检索结果-南通市图书馆

Global weirding at mass extinction horizons

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 10-12页

作者： Gregory J.Retallack department of Earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

关键词：

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean M.Riordan Matthew C.Gernon Peter Koulen department of Ophthalmology School of MedicineUniversity of Missouri department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases.Some of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric disorders.In addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS diseases.This review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS pathologies.In addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS diseases.Cannabinoids and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

A bibliometric analysis and visualization of osteochondral lesions of talus (2004-2021)

在线全文

学校读者我要写书评

暂无评论

Medical Data Mining 2024年第3期7卷 17-25页

作者： Xiao-Jie Sun Shu-Long Wang Zi-Dong Wang Zhao-Jun Chen The Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China department of Hand and Foot Surgery The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing 100029China School of acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China

Background:Osteochondral lesions of the talus(OLTs)are a significant challenge for foot and ankle specialists,which could cause pain and decrease patient function.Researchers can use the findings of this study to shape future directions for research by exploring global trends and hotspots in OLT.Methods:Web of Science Core Collection was used to retrieve literature related to OLT between 2004 and 2021.This report covers the current state of OLTs,such as publications,journals,trends,hotspots,and the performances of relevant countries,institutions and authors.The co-citation analysis,the coauthorship analysis,the cooccurrence analysis,and the bibliographic coupling analysis were conducted with the Bibliometrix R package,VOSviewer v1.***.10.0,and CiteSpace 5.8.R3.Results:During an 18-year review,717 articles and 76 review articles on OLT published from 2004 to 2021 were reviewed.The USA has made the largest contribution to the OLT-related literature,and a significant contribution has been made by Kennedy JG(48/6.05%)and van Dijk CN(30/3.78%).In terms of total link strength,Foot&Ankle International was the leading journal.Analysis showed that the global research hotspots of OLTs focused on the pathogenesis,diagnosis,clinical research,and surgical treatment of OLT.It would be significant to pay close attention to future research on osteochondral autograft transplantation and management,surgery,multidisciplinary integration and mechanisms of OLT,and its related diseases.Conclusions:The study provides information about the current status and hotspots of research in the domain of OLT over the past 18 years that will assist researchers in identifying potential perspectives on hot topics and research frontiers.

关键词： bibliometric analysis hotspots osteochondral lesions of the talus trends visualised analysis

Regenerative medicine strategies for chronic complete spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 818-824页

作者： Shogo Hashimoto Narihito Nagoshi Masaya Nakamura Hideyuki Okano department of Orthopedic Surgery Keio University School of Medicine department of Physiology Keio University School of Medicine

Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases.While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable,most research in this field has focused on the early phase of incomplete injury.However,the majority of patients have chronic severe injuries;therefore,treatments for these situations are of fundamental importance.The reason why the treatment of complete spinal cord injury has not been studied is that,unlike in the early stage of incomplete spinal cord injury,there are various inhibitors of neural regeneration.Thus,we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe pathologies.First,we established a combination therapy of cell transplantation and drug-releasing scaffolds,which contributes to functional recovery after chronic complete transection spinal cord injury,but we found that functional recovery was limited and still needs further investigation.Here,for the further development of the treatment of chronic complete spinal cord injury,we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss,with reference to the literature,which combination of treatments is most effective in achieving functional recovery.

关键词： cell transplantation chronic phase complete transection regenerative medicine spinal cord injury

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA department of Biomedical Engineering Duke UniversityDurhamNCUSA department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various diseases.However,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low purities.Here,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid droplets.By adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the droplet.We demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid biopsies.Due to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2022年第5期42卷 825-832页

作者： FAN Xisheng DU Xiaoyi PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China Depeartment of TCM Pediatric Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050051China department of Experimental acupuncture School of Acupuncture-Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200China department of Rehabilitation School of Acupuncture-Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200China department of Basic Teaching and Research of acupuncture School of Acupuncture-Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200China Hebei International Joint Research Center for Dominant Diseases in Chinese Medicine and acupuncture

OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD.

关键词： dysmenorrhea menstruation infrared thermal imaging acupoint sensitization specific acupoints

Influence of aging, mitochondrial dysfunction, and inflammation on Parkinson's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1197-1198页

作者： Davide Cossu Nobutaka Hatiori department of Neurology Juntendo University department of Biomedical Sciences Sassari University

Aging is associated with chronic form of inflammation called inflammaging,which results from immune system changes.Inflammaging plays a crucial role in the pathogenesis of various neurodegenerative diseases(Dabravolsk...

关键词：

MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1523-1531页

作者： Bridget Martinez Philip V.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of Medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

Chara cterized by positive symptoms(such as changes in behavior or thoughts,including delusions and hallu cinations),negative symptoms(such as apathy,anhedonia,and social withdrawal),and cognitive impairments,schizophrenia is a chro nic,severe,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully reverse all three types of symptoms characte rizing this condition.Schizophrenia is frequently misdiagnosed,resulting in a delay of or inappropriate treatment.Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of schizophrenia.The recent studies reviewed included microRNA profiling in blood-and urine-based materials and nervous tissue mate rials.From the studies that had validated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be miR-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and miR-130b,-193a-3p in blood plasma.Antipsychotic treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b,-193a-3p,-132,-195,-30e,-432 in blood plasma.Further studies are warranted with adolescents and young adults having schizophrenia and consideration should be given to using animal models of the disorder to investigate the effect of suppressing or overexpressing specific microRNAs.

关键词： antipsychotics biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes microRNAs neural stem cells olfactory neuroepithelium schizophrenia whole blood

Effectiveness on post-stroke hemiplegia in patients:electroacupuncture plus cycling vs electroacupuncture alone

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2023年第2期43卷 352-358页

作者： Minh Duc Nguyen Thanh Van Tran Quoc Vinh Nguyen Ninh Khac Nguyen Son Truong Vu Luu Trong Nguyen Linh Vu Phuong Dang Senior Specialist Clinic National Hospital of AcupunctureHanoi 1000Vietnam department of Senior Specialist National Hospital of acupuncture Hanoi 1000Vietnam department of Senior Specialist Military Institute of Traditional MedicineHanoi 1000Vietnam department of Training and Science National Hospital of AcupunctureHanoi 1000Vietnam department of Senior Specialist National Hospital of AcupunctureHanoi 1000Vietnam department of Rehabilitation 108 Military Central HospitalHanoi 1000Vietnam department of Medicine Dai Nam UniversityHanoi 1000Vietnam

OBJECTIVE:To evaluate the effectiveness of cycling in combination with electroacupuncture in treatment of poststroke hemiplegia patients at National Hospital of acupuncture,Vietnam.METHODS:The study was designed as a single-centre,outcome-assessor-blinded parallel randomised controlled trial with 120 post-stroke hemiplegia patients randomly assigned into two groups:electroacupuncture plus cycling(CT group) and electroacupuncture(AT group).Patients were assessed before and after the treatment(using muscle grading,modified Rankin,Barthel,Orgorozo scores and electromyography).Statistical Man–Whitney U test,and Fisher’s exact tests were used to compare between CT and AT groups.RESULTS:The results reported statistically significant improvement in motor function in patients suffering from hemiplegia following ischemic stroke in both CT and AT groups.Patients in CT group experienced a greater improvement compared to those in AT group including better muscle contraction(increased frequency and amplitude of electromyography and increased muscle grading scale);increased recovery(Orgogozo scale),increased independency(Barthel scale) and decreased disability(Modified Rankin scale)(P acupuncture.

关键词： electroacupuncture cycle training post-stroke hemiplegia