检索结果-南通市图书馆

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo Division of Otolaryngology–Head&Neck surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of electroacupuncture on pain after periodontal flap surgery:a randomized controlled trial

引用

Journal of Traditional Chinese medicine 2025年第1期45卷 184-191页

作者： Emre Bulut Didem ?zkal Emino?lu Yasemin ?ay?r department of Periodontology Faculty of DentistryAtatürk University department of Family medicine Faculty of MedicineAtatürk University

OBJECTIVE: To examine the effect of electroacupuncture(EA) application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery. METHODS: In this prospective, randomized and controlled study, patients planned for periodontal surgery were divided into two groups [EA group(n = 22): patients who received electroacupuncture and control group(n = 22): patients who did not receive electroacupuncture]. Electroacupuncture was applied bilaterally to the Hegu(LI4), Daying(ST5), and Jiache(ST5) points of the patients in the EA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate. The patients in the control group underwent flap surgery without applying electroacupuncture. Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form. RESULTS: The total mean score of pain felt in the EA group(16.60 ± 2.78) was found to be significantly lower than that in the control group(31.37 ± 2.78)(P = 0.001). No significant difference was found between the groups regarding the amount of analgesics taken(4.77 ± 4.72, 5.82 ± 3.11)(P = 0.111). CONCLUSIONS: Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery. Overall, more research is needed to fully understand the effects of electroacupuncture on postoperative pain.

关键词： analgesics electroacupuncture pain, postoperative periodontitis randomized controlled trial

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

引用

Oncology Research 2025年第1期33卷 149-160页

作者： NASSER MULLA YOUSEF KATIB ASIM M.ALMUGHAMSI DUAA S.ALKHAYAT MOHAMED MOSAAD SAMIR T.ALFOTIH RAWAN ALAOFI department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia department of surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

引用

Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of Right Ventricular-Pulmonary Arterial Coupling Measured by Echocardiography in Predicting Right Ventricular Dysfunction after Cardiac surgery

引用

World Journal of Cardiovascular surgery 2025年第1期15卷 1-11页

作者： Ismail Nasr El-Sokkary Esam Ahmed Khalil Mohammed Fawzy Eltaweel Ahmed Alherazi Mohammed Samy Bahaa Abdelgawad Elkhonezy Mohamed El Sayed Moussa Mohamed Ahmed Mosaad Zaki Ibrahim Abdel Fattah Yassin Mohamed Kamal Rehan department of Cardiothoracic surgery Faculty of Medicine Al-Azhar University Cairo Egypt department of Cardiology Al-Azhar University Faculty of Medicine Cairo Egypt department of Cardiothoracic surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt department of Cardiothoracic surgery Faculty of Medicine Alexandria University Alexandria Egypt department of Internal medicine Faculty of Medicine Beni Suef University Cairo Egypt

Background: The tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) is an indirect estimate of right ventricular-pulmonary arterial (RV-PA) coupling that has been shown to correlate with invasive measures. We aimed to assess the ability of the tricuspid annular plane systolic excursion/pulmonary systolic pressure ratio (TAPSE/PASP) as a measure for RV-PA coupling to predict the development of RV dysfunction after cardiac surgery. Methods: This prospective study was conducted on 100 patients with ischemic heart disease and undergoing cardiac surgery (coronary artery bypass graft (CABG)) with normal preoperative right ventricular function, classified according to RV function outcomes into 2 groups: Normal RV group (65 patients) and RV dysfunction group (35 patients). All cases underwent per and postoperative transthoracic echocardiography. Results: By using receiver operating characteristic curve analysis, pre-operative TAPSE/PASP ratio could significantly predict the RV dysfunction (P 0.58, with AUC of 94%, 88.6% sensitivity, and 89.2% specificity. Post-operative TAPSE/PASP Ratio could significantly predict the RV dysfunction (P 0.39, with AUC of 84%, 100% sensitivity, and 76.9% specificity. Pre-operative TAPSE/PASP ratio could significantly predict mortality (P Conclusion: The TAPSE/PASP ratio is an excellent tool for CABG patients for its ability to detect and predict the development of RV dysfunction after cardiac surgery, along with the prediction of mortality in post-operative CABG patients.

关键词： Right Ventricular Pulmonary Arterial Coupling Echocardiography Cardiac surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robot assisted anatomical liver resection is safe for patient with hepatocellular carcinoma underlying Fontan-associated liver disease

引用

Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 111-113页

作者： O˘guzhan¸S al Katsunori Sakamoto Kei Tamura Masahiko Honjo Yusuke Nishi Naotake Funamizu Kohei Ogawa Yasutsugu Takada department of Hepato-Biliary-Pancreatic and Breast surgery Ehime UniversityEhime University Graduate School of Medicine454 KouShitsukawaToonEhime 791-0295Japan department of General surgery Istanbul UniversityIstanbul Faculty of MedicineistanbulTürkiye

Fontan operation is indicated in a single ventricle congenital heart disease which creates a shunt between superior vena cava and pulmonary arteries leading to increased pressure in central venous system and congestive hepatopathy,namely,Fontan-associated liver disease(FALD)[1].Recently,the long-term prognosis after Fontan operation has been improving and the number of patients diagnosed with hepatocellular carcinoma(HCC)arising from FALD is increasing[1].There are several publications on the safety of laparoscopic,conventional surgery and interventional radiological modalities in FALD-HCC patients[2-5].However,there are no reports regarding the robotic hepatectomy for the FALD-HCC *** was the first report showing the safety of robotic anatomical hepatectomy in FALD-HCC patients.

