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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

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World Journal of Methodology 2025年第2期15卷 137-144页

作者： Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia department of Central animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND Epilepsy impacts millions of people,with many not responding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of rosuvastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or ***,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/*** Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关键词： Antiepileptic Anticonvulsant Statins Rosuvastatin Maximal electroshock seizure Pentylenetetrazol

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Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy

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Journal of animal Science and Biotechnology 2018年第1期9卷 233-247页

作者： S.J.Moisá P.Ji J.K.Drackley S.L.Rodriguez-Zas J.J.Loor department of animal Sciences Auburn University department of animal Sciences University of Illinois

Background： Dairy cows can readily overconsume dietary energy during most of the prepartum period, often leading to higher prepartal concentrations of insulin and glucose and excessive body fat deposition. The end result of these physiologic changes is greater adipose tissue lipolysis post-partum coupled with excessive hepatic lipid accumulation and compromised health. Although transcriptional regulation of the adipose response to energy availability is well established in non-ruminants, such regulation in cow adipose tissue depots remains poorly ***： Effects of ad-libitum access to high [HIGH; 1.62 Mcal/kg of dry matter（DM）] or adequate（CON; 1.35 Mcal/kg of DM） dietary energy for 8 wk on mesenteric（MAT） and subcutaneous（SAT） adipose tissue transcript profiles were assessed in non-pregnant non-lactating Holstein dairy cows using a 13,000-sequence annotated bovine oligonucleotide microarray. Statistical analysis revealed 409 and 310 differentially expressed genes（DEG） due to tissue and diet. Bioinformatics analysis was conducted using the Dynamic Impact Approach（DIA） with the KEGG pathway database. Compared with SAT, MAT had more active biological processes related to adipose tissue accumulation（adiponectin secretion） and signs of pro-inflammatory processes due to adipose tissue expansion and macrophage infiltration（generation of ceramides）. Feeding the HIGH diet led to changes in m RNA expression of genes associated with cell hypertrophy（regucalcin）, activation of adipogenesis（phospholipid phosphatase 1）,insulin signaling activation（neuraminidase 1） and angiogenesis（semaphorin 4 G, plexin B1）. Further, inflammation due to HIGH was underscored by m RNA expression changes associated with oxidative stress response（coenzyme Q3, methyltransferase）, ceramide synthesis（N-acylsphingosine amidohydrolase 1）, and insulin signaling（interferon regulatory factor 1, phosphoinositide-3-kinase regulatory subunit 1, retinoic acid receptor alpha）. Activation of ribos

关键词： Adipose tissue Dairy cow Dietary energy Transcriptome

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Lipopolysaccharide immune stimulation but not β-mannanase supplementation affects maintenance energy requirements in young weaned pigs

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Journal of animal Science and Biotechnology 2018年第4期9卷 901-916页

作者： Nichole F.Huntley C.Martin Nyachoti John F.Patience department of animal Science Iowa State University department of animal Science University of Manitoba

Background: Pathogen or diet-induced immune activation can partition energy and nutrients away from growth,but clear relationships between immune responses and the direction and magnitude of energy partitioning responses have yet to be elucidated. The objectives were to determine how β-mannanase supplementation and lipopolysaccharide(LPS) immune stimulation affect maintenance energy requirements(MEm) and to characterize immune parameters, digestibility, growth performance, and energy ***: In a randomized complete block design, 30 young weaned pigs were assigned to either the control treatment(CON; basal corn, soybean meal and soybean hul s diet), the enzyme treatment(ENZ; basal diet + 0.056% β-mannanase),or the immune system stimulation treatment(ISS; basal diet + 0.056% β-mannanase, chal enged with repeated increasing doses of Escherichia coli LPS). The experiment consisted of a 10-d adaptation period, 5-d digestibility and nitrogen balance measurement, 22 h of heat production(HP) measurements, and 12 h of fasting HP measurements in indirect calorimetry chambers. The immune chal enge consisted of 4 injections of either LPS(ISS) or sterile saline(CON and ENZ), one every48 h beginning on d 10. Blood was collected pre-and post-challenge for complete blood counts with differential,haptoglobin and mannan binding lectin, 12 cytokines, and glucose and insulin ***: Beta-mannanase supplementation did not affect immune status, nutrient digestibility, growth performance,energy balance, or MEm. The ISS treatment induced fever, elevated proinflammatory cytokines and decreased leukocyte concentrations(P 0.10),but increased total HP(21%) and MEm(23%), resulting in decreased lipid deposition(-30%) and average daily gain(-18%)(P < 0.05).Conclusions: This experiment provides novel data on β-mannanase supplementation effects on immune parameters and energy balance i

