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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of graduate Student Chongqing Medical UniversityChongqingChina department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Pure red cell aplasia caused by pegylated interferon-α-2a plus ribavirin in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2011年第16期17卷 2155-2158页

作者： Cheng-Shyong Chang Hsuan-Yu Lin Fu-Lien Yu Chien-Yu Tsai Sheng-Lei Yan Division of Hematology and Oncology Department of Internal MedicineChanghua Christian Hospital graduate Institute of Nursing Chung Shan Medical University Division of Gastroenterology and Hepatology Department of Internal MedicineChang-Bing Show Chwan Memorial Hospital department and graduate program of bioindustrial technology Dayeh University

Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia,reticulocytopenia and almost complete absence of erythroid precursors in bone *** pathophysiology of PRCA may be congenital or *** our knowledge,there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis *** report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis *** diagnosis of PRCA was confirmed by the typical findings of bone marrow *** possible etiologies of our case are also discussed in this paper.

关键词： Chronic hepatitis C Pegylated interferon-α2a Pure red cell aplasia Ribavirin

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi department of Brain Science Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea department of Neurology Ajou University School of MedicineSuwonSouth Korea department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 496-500页

作者： Shwu-Tzy Wu Chien-Hua Chen Yeh-Huang Hung Tsung-Hsun Yang Vun-Siew Pang Yung-Hsiang Yeh department and graduate program of bioindustrial technology Dayeh UniversityChanghua County 51591TaiwanChina Division of Gastroenterology Department of Internal MedicineShow-Chwan Memorial HospitalChanghuaCity 500TaiwanChina Division of Gastroenterology Department of Internal MedicineChang Bing Show-Chwan Memorial HospitalChanghua County 505TaiwanChina

AIM:To identify the mucosal patterns of Helicobacter pylori(*** )-related gastritis in the gastric corpus using standard endoscopy and to evaluate their ***:A total of 112 consecutive patients underwent upper gastrointestinal *** endoscopists classified the endoscopic findings into 4 *** the second part of the study,90 images were shown to 3 endoscopists in order to evaluate the inter-observer and intra-observer variability in image ***:The mucosal patterns of the gastric bodywere categorized into 4 *** 1 pattern was defined as cleft-like appearance,type 2 as regular arrangement of red dots,type 3 pattern as the mosaic mucosal pattern and type 4 pattern as the mosaic pattern with a focal area of *** 1 and type 2 mucosal patterns were statistically significant in predicting *** status as compared with other mucosal types(χ 2 = 12.79 and 61.25 respectively,P < 0.01).Type 3 and type 4 mucosal patterns were statistically significant in predicting a ***-positive status as compared with other mucosal types(χ 2 = 21.22 and 11.02 respectively,P < 0.01).Furthermore,the sensitivity,specificity,positive and negative predictive values of type 3 plus type 4 patterns for predicting ***-positive gastric mucosa were 100%,86%,94%,and 100%,*** mean κ values for inter-and intra-observer agreement in assessing the various endoscopic patterns were 0.808(95% CI,0.678-0.938) and 0.826(95% CI,0.727-0.925) ***:Our study suggests that mucosal patterns in ***-infected gastric mucosa without atrophy can be reliably identified using standard endoscopy in the gastric corpus.

关键词： Gastric mucosa Helicobacter pylori Gastritis Digestive system diagnostic techniques Endoscopy

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Improving the sensitivity of fiber-optic SPR sensor via radially polarized beam excitation

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Chinese Optics Letters 2009年第10期7卷 909-911页

作者：阎杰鲁拥华王沛顾春郑荣升陈勇明海詹其文 department of Physics University of Science and Technology of ChinaAnhui Key Laboratory of Optoelectronic Science and Technology Electro-Optics graduate program University of Dayton

We study the sensing properties of an intensity-modulated fiber-optic surface plasmon resonance （SPR） sensor using radially polarized beam （RPB）. Because of the rotational symmetry of fiber and RPB, surface plasmon can be excited more efficiently at the sensor surface, which results in an obvious improvement of the sensitivity. Our experiments demonstrate that the sensitivity in the case of RPB illumination is three times higher than that of linearlv polarized beam illumination.

关键词： Fiber optics Plasmons Sensors

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Fabrication of morphology-controlled TiO_2 photocatalyst nanoparticles and improvement of photocatalytic activities by modification of Fe compounds

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Rare Metals 2015年第5期34卷 291-300页

作者： Teruhisa Ohno Szu Ying Lee Yin Yang department of Materials Science Graduate School of Engineering Kyushu Institute of Technology

Our previous studies suggested that redox reaction proceeded separately on specific exposed crystal faces of TiO2 nanoparticles. Site-selective deposition of metal or metal oxide on TiO2 specific exposed crystal faces successfully proceeded using the unique reactivity properties on the surface of TiO2 nanoparticles under photoexcitation. A remarkable improvement ofphotocatalytic activity of shape- controlled brookite and rutile TiO2 nanorods with modification of Fe^3＋ compounds was observed under visible light. Crystal face-selective metal compound modification on exposed crystal faces of TiO2 nanorods with brookite and futile phases was successfully prepared. Brookite and rutile TiO2 nanorods prepared by site-selective modification with metal compounds should be ideal visible-light responsive TiO2 photocatalysts because of the remarkable suppression of back electron transfer from TiO2 to oxidized metal com- pounds on the surface of the TiO2 nanorod with a brookite or rutile phase. In this paper, the development of exposed crystal face-controlled TiO2 nanorods with rutile and brookite phases was described. The obtained rutile and brookite TiO2 nanorod, showing remarkably high activity for degra- dation of organic compounds compared with the photocatalytic activities of anatase fine particles （ST-01）, is one of the most active commercially available photocatalysts for environmental cleanup in Japan. The technology of visiblelight responsive treatment for morphology-controlled rutile and brookite TiO2 nanorods by crystal face-selective modification of Fe^3＋ compounds was also discussed in this paper. The Fe^3＋ compound-modified rutile and brookite TiO2 nanorods show much higher activity than conventional visible-light responsive N-doped TiO2, which is commercially available in Japan.

