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Prognostic roles nutritional index in patients with resectable and advanced biliary tract cancers

World Journal of Gastroenterology 2025年第6期31卷 76-88页

作者： Di Zeng Ning-Yuan Wen Yao-Qun Wang Nan-Sheng Cheng Bei Li Division of Biliary surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Center for Biliary Diseases West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Biliary tract cancer(BTC)is a rare,aggressive malignancy with increasing inci-dence and poor *** preoperative prognostic factors is crucial for effective risk-benefit assessments and patient *** prognostic nutritional index(PNI),which reflects immune-inflammatory and nutritional status,has shown prognostic value in various cancers,but its significance in BTC remains *** To assess the prognostic value of the preoperative PNI in BTC patients,with a focus on overall survival(OS)and disease-free survival(DFS).METHODS Comprehensive searches were conducted in the PubMed,EMBASE,and Web of Science databases from inception to April *** primary outcomes of interest focused on the associations between the preoperative PNI and the prognosis of BTC patients,specifically OS and disease-free survival(DFS).Statistical analyses were conducted via STATA 17.0 *** Seventeen studies encompassing 4645 patients met the inclusion ***-analysis revealed that a low PNI was significantly associated with poorer OS[hazard ratio(HR)1.91,95%CI:1.59-2.29;P<0.001]and DFS(HR 1.93,95%CI:1.39-2.67;P<0.001).Subgroup analyses revealed consistent results across BTC subtypes(cholangiocarcinoma and gallbladder cancer)and stages(resectable and advanced).Sensitivity analyses confirmed the robustness of these findings,and no significant publication bias was *** This study demonstrated that a low preoperative PNI predicts poor OS and DFS in BTC patients,highlighting its potential as a valuable prognostic *** prospective studies are needed to validate these findings and enhance BTC patient management.

关键词： Biliary tract cancer Prognostic nutritional index Predictive marker Meta-analysis Survival outcomes

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Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 456-460页

作者： Meer M Chisthi department of General surgery Government Medical College PathanamthittaKonni 689691KeralaIndia

The rapid evolution of systemic therapies for hepatocellular carcinoma(HCC),one of the most common types of liver cancer,has attracted significant attention especially to hepatic arterial infusion chemotherapy(HAIC)as a highly promising treatment *** method,which delivers chemotherapy directly into the liver's arterial supply,is designed to maximize the concentration of anti-cancer drugs at the tumor site while minimizing systemic side *** the potential and the encouraging results observed in various studies,HAIC has not yet achieved widespread acceptance and *** is a widely used systemic therapy that targets multiple pathways involved in tumor growth and angiogenesis,while transarterial chemoembolization(TACE)is a locoregional therapy that combines arterial embolization with *** treatments have been the mainstay of HCC management,yet they have limitations that HAIC may potentially *** article specifically comments on the network meta-analysis that examined the current research status of HAIC,highlighting its effectiveness and safety profile in comparison to established standard treatments such as Sorafenib and *** an extensive review of existing studies,the authors conclude that patients receiving HAIC often experience better survival rates and longer periods without disease progression compared to those receiving Sorafenib or TACE.

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Network meta-analysis Interventional therapy Systemic treatment

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Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma

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World Journal of Gastroenterology 2025年第7期31卷 160-162页

作者： Yu-Bo Liang Xing-Ming Chen Wan-Ling Luo Yang Ke department of Hepatobiliary surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina department of Hepatobiliary surgery and department of Surgical Education and Research The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina

This letter comments on the recently published manuscript by Yu et al,in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemness and sorafenib resistance of hepatocellular carcinoma(HCC)through ubiquitinspecific peptidase 1-mediated deubiquitination of oncogene short stature homeobox *** the high mortality rate and poor prognosis of HCC,the findings by Yu et al open a new avenue for overcoming HCC burden by focusing on kinesin family member 9-antisense RNA 1 and short stature homeobox 2 as prognostic markers and therapeutic targets.

关键词： Kinesin family member 9-antisense RNA 1 Hepatocellular carcinoma Ubiquitin-specific peptidase 1 Short stature homeobox 2 Chemoresistance

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Challenges for pediatric liver transplantation in the mainland of China:Where we are and where to *** from worldwide largest pediatric liver transplantation program

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 35-38页

作者： Qiang Xia Ming-Xuan Feng department of Liver surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China

In China pediatric liver transplantation(PLT)has become a safe and standardized *** and measures to further improve long-term survival and quality of life for children should be the next *** particular better strategies related to the surgical treatment of high-risk recipients as well as the long-term follow-up of pediatric liver recipients have to be addressed.A particular attention should be given to children presenting significant co-morbidities and those needing retransplantation.A tight mul-tidisciplinary follow-up system addressing both short-and long-term issues of pediatric liver recipients is still a challenge for the Chinese pediatric transplant community.

