检索结果-南通市图书馆

Successful treatment of severe hepatic impairment in erythropoietic protoporphyria:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第6期16卷 966-972页

作者： Tao Zeng Shu-Ru Chen Hao-Qiang Liu Yu-Tian Chong Xin-Hua Li department of infectious diseases Key Laboratory of Liver Disease of Guangdong ProvinceThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina department of infectious diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina department of Blood Transfusion The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Erythropoietic protoporphyria(EPP)is a rare genetic disorder stemming from ferrochelatase gene mutations,which leads to abnormal accumulation of protoporphyrin IX primarily in erythrocytes,skin,bone marrow and *** porphyria-related severe liver damage is rare,its consequences can be severe with limited treatment *** SUMMARY This case study highlights a successful intervention for a 35-year-old male with EPP-related liver impairment,employing a combination of red blood cell(RBC)exchange and therapeutic plasma exchange(TPE).The patient experienced significant symptom relief and a decrease in bilirubin levels following multiple PE sessions and an RBC *** The findings suggest that this combined approach holds promise for managing severe hepatic impairment in EPP.

关键词： Erythropoietic protoporphyria Red blood cell exchange Plasma exchange Delta-aminolevulinic acid Ferrochelatase Case report

Fusobacterium nucleatum:Unraveling its potential role in gastric carcinogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第35期30卷 3972-3984页

作者： Vytenis Petkevicius Konrad Lehr Juozas Kupcinskas Alexander Link department of Gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University HospitalMagdeburg 39120Germany Institute for Digestive Research Lithuanian University of Health SciencesKaunas 50161Lithuania

Fusobacterium nucleatum(***)is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation,such as periodontitis and *** the last 10 years,*** has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression,metastasis and poor disease *** the role of *** in colon carcinogenesis has been intensively studied,its role in gastric carcinogenesis is still poorly *** Helicobacter pylori infection has histo-rically been recognized as the strongest risk factor for the development of gastric cancer(GC),with recent advances in DNA sequencing technology,other members of the gastric microbial community,and *** in particular,have received increasing *** this review,we summarize the existing knowledge on the involvement of *** in gastric carcinogenesis and address the potential translational and clinical significance of *** in GC.

关键词： Fusobacterium nucleatum Gastric microbiota Gastric cancer Preneoplastic changes Prognosis

Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj Kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa KBehera Sanjib Mohanty Pradeep Kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia department of Molecular Biology and infectious diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

Click-hydrogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第1期5卷 244-256页

作者： Xu Chen Meijiao Zhao Qihu Xie Sitong Zhou Xiaoping Zhong Judun Zheng Ronghua Yang Xianjin Du Jinyu Xia Yuhui Liao department of infectious diseases The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina Molecular Diagnosis and Treatment Center for infectious diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina department of Burns and Plastic Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantouChina department of Dermatology TheFirst People’s Hospital of FoshanFoshanChina department of Burn and Plastic Surgery Guangzhou First People’s HospitalSouth China University of TechnologyGuangzhouChina department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanChina

As a high-risk trauma,deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent *** this study,we developed a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties,delivered via a click-chemistry *** aggregation-induced emission photosensitizer of 4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1-(2-hydroxyethyl)pyridin-1-ium bromide(THB)with excellent photodynamic properties was first prepared,and then combined with readily accessible adipose stem cells-derived nanovesicles to generate the THB functionalized nanovesicles(THB@ANVs).The THB@ANVs showed strong antibacterial activity against Gram-positive bacteria(up to 100%killing rate),and also beneficial effects on tissue remodeling,including promoting cell migration,cell proliferation,and regulating *** addition,we prepared a click-hydrogel of carboxymethyl chitosan for effective delivery of THB@ANVs on *** hydrogel could be injected to conform to the wound morphology while responding to the acidic *** vivo evaluations of wound healing revealed that the THB@ANVs hydrogel dressing efficiently accelerated the healing of second-degree burn wounds by reducing bacterial growth,regulating inflammation,promoting early angiogenesis,and collagen *** study provides a promising candidate of wound dressing with diverse functions for deep burn wound repair.

关键词： aggregation-induced emission burn wounds nanovesicles

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan Liu Wei Yuan Xue Mei Jing Li Tao Li Rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng department of infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China department of infectious diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China department of infectious diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina department of infectious diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina department of infectious diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of infectious diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of infectious diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the department of Hepatology or infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of animal Science and Biotechnology 2024年第3期15卷 1158-1172页

作者： Dohyung M.Kim Jing Liu Melanie A.Whitmore Isabel Tobin Zijun Zhao Guolong Zhang department of animal and Food Sciences Oklahoma State UniversityStillwaterOKUSA

