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Chinese Chemical Letters 2024年第8期35卷 128-137页

作者： Ningyue Xu Jun Wang Lei Liu Changyang Gong Division of head&neck tumor Multimodality Treatment Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Radiotherapy(RT)is a crucial treatment for cancer;however,its effectiveness is limited by adverse effects on normal tissues,radioresistance,and tumor *** overcome these challenges,hydrogels have been employed for delivery of radiosensitizers and other therapeutic *** review summarizes recent advancements in the application of hydrogel-based local drug delivery systems for improving the therapeutic efficacy of RT in cancer ***,we introduce the classification and properties of ***,we detail hydrogel-based platforms designed to enhance both external beam radiation therapy and *** also discuss hydrogels used in combination therapy involving RT and ***,we highlight the challenges that hydrogels face in *** surveying the latest developments in hydrogel applications for RT,this review aims to provide insights into the development of more effective and targeted cancer therapies.

关键词： Radiotherapy Drug delivery systems Hydrogel Radiation sensitization Combination therapy

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa Wang Yifan Yang Shizhi He George G.Chen Jason YK.Chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang department of Otolaryngology head and neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology head and neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

Minimally invasive management of parapharyngeal space tumors:Introducing a decision-making algorithm and radiologic tool

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 97-101页

作者： Manuel Schoch Gunesh Rajan Grzegorz Karwacki department of Otolaryngology and head-neck Surgery Hospital of St.GallSt.GallenSwitzerland department of Otolaryngology and head-neck Surgery Hospital of LucerneLuzernSwitzerland department of Radiology and Nuclear Medicine Hospital of LucerneLuzernSwitzerland

Objective Traditionally tumors of the parapharyngeal space(PPS)are resected through transcervical *** recent approaches include endoscopic approaches or transoral robotic surgery(TORS)without directions on when to use which *** objective was to find objective parameters to choose the most suitable *** It is a retrospective study containing 6 patients from May 2019 to May 2021 with tumors of the PPS treated in the department of Otolaryngology and head-neck Surgery at the Hospital of Lucerne,*** The data was analysed in average 53 months after *** resection was completed with TORS in 3 patients and endoscopically in 3 *** operation time was 114 *** major complications *** evidence of tumor was found in magnetic resonance imaging studies postoperatively in all *** We conclude that a resection via TORS or endoscopic technique is safe and ***,we postulate that the further a tumor is located in the upper lateral area of the PPS,an approach via TORS is less possible.

关键词： Oto-rhino-laryngology Endoscopic surgery Robotic surgery Parapharyngeal space tumors

Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments

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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro Tel Marco Maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

Radiomics and artificial intelligence applications in pediatric brain tumors

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World Journal of Pediatrics 2024年第8期20卷 747-763页

作者： Francesco Pacchiano Mario Tortora Chiara Doneda Giana Izzo Filippo Arrigoni Lorenzo Ugga Renato Cuocolo Cecilia Parazzini Andrea Righini Arturo Brunetti department of Precision Medicine University of Campania“L.Vanvitelli”CasertaItaly department of Advanced Biomedical Sciences University of Naples“Federico II”Via Pansini 580131NaplesItaly department of head and neck Neuroradiology UnitAORN MoscatiAvellinoItaly department of Pediatric Radiology and Neuroradiology V.Buzzi Children’s HospitalMilanItaly department of Medicine Surgery and DentistryUniversity of SalernoBaronissiItaly

Background The study of central nervous system(CNS)tumors is particularly relevant in the pediatric population because of their relatively high frequency in this demographic and the significant impact on disease-and treatment-related morbidity and *** both morphological and non-morphological magnetic resonance imaging techniques can give important information concerning tumor characterization,grading,and patient prognosis,increasing evidence in recent years has highlighted the need for personalized treatment and the development of quantitative imaging parameters that can predict the nature of the lesion and its possible *** this purpose,radiomics and the use of artificial intelligence software,aimed at obtaining valuable data from images beyond mere visual observation,are gaining increasing *** brief review illustrates the current state of the art of this new imaging approach and its contributions to understanding CNS tumors in *** sources We searched the PubMed,Scopus,and Web of Science databases using the following key search terms:(“radiomics”AND/OR“artificial intelligence”)AND(“pediatric AND brain tumors”).Basic and clinical research literature related to the above key research terms,i.e.,studies assessing the key factors,challenges,or problems of using radiomics and artificial intelligence in pediatric brain tumors management,was *** A total of 63 articles were *** included ones were published between 2008 and *** nervous tumors are crucial in pediatrics due to their high frequency and impact on disease and *** serves as the cornerstone of neuroimaging,providing cellular,vascular,and functional information in addition to morphological features for brain *** can provide a quantitative approach to medical imaging analysis,aimed at increasing the information obtainable from the pixels/voxel grey-level values and their ***“radiomic workflow”in