关键词： Pediatric liver transplantation Retransplantation Comorbidity

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Liver transplantation for hepatocellular carcinoma: Current status in Hong Kong, China

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 45-49页

作者： Karin Ho Albert Chan Liver Transplant Center Queen Mary HospitalDepartment of SurgeryThe University of Hong KongHong KongChina

With the advances in transplant oncology in recent years, the role of liver transplantation has expanded to make curative treatment a possibility for a wider patient population. We highlight strategies in Hong Kong, China that have enabled preoperative prognostication for judicious patient selection, downstaging therapy to definitive treatment, and postoperative therapies that have provided a growing role for liver transplantation in patients with more advanced hepatocellular carcinoma.

关键词： Living donor liver transplantation Downstaging Conversion therapy Transplant oncology

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IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 246-269页

作者： Jin Zhou Jing-Rui Chen Jin-Ming Li Shuang-Qing Han Xi-Yue Deng Zhong-Min Li Wen Tong Chao Wang Yi Bai Ya-Min Zhang The First Central Clinical School Tianjin Medical UniversityTianjin 300192China department of Hepatobiliary and Pancreatic surgery Tianjin Nankai HospitalTianjin 300070China department of Hepatobiliary surgery Tianjin First Central HospitalTianjin 300070China

BACKGROUND IL-22 plays a pivotal role in the processes of inflammation and tissue healing.,but its role in cholangiocarcinoma(CCA)remains *** study explored the IL-22/IL-22R1 pathway and its impact on CCA progression through the ERK1/2 signaling *** To determine the mechanism of the IL-22/IL-22R1 pathway in CCA and provide new directions for its clinical *** IL-22R1 expression was assessed in human and rat CCA tissues utilizing immunohistochemical techniques,Western blot analysis,and quantitative reverse transcription *** impact of IL-22 on CCA cells was assessed in vitro via tests for proliferation,migration,invasion,and apoptosis *** rat models of thioacetamide-induced CCA and subcutaneous xenografts in nude mice were used to assess the in vivo ***1/2 inhibitors were applied to elucidate the mechanistic role of the *** IL-22R1 was overexpressed in CCA cell lines and ***-22 treatment increased the phosphorylation of ERK1/2,promoting tumor cell proliferation,migration,invasion,and resistance to ***1/2 inhibition considerably reversed these effects both in vitro and in *** The IL-22/IL-22R1 axis promotes CCA progression by activating ERK1/2 *** this pathway with ERK1/2 inhibitors offers potential therapeutic strategies for CCA.

关键词： Cholangiocarcinoma IL-22 IL-22R1 ERK1/2 Cancer progression

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Large-for-size syndrome prophylaxis in infant liver recipients with low body mass

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World Journal of Transplantation 2025年第1期15卷 72-85页

作者： Konstantin Semash Timur Dzhanbekov department of Mini-Invasive surgery National Children's Medical CenterTashkent 100171ToshkentUzbekistan

Transplantation of the left lateral section(LLS)of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children,with variants of the LLS primarily used in ***,the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains *** review explores historical developments,various approaches to measuring the required functional liver mass,and techniques to prevent complications associated with large-for-size grafts in infants.

关键词： Pediatric liver transplantation Large-for-size syndrome Preoperative evaluation of donor and recipient Liver volumetry Monosegmental transplantation Left lateral sector graft Reduced size liver graft Abdominal wall reconstruction Liver transplantation Liver resection

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Advancements and challenges in laparoscopic hepatectomy in Japan

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中国普通外科杂志 2025年第1期34卷 28-32页

作者： Goro HONDA department of surgery Institute of GastroenterologyTokyo Women's Medical UniversityTokyo 162-8666Japan

In the 2010s,laparoscopic hepatectomy(LH) rapidly gained popularity in Japan as a minimally invasive approach for liver *** offers significant advantages,such as reduced postoperative pain and faster *** Glissonean pedicle approach,employed during LH,enables precise anatomical resection,particularly for hepatocellular carcinoma and metastatic liver *** in training,including the use of animal models and the Japan Society for Endoscopic surgery certification program,have been instrumental in improving surgical ***,complex hepatectomies involving vascular or biliary reconstruction pose substantial technical *** hepatectomy(RAH) has shown great potential for improved precision and visualization,though its high costs and uncertain long-term benefits limit its widespread *** technological advancements,enhanced training programs,and large-scale comparative trials are necessary to evaluate the longterm efficacy of both LH and RAH.

关键词： Hepatectomy Laparoscopes Anatomical Hepatectomy Glissonean Pedicle Approach

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Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara E Agko Marina N Kouliou Konstantinos E Koumarelas Dimitris Zacharoulis department of General surgery University Hospital of LarissaLarissa 41110Greece department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany department of Emergency Medicine General Hospital of LarissaLarissa 41221Greece department of surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIE)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIE include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIE’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIE.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

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Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： Xing-Yu Chen Xiang Lan department of Hepatobiliary surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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