Background Necrotic enteritis(NE)is a major enteric disease in poultry,yet effective mitigation strategies remain *** acid(DCA)and butyrate,two major metabolites derived from the intestinal microbiota,have independently been shown to induce host defense peptide(HDP)***,the potential synergy between these two compounds remains *** To investigate the possible synergistic effect between DCA and butyrate in regulating HDP synthesis and barrier function,we treated chicken HD11 macrophage cells and jejunal explants with DCA and sodium butyrate(NaB),either individually or in combination,for 24 ***,we performed RNA isolation and reverse transcrip-tion-quantitative PCR to analyze HDP genes as well as the major genes associated with barrier *** further determine the synergy between DCA and NaB in enhancing NE resistance,we conducted two independent trials with Cobb broiler *** each trial,the diet was supplemented with DCA or NaB on the day-of-hatch,followed by NE induction through sequential challenges with Eimeria maxima and Clostridium perfringens on d 10 and 14,*** recorded animal mortality after infection and assessed intestinal lesions on d *** impact of DCA and NaB on the microbiota in the ileum and cecum was evaluated through bacterial 16S rRNA gene *** We found that the combination of DCA and NaB synergistically induced multiple HDP genes in both chicken HD11 cells and jejunal ***,the gene for claudin-1,a major tight junction protein,also exhibited synergistic induction in response to DCA and ***,dietary supplementation with a combination of 0.75 g/kg DCA and 1 g/kg NaB led to a significant improvement in animal survival and a reduction in intestinal lesions compared to either compound alone in a chicken model of ***,the cecal microbiota of NE-infected chickens showed a marked decrease in SCFA-producing bacteria such as Bacteroides,F

关键词： Bile acids Host defense peptides Metabolites Microbiome Necrotic enteritis Short-chain fatty acids

Isolation and characterization of mpox virus from the first mpox case in Shenzhen,China

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第2期39卷 335-337页

作者： Lin Cheng Liuqing Yang Miao Wang Yabo Peng Haiyan Wang Xiaoxiang Yang Juanjuan Zhao Mingxia Zhang Fuxiang Wang Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalShenzhen518112China department of infectious diseases Shenzhen Third People's HospitalShenzhen 518112China The Second Affiliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China

Dear Editor,Unlike previous outbreaks of the mpox(previously known as monkeypox),which were localized in Africa and resulted in small numbers of infections due to limited human-to-human transmission,the current outbreak beginning in May 2022,has spread rapidly primarily through human-to-human transmission in non-endemic countries(Gong et al.,2022).As of 27 Sep 2023,115 countries and regions have reported cases of mpox to the World Health Organization(WHO),bringing the total number of confirmed cases to 90,618 including 125 *** the number of new cases has decreased in most WHO regions in the second half of 2022,the curves reveal a long outbreak tail in different subregions of the *** worrying,106 mpox cases were reported in the mainland of China in June 2023.

关键词： mainland bringing

Hepatic amyloidosis in a patient with chronic liver failure:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第19期12卷 3918-3924页

作者： Yan Chen Jing Peng Yao Wang Li-Hua Xiao Fang Liu Yin-Bin Wei Xiong-Fei Wu Lu-Wen Wang department of infectious diseases Hanchuan People's HospitalHanchuan 431699Hubei ProvinceChina department of infectious diseases Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Amyloidosis is a rare disorder that can be classified into various types,and the most common type is the systemic light chain *** prognosis of this disease is extremely *** general,amyloidosis mainly affects the kidneys and heart and manifests as abnormal proliferation of clonal plasma *** in which the liver is the primary organ affected by amyloidosis,as in this report,are less common in clinical *** SUMMARY A 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment *** condition persisted,and he developed chronic liver failure,with severe cholestasis in the later stage that was gradually accompanied by renal ***,he was diagnosed with hepatic amyloidosis through liver biopsy and pathological *** Hepatic amyloidosis rarely occurs in the clinic,and liver biopsy and pathological examination can assist in the accurate and effective diagnosis of this condition.

关键词： Hepatic amyloidosis Rare disease Chronic liver failure Liver biopsy Pathological examination Case report

Myostatin gene role in regulating traits of poultry species for potential industrial applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of animal Science and Biotechnology 2024年第5期15卷 1793-1801页

作者： Joonbum Lee Dong‑Hwan Kim Kichoon Lee department of animal Sciences The Ohio State UniversityColumbusOH 43210USA

The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout *** anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced *** poultry species,myo-genesis in cell culture was regulated by modulation of the MSTN ***,different expression levels of the MSTN gene in poultry models with different muscle mass have been reported,indicating the conserved myogenic function of the MSTN gene between mammalian and avian *** advances of CRISPR/Cas9-mediated genome edit-ing techniques have led to development of genome-edited poultry species targeting the MSTN gene to clearly dem-onstrate its anti-myogenic function and further investigate other potential functions in poultry *** review summarizes research conducted to understand the function of the MSTN gene in various poultry models from cells to whole ***,the genome-edited poultry models targeting the MSTN gene are reviewed to inte-grate diverse effects of the MSTN gene on different traits of poultry species.

关键词： Chicken Economic traits Myostatin Quail