关键词： Machine learning Neuroradiology Pediatric brain tumors Radiomics

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

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World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei Zhou Maiying Fan Xiang Li Fang Yu En Zhou Xiaotong Han department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China department of Otolaryngology-head and neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

Rare incidence of mucosa-associated lymphoid tissue lymphoma presenting as buccal fat pad tumor:A case report

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World Journal of Clinical Cases 2024年第31期12卷 6506-6512页

作者： Keitaro Miyake Kazuhiro Hirasawa Haruka Nishimura Kiyoaki Tsukahara department of Otolaryngology Head and Neck SurgeryTodachuo General HospitalToda-shi 335-0023SaitamaJapan department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University HospitalShinjuku-ku 160-0023Japan

BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma,a type of non-Hodgkin lymphoma,originates in the mucosal lining of body organs and internal cavities,including the nose,mouth,lungs,and digestive *** lymphoma develops when the body produces abnormal B *** lymphomas develop at the edge of the lymphoid tissue,called the marginal zone,and,hence,are classified as a type of marginal zone *** are the most common type of marginal zone lymphomas although their occurrence is *** date,no previous cases of MALT lymphoma in the buccal fat pad have been *** SUMMARY We report the case of a patient who presented with a mass on the frontal *** resonance imaging revealed a tumor in the buccal fat pad,and histopathological and immunohistochemical findings confirmed the diagnosis of MALT *** patient had a history of Helicobacter pylori and hepatitis C virus infection,suggesting an association between these infective agents and MALT *** Consideration of MALT lymphoma is essential in the differential diagnosis of frontal cheek masses.

关键词： Mucosa-associated lymphoid tissue lymphoma Extra gastric mucosaassociated lymphoid tissue lymphoma Plain computed tomography Helicobacter pylori Case report

Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice

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Chinese Journal of Natural Medicines 2024年第3期22卷 235-248页

作者： LAI Junzhong LIANG Jiadi CHEN Kunsen GUAN Biyun CHEN Zhirong CHEN Linqin FAN Jiqiang ZHANG Yong LI Qiumei SU Jingqian CHEN Qi LIN Jizhen The Cancer Center Fujian Medical University Union HospitalFuzhou 350001China Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South ChinaFujian Normal UniversityFuzhou 350117China The department of Otolaryngology Head&Neck SurgeryUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA

Carrimycin(CA),sanctioned by China’s National Medical Products Administration(NMPA)in 2019 for treating acute bronchitis and sinusitis,has recently been observed to exhibit multifaceted biological activities,encompassing anti-inflammatory,antiviral,and anti-tumor *** these applications,its efficacy in sepsis treatment remains *** study introduces a novel function of CA,demonstrating its capacity to mitigate sepsis induced by lipopolysaccharide(LPS)and cecal ligation and puncture(CLP)in mice *** research employed in vitro assays,real-time quantitative polymerase chain reaction(RT-qPCR),and RNA-seq analysis to establish that CA significantly reduces the levels of pro-inflammatory cytokines,namely tumor necrosis factor-alpha(TNF-α),interleukin 1 beta(IL-1β),and interleukin 6(IL-6),in response to LPS ***,Western blotting and immunofluorescence assays revealed that CA impedes Nuclear Factor Kappa B(NF-κB)activation in LPS-stimulated RAW264.7 *** these findings,in vivo experiments demonstrated that CA effectively alleviates LPS-and CLP-triggered organ inflammation in C57BL/6 *** insights were gained through 16S sequencing,highlighting CA’s pivotal role in enhancing gut microbiota diversity and modulating metabolic pathways,particularly by augmenting the production of short-chain fatty acids in mice subjected to ***,a comparative analysis revealed that CA’s anti-inflammatory efficacy surpasses that of equivalent doses of aspirin(ASP)and ***,these findings suggest that CA exhibits significant therapeutic potential in sepsis *** discovery provides a foundational theoretical basis for the clinical application of CA in sepsis management.

