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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina department of Respiratory and critical care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Forging an easier path through graduation:Improving the patient transition from paediatric to adult critical care

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World Journal of critical care Medicine 2025年第1期14卷 82-90页

作者： Stephen Warrillow Ben Gelbart Jess Stevens Gordon Baikie Mark E Howard department of Intensive care Austin HealthHeidelberg 3084VictoriaAustralia department of critical care The University of MelbourneParkville 3010VictoriaAustralia department of Intensive care Royal Children’s HospitalParkville 3010VictoriaAustralia Living with Disability Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia department of Neurodevelopment&Disability Royal Children’s HospitalParkville 3010VictoriaAustralia department of Paediatrics The University of MelbourneParkville 3010VictoriaAustralia department of Respiratory and Sleep Medicine Austin HealthHeidelberg 3084VictoriaAustralia department of Medicine Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing *** normal experiences are potentially magnified for teenagers living with chronic illness or disability and their *** in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing *** those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of *** the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general *** there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive *** patients may encounter considerable challenges during this *** may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric *** addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health *** challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.

关键词： Paediatric intensive care Disability Adult intensive care Transition critical care

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Healthcare providers’perspectives on factors influencing their critical care decision-making during the COVID-19 pandemic:An international pilot survey

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World Journal of critical care Medicine 2025年第1期14卷 100-110页

作者： Sonali Vadi Neha Sanwalka Pramod Thaker department of critical care Medicine Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbai 400053MahārāshtraIndia department of Statistics HCJMRIJehangir HospitalPune 411001MahārāshtraIndia Medical Ethics Fellowship Harvard Medical SchoolBostonMA 02138United States

BACKGROUND Understanding a patient's clinical status and setting priorities for their care are two aspects of the constantly changing process of clinical *** analytical technique that can be helpful in uncertain situations is clinical *** must deal with contradictory information,lack of time to make decisions,and long-term factors when emergencies *** To examine the ethical issues healthcare professionals faced during the coronavirus disease 2019(COVID-19)pandemic and the factors affecting clinical *** This pilot study,which means it was a preliminary investigation to gather information and test the feasibility of a larger investigation was conducted over 6 months and we invited responses from clinicians worldwide who managed patients with *** survey focused on topics related to their professional roles and personal *** examined five core areas influencing critical care decision-making:Patients'personal factors,family-related factors,informed consent,communication and media,and hospital administrative policies on clinical *** collected data were analyzed using the χ^(2) test for categorical *** A total of 102 clinicians from 23 specialties and 17 countries responded to the *** was a significant factor in treatment planning(n=88)and ventilator access(n=78).Sex had no bearing on how decisions were *** doctors reported maintaining patient confidentiality regarding privacy and informed *** 50%of clinicians reported a moderate influence of clinical work,with many citing it as one of the most important factors affecting their health and *** from developing countries had a significantly higher score for considering a patient's financial status when creating a treatment plan than their counterparts from developed *** personal experiences,some respondents noted that treatment plans and preferences ch

关键词： Survey Clinical decision-making COVID-19 pandemic

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Digital Innovation in Oral Health care: A Comprehensive Review

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Open Journal of Stomatology 2025年第1期15卷 1-24页

作者： Abir Eddhaoui Tarek Ezzat Aly Saad Haroon department of Dental Primary Health Care Corporation Doha Qatar

The integration of digital technologies into oral health care is transforming the field, driving advancements in diagnostic precision, patient engagement, and access to care. This review evaluates the impact of mobile health (mHealth) applications, tele-dentistry, artificial intelligence (AI), wearable devices, and advanced imaging systems on modern dentistry. Synthesizing findings from 125 studies published between 2010 and 2024, the paper identifies key achievements, including improved patient compliance, enhanced diagnostic capabilities, and expanded access to care in underserved areas. Tele-dentistry has been pivotal in bridging geographical gaps, particularly during the COVID-19 pandemic, while AI tools have revolutionized diagnostics and personalized treatment planning. Wearable devices and mHealth applications have empowered patients with real-time feedback, fostering sustained adherence to oral hygiene practices. The review also highlights the potential of digital tools to reduce healthcare disparities and operational costs, paving the way for more equitable and efficient dental care. By outlining critical advancements and future directions, this paper underscores the transformative potential of digital health technologies in dentistry. It advocates for further research on data security, interoperability, and innovative applications of AI to maximize the benefits of these tools, ultimately shaping a more accessible and patient-focused oral health ecosystem.

