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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Growth phenology adjusts to seasonal changes in water availability in coexisting evergreen and deciduous mediterranean oaks

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Forest Ecosystems 2023年第5期10卷 535-546页

作者： Filipe Campelo Alvaro Rubio-Cuadrado Fernando Montes Michele Colangelo Cristina Valeriano J.Julio Camarero department of Life Sciences University of CoimbraCalçada Martim de FreitasCoimbra3000-456Portugal Departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y Del Medio NaturalUniversidad Politecnica de MadridCiudad Universitaria S/n28040MadridSpain Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanana 1005E-50192ZaragozaSpain Departamento de Dinamica y Gestion Forestal Instituto de Ciencias Forestales(ICIFOR-INIA-CSIC)Ctra.La Coruna Km 7.528040MadridSpain Scuola di Scienze Agrarie ForestaliAlimentari e AmbientaliUniversita Della BasilicataViale Dell’Ateneo Lucano 1085100PotenzaItaly

Different leaf(evergreen *** habit)and xylem(***-porous wood)traits represent contrasting strategies to face seasonal changes in water availability and ***,how contrasting leaf and xylem habits of coexisting tree species affect stem wood formation and tree-ring development remains poorly ***,we investigated the spatio-temporal patterns of wood formation in two deciduous oaks(Quercus faginea and Quercus petraea)and two evergreen oaks(Quercus ilex and Quercus suber)coexisting in seasonally dry Mediterranean forests along an aridity gradient in *** hypothesized that growth responses to drought and intra-and inter-annual growth patterns would differ between functional *** simulated intra-and interannual growth using a modified version of the Vaganov-Shashkin(VS)process-based,growth *** VS model simulations were used to estimate growth changes under a high emission scenario(RCP 8.5)for the current distribution of the study oak species and to forecast their future performance under warm(4.8℃)conditions in the Iberian *** simulations indicate that climate warming would induce a shortening of the ringgrowth season and a reduction of radial growth in evergreen and deciduous Mediterranean oaks,particularly in dry sites from southern and eastern Iberia currently occupied by *** and *** oaks may better recover after dry periods than deciduous oaks by resuming growth after the summer *** soil water availability in spring would be more detrimental to growth of deciduous ***-based growth models should be refined and validated to better forecast changes in tree growth as a function of climate.

关键词： Process-based growth model Quercus ilex Quercus suber Quercus faginea Quercus petraea Tree-ring growth

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Phase-field modeling of fracture for quasi-brittle materials

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Underground Space 2019年第1期4卷 10-21页

作者： Jacinto Ulloa Patricio Rodríguez Cristóbal Samaniego Esteban Samaniego department of Civil Engineering Katholieke Universiteit LeuvenB-3001 LeuvenBelgium Departamento de Recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca 010151Ecuador Universidad de Cuenca Cuenca 010151Ecuador Institut für Kontinuumsmechanik Leibniz Universität HannoverHannover 30167Germany Inria Bordeaux-Sud-Ouest Research Center 200 Avenue de la Vieille TourTalence 33405France Facultad de ingeniería Universidad de CuencaEcuador

This paper addresses the modeling of fracture in quasi-brittle materials using a phase-field approach to the description of crack *** the computational mechanics community,several studies have treated the issue of modeling fracture using phase *** of these studies have used an approach that implies the lack of a damage *** herein explore an alternative model that includes a damage threshold and study how it compares with the most popular *** formulation is systematically explained within a rigorous variational ***,we present the corresponding three-dimensional finite element discretization that leads to a straightforward numerical *** simulations in two dimensions and three dimensions are then *** results show that while an elastic stage and a damage threshold are ensured by the present model,good agreement with the results reported in the literature can be obtained,where such features are generally absent.

关键词： Quasi-brittle materials Fracture Variational formulation Phase fields Gradient damage

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Networked Monitoring and Fault-Tolerant Control of Nonlinear Process Systems

Networked Monitoring and Fault-Tolerant Control of Nonlinear...