关键词： Fontan hepatocellular liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in Depression,Anxiety,and Stress Levels during a Religious Period:A Prospective Cohort Study

引用

International Journal of Mental Health Promotion 2025年第1期27卷 41-49页

作者： Ibrahim M.Gosadi Family and Community medicine department Faculty of MedicineJazan UniversityJazan City45142Saudi Arabia

Objective:There is conflicting evidence suggesting an association between Ramadan and mental ***:This study aims to assess changes in depression,anxiety,and stress levels during Ramadan among university students from Saudi Arabia and to measure the magnitude of change in these levels according to ***:This study is a prospective cohort *** was collected using a structured questionnaire that measured demographic data of the students,and levels of depression,anxiety,and stress utilizing the short form of the Depression Anxiety Stress Scales questionnaire(DASS 21).The assessments were performed starting from the month of Shaban(the month that precedes Ramadan),and the second wave of data collection was initiated beginning the second week of Ramadan until the end of the *** in the proportion of students who are categorized as normal or having abnormal degrees of depression and anxiety between Shaban and Ramadan were tested using either the Chi-square test or Fisher’s exact ***:A total of 321 students completed the assessment during Shaban and *** than half of the students were male(54.2%),with a mean age of 22.A statistically significant di7fference in levels of anxiety,depression,and stress between the assessment periods was detected(p<0.001).The proportion of students classified as normal increased during Ramadan across all measured conditions in comparison to during *** reduction in the number of students classified as having anxiety,depression,and stress between the assessment periods remained statistically significant across both ***,degrees of change appear to be higher among male students than among female ***:This study identified a reduction in levels of depression,anxiety,and stress among students during the month of Ramadan,as well as gender variation concerning levels of *** results support the significance of considering social,religious,and spiritual aspec

关键词： Depression anxiety stress religion Ramadan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Capsule endoscopy:Do we still need it after 24 years of clinical use?

引用

World Journal of Gastroenterology 2025年第5期31卷 140-147页

作者： Ahmed Tawheed Alaa Ismail Mohab S Amer Osama Elnahas Tawhid Mowafy department of Endemic medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt faculty of medicine Helwan UniversityCairo 11795Egypt department of Research SMART Company for Research ServicesCairo 11795Egypt department of Internal medicine Gardenia Medical CenterDoha 0000Qatar

In this letter,we comment on a recent article published in the World Journal of Gastroenterology by Xiao et al,where the authors aimed to use a deep learning model to automatically detect gastrointestinal lesions during capsule endoscopy(CE).CE was first presented in 2000 and was approved by the Food and Drug Administration in *** indications of CE overlap with those of regular diagnostic ***,in clinical practice,CE is usually used to detect lesions in areas inaccessible to standard endoscopies or in cases of bleeding that might be missed during conventional *** the emergence of CE,many physiological and technical challenges have been faced and *** this letter,we summarize the current challenges and briefly mention the proposed methods to overcome these challenges to answer a central question:Do we still need CE?

关键词： Capsule endoscopy Wireless capsule endoscopy Obscure gastrointestinal bleeding Artificial intelligence in gastroenterology Therapeutic capsule endoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rectal ameboma:A new entity in the differential diagnosis of rectal cancer

引用

World Journal of Gastrointestinal surgery 2025年第1期17卷 13-19页

作者： Kemal Bugra Memis Ayse Sena Celik Sonay Aydin Mecit Kantarci department of Radiology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24000Türkiye

We examined the case report written by Ke et al,describing a rare clinical *** this editorial,we would like to emphasize the differential diagnosis of rectal masses through a rare *** describe a case of ameboma,which manifested itself as a mass in the rectum in terms of imaging and rectoscopic features,in an immunocompetent patient who had complaints of constipation and rectal bleeding for *** initial diagnosis suggested malignancy due to imaging and rectoscopic features,but the pathology report reported it as *** ten days of metronidazole and oral amebicide(diloxanide furoate)treatment,the patient’s symptoms and radiological findings were successfully regressed.

关键词： Ameboma Amoebic colitis Rectal mass Immunocompetent patient Imaging findings

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unveiling the intricacies:Insight into gastroesophageal reflux disease

引用

World Journal of Gastroenterology 2025年第1期31卷 24-41页

作者： Nilanka Wickramasinghe Niranga Manjuri Devanarayana department of Physiology Faculty of MedicineUniversity of ColomboColombo 00800Western ProvinceSri Lanka department of Physiology Faculty of MedicineUniversity of KelaniyaRagama 11010Western ProvinceSri Lanka

Gastroesophageal reflux disease(GERD)poses a substantial global health challenge,with prevalence rates exhibiting geographical *** its widespread recognition,the exact prevalence and associated risk factors remain *** article comprehensively analyzed the global burden of GERD,shedding light on its risk factors,underlying pathophysiological mechanisms,current diagnostic modalities,evolving management strategies tailored to diverse patient profiles,and complex determinants contributing to treatment failures.A deeper comprehension of GERD is achieved by dissecting these intricate facets,paving the way for enhanced clinical management and improved patient outcomes.

关键词： Gastroesophageal reflux disease Risk factors Pathophysiological mechanisms Diagnosis Management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：