,000 load cycles,showing 70%improvement compared with conventional *** susceptibility evaluation indicated that CMA-CR had tensile strength ratio(TSR)value of 104%,satisfying the minimum 80%requirement of AASHTO *** also retained more than 96%bitumen *** moisture damage resistance was improved by 12%and 10%in terms of TSR and stripping,*** durability results revealed that the CMA-CR mixture prevented higher mass loss,representing 14%improvement compared with conventional CMA.

关键词： Cup lump rubber Cup lump modified cold mix asphalt Moisture damage Tensile property Rutting Digital imaging

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Sustainable pathways to ammonia:a comprehensive review of green production approaches

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Clean Energy 2024年第2期8卷 60-72页

作者： Hafiz Sharjeel Ahmed Zaid Yahya Waqar Ali khan Ali Faraz University of engineering and Technology(UET) LahorePakistan Chemical engineering department NFC Institute of Engineering and Fertilizer ResearchFaislabadPakistan Chemical engineering department Punjab UniversityLahorePakistan

Ammonia production is vital in global industries but faces increasing environmental concerns,necessitating a shift towards sustainable *** review comprehensively explores diverse hydrogen production approaches and their potential impact on sustainable ammonia *** primary focus is investigating hydrogen production methods that enhance both efficiency and sustainability in ammonia synthesis,which is crucial for reducing its environmental ***,the review highlights the pivotal role of catalysts in improving Faradaic efficiency in ammonia synthesis,emphasizing their significance in overall process *** study identifies innovative technologies that have the potential to revolutionize ammonia production while aligning with global sustainability *** a thorough examination of hydrogen production methods and catalytic advances,this review provides valuable insight into greener and more efficient ammonia production *** conclusion,it emphasizes the importance of exploring hydrogen production methods and leveraging catalysts to improve ammonia production sustainability and *** addresses a critical research gap and paves the way for an environmentally responsible and globally aligned ammonia production industry.

关键词： ammonia production green alternatives sustainability catalyst

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Artificial Intelligence Prediction of One-Part Geopolymer Compressive Strength for Sustainable Concrete

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Computer Modeling in engineering & Sciences 2024年第10期141卷 525-543页

作者： Mohamed Abdel-Mongy Mudassir Iqbal M.Farag Ahmed.M.Yosri Fahad Alsharari Saif Eldeen A.S.Yousef department of Civil engineering College of EngineeringJouf UniversitySakaka72388Saudi Arabia department of Civil engineering University of Engineering and TechnologyPeshawar54890Pakistan Civil engineering department Faculty of EngineeringAl-Azhar UniversityCairo11884Egypt Civil engineering department Faculty of EngineeringAswan UniversityAswan81528Egypt

Alkali-activated materials/geopolymer(AAMs),due to their low carbon emission content,have been the focus of recent studies on ecological *** terms of performance,fly ash and slag are preferredmaterials for precursors for developing a one-part ***,determining the optimum content of the input parameters to obtain adequate performance is quite challenging and scarcely ***,in this study,machine learning methods such as artificial neural networks(ANN)and gene expression programming(GEP)models were developed usingMATLAB and GeneXprotools,respectively,for the prediction of compressive strength under variable input materials and content for fly ash and slag-based one-part *** database for this study contains 171 points extracted from literature with input parameters:fly ash concentration,slag content,calcium hydroxide content,sodium oxide dose,water binder ratio,and curing *** performance of the two models was evaluated under various statistical indices,namely correlation coefficient(R),mean absolute error(MAE),and rootmean square error(RMSE).In terms of the strength prediction efficacy of a one-part geopolymer,ANN outperformed *** and parametric analysis were also performed to identify the significant contributor to *** to a sensitivity analysis,the activator and slag contents had the most effects on the compressive strength at 28 *** water binder ratio was shown to be directly connected to activator percentage,slag percentage,and calcium hydroxide percentage and inversely related to compressive strength at 28 days and curing temperature.

关键词： Artificial intelligence techniques one-part geopolymer artificial neural network gene expression modelling sustainable construction polymers

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Synergistic enhancement of photocatalytic and antimicrobial efficacy of nitrogen and erbium co-doped ZnO nanoparticles

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Journal of Rare Earths 2024年第5期42卷 859-868,I0002页

作者： Sudipta Mondal Moniruzzaman Jamal Sikder Ashikuzzaman Ayon Md Jannatul Ferdous Anik Md Muktadir Billah department of Materials and Metallurgical engineering Bangladesh University of Engineering and TechnologyDhaka1000Bangladesh School of Materials engineering Purdue UniversityWest LafayetteIN47907USA department of Materials Science and engineering University of CaliforniaBerkeleyCA94720USA department of Materials Science and engineering Northwestern UniversityEvanstonI28USA

Using the chemical co-precipitation approach,a series of nitrogen(N) and erbium(Er) co-doped ZnO nanoparticles(NPs) was effectively synthesized to enhance the photocatalytic and antibacterial *** characterization techniques,including X-ray diffraction(XRD),X-ray photoelectron spectro scopy(XPS),scanning electron microscopy(SEM),UV-vis,and photoluminescence(PL) spectroscopy,were carried out to validate the evaluated photocatalytic and antibacterial *** analysis confirms the pure wurtzite ZnO phase without the presence of any secondary *** analysis confirms the succe ssful incorporation of nitrogen and erbium into the ZnO *** optical bandgap of ZnO calculated from UV-vis spectroscopy shows a redshift after Er-N co-doping,with the lowest bandgap of 3.215 eV calculated for Zn_(0.97)Er_(0.03)N_(0.01)O_(0.99) *** images demonstrate the formation of nanorods after N-Er co-doping,followed by gradually increase d rod diameter and length after N-Er ***,the photocatalytic activities of ZnO samples we re measured by their ability to facilitate the photodegradation of Rhodamine B under UV *** with 1 mol% N doping exhibits 88% photodegradation of RhB under UV light within 360 min,and the photodegradation and antibacterial activity are greatly improved with Er *** fact,3 mol% Er-1 mol% N doped ZnO NPs demonstrate the highest photocatalytic activity,with approximately 96% degradation after 360 min,as well as superior antibacterial activity against Staphylococcus aureus(Gram-positive bacteria) and Pseudomonas aeruginosa(Gram-negative bacteria) with the highest zone of inhibition(ZOI) of 16 nm,due to nanorod formation,increased reactive oxygen species(ROS),and decreased electron-hole recombination,as validated by SEM,XPS,and PL spectroscopy.

关键词： Chemical co-precipitation Co-doping Bandgap Photocatalysis Rare earths Antimicrobial

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biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration

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Neural Regeneration Research 2024年第10期19卷 2157-2174页

作者： Shihong Zhu Xiaoyin Liu Xiyue Lu Qiang Liao Huiyang Luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu Jing Chen department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National engineering Research Center for biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina department of Anesthesiology West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Out-patient department West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties

关键词： bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury

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