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A New Approach for the Calculation of Slope Failure Probability with Fuzzy Limit-State Functions

Fluid Dynamics & Materials Processing 2025年第1期21卷 141-159页

作者： Jianing Hao Dan Yang Guanxiong Ren Ying Zhao Rangling Cao department of Engineering Management Sichuan College of Architectural TechnologyDeyang61800China department of Transport and Municipal Engneering Sichuan College of Architectural TechnologyDeyang61800China department of basic Teaching Sichuan College of Architectural TechnologyDeyang61800China Sichuan Hongye Construction Software Co. Ltd.Chengdu610081China

This study presents an innovative approach to calculating the failure probability of slopes by incorporating fuzzylimit-state functions,a method that significantly enhances the accuracy and efficiency of slope stability *** traditional probabilistic techniques,this approach utilizes a least squares support vector machine(LSSVM)optimized with a grey wolf optimizer(GWO)and K-fold cross-validation(CV)to approximate the limit-statefunction,thus reducing computational *** novelty of this work lies in its application to one-dimensional(1D),two-dimensional(2D),and three-dimensional(3D)slope models,demonstrating its versatility andhigh *** proposed method consistently achieves error margins within 3%of Monte Carlo simulation(MCS)results,while substantially reducing computation time,particularly for 2D and 3D *** makes theapproach highly practical for real-world engineering ***,by applying fuzzy mathematics tohandle uncertainties in geotechnical properties,the method offers a more realistic and comprehensive understandingof slope *** water is the main factor influencing the stability of slopes,this aspect is investigatedby calculating the phreatic line after the change in water *** examples are used to show that the failureprobability of a slope under water wading condition can increase by more than 20%(increase rates in 1D,2D and3D conditions being 25%,27%and 31%,respectively)compared with the natural *** influence ofdiverse fuzzy membership functions—linear,normal,and Cauchy—on failure probability is also *** not only provides a strategy for better calculation of the slope failure probability but also pioneers theintegration of computational intelligence,fuzzy logic and fluid-dynamics in geotechnical engineering,presentingan innovative and efficient tool for slope stability analysis.

关键词： Least Squares Support Vector Machine(LSSVM) Grey Wolf Optimizer(GWO) slope stability analysis fuzzy set theory failure probability estimation

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Effects of rare-earth Pr3+-Dy3+ doping on structural,magnetic,optical and dielectric properties of Zn2Y hexaferrite

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Journal of Rare Earths 2025年第2期43卷 329-336页

作者： Ibrahim Mohammed Mohamed E.El Sayed Ali Shawabkeh Mohammad N.Murshed Ibtehaj F.Alshdoukhi Zeinhom M.El-Bahy J.Mohammed A.K.Srivastava department of Physics Lovely Professional University department of Science technology Waziri Umaru Federal Polytechnic Birnin Kebbi Physics department Faculty of Science and ArtsKing Khalid University College of Engineering and technology American University of the Middle East department of basic Sciences College of Science and Health ProfessionsKing Saud Bin Abdulaziz University for Health ScienceKing Abdullah International Medical Research Center department of Chemistry Faculty of ScienceAl-Azhar University department of Physics Faculty of ScienceFederal University Dutse

This study was conducted to investigate the properties of Pr3+-Dy3+doped Zn2Y-type hexaferrite for potential technological applications.X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR） and field-emission scanning electron microscopy（FESEM） were used to analyze structural *** crystallite size in the synthesized samples varies between 57.54 and 68.57 *** vibrational bands at 400 and 600 cm-1,common to all hexaferrites,were confirmed through *** FESEM analysis reveals an agglomeration of magnetic grains and a decrease in the average grain size from 1.24 to1.06 μ*** M-H loops show that,with x values of 0.0,0.1,and 0.2,the saturation magnetization is determined to be 34.76,34.23,and 32.52 emu/g,*** corresponding coercivity values are21.24,30.39,and 33.99 ***-visible spectroscopy using Tauc theory reveals an increase in the optical band gap from 2.32 to 2.50 eV,indicating a tunable energy band structure by incorporating Pr3+-Dy3+*** dielectric constant increases,whereas AC conductivity decreases with increased Pr3+-Dy3+*** obtained results suggest the potential suitability of these materials for various technological applications.

关键词： Dielectric constant Magnetic hysteresis Optical band gap Pr3+-Dy3+ Rare earths Zn2Y-type hexaferrite

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Graduate Student Chongqing Medical UniversityChongqingChina department of basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of basic Medical Sciences Fudan UniversityShanghai 200032China department of basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

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Damage analysis caused by ^(60)Co ions in functionally graded materials

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Defence technology(防务技术) 2025年第2期44卷 248-256页

作者： Zübeyde Özkan Ugur Gökmen Sema Bilge Ocak department of Advanced Technologies Graduate School of Natural and Applied SciencesGazi UniversityAnkara06560Turkiye department of Metallurgical and Materials Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkiye basic and Engineering Sciences Central Laboratory Application and Research Center Gazi UniversityAnkara 06560Turkiye

Functionally graded composite/hybrid materials(FGCM/FGHCM)were produced by adding B_(4)C,TiO_(2),and B_(4)C+TiO_(2)ceramic materials at various ratios(0-50%)into the AA6082 *** analysis of the damage caused by^(60) ions'(1.173-1.1332 MeV)on the material was examined using the SRIM/TRIM Monte Carlo simulation *** the simulation,the following data regarding the atoms of the target materials were obtained:ion distribution,target ionization,total displacements,surface binding energy,lattice binding energy,and displacement *** the studied four materials,the one with the highest ion range value was found to be AA6082 with ***_(2)was found to be the reinforcement material that reduced the ion range the most in the *** to its high binding energy,B_(4)C reinforced AA6082+(0-50%)B_(4)C FGCM was found to have the least vacancy with 4782/ion.