关键词： Morphology-controlled TiO2 Separation of reaction sites Visible-light responsive TiO2 loaded with Fe^3+

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Active modulation of plasmonic signal with a subwavelength metal/nonlinear dielectric material/metal structure

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Chinese Optics Letters 2010年第6期8卷 584-587页

作者：王小蕾王沛陈春翀陈俊学鲁拥华明海詹其文 department of Physics Anhui Key Laboratory of Optoelectronic Science and TechnologyUniversity of Science and Technology of China Electro-Optics graduate program University of Dayton300 College ParkDaytonOH 45469USA

Light propagation through a metal/nonlinear dielectric material/metal（M-NL-M） structure is numerically *** design parameters of the M-NL-M structure are found with the waveguide theory so that the structure only supports the symmetric surface plasmon polaritons（SPP（0）） mode and the antisymmetric surface plasmon polaritons（SPP（1）） *** coupling between the two modes within the M-NL-M structure is *** controlling the propagation constants of the two modes with the intensity-dependent dielectric constant of the nonlinear Kerr material,an effective all-optical control of plasmonic signal modulator can be realized with this M-NL-M structure.

关键词： Modulation Phonons Photons Quantum theory Solids

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Ultrasonic-assisted Synthesis of Fe Nanoparticles in the Presence of Poly（N-vinyl-2-pyrrolidone）

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Chinese Journal of Chemistry 2011年第9期29卷 1829-1836页

作者： Xu, Ying Zhang, Xiaoyan Hsing, Yiming Fang, Yuzhi department of Chemistry East China Normal University Shanghai 200062 China department of Chemical Engineering Bioengineering Graduate Program the Hong Kong University of Science and Technology Hong Kong China

Zero-valent iron particles were prepared by wet reduction chemistry assisted with ultrasonic treatment. Such prepared particles have uniform size, exhibit crystalline structure and show strong pararnagnetic property. Their surface modification by coating poly（N-vinyl-2-pyrrolidone）（PVP） was investigated. The resulting Fe（0）-PVP particles were monodispersed and possessed enhancing magnetization saturation. Those synthesis conditions to control the particle size and distribution were exploited.

关键词： nanoparticles magnetic properties ultrasonic-assisted wet reduction poly(N-vinyl-2-pyrrolidone)

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Dry powder platform for pulmonary drug delivery

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Particuology 2008年第4期6卷 225-238页

作者： Derek Ivan Daniher Jesse Zhu graduate program in Biomedical Engineering Department of Chemical and Biochemical EngineeringThe University of Western OntarioLondonOntarioCanada

The phenomenon of particle interaction involved in pulmonary drug delivery belongs to a wide variety of disciplines of particle technology, in particular, fluidization. This paper reviews the basic concepts of pulmonary drug delivery with references to fluidization research, in particular, studies on Geldart group C powders. Dry powder inhaler device-formulation combination has been shown to be an effective method for delivering drugs to the lung for treatment of asthma, chronic obstructive pulmonary disease and cystic fibrosis. Even with advanced designs, however, delivery efficiency is still poor mainly due to powder dispersion problems which cause poor lung deposition and high dose variability. Drug particles used in current inhalers must be 1–5 μm in diameter for effective deposition in small-diameter airways and alveoli. These powders are very cohesive, have poor flowability, and are difficult to disperse into aerosol due to cohesion arising from van der Waals attraction. These problems are well known in fluidization research, much of which is highly relevant to pulmonary drug delivery.

关键词： Dry powder inhaler Interparticle forces Aerosol Pulmonary drug delivery Carrier particle Fluidization

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Application of machine learning technique for predicting and evaluating chloride ingress in concrete

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Frontiers of Structural and Civil Engineering 2022年第9期16卷 1153-1169页

作者： Van Quan TRAN Van Loi GIAP Dinh Phien VU Riya Catherine GEORGE Lanh Si HO department of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam Civil and Environmental Engineering program Graduate School of Advanced Science and EngineeringHiroshima UniversityHiroshima 739-8527Japan

The degradation of concrete structure in the marine environment is often related to chloride-induced corrosion of reinforcement ***,the chloride concentration in concrete is a vital parameter for estimating the corrosion level of reinforcement *** research aims at predicting the chloride content in concrete using three hybrid models of gradient boosting(GB),artificial neural network(ANN),and random forest(RF)in combination with particle swarm optimization(PSO).The input variables for modeling include exposure condition,water/binder ratio(W/B),cement content,silica fume,time exposure,and depth of *** results indicate that three models performed well with high accuracy of prediction(R2⩾0.90).Among three hybrid models,the model using GB_PSO achieved the highest prediction accuracy(R2=0.9551,RMSE=0.0327,and MAE=0.0181).Based on the results of sensitivity analysis using SHapley Additive exPlanation(SHAP)and partial dependence plots 1D(PDP-1D),it was found that the exposure condition and depth of measurement were the two most vital variables affecting the prediction of chloride *** the number of different exposure conditions is larger than two,the exposure significantly impacted the chloride content of concrete because the chloride ion ingress is affected by both chemical and physical *** study provides an insight into the evaluation and prediction of the chloride content of concrete in the marine environment.

关键词： gradient boosting random forest chloride content concrete sensitivity analysis

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