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New grating compressor designs for XCELS and SEL-100 PW projects

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High Power Laser Science and Engineering 2024年第3期12卷 126-133页

作者： Efim Khazanov Gaponov-Grekhov Institute of applied Physics of the Russian Academy of sciences Niznij NovgorodRussia

The problem of optimizing the parameters of a laser pulse compressor consisting of four identical diffraction gratings is solved *** goal of optimization is to obtain maximum pulse power,completely excluding both beam clipping on gratings and the appearance of spurious diffraction *** analysis is carried out in a general form for an out-of-plane *** particular‘plane'cases attractive from a practical point of view are analyzed in more detail:a standard Treacy compressor(TC)and a compressor with an angle of incidence equal to the Littrow angle(LC).It is shown that in both cases the LC is superior to the ***,for 160-cm diffraction gratings,optimal LC design enables 107 PW for XCELS and 111 PW for SEL-100 PW,while optimal TC design enables 86 PW for both projects.

关键词： Littrow angle compressor multi-petawatt lasers Treacy compressor

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Semi-analytical investigation of heat transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

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applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 197-216页

作者： C.G.PAVITHRA B.J.GIREESHA M.L.KEERTHI department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian decomposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic field

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Introducing urea into tirapazamine derivatives to enhance anticancer therapy

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National Science Review 2024年第4期11卷 245-253页

作者： Yajun Xu Jianlin Lv Chaoying Kong Ya Liu Kun Wang Zhaohui Tang Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of applied Chemistry and Engineering University of Science and Technology of China

Tirapazamine（TPZ） has been approved for multiple clinical trials relying on its excellent anticancer ***,as a typical hypoxia-activated prodrug（HAP）,TPZ did not exhibit survival advantages in Phase Ⅲ clinical trials when used in combination therapy due to the insufficient hypoxia levels in patients' *** this study,to improve the therapeutic effects of TPZ,we first introduced urea to synthesize a series of urea-containing derivatives of *** urea-containing TPZ derivatives showed increased hypoxic cytotoxicity（9.51-30.85-fold） compared with TPZ,while maintaining hypoxic ***,one of these derivatives,showed 20-fold higher cytotoxicity than TPZ while maintaining a similar hypoxic cytotoxicity *** highly efficiently deliver TPZP to the tumors and reduce its side effects on healthy tissues,we further prepared TPZP into a nanodrug with fibrin-targeting ability:***4-NPs,a vascular disrupting agent,was used to increase the fibrin level within tumors and exacerbate tumor *** being combined with CA4-NPs,FT11-TPZP-NPs can accumulate in the hypoxia-aggravated tumors and activate sufficiently to kill tumor *** a single-dose treatment,FT11-TPZP-NPs+CA4-NPs showed a high inhibition rate of 98.1% against CT26 tumor models with an initial volume of ～480 mm3and four out of six tumors were completely eliminated;it thereby exerted a significant antitumor *** study provides a new strategy for improving the therapeutic effect of TPZ and other HAPs in anticancer therapy.

关键词： tirapazamine vascular disrupting agent hypoxia-activated prodrug combretastatin A4 urea

Performance of Text-Independent Automatic Speaker Recognition on a Multicore System

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Tsinghua Science and Technology 2024年第2期29卷 447-456页

作者： Rand Kouatly Talha Ali Khan Faculty of Tech and Software Engineering University of Europe for Applied SciencesPotsdam 14469Germany

This paper studies a high-speed text-independent Automatic Speaker Recognition(ASR)algorithm based on a multicore system's Gaussian Mixture Model(GMM).The high speech is achieved using parallel implementation of the feature's extraction and aggregation methods during training and testing *** memory parallel programming techniques using both OpenMP and PThreads libraries are developed to accelerate the code and improve the performance of the ASR *** experimental results show speed-up improvements of around 3.2 on a personal laptop with Intel i5-6300HQ(2.3 GHz,four cores without hyper-threading,and 8 GB of RAM).In addition,a remarkable 100%speaker recognition accuracy is achieved.

关键词： Automatic Speaker Recognition(ASR) Gaussian Mixture Model(GMM) shared memory parallel programming PThreads OpenMP

Metabologenomics and network pharmacology to understand the molecular mechanism of cancer research

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World Journal of Clinical Cases 2024年第3期12卷 474-478页

作者： Yusuf Tutar department of Basic Pharmaceutical sciences Faculty of PharmacyDivision of BiochemistryUniversity of Health SciencesIstanbul 34668Turkey health sciences Faculty Recep Tayyip Erdogan UniversityRize 53350Turkey Molecular Oncology Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey Molecular Medicine Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey

