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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： YAN-NAN LI YUN-HONG XIU YAN-JUN TANG JING-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI CHENG-HAO JIN department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina department of Food Science and engineering Heilongjiang Bayi Agricultural UniversityDaqingChina department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

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Weizmannia coagulans:an ideal probiotic for gut health

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Food Science and Human Wellness 2024年第1期13卷 16-26页

作者： Shiqi Zhang Pinglan Li Suwon Lee Yu Wang Chunming Tan Nan Shang Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Coree Beijing Co. Ltd.Beijing 101312China Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China College of engineering China Agricultural UniversityBeijing 100083China

Weizmannia coagulans(formerly Bacillus coagulans)is a spore-forming and lactic acid-producing *** has recently attracted much attention from researchers and food manufacturers due to its probiotic functions and stability in processing and *** is capable of improving gut health through the regulation of gut microbiota,modulation of immunity,and improving digestibility and ***,germinated cells and metabolites of *** modulate the gut micro-environment and further affect other *** is an environment-friendly probiotic since it can contribute to the host by reconstructing the balance of gut microbiota and only temporarily resides in the intestine after *** has been generally recognized as safe(GRAS)by the US Food and Drug Administration(FDA),thus it is an ideal probiotic for improving gut *** merit of its stability in processing and storage provides *** spores many possibilities for its use in various types of functional *** review presents an overview of the characteristics of *** that make it an ideal probiotic candidate and highlights the proposed health benefits with scientific evidence conferred by the administration of ***.

关键词： Weizmannia coagulans Spore former Probiotics Microbiota Gut disorders

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A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： Lan-Lan Li Yu Zhao Li-Jia Pan Jian-Bin Xu Yi Shi College of Mechanical and Electrical engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China department of Electronic engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

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Sustainable Biofuel Production from Brown and Green Macroalgae through the Pyrolysis

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Journal of Renewable Materials 2024年第6期12卷 1087-1102页

作者： Apip Amrullah Widya Fatriasari Novia Amalia Sholeha Edy Hartulistiyoso Obie Farobie Departement of Mechanical engineering Lambung Mangkurat UniversityBanjarmasinSouth KalimantanIndonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)CibinongBogorIndonesia College of Vocational Studies IPB UniversityBogorWest JavaIndonesia department of Mechanical and biosystem engineering IPB UniversityBogorWest JavaIndonesia

The escalating demand for energy coupled with environmental concerns necessitates exploring sustainable alternatives to fossil *** study explores the viability of using large ocean-based seaweeds as a source of thirdgeneration biomass,specifically focusing on their conversion to biofuel via the process of *** plagiophyllum and Ulva lactuca represent prevalent forms of macroalgae,posing significant discharge challenges for coastal regions ***,the exploration of their potential for bio-oil generation via pyrolysis remains *** study investigates the pyrolysis process of *** and *** for biofuel production,aiming to provide valuable insights into their utilization and *** experiments were conducted within temperature ranges of 400°C to 600°C and durations of 10 to 50 min using a batch *** chemical analysis of the synthesized bio-oil indicated it contains critical compounds such as organic acid derivatives,furans,nitrogenous aromatics,and aliphatic *** effectiveness of converting the initial biomass into bio-oil is significantly influenced by the pace at which the biomass undergoes decomposition,underscoring the importance of comprehending the kinetic aspects of this *** applying the Arrhenius formula,we calculated the activation energies and frequency factors,with the findings for *** being 15.27 kJ/mol and 0.477 s^(-1),and for ***,the values were 43.17 kJ/mol and 0.351 s^(-1),*** findings underscore the potential of brown and green macroalgae as sustainable sources for biofuel production via pyrolysis,offering insights for further optimization and valorization efforts in the quest for renewable energy solutions.

