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探究非编码RNA在学习记忆过程中的作用机制

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Science Bulletin 2023年第15期68卷 1591-1594页

作者：李定丰张娟刘强 department of Neurology The First Affiliated Hospital of USTCCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230027China Institute on Aging and Brain Disorders The First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefei 230027China Anhui Province Key Laboratory of Biomedical Aging Research University of Science and Technology of ChinaHefei 230027China CAS Key Laboratory of Brain Function and Disease University of Science and Technology of ChinaHefei 230026China Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of ChinaHefei 230027China

The mechanisms underlying learning and memory have been a longstanding focus of neuroscience *** recent decades,there has been a substantial increase in the investigation and understanding of the intricate molecular processes involved in learning and *** mechanisms,which encompass dynamic and reversible modifications at various levels of cellular regulation.

关键词： has learning research.

Correction to:Microglia Interact with Neurons by Forming Somatic Junctions

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neuroscience Bulletin 2020年第9期36卷 1092-1092页

作者： Yongjie Wang Zhihui Huang Key Laboratory of Elemene Anti-Cancer Medicine of Zhejiang Province and Holistic Integrative Pharmacy Institutes Hangzhou Normal UniversityHangzhou 311121China Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province and Holistic Integrative Pharmacy Institutes Hangzhou Normal UniversityHangzhou 311121China department of Neurosurgery The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015China

The original version of this article unfortunately contained two *** paragraph 3 of page 3,the sentence starting with "In vivo two-photon imaging revealed that the number of mitochondria significantly increases…" sho... 详细信息

关键词： starting photon s.

Brain-wide N2cG compensation permits glycoprotein-deleted rabies virus to trace neural circuits across multiple synapses

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Journal of Innovative Optical Health Sciences 2023年第6期16卷 13-21页

作者： Nengsong Luo Zengpeng Han Jiaxin Kou Yuxiang Cai Xin Yang Jie Wang Kunzhang Lin Fuqiang Xu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074P.R.China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China Shenzhen Key Laboratory of Viral Vectors for Biomedicine Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Productsthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen518055P.R.China department of Pathophysiology Key Lab of Neurological Disorder of Education MinistrySchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanP.R.China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen518055P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai200031P.R.China

Rabies-viruses-based retrograde tracers can spread across multiple synapses in a retrograde direction in the nervous system of rodents and primates,making them powerful tools for determining the structure and function of the complicated neural circuits of the ***,they have some limitations,such as posing high risks to human health and the inability to retrograde trans-synaptic label inputs from genetically-de¯ned starter ***,we established a new retrograde trans-multi-synaptic tracing method through brain-wide rabies virus glycoprotein(RVG)compensation,followed by glycoprotein-deleted rabies virus(RV-△G)infection in specific brain ***,in combination with the avian tumor virus receptor A(TVA)controlled by a cell-type-specific promoter,we found that EnvA-pseudotyped RV-△G can mediate e±cient retrograde trans-multi-synaptic transduction from cell-type-specific starter *** study provides new alternative methods for neuroscience researchers to analyze the input neural networks of rodents and nonhuman primates.

关键词： Rabies virus retrograde tracers trans-multi-synaptic tracing AAV-PHP.eB celltype-specific input neural networks

Presymptomatic Diagnosis and Gene Therapy for Alzheimer’s Disease: Genomic, Therapeutic, and Ethical Aspects—A Systematic Review

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Advances in Alzheimer's Disease 2023年第4期12卷 55-74页

作者： Théodora M. Zohoncon Joseph Sawadogo Abdoul Karim Ouattara Abdou Azaque Zoure Marie N. L. Ouedraogo Paul Ouedraogo Florencia W. Djigma Christelle W. M. Nadembèga Raphael Kabore Djénéba Ouermi Dorcas Obiri-Yeboah Jacques Simpore Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculty of Medicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouaga Burkina Département de Biochimie microbiologie Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Over the past three decades, genomic and epigenetic sciences have identified more than 70 genes involved in the molecular pathophysiology of Alzheimer’s disease (AD). DNA methylation, abnormal histone and chromatin regulation and the action of various miRNAs induce AD. The identification of mutated genes has paved the way for the development of diagnostic kits and the initiation of gene therapy trials. However, despite major advances in neuroscience research, there is yet no suitable treatment for AD. Therefore, the early diagnosis of this neurodegenerative disease raises several ethical questions, including the balance between the principle of non-maleficence and the principle of beneficence. The aims of this research were to present the genomic and ethical aspects of AD, and to highlight the ethical principles involved in its presymptomatic diagnosis and therapy. A systematic review of the literature in PubMed, Google Scholar and Science Direct was carried out to outline the genomic aspects and ethical principles relating not only to the presymptomatic diagnosis of AD, but also to its gene therapy. A total of 16 publications were selected. AD is a multifactorial disease that can be genetically classified into Sporadic Alzheimer’s Disease and Familial Alzheimer’s Disease based on family history. Gene therapy targeting specific disease-causing genes is a promising therapeutic strategy. Advancements in artificial intelligence applications may enable the prediction of AD onset several years in advance. While early diagnosis of AD may empower patients with full decision competence for early decision-making, it also carries implications for the patient’s family members, who are at risk of developing the disease, potentially becoming a source of confusion or anxiety. AD has a significant impact on the life of individuals at risk and their families. Given the absence of disease modifying therapy, genetic screening and early diagnosis for this condition raise ethical issue

关键词： Neurodegenerative Diseases Alzheimer’s Disease Molecular Mechanism Gene Therapy Presymptomatic Diagnosis Ethics Gene Therapy Ethics

Learning and competence development via clinical cases-what elements should be investigated to best train good medical doctors?