关键词： SRIM/TRIM Damage analysis AA6082 ^(60)Co ion

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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The regulatory effects of gut microbiota on breast health and human milk composition via gut-mammary gland axis

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Food Science and Human Wellness 2025年

作者： Manlin Zhou Xi He Qidi Xue Muhammad Naveed Binqi Rui Ye Wang Yinhui Liu Ming Li department of Microecology， College of basic Medical Science， Dalian Medical University

The gut-mammary gland axis connects the communication between the gut microbiota and the mammary gland. Studies have reported that dysbiosis in gut microbiota is involved in the pathogenesis of breast diseases such as mastitis and breast cancer. In addition， different diets， including the supplementation of probiotics or prebiotics， which are closely related to the alteration of gut microbiota， were found to affect the nutritional contents of human milk and contribute to the development or alleviation of breast diseases. These studies suggested that the gut microbiota might be a new target for the regulation of human milk components or breast diseases. In this article， we summarized recent research advances in the gut-mammary gland axis and discussed some of the effective mechanisms and pathways involved， including distal translocation of gut microbiota， circulation of metabolites across the blood-milk barrier， the delivery of immune cells and their secreted antibodies to the mammary gland. This article also provides new strategies for preventing women's breast diseases and improving the composition of human milk through the gut-mammary axis.

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Intelligent integrated sensing and communication:a survey

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Science China(Information Sciences) 2025年第03期68卷 5-46页

作者： Jifa ZHANG Weidang LU Chengwen XING Nan ZHAO Naofal AL-DHAHIR George K.KARAGIANNIDIS Xiaoniu YANG School of Information and Communication Engineering Dalian University of Technology College of Information Engineering Zhejiang University of Technology School of Information and Electronics Beijing Institute of Technology department of Electrical and Computer Engineering The University of Texas at Dallas department of Electrical and Computer Engineering Aristotle University of Thessaloniki

Integrated sensing and communication (ISAC) is a promising technique to increase spectral efficiency and support various emerging applications by sharing the spectrum and hardware between these functionalities. However, the traditional ISAC schemes are highly dependent on the accurate mathematical model and suffer from the challenges of high complexity and poor performance in practical scenarios. Recently, artificial intelligence (AI) has emerged as a viable technique to address these issues due to its powerful learning capabilities, satisfactory generalization capability, fast inference speed, and high adaptability for dynamic environments, facilitating a system design shift from model-driven to data-driven. Intelligent ISAC, which integrates AI into ISAC, has been a hot topic that has attracted many researchers to investigate. In this paper, we provide a comprehensive overview of intelligent ISAC, including its motivation, typical applications, recent trends, and challenges. In particular, we first introduce the basic principle of ISAC, followed by its key techniques. Then, an overview of AI and a comparison between model-based and AI-based methods for ISAC are provided. Furthermore, the typical applications of AI in ISAC and the recent trends for AI-enabled ISAC are reviewed. Finally, the future research issues and challenges of intelligent ISAC are discussed.

关键词： artificial intelligence deep learning deep reinforcement learning federated learning generative artificial intelligence integrated sensing and communication machine learning transfer learning

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Noncommutativity and its role in constant-roll inflation models with non-minimal coupling constrained by swampland conjectures

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Chinese Physics C 2025年第02期 241-258页

作者： Saeed Noori Gashti Mohammad Reza Alipour Mohammad Ali S.Afshar Jafar Sadeghi School of Physics Damghan University department of Physics Faculty of Basic SciencesUniversity of Mazandaran

In this paper, using Hamiltonian formalism, we obtain solutions for constant-roll inflation according to the noncommutativity and the non-minimal coupling field of the Lagrangian. We consider three different types of couplings: power-law, exponential, and logarithmic. Subsequently, by plotting some figures, we study the effects of these coupling in constant-roll inflation with noncommutative parameters. We identify and specify the permissible regions of each case of the swampland conjecture and determine the best model. We find that the exponential, logarithmic, and power-law couplings with θ>0 ar results in both cases, some of which are compatible and some incompatible with the dS swampland ***,θ>0 is more compatible than θ<0, and the consistency value in the second boundary condition is much higher than in the first. The order of better compatibility of couplings with the swampland conjecture is ranked as follows: exponential non-minimal coupling, logarithmic non-minimal coupling, and power-law non-minimal coupling. For each type of coupling, we calculate the values of the scalar spectral index n s and the tensor-to-scalar ratio r for two different potentials and compare them with the observational data from Planck 2018. We also determine the range of the free parameters(a, b, q)model consistent with the conjecture. We find that the model satisfies the FRDSSC for all types of couplings and both potentials, with some constraints on the parameters.

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