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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi department of Brain Science Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea department of Neurology Ajou University School of MedicineSuwonSouth Korea department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Enhanced Surface Mechanical Properties and Microstructure Evolution of Commercial Pure Titanium Under Electropulsing-Assisted Ultrasonic Surface Rolling Process

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1272-1280页

作者： Yong-Da Ye Xiao-Pei Li Zhi-Yan Sun Hai-Bo Wang Guo-Yi Tang advanced materials Institute Graduate School at ShenzhenTsinghua University school of materials Science and engineering Tsinghua University

The effects of electropulsing-assisted ultrasonic surface rolling process on surface mechanical properties andmicrostructure evolution of commercial pure titanium were investigated. It was found that the surface mechanical prop-erties were significantly enhanced compared to traditional ultrasonic surface rolling process （USRP）, leading to smallersurface roughness and smoother morphology with fewer cracks and defects. Moreover, surface strengthened layer wasremarkably enhanced with deeper severe plastic deformation layer and higher surface hardness. Remarkable enhancementsof surface mechanical properties may be related to the gradient refined microstructure, the enhanced severe plasticdeformation layer and the accelerated formation of sub-boundaries and twins induced by coupling effects of USRP andelectropulsing. The primary intrinsic reasons for these improvements may be attributed to the thermal and athermal effectscaused by electropulsing treatment, which would accelerate dislocation mobility and atom diffusion.

关键词： Electropulsing-assisted ultrasonic surface rolling process (EP-USRP) Commercial pure titanium Roughness Hardness Microstructure evolution

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A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

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Computer Modeling in engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu Zhou Xiaobing Chen Salman A.AlQahtani Hongrong Chen Bo Yang Siyu Lu Wenfeng Zheng department of Computer Science and engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea school of Electrical and Computer engineering Louisiana State UniversityBaton RougeLA 70803USA department of Computer engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia school of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen graduate school Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food engineering China Astronaut Research and Training CenterBeijing 100094China department of Gastroenterology The Air Force Medical CenterBeijing 100142China department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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Optimizing the crystallinity and acidity of H-SAPO-34 by fluoride for synthesizing Cu/SAPO-34 NH_3-SCR catalyst

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Journal of Environmental Sciences 2016年第3期28卷 244-251页

作者： Jing Ma Zhichun Si Xiaodong Wu Duan Weng Yue Ma The Key Laboratory of advanced materials of Ministry of Education School of Materials Science and EngineeringTsinghua University advanced materials Institute Graduate School at ShenzhenTsinghua University

A series of H-SAPO-34 zeolites were synthesized by a hydrothermal method in fluoride *** as-synthesized H-SAPO-34 zeolites were characterized by X-ray diffraction（XRD）,scanning electron microscopy（SEM）,N_2 physisorption,temperature-programmed desorption of NH_3（NH_3-TPD） and nuclear magnetic resonance（NMR） *** results showed that a certain concentration of F- anions promoted the nucleation and crystallization of *** H-SAPO-34 synthesized in the fluoride media showed high crystallinity,uniform particle size distribution,large specific surface area and pore volume,and enhanced ***,Cu/SAPO-34 based on the fluoride-assisted zeolite showed a broadened temperature window for the selective catalytic reduction of NO by NH_3（NH_3-SCR） reaction due to the enhanced acidity of the zeolite and the improved dispersion of copper species.

关键词： H-SAPO-34 Fluoride media Crystallinity Acidity Selective catalytic reduction(SCR)of NO

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Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui Lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen Wen Luo Lars Allmendinger Andreas Tittl Leonardo de Souza Menezes Guillaume Maurin Shihe Yang and Stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut Charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of advanced Technology for materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil school of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： K.MUHAMMAD M.SARFRAZ department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Influence of intermediate annealing on the microstructure and texture of Ni-9.3at%W substrates

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International Journal of Minerals,Metallurgy and materials 2014年第2期21卷 162-168页

