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Neural Regeneration Research 2024年第10期19卷 2097-2098页

作者： Antara Verma Stephen K.Agadagba Leanne Lai-Hang Chan department of Electrical Engineering City University of Hong KongKowloonHong Kong Special Administrative RegionChina Centre for Eye and Vision Research Ltd. Hong Kong Special Administrative RegionChina Pennsylvania State University University ParkPAUSA

The connection and interaction between the eye and the brain are crucial to understanding brain disorders(Marchesi et al.,2021).Both the eye and the brain have a limited regenerative capacity as there are few progenitor cells,and nerve cells do not ***,neurodegeneration implicates irreversible damage to the central nervous system,as observed in several neurodegenerative diseases(Marchesi et al.,2021).

关键词： stimulation degenerative

Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.H.Sy Ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang Stephen Temitayo Bello department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

2D multifunctional devices:from material preparation to device fabrication and neuromorphic applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 91-118页

作者： Zhuohui Huang Yanran Li Yi Zhang Jiewei Chen Jun He Jie Jiang Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangshaHunanPeople’s Republic of China department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neuromorphic computing systems,which mimic the operation of neurons and synapses in the human brain,are seen as an appealing next-generation computing method due to their strong and efficient computing ***-dimensional (2D) materials with dangling bond-free surfaces and atomic-level thicknesses have emerged as promising candidates for neuromorphic computing *** a result,2D neuromorphic devices may provide an ideal platform for developing multifunctional neuromorphic ***,we review the recent neuromorphic devices based on 2D material and their multifunctional *** synthesis and next micro–nano fabrication methods of 2D materials and their heterostructures are first *** recent advances of neuromorphic 2D devices are discussed in detail using different operating *** importantly,we present a review of emerging multifunctional neuromorphic applications,including neuromorphic visual,auditory,tactile,and nociceptive systems based on 2D *** the end,we discuss the problems and methods for 2D neuromorphic device developments in the *** paper will give insights into designing 2D neuromorphic devices and applying them to the future neuromorphic systems.

关键词： 2D material micro–nano fabrication multifunctional system neuromorphic electronics artificial intelligence

Aerodynamic Super-Repellent Surfaces

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Research 2024年第2期2023卷 115-122页

作者： Fanfei Yu Jinlong Yang Ran Tao Yao Tan Jinpei Wang Dehui Wang Longquan Chen Zuankai Wang Xu Deng Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054P.R.China department of Mechanical Engineering City University of Hong KongKowloonHong Kong Special Administrative Region 999077P.R.China School of Physics.University of Electronic Science and Technology of China Chengdu 610054P.R.China department of Mechanical Engineering Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative Region 999077P.R.China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110P.R.China

Repelling liquid drops from engineering surfaces has attracted great attention in a variety of *** achieve efficient liquid shedding,delicate surface textures are often introduced to sustain air pockets at the liquid-solid ***,those surfaces are prone to suffer from mechanical failure,which may bring reliability issues and thus limits their ***,inspired by the aerodynamic Leidenfrost effect,we present that impacting drops are directionally repelled from smooth surfaces supplied with an exogenous air *** theoretical analysis reveals that the synchronized nonwetting and oblique bouncing behavior is attributed to the aerodynamic force arising from the air *** versatility and practicability of our approach allow for drop repellency without the aid of any surface wettability treatment and also avoid the consideration of mechanical stability issues,which thereby provides a promising candidate for the applications that necessitate liquid shedding,e.g.,resolve the problem of tiny raindrop adhesion on the automobile side window during driving.

