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Existence of Multiple Normalized Solutions for Schr?dinger-Choquard Equation with Mixed Nonlinearities

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Acta Mathematicae Applicatae Sinica 2024年

作者： Li-qin TANG Li WANG Jun WANG School of Mathematics Sun Yat-sen University department of basic courses Hefei University of economics College of Science East China Jiaotong University

This paper considers the existence of multiple normalized solutions of the following SchrodingerChoquard equation where c,ε,μ> 0,N≥3,α∈(0,N),(N+α)/N

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Giant and controllable Goos–H?nchen shift of a reflective beam off a hyperbolic metasurface of polar crystals

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Chinese Physics B 2024年第1期 300-307页

作者：薛天李宇博宋浩元王相光张强付淑芳周胜王选章 Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Educationand School of Physics and Electronic EngineeringHarbin Normal University department of basic courses Guangzhou Maritime University

We conduct a theoretical analysis of the massive and tunable Goos–H¨anchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH shifts.Based on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ0is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 108λ0/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.

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Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： S.W.Wi Y.S.Lee department of Physics and Integrative Institute of basic Sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction method.The red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission significantly.This improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence Sensitizer Rare earths

MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina department of basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths globally.The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality rate.Unfortunately,there is currently no specific and effective marker to predict and treat metastasis in ESCC.MicroRNAs(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in length.miRNAs are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of cancer.Here,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic factors.This review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

Engineering the spectra of photon triplets generated from micro/nanofiber

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Chinese Physics B 2024年第3期33卷 408-414页

作者：瞿川郭东琴李笑笑刘振旗赵义张胜海卫正统 The College of basic department Information Engineering UniversityZhengzhou 450000China

Quantum light sources are the core resources for photonics-based quantum information processing.We investigate the spectral engineering of photon triplets generated by third-order spontaneous parametric down-conversion in micro/nanofiber.The phase mismatching at one-third pump frequency gives rise to non-degenerate photon triplets,the joint spectral intensity of which has an elliptical locus with a fixed eccentricity of√6/3.Therefore,we propose a frequency-division scheme to separate non-degenerate photon triplets into three channels with high heralding efficiency for the first time.Choosing an appropriate pump wavelength can compensate for the fabrication errors of micro/nanofiber and also generate narrowband,non-degenerate photon triplet sources with a high signal-to-noise ratio.Furthermore,the long-period micro/nanofiber grating introduces a new controllable degree of freedom to tailor phase matching,resulting from the periodic oscillation of dispersion.In this scheme,the wavelength of photon triplets can be flexibly tuned using quasi-phase matching.We study the generation of photon triplets from this novel perspective of spectrum engineering,and we believe that this work will accelerate the practical implementation of photon triplets in quantum information processing.

关键词： photon triplets micro/nanofiber spectrum engineering

Single-cell RNA sequencing to understand host-virus interactions

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Virologica Sinica 2024年第1期39卷 1-8页

作者： Jia-Tong Chang Li-Bo Liu Pei-Gang Wang Jing An department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Single-cell RNA sequencing(scRNA-seq)has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution.This review summarizes the existing scRNA-seq technologies together with their strengths and weaknesses.The applications of scRNA-seq in various virological studies are discussed in depth,which broaden the understanding of the immune atlas,host-virus interactions,and immune repertoire.scRNA-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

关键词： Single-cell RNA sequencing(scRNA-seq) Host-virus interaction COVID-19 Flavivirus

Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages

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World Journal of Stem Cells 2024年第4期16卷 434-443页

作者： Fatimah Almahasneh Ejlal Abu-El-Rub Ramada R Khasawneh Rawan Almazari department of basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory properties.Serial passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized yet.AIM To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of MSCs.METHODS In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and P10.Proliferation,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,respectively.RESULTS Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress conditions.At P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at P6.Cells cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was observed.On the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at P8.CONCLUSION These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.

关键词： Mesenchymal stem cells High glucose Hypoxia Stressful microenvironment Serial passage Senescence Apoptosis

Higgs-like(pseudo)scalars in AdS_(4),marginal and irrelevant deformations in CFT_(3),and instantons on S^(3)

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Chinese Physics C 2024年第4期48卷 68-81页

作者： M.Naghdi department of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Employing a 4-form ansatz of 11-dimensional supergravity over a non-dynamical AdS_(4)×S^(7)/Z_(k)background and setting the internal space as an S1 Hopf fibration on CP3,we obtain a consistent truncation.The(pseudo)scalars,in the resulting scalar equations in Euclidean AdS_(4)space,may be considered to arise from(anti)M-branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed M2-brane background(as the resulting theory is for anti-M2-branes),thus realizing the modes after swapping the three fundamental representations 8_(s),8_(c),and 8_(v) of SO(8).Taking the backreaction on the external and internal spaces,we obtain the massless and massive modes,corresponding to exactly marginal and marginally irrelevant deformations on the boundary CFT3,respectively.Subsequently,we obtain a closed solution for the bulk equation and compute its correction with respect to the background action.Next,considering the Higgs-like(breathing)mode m^(2)=18,having all supersymmetries as well as parity and scale-invariance broken,solving the associated bulk equation with mathematical methods,specifically the Adomian decomposition method,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the SU(4)×U(1)-singlet sectors of the ABJM model.Then,introducing the new dual deformationΔ_(+)=3,6 operators made of bi-fundamental scalars,fermions,and U(1)gauge fields,we obtain the SO(4)-invariant solutions as small instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： AdS_(4)/CFT_(3)correspondence scalar equations in AdS_(4) instantons marginal and irrelevant operators (anti)M-branes

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA Zhe GENG Qing-hua LI Yu-lin REN Chun-guang David P.Molloy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma cells.Methods Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,respectively.Quantitative reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was explored.Results Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-2.In addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin pathway.This underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii