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Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of animal science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic animal Resource&Research center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea department of animal science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea department of animal science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea department of Functional genomics University of Science and TechnologyDaejeon 34113Republic of Korea department of animal science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on d2 and d6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

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A bird's-eye overview of molecular mechanisms regulating feed intake in chickens—with mammalian comparisons

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animal Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia R.Volyanskaya Ilya R.Akberdin Mikhail A.Kulyashov Ivan S.Yevshin Michael N.Romanov Elena I.Shagimardanova Oleg A.Gusev Fedor A.Kolpakov department of Natural sciences Novosibirsk State University Biosoft.Ru Ltd. Sirius University of science and Technology School of Biosciences University of Kent L.K.Ernst Federal Research Centre for animal Husbandry Regulatory genomics Research center Institute of Fundamental Medicine and BiologyKazan Federal University Life Improvement By Future Technologies (LIFT) center Intractable disease Research center Juntendo University

In recent decades, a lot of research has been conducted to explore poultry feeding behavior. However, up to now, the processes behind poultry feeding behavior remain poorly understood. The review generalizes modern expertise about the hormonal regulation of feeding behavior in chickens, focusing on signaling pathways mediated by insulin, leptin, and ghrelin and regulatory pathways with a cross-reference to mammals. This overview also summarizes state-of-the-art research devoted to hypothalamic neuropeptides that control feed intake and are prime candidates for predictors of feeding *** analysis of the signaling pathways that mediate the feed intake regulation allowed us to conclude that there are major differences in the processes by which hormones influence specific neuropeptides and their contrasting roles in feed intake control between two vertebrate clades.

关键词： Chicken Feed intake Hypothalamus Neuropeptide Signaling pathway Hormone

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Integration of molecular genetic technology with quantitative genetic technology for maximizing the speed of genetic improvement

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华南农业大学学报 2005年第S1期26卷 104-117页

作者： Jack C.M. dEKKERS department of animal science and center for integrated animal genomics 239d kildee hall Iowa State University Ames IA 50011 USA

To date,most genetic progress for quantita-tive traits in livestock has been made by selec-tion on phenotype or on estimates of breedingvalues(BBV)derived from phenotype,withoutknowledge of the number of genes that affect thetrait or the effects of each *** this quantita-tive genetic approach to genetic improvement,the genetic architecture of traits of interest hasessentially been treated as a‘black box’.de-spite this,the substantial rates of genetic im-provement that have been and continue to be a-chie...

关键词： molecular genetics quantitative genetic QTL MAS

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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation

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Journal of Genetics and genomics 2024年第8期51卷 877-879页

作者： Yuxin Kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li College of animal science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China department of animal science Fars Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation&Extension Organization(AREEO)FarsIran Author links open overlay panel

Hemoglobin is responsible for transporting oxygen from the lungs to body ***,this protein is a tetramer composed of two a-globin chains and twoβ-globin *** sheep,the β-globin locus is of particular interest because it contains two different haplotypes,namely haplotype A(hap A)and hap B,which differ in length by more than 30 kb and do not undergo recombination with each other due to low sequence similarity(Bauer and Jung,1975;Jiang et al.,2015).The two haplotypes also differ in gene content with hap A possessing two clusters of hemoglobin gene families and hap B possessing only one(Aguiletam et al.,2004),which implies differentiation in their functional *** A was speculated to be associated with high-altitude adaptation in sheep(Hu et al.,2019).

关键词： chains altitude similarity

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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research center for animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China animal genomics ETH ZürichZürich 8092Switzerland Institute of animal science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction

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animal Models and Experimental Medicine 2024年第4期7卷 408-418页

作者： Guofeng Bai Jinghao Yang Weili Liao Xiaofeng Zhou Yingting He Nian Li Liuhong Zhang Yifei Wang Xiaoli dong Hao Zhang Jinchun Pan Liangxue Lai Xiaolong Yuan Xilong Wang Guangdong Provincial Key Laboratory of Laboratory animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouChina Guangdong Laboratory of Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine IndustryState Key Laboratory of Swine and Poultry Breeding IndustryGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular BreedingCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina Huidong County animal Quarantine and Inspection Institute HuizhouGuangdongChina department of Cardiology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHainan Clinical Medicine Research InstitutionHaikouPeople's Republic of China Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdongChina

Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood *** research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in *** the specific mechanism remains *** this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and ***:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial *** we identified ATG7,which was the down-stream target gene of *** expression of miR-106a and ATG7 was investi-gated in the rat model of ***:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial ***,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by *** expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction ***:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting *** mechanism may be a potential therapeutic treatment for MI.

关键词： angiogenesis ATG7 autophagy miR-106a miRNAs myocardial infarction

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Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

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Genes & diseases 2024年第1期11卷 413-429页

作者： dongsheng Zhang Wenjuan Tang Haitao Niu William Tse Hai-Bin Ruan Helmut dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han division of Hematology and Oncology Division of Cancer BiologyDepartment of MedicineMetroHealth Medical Center(MHMC)Case Western Reserve University(CWRU)School of MedicineClevelandOH 44109USA Cancer genomics and Epigenomics Program Case Comprehensive Cancer CenterCase Western Reserve University(CWRU)ClevelandOH 44106USA division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical Center(CCHMC)CincinnatiOH 45229USA Children’s Hospital of Fudan University Shanghai 201102China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Laboratory animal science(ILAS) Chinese Academy of Medical Science(CAMS)and Peking Union Medical College(PUMC)Beijing 100006China department of Integrative Biology and Physiology University of Minnesota Medical SchoolMinneapolisMI 55455USA Institute of Medical Genetics Medical University of ViennaVienna 1040Austria Institute of Pathology Ludwig-Maximilians-University MunichMunich 80539Germany Institute of Biochemistry II University Hospital JenaJena 07743Germany Laboratory animal Pathology University of Veterinary Medicine ViennaVienna 1210Austria department of Pathology University of CincinnatiCincinnatiOH 45221USA department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266005China department of Pathology Medical University of ViennaVienna 1040Austria Ludwig Boltzmann Institute for Cancer Research Vienna 1090Austria Medical University of Vienna Vienna 1040Austria Institute of animal Breeding and Genetics University of Veterinary Medicine ViennaVienna 1210Austria division of Experimental Hematology CCHMCCincinnatiOH 45229USA

