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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)key laboratory for Quality Research and Evaluation of cell Products GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Engineering and technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia Lei Baozeng Sun Xiaoyu Yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology key laboratory of Advanced Functional Polymer Membrane Materials of Jilin province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

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Effect of thermal treatment on structural change of anode electrocatalysts for direct methanol fuel cells

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Particuology 2014年第4期12卷 45-50页

作者： Mingjia Han Jianhuang Zeng Jianwei Xia Shijun Liao School of Chemistry and Chemical Engineering South China University of TechnologyKey Laboratory of Fuel Cell Technology of Guangdong Province

Commercially available carbon-supported Pt, PtCo and PtRu catalysts from E-TEK are heat-treated in turn at 600℃ and 800℃ each for an hour. The as-received and as-heated catalysts are used as anode catalysts for direct methanol fuel cells. Structural and surface composition changes induced by heating are analyzed by X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS）, respectively. For the Pt catalyst, heating the catalysts caused only the mass activity decrease due to particle sintering, whereas the specific activity and CO tolerance remained unchanged. The performance of the PtCo and PtRu catalysts is affected differently by heating. Heating the PtRu catalyst adversely affects its catalytic activity and its CO tolerance due to Pt depletion at the surface. In contrast, although Pt depletion also takes place for the heated PtCo catalysts, these catalysts show an even higher specific activity and approximately the same CO tolerance. The observed difference is likely due to the optimum atomic ratio difference for Ru/Pt and Co/Pt; an increased atomic ratio on the surface for Co/Pt results in an activity enhancement, which is contrary to the effect of the increase of Ru/Pt atomic ratio.

关键词： Structural changesMethanol electrooxidationCO tolerancePt depletion

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Applications of M/N/C analogue catalysts in PEM fuel cells and metal-air/oxygen batteries: Status quo, challenges and perspectives

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Progress in Natural Science:Materials International 2020年第6期30卷 807-814页

作者： Bin Chi Xiaorong Zhang Mingrui Liu Shijie Jiang Shijun Liao The key laboratory of fuel cell technology of guangdong province & The key laboratory of New Energy technology of guangdong Universities School of Chemistry and Chemical Engineering South China University of Technology

To meet the sharp increase in demand for clean and renewable energy, it is necessary to develop new energyconversion and storage technologies, such as proton exchange membrane fuel cells(PEMFCs) and metal-air/oxygen batteries(MABs). Due to the sluggish reaction kinetics of the oxygen reduction reaction(ORR) and the oxygen evolution reaction(OER) in the cathodes of PEMFCs and MABs, significant amounts of precious metal catalysts need to be used, driving up the cost of fuel cells and MABs and thereby hindering their commercialization on a large scale. Transition metal and nitrogen co-doped carbonaceous catalysts(M/N/C) have high catalytic activity towards the ORR and OER once the catalysts are modified with certain promoters/additives. In addition, M/N/C catalysts can be prepared from abundant, inexpensive materials, making their cost negligible compared with precious metal catalysts, a development that would efficiently decrease the cost of PEMFCs and MABs. In last decade, numerous researchers have attempted to realize these applications of M/N/C catalysts, and some exciting results have been achieved, making these promising replacements for precious metal ***, some serious problems and significant challenges remain. In this paper, we review the research on the application of M/N/C analogue catalysts in PEMFCs and MABs in the last 10 years, indicate the remaining challenges, and suggest the future research directions.

关键词： PEM fuel cell MABs M/N/C catalysts Oxygen reaction

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One New Zinc Coordination Polymer Based on 2-Chloro-benzoate and 4,4'-Bipyridine: Synthesis, Crystal Structure and Luminescence

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Chinese Journal of Structural Chemistry 2013年第8期32卷 1229-1235页

作者：马德运郭海福覃亮 School of Chemistry and Chemical Engineering Zhaoqing University key laboratory of fuel cell technology of guangdong province South China University of Technology

A Zn-based coordination polymer [Zn（2-cb）2（4,4′-bpy）0.5]n （1, 2-cb = 2-chloro- benzoate, 4,4＇-bpy = 4,4′-bipyridine） was prepared by hydrothermal synthesis using 2-chloro- benzoic acid and 4,4′-bipyridyl as ligands. The compound was characterized by elemental analysis, IR, TGA, and X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group PI with a = 8.0471（5）, b = 9.7338（6）, c = 11.7830（7） A, a = 96.2230（10）, β = 92.542（2）, γ = 103.7560（10）°, V = 888.84（9） A3, Z = 2, Mr = 454.57, Dc = 1.698 g/cm3,μ（MoKa） = 1.708 mm.1, F（000） = 458, the final R = 0.0359 and wR = 0.0936 for 3167 observed reflections with I 〉 2σ（I）. The crystal analysis indicates that 1 exhibits a 1-D chain structure constructed by 4,4′-bpy and a dicaryon secondary-building-unit of [Zn2（2-cb）4]. Luminescence analysis revealed that compound 1 emits blue fluorescence with a fluorescence lifetime of 55.03 ns.

