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Anti-atherosclerotic activity of root bark of Premna integrifolia *** high fat diet induced atherosclerosis model rats

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Journal of Pharmaceutical Analysis 2017年第2期7卷 123-128页

作者： Chitra Subramani Arivukkodi Rajakkannu Arunadevi Rathinam Sudesh Gaidhani Ilavarasan Raju Dhiman Vaidya Kartar Singh department of Biochemistry Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital CampusArumbakkamChennai 600106India department of Pharmacology Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital CampusArumbakkamChennai 600106India Ayurveda Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital Campus ArumbakkamChennai 600106India

Premna integrifolia Linn. is a medicinal plant used in ＂Dhasamula＂ drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation,hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract（HAE） of root bark of *** was evaluated in high fat diet induced atherosclerosis rats. Sixty Wistar rats were divided into six groups： the first group served as control, the second group was fed with high fat diet and the other three groups were fed with high fat diet along with various concentrations of HAE and the last group was treated with atorvastatin for 30 days. Lipid and lipoprotein profile, atherogenic index, and cardiac markers and histopathological evaluation of aorta were determined in high fat diet induced atherosclerosis rats. HAE of *** produced a significant and dose-dependent anti-atherosclerotic activity in terms of reduction in lipids and lipoprotein profile, atherogenic index, HMG-Co A reductase activity, marker enzymes such as lactate dehydrogenase（LDH）, creatine phosphokinase（CPK）, aspartate transaminase（AST）, alanine transaminase（ALT） and alkaline phosphatase（ALP）, alteration in collagen and calcium contents, mild mineralization and focal rupture of intima and media of aorta was noticed in treated groups as compared to the control. The results suggested that anti-atherosclerotic activity of HAE of P. integrifolia Linn. was due to its modulatory activity on metabolic pathway of lipid. The results contribute to the validation of the traditional use of Agnimantha in high fat diet induced atherosclerosis rats.

关键词： P.integrifolia HMG-CoA reductase Atherogenic index Biomarkers Atherosclerosis

Update on the preclinical and clinical assessment of Withania somnifera: from ancient Rasayana to modern perspectives

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Traditional Medicine Research 2022年第5期7卷 50-64页

作者： Akanksha Rashmi Singh Atiqul Islam Rimpi Arora Harjeet Singh Alok Sharma department of Pharmacognosy ISF College of PharmacyMogaPunjab 142001India department of Pharmacology ISF College of PharmacyMogaPunjab 142001India CCRAS Ministry of AYUSHJhansiUttar Pradesh 212658India

The Rasayana plant Withania somnifera(***)Dunal,also known as“Ashwagandha”,has been mentioned in various classical Ayurvedic texts,such as Charaka Samhita,Sushruta Samhita,and *** Ayurvedic drug has been referred to as a tonic that renews the body,provides physical and mental vigor in weakened states,and promotes endurance and *** possesses notable biological activity in many ailments,such as diabetes,conjunctivitis,insomnia,senile dementia,Parkinson’s disease,nervous system disorders,rheumatism,and *** pharmacological activities are due to the presence of diverse active components and their *** lead compounds are found to be effective against anxiety and other central nervous system *** has been proven to be effective and safe for a wide range of ailments from ancient to modern *** reported properties represent the traditional use of *** as indicated in the literature;furthermore,*** is one of the most important prescribed drugs in Ayurveda for its multimodal *** current review highlights the bioactive present and provides an overview of the toxicological and pharmacological studies on ***,including preclinical and clinical *** its earliest utilization to its current application,*** has been recognized to be effective at clinical levels for human health and *** attention to the safety and efficacy of *** would provide more scientific evidence,promoting global acceptance of the Ayurvedic plant.

关键词： Withania somnifera Ayurveda Rasayana pharmacological profile preclinical study clinical study

Colon cancer and their targeting approaches through nanocarriers:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 104-111页

作者： Richa Kumari Nitin Sharma Ritu Karwasra Kushagra Khanna department of Pharmaceutics ISF College of PharmacyFerozepur GT RoadMogaPunjab142001India Central Council for Research in Unani Medicine Ministry of AyushJanakpuriNew Delhi110058India Faculty of Pharmaceutical Science UCSI UniversityKualalumpur56000Malaysia

Colon cancer is the fifth most common type of cancer in the *** cancer develops when healthy cells in the lining of the colon or rectum alter and grow uncontrollably to form a mass known as a *** major medical improvements,colon cancer is still one of the leading causes of cancer-related mortality *** of the main issues of chemotherapy is toxicity related to conventional *** targeted delivery systems are considered the safest and most effective by increasing the concentration of a therapeutic substance at the tumor site while decreasing it at other ***,these delivery systems required lower doses for high therapeutic value with minimum side *** current review focuses on targeting therapeutic substances at the desired site using ***,the diagnostic applications of nanocarriers in colorectal cancer are also discussed.