关键词： Biomass bio-oil macroalgae pyrolysis reaction kinetics

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Effects of high-pressure activated slightly acidic electrolyzed water on cleaning and sterilization of pig transfer vehicles

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International Journal of agricultural and Biological engineering 2024年第4期17卷 53-59页

作者： Xuedong Zhao Shengnan Tao Fei Qi Hao Li Zhengxiang Shi department of agricultural Structure and Bioenvironmental engineering College of Water Resources&Civil EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of agricultural engineering in Structure and Environment Ministry of Agriculture and Rural AffairsBeijing 100083China Beijing engineering Research Center on Animal Healthy Environment Beijing 100083China

The establishment of biosafety system is of enormous importance to the livestock and poultry production in terms of mitigating the transmission of diseases and implementing regional prevention and control ***,the current sterilization technology presents several drawbacks,including time-consuming procedures,chemical residues,and challenges in treating the sewage after *** this study,a novel cleaning and sterilization method that combines slightly acidic electrolyzed water and high pressure water-jet was *** orthogonal test was conducted to examine the correlation between high-pressure conditions and the various non-structural parameters on the efficacy of sterilization *** a field test,the effectiveness of the technology in cleaning pig transfer vehicles was evaluated by the total plate count and variations of community *** findings revealed that the combination of process parameters,including an available chlorine concentration of 200 mg/L,rinsing pressure of 170 bar,rinsing duration of 10 s,and residence time of 15 min,resulted in a removal rate of colony concentration on the surface of pig transfer vehicles of(96.50±0.91)%.Moreover,it was demonstrated to effectively inhibit a variety of pathogenic *** innovative cleaning system has the potential to replace traditional methods and reduces pollution while saving time and *** introduces a novel approach for sterilization of transportation in livestock and poultry farms as well as the biosafety construction of the animal husbandry.

关键词： slightly acidic electrolyzed water high pressure water-jet sterilization biosafety concentrated animal production

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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates Blake Nassar Ethan Littlefield Elizabeth C.Martin Adam T.Melvin Cain department of Chemical engineering Louisiana State UniversityBaton RougeLA 70803USA department of Chemical and Biological engineering Clemson UniversityClemsonSC 29634USA Biological and agricultural engineering Louisiana State UniversityBaton RougeLA 70803USA department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the MCF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOR,and p-STAT3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Balancing machine learning and artificial intelligence in soil science with human perspective and experience

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Pedosphere 2024年第1期34卷 9-12页

作者： David C.WEINDORF Somsubhra CHAKRABORTY department of Earth and Atmospheric Science Central Michigan Universityount Pleasant M148859USA agricultural and Food engineering department Indian Institute of TechnologyKharagpur 721302India

Machine learning and artificial intelligence continue to evolve at a rapid pace, with many potential applications related to soil science. Even so, human experience and perception play an invaluable role in characterizing soil properties, especially qualitative properties that may elude sensing/computer-based modeling approaches. The elegant solution to this conundrum relies on the synthesis of computer-aided predictive modeling with human insight and *** global population surpasses 8 billion, the importance of optimized agronomic production to feed a hungry world has never been more important.

关键词： soil elude qualitative

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Rice stem lodging properties and bending modeling under the influence of circadian temperature difference

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International Journal of agricultural and Biological engineering 2024年第3期17卷 21-32页

作者： Bangzhui Wang Zhong Tang Liyun Lao Guoqiang Wang Tiantian Jing Yao Yu School of agricultural engineering Jiangsu UniversityZhenjiang 212013JiangsuChina School of Water Energy and EnvironmentCranfield UniversityMK430ALUK department of agricultural engineering Jiangsu Agriculture&Animal Husbandry Science and Technology Vocational CollegeTaizhou 225300JiangsuChina

Under diurnal temperature stress,the vascular bundle content of mature rice stems will change which will cause a change in the modulus of ***,the rice stems will collapse with the reduction in bending resistance because of the change in the modulus of *** order to reveal the distribution of vascular bundle gradients in rice stems under different climatic temperatures and explore the locations where stems are prone to bending and the form of stem damage,this study established a model of stem stiffness under free loading based on observing microstructure of the *** lodging characteristics of rice stems was explored seldom in different environmental temperatures from a micro structure of rice ***,the statistical analysis and t-tests were carried out on stems 1 to 4 in combination for cantilever bending tests at room temperature on stem internodes 3,versus three-point bending tests at-10℃ to 65℃ temperature *** showed that the bending resistance of the stem can be well predicted by using the vascular bundle distribution regression model and the variable stiffness mechanical *** bending resistance of No.3 stem was established by using the results obtained from the three-point bending test in a temperature range between 10℃-65℃.The correction coefficient TF of stem bending resistance under temperature difference induced stress was established based on the Gauss regression *** analysis showed that the bending resistance of No.3 stem was relatively large in a temperature range of 16℃-34℃.This study elucidated the variations of the mechanical properties of rice stems under temperature difference induced stress and provided a theoretical foundation for understanding the lodging characteristics of rice during mechanized harvesting.