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World Journal of Meta-Analysis 2020年第3期8卷 178-189页

作者： Henriette Löffler-Stastka Guoruey Wong department of Psychoanalysis and Psychotherapy and Postgraduate UnitTeaching CenterMedical University of ViennaVienna 1090Austria Facultéde Médecine Universitéde MontréalMontréal H3T 1J4QuebecCanada

In European higher education,application of information technology,concentration on the learning-processes,consistent implementation,transfer learning,case-based learning,autonomous learning has been extensively studied in the last *** sciences based on neuroscientific findings use brain-based learning and teaching,including integrated thematic instructions and *** essential to this strategy,such as theory and methods for learning,competencies,attitudes,social reality,and a metadiscourse are described *** on learning tends to focus on declarative knowledge,associative learning with conditional stimuli,and procedural knowledge with polythematic/crosslinking *** on competencies:In research on competencies(e.g.,for clinical reasoning,decision-making),intuitive and analytical components are *** repeated presentation and exercising of clinical cases is crucial for an efficient learning process,the implementation of interactive scenarios including affectively involving didactics is *** competence-development observational methods,questionnaires/item sets or factors have to be targeted and empirically *** and social reality:Clinical decision-making,identification processes and attitudes(“Hidden curriculum”),as well as secondary socialization processes(integration of social norms,values,preparation of role-acquisition,occupational role)are studied via process research,conceptual research,and observational *** respect to social reality research,conscious and unconscious bargaining processes have to be taken into ***:neuroscience-memory,neuronal,molecular biology,and computer science(Neurocircuits)are integrated into observational process research(e.g.,affective-cognitive interface,identification processes)and conceptual research is added and studied on the meta-level,including discussion of research *** discussion provides ongoing feedback to pro

关键词： Social neuroscience Case-based learning Mixed-method design Hidden curriculum Socialization Research

探究非编码RNA在学习记忆过程中的作用机制（英文）

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Science Bulletin 2023年第15期 1591-1594页

作者：李定丰张娟刘强 department of Neurology The First Affiliated Hospital of USTC Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and Medicine University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Institute on Aging and Brain Disorders The First Affiliated Hospital of USTC University of Science and Technology of China Anhui Province Key Laboratory of Biomedical Aging Research University of Science and Technology of China CAS Key Laboratory of Brain Function and Disease University of Science and Technology of China Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China

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Ion-speciﬁc effects in conﬁned nanochannels and neural

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聚集体(英文)

聚集体(英文) 2023年第2期4卷 123-136页

作者： Weichen Wei Xuejiao Wang Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering Engineering Research Center of Industrial BiocatalysisCollege of Chemistry and Materials ScienceFujian Normal UniversityFuzhouChina department of Nanoengineering University of California San DiegoLa JollaCaliforniaUSA

Since the discovery of biological ion channels and their role in physiology,scientists have been trying to create artificial structures that mimic biological ion *** such as biological/solid-state nanopores and porous nanostructures can have fine-tuned ion behaviors in a confined space where ions are“aggregated”.Thus,one of the most exciting applications of nanochannels is artificial neurons and neural network based on the ion-specific effects and *** this review article,it is the first time that the ion aggregation behaviors inside the confined nanochannels are summarized,and their connection to neuroscience,especially the artificial neurons and neural network,is explored and envisioned.

关键词： aggregate confined space ion-specific effect

Microglial Depletion does not Afect the Laterality of Mechanical Allodynia in Mice

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神经科学通报:英文版 2023年第8期39卷 1229-1245页

作者： Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of Gene Regulation and Systems Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China department of Biology Brain Research CenterSouthern University of Science and TechnologyShenzhen 518055China Institute of Life Science Nanchang UniversityNanchang 330031China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China

Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain *** peripheral injuries result in the development of bilateral MA,while most injuries usually led to unilateral *** date,the control of such laterality remains poorly ***,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in ***,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate ***,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn *** with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβpathways in the superficial dorsal *** study challenges the role of microglia in the control of MA laterality in *** studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific.

关键词： Microglia Mechanical allodynia Laterality Spinal dorsal horn Aβ Dynamic allodynia Punctate allodynia

Correction to: Major Depressive Disorder: Advances in neuroscience Research and Translational Applications

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neuroscience Bulletin 2021年第6期37卷 904-904页

作者： Zezhi Li Meihua Ruan Jun Chen Yiru Fang Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China department of Neurology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Chinese Academy of Science Shanghai Institute of nutrition and HealthShanghai Information Center for Life SciencesShanghai 200031China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic disorders Shanghai 201108China

Correction to:***.2021 https://***/10.1007/sl2264-021-00638-3 The original version of this article unfortunately contained two *** the“Acknowledgements”,the“the National Basic Research”should be changed into“the ... 详细信息

关键词： Basic Major knowledge