关键词： Digital Dentistry Tele-Dentistry Artificial Intelligence Mobile Health Wearable Technology Diagnostic Innovation Oral Health care

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Current role of extracorporeal membrane oxygenation for the management of trauma patients:Indications and results

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World Journal of critical care Medicine 2025年第1期14卷 42-48页

作者： Mohammed Abdulrahman Maryam Makki Malak Bentaleb Dana Khamis Altamimi Marcelo AF Ribeiro Junior department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates department of Surgery Sheikh Shakhbout Medical CityAbu Dhabi 91888ADUnited Arab Emirates department of Surgery R Adams Cowley Shock Trauma CenterUniversity of MarylandBaltimoreMD 21201United States

Extracorporeal membrane oxygenation(ECMO)has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional *** allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon *** blood is then reintroduced into the patient’s circulatory *** process makes ECMO essential for treating various medical conditions,both as a standalone therapy and as adjuvant ***-venous(VV)ECMO primarily supports respiratory function and indicates respiratory ***,veno-arterial(VA)ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related *** study reviews recent literature to elucidate the evolving role of ECMO in trauma care,considering its procedural intricacies,indications,contraindications,and associated ***,the use of ECMO in trauma patients,particularly for acute respiratory distress syndrome and cardiogenic shock,has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury,bleeding,thrombosis,and *** studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation,whereas other studies have reported that VA ECMO was associated with lower survival rates than VV *** plays a critical role in managing trauma patients,particularly those with acute respiratory *** research is necessary to explore the full potential of ECMO in trauma *** should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.

关键词： Extracorporeal membrane oxygenation treatments Multiple trauma Respiratory distress syndrome Cardiogenic shock Contraindications Anticoagulants

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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies

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重症医学（英文） 2025年第1期5卷 12-22页

作者： Rouby Jean-Jacques Xia Jing Dhanani Jayesh Bassi Gianluigi Li Monsel Antoine Torres Antoni department of anaesthesiology and critical care Sorbonne University GRC 29 Assistance Publique H?pitaux de Paris (AP-HP) DMU DREAM Multidisciplinary Intensive Care Unit Pitié-Salpêtrière Hospital Paris France Emergency department The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China Faculty of Medicine University of Queensland Centre for Clinical Research Brisbane QLD Australia department of Intensive care Medicine Royal Brisbane and Women’s Hospital Brisbane Australia critical care Research Group The Prince Charles Hospital Chermside Australia Institute for Molecular Bioscience University of Queensland St Lucia QLD Australia Institut National de la Santé et de la Recherche Médicale (INSERM) Unité mixte de recherche (UMR)-S 959 Immunology-Immunopathology-Immunotherapy Paris H?pital Pitié-Salpêtrière Assistance Publique-H?pitaux de Paris Paris France department of Pneumology Institut Clinic del Tórax Hospital Clinic of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona - SGR 911-Ciber de Enfermedades Respiratorias (Ciberes) Barcelona Spain

Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations (MIC). When administered intravenously, they exhibit poor lung penetration and high systemic renal and ototoxicity, imposing to restrict their administration to 5 days. Experimental studies conducted in anesthetized and mechanically ventilated sheep and pigs provide evidence that high doses of nebulized aminoglycosides induce a rapid and potent bacterial killing in the infected lung parenchyma. They also confirm that the alveolar-capillary membrane, either normal or injured by the infectious process, restricts the penetration of intravenous aminoglycosides in the infected lung parenchyma, precluding a bactericidal effect at the site of infection. However, injury of the alveolar-capillary membrane promotes the systemic diffusion of nebulized aminoglycosides. Based on experimental data obtained in animals with inoculation pneumonia, it challenges the classical belief that nebulization protects against systemic toxicity. Loss of lung aeration decreases the lung penetration of nebulized aminoglycosides. Nevertheless, lung tissue concentrations measured in non-aerated lung regions with severe and extended pneumonia are most often greater than 5 times the MICs, resulting in a bactericidal effect followed by a progressive pulmonary reaeration. It is likely that the penetration into the consolidated lung, results from the bronchial diffusion of nebulized aminoglycosides toward adjacent non-aerated infected alveolar spaces and their penetration into mechanical ventilation-induced intraparenchymal pseudocysts and distended bronchioles. In animals receiving nebulized aminoglycosides, epithelial lining fluid concentrations grossly overestimate lung interstitial fluid concentrations because of the bronchial contamination of the distal tip of the bronchoscope during the bronch

关键词： Aminoglycosides Ventilator-associated pneumonia Nebulized amikacin Nebulized tobramycin Lung microdialysis Experimental intensive care unit

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Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study

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重症医学（英文） 2025年第1期5卷 64-69页

作者： Windsor Camille Joseph Adrien Pons Stephanie Mokart Djamel Pène Frederic Kouatchet Achille Demoule Alexandre Bruneel Fabrice Nyunga Martine Borcoman Edith Legrand Matthieu Darmon Michael Zafrani Lara Azoulay Elie Lemiale Virginie Medical Intensive care Unit APHP Saint-Louis University Hospital Paris France Human Immunology and Immunopathology Institut National de la Santé et de la Recherche Médicale (INSERM) U 976 University of Paris Cité Paris France critical care department Institut Paoli Calmettes Marseille France Medical Intensive care Unit APHP Cochin University Hospital Paris France Medical Intensive care Unit Centre Hospitalier Universitaire d’Angers Angers France Medical Intensive care Unit H?pital Pitié-Salpêtrière Paris France Medical Intensive care Unit Centre Hospitalier de Versailles Hopital Andre Mignot Le Chesnay France Medical Intensive care Unit Centre Hospitalier de Roubaix Roubaix France department of Drug Development and Innovation (D3i) Institut Curie Paris France department of Anesthesia and Perioperative care University of California San Francisco CA USA

Background::Cancer patients who are exposed to sepsis and had previous chemotherapy may have increased severity. Among chemotherapeutic agents, anthracyclines have been associated with cardiac toxicity. Like other chemotherapeutic agents, they may cause endothelial toxicity. The aim of this study was to evaluate the effect of anthracycline treatment on the outcome of cancer patients with ***::Data from cancer patients admitted to intensive care units (ICUs) for sepsis or septic shock were extracted from the Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique database (1994-2015). Comparison between patients who received anthracycline and those who did not was performed using a propensity score, including confounding variables (age and underlying diseases). A competing risk adjusted for severity of illness (Sequential Organ Failure Assessment [SOFA] score) was used to analyze the duration of vasopressor ***::Among 2046 patients, 1070 (52.3%) patients who received anthracycline were compared with 976 (47.7%) who did not. The underlying disease was mostly acute hematological malignancy (49.2%). Sepsis, mostly pneumonia (47.7%), had developed 2 days (interquartile range [IQR]:1-4 days) prior to ICU admission. Most patients ( n=1156/1980,58.4%) required vasopressors for 3 days (IQR: 2-6 days). Factors associated with the need for vasopressors were aplasia (hazard ratio [HR]=1.72, 95% confidence interval [CI]: 1.21 to 2.47, P=0.002) and day 1 respiratory SOFA score (HR=7.07, 95% CI: 2.75 to 22.1, P <0.001). Previous anthracycline treatment was not associated with an increased risk of vasopressor use. The duration of vasopressors was not different between patients who received anthracycline and those who did not ( P=0.79). Anthracycline was not associated with ICU mortality. Conclusion::Previous anthracycline treatment did not alter the course of sepsis in a cohort of cancer patients admitted to inten

关键词： Cancer Sepsis ICU Anthracycline Vasopressor

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Eosinophils in asthma

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Chinese Medical Journal 2004年第5期117卷 792-794页