关键词： Colon cancer Targeting approaches Chemotherapies Nanocarriers Gold nanoparticles Liposomes

Combination of nutritional ketosis and hyperoxygenation therapy-promising ground for integrative cancer treatment: a systematic review

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TMR Integrative Medicine 2021年第24期5卷 1-8页

作者： Santhosh John ayush Medical Officer(Naturopathy&Yoga) National Health MissionDepartment of Health and Family welfareGovernment of India

Though the cancer is a multifactorial disease,where various types of cancers exhibit varying mechanisms,pathways,genetic and cellular defects,the study of tumor micro-environment confirms that upregulated glycolysis and hypoxia are the part and parcel of almost every cancer ***,targeting them with nutritional ketosis and hyper-oxygenation therapies could create an unfavourable environment for cancers to *** aim of this review is to study the significance of these interventions in the integrative cancer *** search has been carried out through the online scientific database like PubMed and other medical journals with the search words,‘cancer metabolism’,‘tumor micro environment’,‘hypoxia and tumor’,‘ketosis and cancer treatment’,‘hyperbaric oxygen therapy and cancer’and‘ozone therapy and cancer’.All biomolecule studies,preclinical and clinical studies,received as search results are *** addition,a nutritional book,named‘Healing with Whole Foods:Asian Traditions and Modern Nutrition’by Paul Pitchford is also *** studies recommend the use of various therapeutic approaches like ketogenic diet,ketone supplementation,hyperbaric oxygen therapy and intravenous ozone therapy,individually or in combination with standard therapies,based on its antitumor effects,safety,tolerability,its ability to potentiate the radio and chemo therapy,while decreasing its side effects and its efficiency to improve the quality of ***,when combined,the synergistic action of nutritional ketosis and hyperoxygenation therapies elicited profound,supra additive anti-cancer *** per present studies,these therapies are safe to include in an Integrative cancer treatment,though large clinical trials are needed to systematize its clinical usage.

关键词： Cancer treatment Naturopathy Nutritional ketosis Hyperoxygenation therapies

Model for Assessment of Child Mortality under Different Parity: A Bayesian Swatch

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Journal of Biosciences and Medicines 2019年第5期7卷 113-126页

作者： Arunabh Tripathi G. P. Singh Abhinav Singh NIIMH CCRAS Ministry of AYUSH Hyderabad India department of Statistics and DST-CIMS BHU Varanasi India department of Statistics University of Allahabad Allahabad India

In this study a model is conceptualized to measure the child mortality under different parity of women such that a better strategy can be formulated to bring down mortality rates. In the estimation of probability of child mortality some socio demographic variables are taken in consideration. The estimates are obtained under Bayesian procedure. Two different models are formulated for it and model fitting is observed by graphical approach along with the chi square test. First model is betabinomial and second is binomial regression model. Second model shows the better fit on the data. The estimate of probability of child mortality at higher parities namely, parity 3, parity 4 and parity 5 were obtained as 0.06, 0.09 and 0.13 respectively on the basis of the second model.

关键词： Child Mortality Model Fitting Bayesian Procedure

Pharmacological, Ethnomedicinal, and Evidence-Based Comparative Review of Moringa oleifera Lam.(Shigru) and Its Potential Role in the Management of Malnutrition in Tribal Regions of India, Especially Chhattisgarh

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 314-338页

作者： Kishor Sonewane Sharda Swaroop Chouhan Mariappan Rajan Nagendra Singh Chauhan Om Prakash Rout Awanish Kumar Gyanendra Singh Baghel Prashant Kumar Gupta department of Kaumarabhritya-Balaroga Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia department of Natural Chemistry Madurai Kamraj UniversityMaduraiTamil NaduIndia Drug Testing Lab Avam Anushandhan Kendra Department of AYUSHChhattisgarhIndia department of Dravya Guna Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia department of Biotechnology National Institute of TechnologyRaipurChhattisgarhIndia

Moringa oleifera Lam.(Shigru)(Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac,liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya(nourishing) as well as Medohara(antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry,botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books(Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic,anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry,pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities,clinical efficacy, and safety.