关键词： Acute phase proteins β-Mannan Cytokines Digestibility Feed induced immune response Heat production Inflammation Lipopolysaccharide Nitrogen balance Swine

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Non-antibiotic feed additives in diets for pigs:A review

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animal Nutrition 2018年第2期4卷 113-125页

作者： Yanhong Liu Charmaine D.Espinosa Jerubella J.Abelilla Gloria A.Casas L.Vanessa Lagos Su A.Lee Woong B.Kwon John K.Mathai Diego M.D.L.Navarro Neil W.Jaworski Hans H.Stein department of animal Science University of California department of animal Sciences University of Illinois department of animal Production College of Animal and Veterinary SciencesUniversity of Colombia Trouw Nutrition

A number of feed additives are marketed to assist in boosting the pigs' immune system, regulate gut microbiota, and reduce negative impacts of weaning and other environmental *** most commonly used feed additives include acidifiers, zinc and copper, prebiotics, direct-fed microbials, yeast products, nucleotides, and plant *** of pharmacological levels of zinc and copper, certain acidifiers, and several plant extracts have been reported to result in improved pig performance or improved immune function of *** is also possible that use of prebiotics, direct-fed microbials, yeast,and nucleotides may have positive impacts on pig performance, but results have been less consistent and there is a need for more research in this area.

关键词： Acidifiers Direct-fed microbials Minerals Plant extracts Prebiotics Pigs

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Performance and plasma concentration of metabolites in transition dairy cows supplemented with vitamin E and fat

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Journal of Integrative Agriculture 2016年第5期15卷 1076-1084页

作者： Rohollah Amirifard Mohammad Khorvash Masiholla Forouzmand Hamid-Reza Rahmani Ahmad Riasi Mohammad Malekkhahi Mojtaba Yari Morteza Hosseini-Ghaffari department of animal Science College of Agriculture Isfahan University of Technology department of animal Science College of Agriculture Yasouj University department of animal Science Faculty of Agriculture Ferdowsi University of Mashhad department of animal Science College of Agriculture Malayer University

The objective of this study was to evaluate the effects of vitamin E（VE; 1 500 or 3 000 international units（IU） d^（-1）） and fat（2% of dry matter calcium salt of soybean oil） supplementation during the transition period on feed intake, milk yield and composition and blood metabolites of dairy cows. 48 multiparous Holstein cows were randomly assigned into one of four treatments in a 2×2 factorial arrangement of vitamin E and supplemental dietary fat during the transition period. Treatments were： 1） 1 500 IU d^（-1） vitamin E without fat supplementation（1 500VE-F）; 2） 1 500 IU d^（-1） vitamin E with fat supplement（1 500VE＋F）; 3） 3 000 IU d^（-1） vitamin E without fat supplementation（3 000VE-F）; and 4） 3 000 IU d^（-1） vitamin E with fat supplement（3 000VE＋F）. Dietary treatments were initiated at approximately 28 d before expected calving dates and continued through 28 d postpartum. Dry matter intake（DMI） was unaffected（P〉0.05） by prepartum treatment. Regardless of vitamin E supplementation, DMI was greater（P〈0.01） in fat-supplemented cows compared with un-supplemented cows（19.60 vs. 18.45 kg d^（-1）; SEM=0.42） during the postpartum period. Energy balance and body weight were not affected（P〉0.05） by treatments. Postpartum diets had no significant effect on milk yield or milk composition. Plasma concentrations of non-esterified fatty acids, glucose, and insulin were not affected（P〉0.05） by treatments. Regardless of vitamin E supplementation, plasma β-hydroxybutyrate concentration was greater（P〈0.05） in fat-supplemented cows compared with un-supplemented cows during the postpartum period. These results showed no indication of positive effects on lactation performance associated with vitamin E and dietary fat supplement in transition cows.