关键词： thereby driving attributed

The Lambert-G Family:Properties,Inference,and Applications

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 513-536页

作者： Jamal N.Al Abbasi Ahmed Z.Afify Badr Alnssyan Mustafa S.Shama Accounting department Ashur UniversityBaghdad10011Iraq department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt department of Management Information Systems and Production Management College of Business and EconomicsQassim UniversityBuraydah51452Saudi Arabia department of Basic Sciences Common First Year(CFY)King Saud UniversityRiyadh11362Saudi Arabia department of Mathematics and Statistics Osim Higher Institute of Administrative ScienceOsim12961Egypt

This study proposes a new flexible family of distributions called the Lambert-G *** Lambert family is very flexible and exhibits desirable *** three-parameter special sub-models provide all significantmonotonic and non-monotonic failure rates.A special sub-model of the Lambert family called the Lambert-Lomax(LL)distribution is *** expressions for the LL statistical properties are *** of the LL distribution are addressed mathematically based on its hazard *** estimation of the LL parameters is discussed using six estimation *** performance of this estimation method is explored through simulation *** usefulness and flexibility of the LL distribution are demonstrated empirically using two real-life data *** LL model better fits the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions.

关键词： Lambert function Lomax distribution maximum likelihood hazard function statistical model simulation

Device design principles and bioelectronic applications for flexible organic electrochemical transistors

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International Journal of Extreme Manufacturing 2024年第1期6卷 126-153页

作者： Lin Gao Mengge Wu Xinge Yu Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054People’s Republic of China department of Biomedical Engineering City University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Organic electrochemical transistors(OECTs) exhibit significant potential for applications in healthcare and human-machine interfaces, due to their tunable synthesis, facile deposition, and excellent biocompatibility. Expanding OECTs to the fexible devices will significantly facilitate stable contact with the skin and enable more possible bioelectronic applications. In this work,we summarize the device physics of fexible OECTs, aiming to offer a foundational understanding and guidelines for material selection and device architecture. Particular attention is paid to the advanced manufacturing approaches, including photolithography and printing techniques, which establish a robust foundation for the commercialization and large-scale fabrication. And abundantly demonstrated examples ranging from biosensors, artificial synapses/neurons, to bioinspired nervous systems are summarized to highlight the considerable prospects of smart healthcare. In the end, the challenges and opportunities are proposed for fexible OECTs. The purpose of this review is not only to elaborate on the basic design principles of fexible OECTs, but also to act as a roadmap for further exploration of wearable OECTs in advanced bio-applications.

关键词： flexible organic electrochemical transistors wearable bioelectronics manufacturing approaches device physics neuromorphic applications

Bayesian and Non-Bayesian Analysis for the Sine Generalized Linear Exponential Model under Progressively Censored Data

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2795-2823页

作者： Naif Alotaibi A.S.Al-Moisheer Ibrahim Elbatal Mohammed Elgarhy Ehab M.Almetwally department of Mathematics and Statistics Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia department of Mathematics College of ScienceJouf UniversityP.O.Box 848Sakaka72351Saudi Arabia Mathematics and Computer Science department Faculty of ScienceBeni-Suef UniversityBeni-Suef62521Egypt department of Basic Sciences Higher Institute of Administrative SciencesBelbeisEgypt Faculty of Business Administration Delta University for Science and TechnologyGamasa11152Egypt

This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)*** SGLE distribution utilizes the sine transformation to enhance its *** updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability *** suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique *** model includes many well-known lifespan distributions as separate *** suggested model is accompanied with a range of statistical *** model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored *** order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing *** relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models.

关键词： Sine G family generalized linear failure rate progressively censored data moments maximum likelihood estimation Bayesian estimation simulation

Transparency of Tax Law and Tax Administration

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Belt and Road Initiative Tax Journal 2024年第1期5卷 26-30页

作者：无 Inland Revenue department Government of the Hong Kong Special Administrative Regionthe People's Republic of China

Transparency of tax law and tax administration is vital to the fair,effective and efficient operation of a tax *** achieve and improve transparency,various means and channels are *** article sets out the measures adopted by the Government of the Hong Kong Special administrative Region in promoting and improving transparency of tax law and tax administration.

关键词： Transparency of tax law and tax administration Channels for dissemination of tax information Communication with taxpayers Stakeholder consultation and engagement