关键词： Ethnobotanical practices ethnomedicine Moringa oleifera phytochemicals pharmacological action

Mitigating and managing COVID-19: promises and propositions from traditional health care practices in India and China

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History & Philosophy of Medicine 2021年第3期3卷 9-14页

作者： Sanjeev Rastogi Raj Kamal Yadav Deep Narayan Pandey department of Kaya Chikitsa State Ayurvedic College and HospitalLucknow-226003India department of ayush Govt of Uttar PradeshLucknowIndia department of Environment/Forest Govt of RajasthanJaipurIndia

Whole world is currently facing the ongoing COVID-19 *** pandemic has affected globaleconomy,culture,societal structure,values and human psyche in an unprecedented *** review done through published researches in the relevant area proposes that it is highly imperative for traditional and modern health sciences to come together against ***-dences collected through practical experience,published research and classical health care wisdom spread through Chinese and Indian traditional health care texts set a point for integrative health care needs to manage *** are also suggestive of the supportive role of Ayurveda and TCM in COVID-19 mitigation and *** systems should therefore be fully explored for their potential as supportive care in on-going pandemic.

关键词： Ayurveda COVID-19 TCM Pandemic

Stem cell therapy: A paradigm shift in breast cancer treatment

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World Journal of Stem Cells 2021年第7期13卷 841-860页

作者： Sabiha Khan Moushumi Suryavanshi Jasamrit Kaur Debadatta Nayak Anil Khurana Raj Kumar Manchanda Chanderdeep Tandon Simran Tandon Amity Institute of Molecular Medicine and Stem Cell Research Amity UniversityNoida 201313Uttar PradeshIndia department of Pathology Rajiv Gandhi Cancer Institute and Research CentreNew Delhi 110085India department of Chemistry Goswami Ganesh Dutta Sanatan Dharma CollegeChandigarh 160030India Central Council for Research in Homeopathy New Delhi 110058India department of ayush Karol BaghNew Delhi 110011India Amity Institute of Biotechnology Amity UniversityNoida 201313Uttar PradeshIndia

As per the latest Globocan statistics,the high prevalence rate of breast cancer in low-and middle-income countries has led to it becoming the most common cancer to be diagnosed,hence posing a major public health *** per this data,more than 11.7%of the estimated new cancer cases in 2020 were due to breast cancer.A small but significant subpopulation of cells with self-renewing ability are present in the tumor stroma and have been given the nomenclature of cancer stem cells(CSCs).These cells display a high degree of plasticity owing to their ability to transition from the slowly cycling quiescent phase to the actively proliferating *** attribute of CSCs allows them to differentiate into various cell types having diverse *** CSCs have a pivotal role in development,metastasis,treatment resistance and relapse of breast *** review focuses on the pathways regulating breast CSC maintenance and the current strategies that are being explored for directing the development of novel,targeted,therapeutic approaches for limiting and eradicating this aberrant stem cell population.

关键词： Molecular genomics Breast cancer stem cells Tumor microenvironment Molecular pathways Targeted therapy Inhibitors

In vitro cytotoxic studies of red algae Portieria hornemannii and Spyridia fusiformis against Dalton’s lymphoma ascite and Ehrlich ascite carcinoma cell lines

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Journal of Coastal Life Medicine 2016年第12期4卷 949-952页

作者： Murugesan Subbiah Bhuvaneswari Sundaresan Thamizh Selvam Natarajan Sivamurugan Vajiravelu Division of Algal Biotechnology and Bionano Technology Post Graduate and Research Department of BotanyPachaiyappa’s CollegeChennai-600030India Central Ayurveda Research Institute for Neuromuscular and Musculo-Skeletal Disorders (CCRASMinistry of AyushGovt.of India)CheruthuruthyThrissurKerala-679531India Post Graduate and Research department of Chemistry Pachaiyappa’s CollegeChennai 600030India

Objective:To study the in vitro cytotoxic activities of methanol extract of Portieria hornemannii(***)and Spyridia fusiformis(***)using Dalton’s lymphoma ascite and Ehrlich ascite carcinoma cell ***:The effect of cytotoxicity of *** and *** was evaluated with the concentrations(100 to 200μg/mL)and assessed for the antitumour activity *** selected cell lines using Trypan blue ***:The methanol extracts of *** and *** showed potent cytotoxic activity with IC_(50)values of(209.00±0.05)μg/mL and(190.00±0.05)μg/mL against the Dalton’s lymphoma ascite cell line and IC_(50)values of(190.00±0.05)μg/mL and(182.00±0.05)μg/mL against the Ehrlich ascite carcinoma cell line *** vitro cytotoxicity against the tested cancer cell lines showed strong activity by the abnormal activities of algal residue in the normal ***:The methanol solvent residue of red algae(*** and ***)could be a good *** would be a novel marine resource as a antitumor medicine demonstrated by cytotoxic studies that the above marine algae can be a potential candidate sources as antitumor drugs.

关键词： Cytotoxic activity Red algae Dalton’s lymphoma ascite cell line Ehrlich ascite carcinoma cell line