关键词： transition cow vitamin E fat milk production blood metabolites

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Dosage Effects of Fadrozole on Growth and Development of Sex-Reversed Genetic Female Chickens

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Journal of Integrative Agriculture 2013年第6期12卷 1049-1053页

作者： YANG Xiu-rong JIANG He-sheng ZHENG Jiang-xia QU Lu-jiang CHEN Si-rui LI Jun-ying XU Gui- yun YANG Ning department of animal Genetics and Breeding Guangxi University department of animal Genetics and Breeding National Engineering Laboratory for Animal Breeding China Agricultural University

Fadrozole, an aromatase inhibitor, can masculinize genetic female chickens and high-dose decreases the hatchability. Therefore, it is important to study the growth and development of sex-reversed females after hatch. Chick embryos from a population of CAU3 egg-type were treated with different concentrations of Fadrozole prior to the sexual differentiation at E3.0 （st18）. At hatch, the phenotypic sex and genetic sex were identified by vent sexing and genetic diagnosis with CHD1, respectively. Body weight and shank length of sex reversal were tested at 8 and 20 wk, respectively. Testicular development, oviduct and ovarian degeneration were observed and serum concentration of estradiol and testosterone were tested with radioimmunoassay （RIA） at 30 wk. The results showed that body weight and shank length of sex- reversed females were not significantly different between low-dose groups （0.1, 0.3, and 0.5 mg for F1, F2, and F3, respectively） and high-dose groups （1.0 and 1.3 mg for F4 and F5, respectively）（P〉0.05）. Left and right testes or ovotestes in F2, F3, F4, and F5 groups were heavier than that of in F1 group （P〈0.05）. While the gonad weight of treatment groups were less than that in male control （P〈0.05）, oviduct weight in F2, F3, F4, and F5 groups were significant differences compared with female control and F1 group （P〈0.05）. Egg number from onset of laying egg to 30 wk in F4 and F5 groups were less than in female control, F1 and F2 groups （P〈0.05）. Serum testosterone level in F5 group was significant higher compared with female control, F1, F2, F3, and F4 groups （P〈0.05）, but significant lower compared with male control （P〈0.05）. While concentration of serum estradiol in F5 group was significant lower compared with female control, F1, F2, and F4 groups （P〈0.05）. In conclusion, the concentration of Fadrozole do not affect postnatal growth of sex-reversed female chicken and the degree of sex-reversed females elevate with the increase of Fadrozole concentration at

关键词： chicken Fadrozole growth and development reproductive system sex reversals

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GLP1 and GIP are involved in the action of synbiotics in broiler chickens

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Journal of animal Science and Biotechnology 2018年第2期9卷 451-459页

作者： Pawel Antoni Kolodziejski Maciej Sassek Daniela Chalupka Natalia Leciejewska Leszek Nogowski Pawel Mackowiak Damian Jozefiak Katarzyna Stadnicka Maria Siwek Marek Bednarczyk Tomasz Szwaczkowski Ewa Pruszynska-Oszmalek department of animal Physiology and Biochemistry Poznan University of Life Sciences department of animal Nutrition and Feed Management Poznan University of Life Sciences department of animal Biochemistry and Biotechnology UTP University of Science and Technology department of Genetics and animal Breeding Poznan University of Life Sciences

Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested:(Lactobacillus salivarius IBB3154 plus galactooligosaccharide(Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides(Syn2).Methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12 thday of egg incubation(2 mg of prebiotics + 105 cfu bacteria per egg).Hatched roosters(total 2,400) were reared on an experimental farm, kept in pens(75 animals per pen), with free access to feed and water. After 42 d animals were slaughtered. Blood serum, pancreas, duodenum and duodenum content were ***: Syn2 increased trypsin activity by 2.5-fold in the pancreas and 1.5-fold in the duodenal content. In the duodenum content, Syn2 resulted in ca 30% elevation in lipase activity and 70% reduction in amylase ***1 and Syn2 strongly decreased expression of m RNA for GLP-1 and GIP in the duodenum and for GLP-1 receptors in the pancreas. Simultaneously, concentrations of the incretins significantly diminished in the blood serum(P < 0.05). The decreased expression of incretins coincides with changed activity of digestive enzymes in the pancreas and in the duodenal content. The results indicate that incretins are involved in the action of Syn1 and Syn2 or that they may even be their target. No changes were observed in key hormones regulating metabolism(insulin, glucagon, corticosterone, thyroid hormones, and leptin) or in metabolic indices(glucose,NEFA, triglycerides, cholesterol). Additionally, synbiotics did not cause significant changes in the activities of alanine and aspartate aminotransferases in broiler chickens. Simultaneously, the activity of alkaline phosphatase and gamma glutamyl transferase diminished after Syn2 and Syn1, ***: The selected synbiotics may be used as

关键词： GIP GLP-1 Incretins In ovo Synbiotics

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