CdC42 controls intestinal epithelial(IEC)stem cell(IESC)*** aberrant CdC42 initiates intestinal inflammation or neoplasia is *** utilized models of inflam-matory bowel diseases(IBd),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and *** specimens were collected to determine the levels of CdC42 in IBd or colorectal ***42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient ***,colitis,aging,and intestinal organoid were used to evaluate CdC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC *** studies revealed that increased CdC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CdC42 were found in the inflamed IBd *** Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt *** Cdc42 depletion markedly enhanced irra-diation-or chemical-induced *** or inhibition of Cdc42 reduced colonic Lgr5+IESC *** conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal *** monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.

关键词： Cell divisioncycle 42(CdC42) Colitis Colorectal cancer(CRC) Inflammatory bowel diseases(IBd) Intestinal epithelial cell(IEC) Intestinal epithelial stem cell(IESC) Irradiation

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Knockdown of neuronal dAF-15/Raptor promotes healthy aging in ***

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Journal of Genetics and genomics 2024年第5期51卷 507-516页

作者： Xiao Zang Qi Wang Hanxin Zhang Yiyan Zhang Zi Wang Zixing Wu di Chen Model animal Research center of Medical School Nanjing UniversityNanjingJiangsu 210061China Zhejiang University-University of Edinburgh Institute School of MedicineZhejiang UniversityHainingZhejiang 314400China department of Colorectal Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China

The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across *** studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caenorhabditis ***,it has not been clear whether TORC1 perturbation affects aging in a spatiotemporal ***,we apply the auxin-inducible degradation tool to knock down endogenous dAF-15,the *** ortholog of regulatory associated protein of TOR(Raptor),to characterize its roles in *** or tissue-specific inhibition of dAF-15 during development results in various growth defects,whereas neuron-specific knockdown of dAF-15 during adulthood significantly extends lifespan and *** neuronal dAF-15 deficiency-induced longevity requires the intestinal activities of dAF-16/FOXO and PHA-4/FOXA transcription factors,as well as the AAK-2/AMP-activated protein kinaseαcatalytic *** profiling reveals that the neuronal dAF-15 knockdown promotes the expression of genes involved in *** findings define the tissue-specific roles of TORC1 in healthy aging and highlight the importance of neuronal modulation of aging.

关键词： Aging targetof rapamycin dAF-15 dAF-16 C.elegans

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分子遗传技术与数量遗传技术结合使遗传改良速度最大化

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华南农业大学学报 2005年第S1期26卷 117-124页

作者： Jack C.M. dEKKERS 张豪朱良瑞梅盈杰 department of animal science and center for integrated animal genomics 239d kildee hall Iowa State University Ames IA 50011 USA

随着分子遗传学的发展,为家畜的遗传改良提供了新的手段,可以直接选择影响性状的基因或包含基因的染色体区域,即所谓数量性状基因座(QTL)。QTL的检测和应用依赖于可以分型的遗传标记和QTL之间是否存在连锁不平衡.本文对畜群中存在的或... 详细信息

随着分子遗传学的发展,为家畜的遗传改良提供了新的手段,可以直接选择影响性状的基因或包含基因的染色体区域,即所谓数量性状基因座(QTL)。QTL的检测和应用依赖于可以分型的遗传标记和QTL之间是否存在连锁不平衡.本文对畜群中存在的或可以在试验畜群中产生的连锁不平衡的特性、及其在QTL检测和标记辅助选择中的作用进行了综述,并且概述了标记辅助选择的不同策略的优缺点.S主要的观点是利用标记辅助选择加快遗传改良的速度是可行的,特别是可以利用群体范围的连锁不平衡时更是如此,但是这需要认真地分析并在现有育种方案中落实。

关键词：分子遗传数量遗传数量性状基因座标记辅助选择

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Integration of molecular genetic technology with quantitative genetic technology for maximizing the speed of genetic improvement

Integration of molecular genetic technology with quantitativ...

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农业部“948”项目-Ensminger School国际猪遗传育种技术研讨会

作者： Jack C.M.dEKKERS department of animal science and center for integrated animal genomics 239d kildee hall Iowa State UniversityAmesIA50011USA

Advances in molecular genetics have opened opportunities to enhance strategies for genetic improvement of livestock by directly selecting on genes or chromosomal regions that harbor genes that af- fect traits of interest,so-called quantitative trait loci(QTL).detection and use of QTL relies on pres- ence of linkage disequilibrium between genetic markers that can be genotyped and *** nature of linkage disequilibrium that exists in populations or that can be created in experimental populations and its use in QTL detection and marker-assisted selection are *** and opportunities for alternate strategies for marker-assisted selection are *** main conclusion is that opportunities for use of marker-assisted selection to enhance rates of genetic improvement exist,in particular using population-wide disequilibrium,but they require careful analysis and implementation in existing breeding programs.

关键词： molecular genetics quantitative genetic QTL MAS

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