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World Journal of Hepatology 2025年第1期17卷 187-190页

作者： Lei-Yang Jin Kai Wang Bo-Tao Xu department of Hepatobiliary surgery Zhuji People’s HospitalZhuji 311800Zhejiang ProvinceChina department of Cardiothoracic surgery Zhuji People’s HospitalZhuji 311800Zhejiang ProvinceChina

This letter discusses the recent study by Mukherjee et al,which identifies a significant prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)among newly diagnosed type 2 diabetes mellitus(T2DM)patients in Bihar,India,and underscores the pressing need for integrated MASLD mana-gement within T2DM *** 72.3%of the study cohort affected by MASLD,implementing routine liver function tests and ultrasound screenings is recom-mended as a standard practice in diabetes care,especially in regions with high prevalence *** study also advocates for dietary and lifestyle modifications,particularly the reduction of saturated fats,to slow MASLD *** education on monitoring body mass index and waist circumference,coupled with the integration of these metrics into digital health records,could enhance patient involvement and support proactive health ***,the letter emphasizes the advantages of developing a region-specific MASLD risk model that incorporates local dietary patterns and socioeconomic *** research into genetic and environmental determinants of MASLD remains es-sential for advancing our understanding of its etiology and informing targeted public health strategies.

关键词： Body mass index Dietary intervention Fatty liver Genetic factors Liver health Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes mellitus

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Sequential living donor liver transplantation after liver resection optimizes outcomes for patients with high-risk hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 50-56页

作者： Itsuko Chih-Yi Chen Leona Bettina P Dungca Chee-Chien Yong Chao-Long Chen Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao-SungKaohsiungTaiwanChina

Background:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. While liver transplantation (LT) provides the best long-term survival, it is constrained by organ scarcity and strict criteria. Liver resection (LR) is often the initial treatment for patients with solitary tumors and preserved liver function. The high recurrence rates associated with LR has prompted the exploration of sequential living donor liver transplantation (seq LDLT) after LR as a strategy for HCC patients with high-risk of ***:We analyzed data from 27 adult patients who underwent seq LDLT after LR for HCC at Kaohsiung Chang Gung Memorial Hospital (KCGMH) between June 1994 and December 2023. Patients were selected based on high-risk histopathological features post-LR or as part of downstaging strategy. Outcomes measured included overall survival (OS) and disease-free survival (DFS).Results:Among 765 HCC patients who underwent LDLT, 204 received LR before LDLT, and 27 underwent seqL DLT. Five patients (19%) underwent living donor liver transplantation (LDLT) following LR as a downstaging strategy while the rest received seqL DLT as a preemptive strategy. The median age was 53.5 years with 85%males. Chronic hepatitis B was the predominant underlying disease (74%). The 1-, 3-, and 5-year OS and DFS rates were 100%, 96.0%, 96.0%and 100%, 96.2%, 96.2%, respectively, with two patients experiencing HCC recurrence. One patient died from HCC recurrence. High-risk histopathological features included microvascular invasion (52%), satellite nodules (15%), multiple tumors (26%), tumors> 5 cm(19%), and a total tumor diameter> 10 cm (7%).Conclusions:Seq LDLT offers a promising, tailored approach for managing HCC with adverse histopathologic features. Combining seq LDLT, downstaging strategies, and multidisciplinary treatments can achieve satisfactory OS and DFS in carefully selected patients, highlighting the need for refined criteria to identify the best candidates.

关键词： Living donor liver transplantation Liver resection High-risk hepatocellular carcinoma Sequential living donor liver transplantation Salvage living donor liver transplantation

Two cases of complex traumatic aortic dissection combined with multiple organ injuries

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Chinese Journal of Traumatology 2025年第1期28卷 29-34页

作者： Qingpeng Song Lili Bao Xuejun Wu Bingqi Liu Maohua Wang department of Vascular surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China

Traumatic aortic injury(TAI)is an acute,critical,and severe disease,and then combined with multiple organ damage,it is even more *** progresses very rapidly,with a pre-hospital mortality rate of 57%-80%,and even when arriving at the hospital,more than one-third of the patients die within 4 h,and it is the 2nd leading cause of death in individuals aged 4-34 *** addition,the incidence of TAI combined with injury was 81.4%.Therefore,early diagnosis,expeditious surgery,and timely and effective multidisciplinary cooperation are essential for successful *** authors report 2 patients with acute traumatic aortic dissection combined with multiple organ injuries and treated with emergency endovascular surgery to discuss their clinical characteristics and treatment experience,and to provide experience in the diagnosis and treatment of such patients.