关键词： rice stem vascular gradient stiffness model stem bending temperature stress

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Fukushima wastewater release:unanswered questions and global concerns

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International Journal of agricultural and Biological engineering 2024年第2期17卷 289-290页

作者： Samuel Ariyo Okaiyeto Parag Prakash Sutar Arun SMujumdar Hongwei Xiao College of engineering China Agricultural UniversityBeijing 100083China department of Food Process engineering National Institute of Technology RourkelaRourkela 769008India department of Bioresource engineering McGill UniversitySte.Anne de BellevueQuebecCanada

The decision by Japan to begin discharging the Fukushima wastewater into the ocean on August 24,2023 was followed by protests from several countries,including China,Russia,Korea,Vietnam,and deep concerns from the international *** decision is related to the aftermath of the Fukushima Daiichi nuclear disaster that occurred in 2011,which destroyed the cooling system of the nuclear power plant and caused the reactor cores to *** water was used to cool down the reactors fuel rods;about 1.3 million cubic meters contaminated water with highly radioactive material was generated,which can fill more than 500 Olympic swimming pools[1].In order to reduce the levels of radioactivity,an Advanced Liquid Processing System(ALPS)was used to remove most radioactive contaminants from *** works by circulating water through a system of tanks and filters,which removes specific contaminants such as cesium and strontium,using a multi-step process that includes coagulation,flocculation,ion exchange,and absorption[1].Japan's government and some scientists have argued that the ALPS-treated water is safe for release into the *** to their claims,the discharged water poses minimal risk to human health and the ***,concerns about the long-term effects of this discharge remain in scientists′minds.

关键词： Fukushima wastewater nuclear disaster discharge radioactive contaminants

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Tracing suspended and bed sediments during high and low water periods using geochemical characteristics-Case study:Vazrood watershed,northern Iran

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Journal of Mountain Science 2024年第2期21卷 470-483页

作者： KARIMI Nabiyeh GHOLAMI Leila KAVIAN Ataollah KHALEDI DARVISHAN Abdulvahed department of Watershed Management Faculty of Natural ResourcesSari Agricultural Sciences and Natural Resources UniversitySari ***Iran department of Watershed Management engineering Faculty of Natural ResourcesTarbiat Modares UniversityNoor ***Iran

Complete and comprehensive information about sediment dynamic and identification of hotspots of sediment production and transport are necessary for understanding the erosion processes and increasing the efficiency of soil and water conservation *** studies used the sediment fingerprint techniques to investigate the contribution of different sources in suspended and bed sediment yield of the ***,the contribution of various land use/land covers in suspended and bed sediment yield for the great Caspian Sea basin is in an aura of ambiguity and the present study was conducted to gather information about an important part of this area in northern Iran,where rangelands are located upstream of Hyrcanian forests and dense agricultural lands are located *** surface soil of different land use/land covers including forest,rangeland,agriculture and streambank lands were sampled in 30 *** and bed sediments were sampled in the watershed outlet in two high and low water *** characteristics of soil and sediment samples containing 59 elements were measured using ICP-OES GBC *** reliable and suitable tracers from 59 elements were then selected using Range test,Kruskal-Wallis and Discriminant Function Analysis,respectively,in FingerPro package of R *** results showed that for suspended sediment,streambank and rangeland had the highest contributions of 86.2%and 47.5%,respectively,in two high and low water *** bed sediment,in two high and low water periods,rangeland and streambank had the highest contributions of 73.8%and 84.4%,*** use change and especially human activities such as agriculture,road construction and development of residential areas along the main river riparian zone has led to a significant increase in suspended and bed sediments.

关键词： Caspian Sea basin FingerPro Geochemistry Sediment transport Tracer combination

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