作者： Jia-nan Liu Wei Liu Guo-yi Tang Ru-fei Zhu advanced materials Institute and Cleaner Production Key Laboratory Graduate School at Shenzhen Tsinghua University Key Laboratory of advanced materials Department of Materials Science and Engineering Tsinghua University

The effects of intermediate annealing （IA） on the microstructure and texture of Ni-9.3at%W substrates have been investigated by using electron backscattering diffraction and X-ray diffraction. Results suggest that IA can optimize the homogeneity of deformation micro-structure. Higher IA temperatures （without undergoing recrystallization during IA） will increase the copper-type components of deformation texture and improve the content of cube texture after recrystallization. Sharp cube texture （97.2%） can be obtained at the optimum IA tem-perature of 650°C. The mechanism underlying the transition of deformation texture can be interpreted as that IA increases the dislocation slipping ability and suppresses the twinning deformation of Copper orientation in the subsequent rolling process. The observed strengthening of cube texture as a result of IA treatment is presumably attributed to the reduction of noncube nucleation and the optimization of preferential growth surrounding the cube nuclei.

关键词： nickel tungsten alloys annealing textures rolling

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Multi-Scale Dilated Convolution Network for SPECT-MPI Cardiovascular Disease Classification with Adaptive Denoising and Attenuation Correction

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Computer Modeling in engineering & Sciences 2025年第1期142卷 299-327页

作者： A.Robert Singh Suganya Athisayamani Gyanendra Prasad Joshi Bhanu Shrestha department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia school of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia department of Artificial Intelligence&Software Kangwon National UniversitySamcheok25913Republic of Korea department of Information Convergence System Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myocardial perfusion imaging(MPI),which uses single-photon emission computed tomography(SPECT),is a well-known estimating tool for medical diagnosis,employing the classification of images to show situations in coronary artery disease(CAD).The automatic classification of SPECT images for different techniques has achieved near-optimal accuracy when using convolutional neural networks(CNNs).This paper uses a SPECT classification framework with three steps:1)Image denoising,2)Attenuation correction,and 3)Image *** denoising is done by a U-Net architecture that ensures effective image *** correction is implemented by a convolution neural network model that can remove the attenuation that affects the feature extraction process of ***,a novel multi-scale diluted convolution(MSDC)network is *** merges the features extracted in different scales and makes the model learn the features more *** scales of filters with size 3×3 are used to extract *** three steps are compared with state-of-the-art *** proposed denoising architecture ensures a high-quality image with the highest peak signal-to-noise ratio(PSNR)value of *** proposed classification method is compared with the five different CNN models,and the proposed method ensures better classification with an accuracy of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,and F1-score of 87%.To demonstrate the importance of preprocessing,the classification model was analyzed without denoising and attenuation correction.

关键词： SPECT-MPI CAD MSDC denoising attenuation correction classification

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Fabrication of a Gradient Nano-/Micro-structured Surface Layer on an Al–Si Casting Alloy by Means of Ultrasonic–Electropulsing Coupling Rolling Process

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1258-1264页

作者： Xiao-Pei Li Song-Zhu Kure-Chu Toru Ogasawara Hitoshi Yashiro Hai-Bo Wang Zi-Zhen Xu Xiao-Hui Li Guo-Lin Song Guo-Yi Tang advanced materials Institute Graduate School at ShenzhenTsinghua University school of materials Science and engineering Tsinghua University department of Chemistry and Bioengineering Iwate University

By using a novel surface modification technique named ultrasonic-electropulsing coupling rolling （UECR） process on an Al-Si casting alloy rod, the surface of material was smoothened significantly. Meanwhile, a strengthened layer with agradient change in hardness was obtained in the outer surface, corresponding to a homogeneous gradient nano-/micro-structure. The thickness of nanometer-thick laminated structures was at least 40 μm, which was much thicker thanconventional ultrasonic rolling process. During UECR, the formation of the well-defined nanocrystalline structure wasattributed to the high strain rate and simultaneous annealing process realized by ultrasonic impact and electropulsingtreatment.

关键词： Nanocrystalline materials Indentation and hardness Al-Si alloy Microstructure

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