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Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Benjamin J.Ohran Jinfeng Liu David Muoz de la Pea Panagiotis D.Christofides James F.Davis department of Chemical and Biomolecular Engineering University of California Departamento de ingeniería de Sistemas y Automática Universidad de Sevilla department of Electrical Engineering University of California

This work focuses on a general class of nonlinear process systems controlled by a two-tier networked control system integrating a local control system using continuous sensing/actuation with a networked control system using asynchronous sensing/actuation. To deal with control actuator faults that may occur in the closed-loop system and eliminate the ability of the two-tier networked control system to stabilize the process, a networked fault detection and isolation（FDI）and fault-tolerant control（FTC） system is designed which detects and isolates actuator faults and determines how to reconfigure the two-tier networked control system to handle the actuator faults and ensure closed-loop stability. The method is demonstrated using a reactor-separator process example.

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Assessing the Performance of Two Hydrologic Models for Forecasting Daily Streamflows in the Cazones River Basin (Mexico)

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Open Journal of Modern Hydrology 2016年第3期6卷 168-181页

作者： Fernando González-Leiva Rodrigo Valdés-Pineda Juan B. Valdés Laura A. Ibáñez-Castillo Posgrado en ingeniería Agrícola y Uso Integral del Agua Universidad Autónoma Chapingo Chapingo México department of Hydrology and Water Resources University of Arizona Tucson AZ USA

Floods have caused significant human and economic losses in the Cazones River Basin, located on the Gulf of Mexico. Despite this knowledge, steps towards the design and implementation of an early warning system for the Cazones are still a pending task. In this study we contributed by establishing a hydrological scheme for forecasting mean daily discharges in the Cazones Basin. For these purposes, we calibrated, validated and compared the HyMod model (HM) which is physics-based, and an autoregressive-based model coupled with the Discrete Kalman Filter (ARX-DKF). The ability of both models to accurately predict discharges proved satisfactory results during the validation period with RMSEHyMOD = 2.77 [mm/day];and RMSEARX-DKF = [2.38 mm/day]. Further analysis based on a Streamflow Assimilation Ratio (SAR) revealed that both models underestimate the discharges in a similar proportion. This evaluation also showed that, under the most common conditions, the simpler stochastic model (ARX-DKF) performs better;however, under extreme hydrological conditions the deterministic HM model reveals a better performance. These results are discussed under the context of future applications and additional requirements needed to implement an early warning hydrologic system for the Cazones Basin.

关键词： Hydrologic Models Cazones Basin HyMod Discrete Kalman Filter Hydrologic Uncertainty

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Improving the Performance of Fixed-Bed Catalytic Reactors by Innovative Catalyst Distribution

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Journal of Applied Mathematics and Physics 2020年第4期8卷 672-683页

作者： Violeta Alejandra Chichique Martínez Farhang Shadman department of Chemical and Environmental Engineering University of Arizona Tucson AZ USA Departamento de ingeniería de Procesos y Ciencias Ambientales Universidad Centroamericana “José Simeón Cañas” (UCA) San Salvador El Salvador

A comprehensive mathematical model is developed to simulate the interactions of the complex processes that take place in typical catalytic chemical reactors. This mathematical model includes correlations representing various modes of mass transport and chemical reactions. To illustrate the application and value of this approach for reactor optimizations, the model is applied to the case of series reactions with a desirable intermediate compound and the risk of degradation of this compound if the process conditions are not optimized. The modeling results show that in such cases, which are very common in practice, replacing the conventional uniform catalyst distribution with a novel non-uniform distribution will significantly improve the performance of the reactor and the production of the desirable compound. Various catalyst distribution options are compared, and a novel non-uniform loading of catalyst is identified that gives a much better performance compared to the conventional approach. The model is versatile and useful for both the design as well as the optimization of the catalytic fixed-bed reactors in a wide variety of reactor and reaction conditions.