关键词： Traumatic aortic injury Multi-organ failure Endovascular surgery

Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined

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World Journal of Transplantation 2025年第2期15卷 218-227页

作者： William H Archie Maria Baimas-George Nathanael Haynes Souma Kundu Katheryn Peterson Chase J Wehrle Damien Huckleberry Lon Eskind David Levi Jose R Soto Roger Denny Vincent Casingal Allyson Cochran Erin H Rein Dionisios Vrochides Division of Adominal Transplant Department of SurgeryCarolinas Medical CenterCharlotteNC 28203United States department of Hepato-Pancreato-Biliary/Liver Transplant surgery Cleveland Clinic Transplant Research CenterClevelandOH 44195United States department of surgery Carolinas Center for Surgical Outcomes ScienceCarolinas Medical CenterCharlotteNC 28203United States

BACKGROUND The normothermic machine perfusion pump(NMPP)could shape the future of *** ex-vivo optimization,NMPP attenuates ischemic insult while replenishing *** understanding of machine perfusion time(MPT)impact and potential clinical benefits is paramount and necessitates *** To investigate the relationship between MPT and post-transplant graft *** Retrospective review of the first 50 donation after circulatory death(DCD)grafts preserved using NMPP in a tertiary institution was *** preser-vation time points,graft parameters,recipient information,and postoperative outcomes were prospectively *** allograft dysfunction(EAD),L-Graft7 score and 90-day outcomes were collected for all *** first 20 re-cipients were allocated into the early group,considered the learning curve population for the *** subsequent 30 were allocated into the late *** were also stratified into cohorts depending on MPT,i.e.,short(16 hours).RESULTS NMPP operational parameters were not predictive of EAD,L-GrAFT7 or 90-day *** early group had significantly less MPT and cold ischemia time than the late group(553 minutes vs 850 minutes,P<0.001)and(127.5 minutes vs 154 minutes,P=0.025),*** had no impact in either *** Increased MPT of DCD liver grafts had no adverse recipient results for the times utilized in this population,indicating its upper limits,likely beyond 24 hours,are not demonstrated within this *** studies are necessary to determine whether longer MPT is beneficial or detrimental to graft function and,if the latter,what is the maximum safe *** studies of the effect of normothermic machine perfusion pump duration on long-term outcomes are also needed.

关键词： Normothermic machine pump perfusion Liver transplant Donation after circulatory death Ex-vivo perfusion Ischemic cholangiopathy

Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients:A multicenter retrospective study

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 56-66页

作者： Xian-Bei Yuan Gang Sun Jun Niu Lei Dong Yi Sui Yong-Zhu Lv department of General surgery No.967 Hospital of the People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina department of Trauma surgery The No.967 Hospital of People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina department of General surgery The First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina department of General surgery The Fifth People's Hospital of ShenyangShenyang 110000Liaoning ProvinceChina department of General surgery The Fifth People's Hospital of DalianDalian 116000Liaoning ProvinceChina

BACKGROUND Gastric cancer(GC)poses a significant threat to public ***,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node ***,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of *** To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and *** Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient *** Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for *** Significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all P<0.05).Lymph node metastasis rates were highest for Siewert type II patients in groups Nos.1,3,2 and 7;for Siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,*** the lower GC samples,the sequences were Nos.3,6,7,*** type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node ***,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic *** Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.