关键词： Zn-based coordination polymer hydrothermalsynthesis crystal structure luminescence

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Copper-cobalt Bimetallic Oxides-doped Alumina Hollow Spheres: a Highly Efficient Catalyst for Epoxidation of Styrene

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Chemical Research in Chinese Universities 2019年第1期35卷 125-132页

作者： LI Baitao HUANG Jing WANG Xiujun key laboratory of fuel cell technology of guangdong province School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640P.R.China

Copper-cobalt bimetallic oxides-doped alumina hollow spheres(CuCo/AHS)were labricatcd through the sacrificial carbonaceous template *** dependence of the physicochemical properties and morphologies of CuCo/AHS on the composition of copper and cobalt in CuxCoy/AHS(x/y=9/1,7/3,5/5,and 3/7)was characterized bv means of X-ray powder diffraction,nitrogen physisorption,atomic adsorption spectroscopy,scanning electron microscopy,transmission electron microscopy and X-ray photoelectron *** these catalysts, Cu7-Co3/AHS catalyst exhibited perfect hollow sphere structure,thin wall,and big pore *** calcined catalysts were examined for the epoxidation of styrene with tert-butyl hydroperoxide as *** with the monometallic counterparts(Cu/AHS and Co/AHS)and other CuxCoy/AHS catalysts,Cu7Co3/AHS catalyst showed higher performance,yielding a styrene conversion of 64.6% with 93.0% selectivity toward styrene *** addition,the strong interaction of Cu^2+or Co^2+ with AHS ensured good stability after four consecutive reactions.

关键词： Alumina hollow sphere Styrene epoxidation Cu-Co bimetallic catalyst Styrene oxide

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Synthesis and Properties of Hydroxide Conductive Polymers Carrying Dense Aromatic Side-chain Quaternary Ammonium Groups

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Chinese Journal of Polymer Science 2017年第7期35卷 823-836页

作者： Guang-hui Nie Wen-Jun Wu Xi Yue Shi-jun Liao 李秀华 School of Chemistry&Chemical Engineering South China University of TechnologyGuangzhou 510641China The key laboratory of fuel cell technology of guangdong province South China University of TechnologyGuangzhou 510641China

A series of hydroxide conductive polymers QTBMs carrying dense aromatic side-chain quaternary ammonium groups has been synthesized by using a new monomer of 3,3＇-di（3＂,5＂-dimethylphenyl）-4,4＇-difluorodiphenyl sulfone and other commercial monomers via polycondensation reaction, and subsequent bromination, quaternization and alkalization. The chemical structures of the ionomers were confirmed by 1H- and 13C-NMR spectroscopy. Water uptake, swelling ratio, hydroxide conductivity, the number of bonded water per ammonium group （A）, volumetric ion exchange capacity （IECvwet）, mechanical and thermal properties, and chemical stability were systematically evaluated for the series of QTBMs membranes. QTBMs showed IECs ranging from 1.02 meq·g-1 to 2.11 meq·g-1; in particular, QTBM-60 membrane with the highest IEC （2.11 meq·g-1） had very high hydroxide ion conductivity of 131.9 mS·cm-1 at 80 ℃, which was attributed to the well assembled nano-channels with distinct phase separation evidenced by small-angle X-ray scattering （SAXS）. It was found that the hydrated QTBMs membranes were mechanically stable with moderate water uptakes and swelling ratios, high chemical stability under the harsh alkaline conditions. This work provides a facile way to prepare anion exchange membranes （AEMs） with high performances for the application in alkaline fuel cells.

关键词： Aromatic side-chain quaternary ammonium Bromination Alkaline anion exchange membrane Poly(aryleneether sulfone)s

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Novel fusiform core-shell-MOF derived in tact metal@carb on composite:An efficient cathode catalyst for aqueous and solid-state Zn-air batteries

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Journal of Energy Chemistry 2022年第1期31卷 385-394,I0011页

作者： Di Zhou Hongquan Fu Jilan Long Kui Shen Xinglong Gou Chemical Synthesis and Pollution Control key laboratory of Sichuan province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637000SichuanChina key laboratory of fuel cell technology of guangdong province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640GuangdongChina

Owing to the varied mechanisms of ORR/OER,exploiting cost-effective bifunctional catalysts with robust ORR/OER activities and excellent performances in Zn-air batteries is still a *** this work,the Co/CoO@NSC bifunctional catalyst is obtained by using Zn-MOF@Co-MOF as *** Co/CoO@NSC composite has interconnected porous architecture with in tact metal@carb on structure,exhibiting superior electrocatalytic activities toward ORR and OER that can be comparable with the Pt/C and RuO_(2) catalysts,*** Co/CoO@NSC-based aqueous Zn-air battery achieves a high specific capacity(759.7 mAh/g)and energy density(990.5 Wh/kg),and ultra-long rechargeable property(more than 400 h/1200 cycles).The Co/CoO@NSC-based solid-state Zn-air battery also delivers an excellent performance with a long cycle life(more than 143 h/858 cycles).Most importantly,the newly synthesized and recharged Co/CoO@NSC-based solid-state Zn-air battery can be used to light up a 2 V LED lamp for more than 28 h,demonstrating the superior practicability as rechargeable power source.

关键词： Core-shell structure Metal organic framework Aqueous Zn-air battery Solid-state Zn-air battery Ultra long cycle life

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Oxygen reduction reaction on single Pt nanoparticle

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Journal of Energy Chemistry 2020年第10期29卷 323-326页

作者： Zhi-Peng Xiang Ai-Dong Tan Zhi-Yong Fu Jin-Hua Piao Zhen-Xing Liang key laboratory on fuel cell technology of guangdong province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641GuangdongChina School of Food Science and Engineering South China University of TechnologyGuangzhou 510641GuangdongChina

Nanocollision electrochemistry is employed to evaluate the ORR’s activity of one single Pt nanoparticle,the effect of the size and ligand is *** size-normalized activity of the Pt nanoparticle of 4 nm is two times higher than that of 25 nm,confirming that the intrinsic activity does depend on the size of the *** is further found that the adsorbed ligand does yield effect on electrocatalysis,and the adsorption strength follows the order of PVP>CTAB>*** work is of significance to understand the nature of the ORR’s electrocatalysis at the level of an individual entity,which makes the structure-activity correlation in a more reliable way.

关键词： Ligand effect Nano-collision electrochemistry Oxygen reduction reaction Single Pt nanoparticle

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