关键词： Carrimycin Inflammation Lipopolysaccharide Cecal ligation and puncture Sepsis Gut microbiota

Laryngeal leiomyoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第18期12卷 3529-3533页

作者： Yu Wu Jing-Man Li Tian-Jiao Zhang Xin Wang department of Otolaryngology Head and Neck SurgeryThe First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Leiomyomas(LMs)are mesenchymal tumors that arise from smooth muscle *** most commonly arise in organs with an abundance of smooth muscle such as the uterus and gastrointestinal ***,LMs are rarely detected in the head and neck *** this study,we report a rare case of laryngeal LM(LLM)and summarized the clinical characteristics of reported LLMs to help clinicians better understand this rare disease and improve its diagnosis,treatment,and postoperative *** SUMMARY A 49-year-old man was admitted to our ENT outpatient clinic with a chief complaint of pharynx discomfort for 2 *** performed under topical anesthesia revealed a solitary,pink mass at the tubercle of *** via laryngeal endoscopy was performed under general anesthesia,and the lesion was excised *** immunohistochemical staining for desmin and smooth-muscle actin indicated a smooth muscle origin and the diagnosis was laryngeal *** surgery,the patient’s condition was stable,and he was discharged 2 d after *** the 1-year postoperative period,the patient’s condition remained stable without evidence of *** Surgical resection is the preferred treatment for LLMs,its early diagnosis and differential diagnosis have important clinical significance.

关键词： Leiomyoma Larynx Smooth tumor Endoscopic surgery Case report

Pleomorphic Adenoma of the Salivary Glands: Two Atypical Locations

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International Journal of Otolaryngology and head & neck Surgery 2024年第3期13卷 251-257页

作者： Sidibé Youssouf Diarra Abraham Samaké Djibril Sanogo Boubacar Traoré Abdoul Moumine Diarra Kassim Coulibaly Bourama Diakité Youssouf Keita Mohamed Amadou department of ENT and head and neck Surgery Mother-Child University Hospital “ Le Luxembourg&#8221 Bamako Mali Faculty of Medicine and Odontostomatology Bamako Mali department of ENT and head and neck Surgery The Mali-Gavardo Hospital Bamako Mali Ministry of Higher Education and Scientific Research Bamako Mali ENT and head and neck Surgery department of the Commune V Reference Health Center (CSRef CV) Bamako Mali department of ENT and head and neck Surgery at CHU Gabriel Touré Bamako Mali department of Anatomy and Pathological Cytology Gabriel Tour&#233 University Hospital Center Bamko Mali department of Oral Surgery Sikasso Regional Hospital Sikasso Mali

Pleomorphic adenoma is the most common tumor of the salivary glands, accounting for approximately 50% of salivary gland lesions. It develops mainly in the salivary glands: parotid (80%), submaxillary (10%), sublingual (1%) and in the accessory oral-pharyngeal glands (9%). The aim of this work was to report 2 cases of pleomorphic adenoma of atypical location and then to discuss the difficulties linked to its diagnostic and therapeutic management in the Malian context. They were a 40-year-old man and a 72-year-old woman. They were admitted to the ENT department of the “Luxembourg Mere-infant” hospital for oropharyngeal swelling for the first and swelling of the palate for the second. The clinical expression was a swelling in both cases, of a hard, mobile consistency with healthy mucosa on their surface. The remainder of the physical examination was unremarkable. The diagnosis of a tumor of the oropharynx and palate was made following clinical radiological examinations. The histopathological examination of the surgical specimen made it possible to make the diagnosis of pleomorphic adenoma of the palate and the left palatine tonsil. The follow-up surgery was straightforward, with a favorable outcome. Pleomorphic adenomas are relatively rare benign tumors of the accessory salivary glands;their clinical expression remains swelling. Therapeutic management is surgery and the diagnosis is confirmed by histopathological examination.

关键词： Pleomorphic Adenoma Palate Tonsil Mali