作者：施焕中 department of Pulmonary and critical care Medicine

The contribution of eosinophils to host-defense and inflammatory responses has undergone periodic reevalu-ations. Thirty years ago, eosinophil was considered as a principal effector cell in host-defense against parasites. Furthermore, the actions of eosinophil enzymes, like histaminase, were thought to suppress mast cell-released allergic mediators. Asthma is a chronic inflammatory condition of the airways that is characterized by a prominent eosinophilic inflammatory infiltration into the bronchial mucosa. Activated eosinophils secrete granular basic proteins that damage the bronchial epithelium and membrane-derived lipid mediators, which contract smooth muscle, increase mucous secretion, and cause vasodilation. The correlation between eosinophil numbers and disease severity supports the hypothesis that the eosinophil is the central effector cell in ongoing airway inflammation in asthma. However, it would be unwise to totally overestimate eosinophil\' s potential in the development of asthma unless we have effective and selective methods of depleting the cells from the tissues.

关键词： IL SCH Eosinophils in asthma

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Thrombolysis in dysfunctional valve and stroke

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World Journal of critical care Medicine 2025年第2期14卷 178-184页

作者： Dormar David Barrios-Martínez Yuri Valentina Pinzon Veronica Giraldo Gina Gonzalez department of critical care Hospital Universitario San Vicente FundaciónMedellin 050010AntioquiaColombia department of critical care Hospital General de MedellínMedellin 050015AntioquiaColombia department of critical care CES UniversityMedellin 050010AntioquiaColombia department of critical care Somer ClinicRionegro 054040AntioquiaColombia department of critical care Hospital Universitario Mayor-MederiBogota 110311Colombia department of Cardiology Hospital Universitario Fundación Santa FeBogota 505000Colombia

BACKGROUND Valvular heart disease affects more than 100 million people worldwide and is associated with significant morbidity and *** prevalence of at least moderate valvular heart disease is 2.5%across all age groups,but its prevalence increases with *** regurgitation and aortic stenosis are the most frequent types of valvular heart disease in the community and hospital context,*** valve replacement(or mitral valve repair)is the standard of care for treating heart valve ***,the replacement of a prosthetic heart valve can lead to complications,either in the peri-procedural phase or in the long-term follow-up *** SUMMARY We present a case of a 71-year-old female patient with a history of mitral valve replacement and warfarin anti-coagulation *** was admitted to the intensive care unit due to spontaneously reperfused ischemic stroke of probable cardioembolic etiology.A dysfunctional mitral prosthesis was identified due to malfunction of one of the fixed ***,a possible microthrombotic lesion was ***,systemic thrombolysis was performed with subsequent normalization of mitral disc opening and *** This case underscores the critical importance of a multidisciplinary approach for timely decision-making in critically ill patients with prosthetic valve complications.

关键词： Mitral valve thrombolysis Stroke Recombinant human plasminogen tissue activator Heart valve disease Prosthetic valve-associated thrombosis Thrombotic dysfunction

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Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review

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World Journal of critical care Medicine 2025年第1期14卷 49-59页

作者： Angajendra N Ghosh Calum J Walsh Matthew J Maiden Tim P Stinear Adam M Deane department of Intensive care The Northern HospitalEpping 3076VictoriaAustralia department of Microbiology and Immunology The Peter Doherty Institute for Infection and ImmunityMelbourne 3052VictoriaAustralia department of Intensive care The Royal Melbourne HospitalThe University of MelbourneParkville 3050VictoriaAustralia department of Intensive care Medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly *** strategies to modulate the GI microbiota during chronic diseases have demonstrated *** changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain *** fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI *** aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical *** controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were *** show dietary fibres have an impact on faecal microbiota in health and *** fibre,inulin,has a marked and specific effect on increasing the abundance of faecal *** chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient *** few trials have evaluated the effect of dietary fibre on the GI microbiota during critical *** research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关键词： Gastrointestinal microbiota Dietary fibre Health critical illness Short chain fatty acids

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