关键词： Catalyst Reactor Optimization Series Reactions Uniform Catalyst Distribution Non-Uniform Catalyst Distribution Catalyst Deactivation

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Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit

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Horticulture Research 2019年第1期6卷 1638-1654页

作者： JoséG.Vallarino Delphine M.Pott Eduardo Cruz-Rus Luis Miranda Juan J.Medina-Minguez Victoriano Valpuesta Alisdair R.Fernie JoséF.Sánchez-Sevilla Sonia Osorio Iraida Amaya department of Molecular Biology and Biochemistry Instituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”University of Málaga–Consejo Superior de Investigaciones Científicas(IHSM-UMA-CSIC)Campus de Teatinos29071 MálagaSpain Max-Planck-Institut für Molekulare Pflanzenphysiologie Am Mühlenberg 114476 Potsdam-GolmGermany Genómica y Biotecnología Centro de MálagaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140 MálagaSpain ingeniería y Tecnología Agroalimentaria Centro Las Torres-TomejilInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)Alcaládel RíoSevillaSpain ingeniería y Tecnología Agroalimentaria Centro de HuelvaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)HuelvaSpain

Improvement of nutritional and organoleptic quality of fruits is a key goal in current strawberry breeding *** ratio of sugars to acids is a determinant factor contributing to fruit liking,although different sugars and acids contribute in varying degrees to this complex trait.A segregating F1 population of 95 individuals,previously characterized for several fruit quality characters,was used to map during 2 years quantitative trait loci(QTL)for 50 primary metabolites,L-ascorbic acid(L-AA)and other related traits such as soluble solid content(SSC),titratable acidity(TA),and pH.A total of 133 mQTL were detected above the established thresholds for 44 *** 12.9%of QTL were detected in the 2 years,suggesting a large environmental influence on primary metabolite *** objective of this study was the identification of key metabolites that were associated to the overall variation in SSC and *** it was observed in previous studies,a number of QTL controlling several metabolites and traits were co-located in homoeology group V(HG V).mQTL controlling a large variance in raffinose,sucrose,succinic acid,and L-AA were detected in approximate the same chromosomal regions of different homoeologous linkage groups belonging to HG *** genes for selected mQTL are proposed based on their co-localization,on the predicted function,and their differential gene expression among contrasting F1 progeny ***-seq analysis from progeny lines contrasting in L-AA content detected 826 differentially expressed genes and identified Mannose-6-phosphate isomerase,FaM6PI1,as a candidate gene contributing to natural variation in ascorbic acid in strawberry fruit.

关键词： straw breeding trait

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A facile one-pot hydrothermal synthesis as an efficient method to modulate the potassium content of cryptomelane and its effects on the redox and catalytic properties

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Chinese Journal of Catalysis 2019年第6期40卷 940-952页

作者： Huiyan Pan Xiaowei Chen Oihane Sanz Miguel A.Cauquia Jose M.Rodriguez-Izquierdoa Juan J.Delgado Departamento de Ciencia de los Materiales e ingeniería Metalúrgica y Química Inorgánica Facultad de CienciasUniversidad de CádizCampus Río San PedroPuerto Real(Cádiz)E-11510Spain Applied Chemistry department University of Basque Country(UPV-EHU)Apdo.1072San Sebastian20080Spain

Cryptomelane has been widely applied as catalyst in oxidation reactions due to its excellent redox properties and low ***,a novel one-pot hydrothermal synthesis using a potassium permanganate aqueous solution as precursor and ethanol as reducing agent has successfully been developed to obtain cryptomelane *** synthetic route makes it possible to control the amount of potassium incorporated into the structure of the cryptomelane by selecting the appropriate synthesis temperature and ethanol initial *** advantage of this approach,the effect of potassium concentration on the structural stability and reducibility of the cryptomelane,which are poorly discussed in the literature,has been *** have observed that samples with low content of potassium(~11%)show high conversions of CO to CO2 especially at low *** lower activity of the samples with high K contents(~16%)can be ascribed to the beneficial effect of K on the structural stability of cryptomelane in detriment of labile oxygen on cryptomelane surface.