关键词： Upper gastric cancer Lower gastric cancer Metastatic lymph nodes Prognosis Retrospective study

Significance of monitoring imatinib plasma concentration in secondline treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 81-90页

作者： Hai-Tao Li Yun-Yun Du Zhen Huang Jin-Jin Li Jun Zhang department of Gastrointestinal surgery Nanchuan Hospital of Chongqing Medical UniversityChongqing 408400China department of Oncology Nanchuan Hospital of Chongqing Medical UniversityChongqing 408400China department of Gastrointestinal surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND For patients with advanced gastrointestinal stromal tumors(GISTs)carrying the ckit exon 11 mutation,imatinib(IM)at a standard dosage of 400 mg per day is the preferred first-line *** cases where treatment with IM fails,there is an urgent need for a more precise assessment method to determine whether to switch therapies or escalate the IM *** approach will enhance clinical decision-making and optimize patient *** To investigate IM plasma concentration’s role in second-line treatment decisions for c-kit 11-mutated advanced GISTs post-IM *** Patients with advanced GIST harboring c-kit 11 mutation who experienced failure with IM 400 mg per day as first-line treatment at our hospital were retrospectively *** were categorized into a low plasma(LP)concentration group(LP group,0.05).For the HP group(n=47),Group B(n=18)had a higher DCR and longer PFS than Group A(n=29)(P=0.008 and P=0.03,respectively).No difference in OS was observed between the two subgroups(P>0.05).CONCLUSION Increasing IM dosage for c-kit 11-mutated advanced GISTs post-IM failure may prolong OS if plasma concentration is<1100 ng/*** tyrosine kinase inhibitors may improve DCR and PFS if≥1100 ng/mL.

关键词： Gastrointestinal stromal tumor C-kit exon 11 Imatinib Plasma concentration Second-line treatment

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan department of Hepatobiliary surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Research and analysis of circulating tumor cell detection in the diagnosis and treatment of gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 165-170页

作者： Han-Shu Ji Second department of General surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Circulating tumor cells(CTCs)are crucial for improving our knowledge regarding tumor progress,prognosis,and recurrence *** To evaluate the role of CTCs in the early diagnosis and treatment of gastric *** From June 2020 to December 2021,a randomized study was conducted in our institution involving 80 patients scheduled for surgery for gastric *** patients were divided into two groups:A control group that was tested for traditional serum markers and a study group that was assessed for serum *** In the study cohort,CTC levels did not correlate significantly with patient age,gender,or degree of tumor differentiation(P>0.05).However,there was a significant correlation with the tumor-node-metastasis stage of the tumor(P<0.05).In the study group,the CTC diagnostic positivity rate was 62.50%(25 out of 40 patients),while the positivity rate for conventional serum markers in the control group was 47.50%(19 out of 40 patients).The positive detection rate in the study group was significantly higher than that of the control group(P<0.05).CONCLUSION CTCs have slight invasion and high sensitivity and specificity,presenting great value for early clinical diagnosis of recurrence and *** will improve the deceleration of disease development and increase the survival rate.

关键词： Gastric cancer Circulation Tumor cells Early diagnosis Randomized controlled trial

Laparoscopic donor hepatectomy: Are there obstacles on the path to global widespread?

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Laparoscopic, Endoscopic, and Robotic surgery 2025年第1期8卷 13-22页

作者： Semash, Konstantin Dzhanbekov, Timur department of Mini-invasive surgery National Children's Medical Center Tashkent 100171 Uzbekistan

Laparoscopic liver resection in living donors is a relatively novel surgical approach that has the potential to enhance donor safety and facilitate faster recovery. Following an initial development period during which donor safety was not effectively validated, the minimally invasive approach now yields better outcomes, provided that these procedures are performed by experienced surgeons. The key factors include donor selection criteria, the clinical infrastructure, and the learning curve for surgeons. This review outlines the current status of the development of laparoscopic liver resection in living donors and discusses the obstacles to the advancement of this surgical technique. © 2024 Zhejiang University

关键词： Laparoscopic donor hepatectomy Laparoscopic liver resection Living donation Living donor liver transplantation Minimally invasive donor hepatectomy