In this editorial I comment on the article“Network pharmacological and molecular docking study of the effect of Liu-Wei-Bu-Qi capsule on lung cancer”published in the recent issue of the World Journal of Clinical Cases 2023 November 6;11(31):*** all living forms are able to manufacture particular chemicals-metabolites that enable them to differentiate themselves from one another and to overcome the unique obstacles they encounter in their natural *** methods for chemical warfare,communication,nutrition acquisition,and stress prevention are made possible by these specialized *** is a popular technique for collecting direct mea-surements of metabolic activity from many biological ***,con-fusing metabolite identification is a typical issue,and biochemical interpretation is frequently constrained by imprecise and erroneous genome-based estimates of enzyme *** annotation and gene integration uses a biochemical reaction network to obtain a metabolite-gene association so called *** network uses an approach that emphasizes metabolite-gene consensus via biochemical *** metabolomics and genomics data is ***,computer networking proposes that using meta-bolomics data may improve annotations in sequenced species and provide testable hypotheses for specific biochemical *** The genome and metabolites of biological organisms are not fully characterized with current ***,increasing high-throughput metabolomics and genomics data provide promising generation of paired data sets to understand the molecular mechanism of biochemical processes as well as determining targets for pharmaceutical drug *** network infrastructures to integrate omics analysis can provide molecular mechanism of biochemical ***,clinical data may be integrated to gene expression–metabolite expression by system genetics appr

关键词： Network pharmacology Metabologenomics Genome Pathways Cancer

Source localization based on field signatures:Laboratory ultrasonic validation

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Journal of Electronic Science and Technology 2024年第3期22卷 47-56页

作者： Mahmoud Eissa Dmitry Sukhanov department of Radiophysics Tomsk State UniversityTomsk634050Russia Higher Institute for applied sciences and Technology(HIAST) Damascus31983Syria

Location awareness in wireless networks is essential for emergency services,navigation,gaming,and many other *** article presents a method for source localization based on measuring the amplitude-phase distribution of the field at the base *** existing scatterers in the target area create unique scattered field interference at each source *** unique field interference at each source location results in a unique field signature at the base station which is used for source *** the proposed method,the target area is divided into a grid with a step of less than half the *** grid node is characterized by its field signature at the base *** signatures corresponding to all nodes are normalized and stored in the base station as fingerprints for source *** normalization of the field signatures avoids the need for time synchronization between the base station and the *** a source transmits signals,the generated field signature at the base station is normalized and then correlated with the stored *** maximum correlation value is given by the node to which the source is the *** simulations and results of experiments on ultrasonic waves in the air show that the ultrasonic source is correctly localized using broadband field signatures with one base station and without time *** proposed method is potentially applicable for indoor localization and navigation of mobile robots.

关键词： Base station Field signature Fingerprints Localization Ultrasonic frequencies

The prescribed Gauduchon scalar curvature problem in almost Hermitian geometry

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Science China Mathematics 2024年第10期67卷 2357-2372页

作者： Yuxuan Li Wubin Zhou Xianchao Zhou School of Mathematical sciences Tongji UniversityShanghai 200092China department of applied Mathematics Zhejiang University of TechnologyHangzhou 310023China

In this paper,we consider the prescribed Gauduchon scalar curvature problem on almost Hermitian *** deducing the expression of the Gauduchon scalar curvature under the conformal variation,we reduce the problem to solving a semi-linear partial differential equation with exponential *** the super-and sub-solutions method,we show that the existence of the solution to this semi-linear equation depends on the sign of a constant associated with the Gauduchon *** the sign is negative,we give both necessary and sufficient conditions such that a prescribed function is the Gauduchon scalar curvature of a conformal Hermitian ***,this paper recovers the Chern-Yamabe problem,the Lichnerowicz-Yamabe problem,and the Bismut-Yamabe problem.

关键词： almost Hermitian manifold Gauduchon connection prescribed scalar curvature problem

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Modeling and optimal control of COVID-19 with comorbidity and three-dose vaccination in Indonesia

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Journal of Biosafety and Biosecurity 2024年第3期6卷 181-195页

作者： Muhammad Abdurrahman Rois Fatmawati Cicik Alfiniyah Santi Martini Dipo Aldila Farai Nyabadza department of Mathematics Faculty of Science and TechnologyUniversitas AirlanggaSurabayaIndonesia department of Mathematics Universitas Islam Negeri SalatigaSalatigaIndonesia department of Epidemiology BiostatisticsPopulation and Health PromotionFaculty of Public HealthUniversitas AirlanggaSurabayaIndonesia department of Mathematics Faculty of Mathematics and Natural SciencesUniversitas IndonesiaDepokIndonesia department of Mathematics and applied Mathematics University of JohannesburgAuckland ParkSouth Africa department of applied sciences Emirates Aviation UniversityUnited Arab Emirates

This paper presents and examines a COVID-19 model that takes comorbidities and up to three vaccine doses into *** analyze the stability of the equilibria,examine herd immunity,and conduct a sensitivity analysis validated by data on COVID-19 in *** disease-free equilibrium is locally and globally asymptotically stable whenever the basic reproduction number is less than one,while an endemic equilibrium exists and is globally asymptotically stable when the number is greater than ***,the model incorporates two effective measures,namely public education and enhanced medical care,to determine the most advantageous approach for mitigating the transmission of the *** optimal control model is then determined using Pontryagin’s maximum *** integrated control strategy is the best method for reliably safeguarding the general population against COVID-19 *** evaluations and numerical simulations corroborate this conclusion.

关键词： COVID-19 Comorbidity Stability Herd immunity Optimal control Cost evaluation

Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2