关键词： Cryptomelane Pyrolusite Catalytic CO oxidation Hydrothermal synthesis Potassium content

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Possibilities of using silicate rock powder:An overview

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Geoscience Frontiers 2022年第1期13卷 446-456页

作者： Claudete Gindri Ramos James C.Hower Erika Blanco Marcos Leandro Silva Oliveira Suzi Huff Theodoro department of Civil and Environmental Engineering Universidad de la CostaCalle 58#55-66BarranquillaColombia Departamento de ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru Center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA department of Earth&Environmental Sciences University of KentuckyLexingtonKY 40511USA Postgraduate Program of Environment and Rural Development(PPG-MADER) Área Universitária01Vila Nossa Senhora de Fátima–Campus UnBPlanaltinaDFBrazil

This study evaluates the on use of crushed rocks(remineralizers)to increase soil fertility levels and which contributed to increase agricultural productivity,recovery of degraded areas,decontamination of water,and carbon *** use of these geological materials is part of the assumptions of rock technology and,indirectly,facilitates the achievement of sustainable development goals related to soil management,climate change,and the preservation of water *** over the past 50 years on silicate rocks focused on soil fertility management and agricultural *** recently,the combined use with microorganisms and organic correctives have shown positive results to mitigate soil degradation;to expand carbon sequestration and storage;and to contribute to the adsorption of contaminants from water and *** this article we show results obtained in several countries and we show that this technology can contribute to the sustainability of agriculture,as well as to reverse global *** mineral nutrients are released more slowly from these types of inputs,they remain in the soil for a longer time,stimulating the soil *** addition,they are a technology to soluble synthetic fertilizers replace,since the few nutrients derived from such inputs not consumed by plants are lost by leaching,contaminating groundwater and water *** addition,conventional methods rely heavily on chemical pesticides which cause damage to soil’s microfauna(responsible for the decomposition of organic matter and nutrient cycling)and the loss of organic carbon(in the form of dioxide),which is quickly dispersed in the *** rock powders are applied in natura,have long-lasting residual effects and reduce greenhouse gas emissions.

关键词： Rock powder Soil management Carbon storage Water contaminant adsorption

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Resource manipulation reveals flexible allocation rules to growth and reproduction in a Mediterranean evergreen oak

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Journal of Plant Ecology 2014年第1期7卷 77-85页

作者： Fernando Pulido Gerardo Moreno Eustolia García José J.Obrador Raúl Bonal Mario Díaz Grupo de Investigación Forestal Ingeniería Forestal y del Medio NaturalUniversidad de ExtremaduraE-10600 PlasenciaCáceresSpain Colegio de Postgraduados Campus TabascoMX-86500 CárdenasTabascoMexico Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM-JCCM)University of Castilla-La ManchaCiudad RealSpain department of Biogeography and Global Change(BCG-MNCN) Museo Nacional de Ciencias NaturalesCSICE-28006 MadridSpain

Aims In plants,resource allocation to growth and reproduction may depart from trade-off expectations if(i)investment in growth and reproduction relies on different resource pools,(ii)allocation to reproduction is dependent upon reaching some growth threshold or(iii)reproduction is developmentally linked to growth,both functions relying on the same resource *** examined the effects of enhanced resource level on patterns of resource allocation to growth and reproduction in holm oak(Quercus ilex ***),a Mediterranean evergreen *** In the experimental year(2003),we manipulated the amount of soil nutrients in autumn(to increase nutrient uptake during shoot elongation in the following spring)and soil water in summer(to increase water uptake during acorn growth).Indicators of growth and male and female reproduction were estimated in the preexperimental(2002),experimental(2003)and post-experimental(2004)*** Findings Fertilized trees produced significantly longer shoots,but the number of female flowers per shoot was not affected by *** production of male catkins was also enhanced by *** did not affect the production of female flowers or abortion *** and female reproduction showed no consistent relationship in untreated trees,but resource addition elicited a growth-female reproduction trade-off in the experimental *** sign of this significant relationship changed in the post-experimental year,indicating the existence of lagged effects of resource manipulation on acorn ***,patterns of allocation to growth and reproduction varied as a function of sex,resource availability and year,a result consistent with extreme allocational plasticity in holm oak.

关键词： acorn abortion allocational plasticity dehesa growthreproduction trade-offs nutrient addition Quercus ilex resource allocation

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