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Invasive ant learning is not affected by seven potential neuroactive chemicals

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Current Zoology 2024年第1期70卷 87-97页

作者： Henrique Galante Tomer J.Czaczkes department of Zoology and evolutionary Biology Animal Comparative Economics LaboratoryUniversity of Regensburg93053 Regensburg Germany

Argentine ants Linepithema humile are one of the most damaging invasive alien species *** or disrupting cognitive abilities,such as learning,has the potential to improve management efforts,for example by increasing preference for a bait,or improving ants'ability to learn its characteristics or ***-feeding insects are often the victims of psychoactive manipulation,with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often alter learning,foraging,or ***,the effect of neuroactive chemicals has seldomly been explored in ***,we test the effects of seven potential neuroactive chemicals-two alkaloids:caffeine and nicotine;two biogenic amines:dopamine and octopamine,and three nonprotein amino acids:β-alanine,GABA and taurineon the cognitive abilities of invasive *** using bifurcation *** results confirm that these ants are strong associative learners,requiring as little as one experience to develop an ***,we show no short-term effect of any of the chemicals tested on spatial learning,and in addition no effect of caffeine on short-term olfactory *** lack of effect is surprising,given the extensive reports of the tested chemicals affecting learning and foraging in *** mismatch could be due to the heavy bias towards bees in the literature,a positive result publicationbias,ordifferences inmethodology.

关键词： associativelearning caffeine memory neuroactivechemicals

Exploring the molecular landscape of NNK-induced transformation:A comprehensive genome-wide CRISPR/Cas9 screening

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Genes & Diseases 2024年第4期11卷 42-44页

作者： Trang Dinh Mira Rahm Zhenghe Wang Christopher McFarland Athar Khalil department of genetics and Genome Sciences Case WesternReserve UniversityClevelandOH44106USA

Lung cancer is the leading cause of cancer-related deaths worldwide,with an estimated 1.8 million deaths in 2020 alone.1 While several risk factors are associated with lung cancer,smoking remains the most significant environmental cause of the disease.1 One of the most potent carcinogens in tobacco smoke is 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),which is produced from nicotine through a series of metabolic reactions.

关键词： CRISPR/Cas9 NNK lung

ChMYB1-ChbHLH42-ChTTG1 module regulates abscisic acidinduced anthocyanin biosynthesis in Cerasus humilis

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Horticultural Plant Journal 2024年第1期10卷 51-65页

作者： Xiaolong Ji Zhe Li Mingyu Zhang Shaoyu Lang Xingshun Song State Key Laboratory of Tree genetics and Breeding Northeast Forestry UniversityHarbinHeilongjiang 150040China department of genetics College of Life ScienceNortheast Forestry UniversityHarbinHeilongjiang 150040China

Cerasus humilis is a kind of economic fruit tree peculiar to China,which is widely used in the food,landscape,and pharmaceutical *** are a phenolic metabolite that plays an essential role in fruit ***,the regulatory network of *** in anthocyanin biosynthesis is still *** this study,the R2R3-MYB transcription factor ChMYB1 was isolated from the full genome of the *** one-hybrid,dual-luciferase assays,and GUS staining showed that ChMYB1 significantly increased anthocyanin contents in *** fruit by promoting the expression of ChCHS and ChUFGT by binding MBS(MYB-binding elements).ChMYB1 interacted with ChbHLH42and ChTTG1 to form the MBW complex and further enhanced the expression of *** addition,abscisic acid(ABA)treatment promoted the expression of ChMYB1 and anthocyanin accumulation in *** ***,ABA treatment enhanced the interaction between ChMYB1 and ***,ChABI5 inhibited the interaction between ChMYB1 and *** data elucidated the primary molecular mechanism of anthocyanin biosynthesis in *** fruit,deepening the understanding of the regulatory network affecting anthocyanin metabolism in edible fruit crops.

关键词： Cerasus humilis Anthocyanin ChMYB1 Fruit ABA

Foraging valor linked with aggression:selection against completely abandoning aggression in the high-elevation ant Tetramorium alpestre?

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Insect Science 2024年第3期31卷 953-970页

作者： Marie-Luise Contala Patrick Krapf Florian M.Steiner Birgit C.Schlick-Steiner Molecular Ecology Group Department of EcologyUniversitat InnsbruckInnsbruckAustria rganismal&evolutionary Biology Research Programme University of HelsinkiHelsinkiFinland

Aggression has multiple benefits and is often coupled with other behaviors("behavioral syndromes").The level of aggressiveness is influenced by an adaptive benefit-cost ratio suggesting that benefits should outweigh the costs of ***,we assess if several behaviors are coupled in two behaviorally different populations(aggressive,peaceful)of the high-elevation ant Tetramorium *** three weeks,we collected colony fragments and analyzed boldness,exploring,foraging,and risk-taking *** hypothesized that the aggressive population is bolder,more explorative and risk-prone,and forages more food than the peaceful *** test whether(a)the combination of experiments and parameters used yields a good setup,(b)populations differ behaviorally,and(c)populations display behavioral syndromes,we assessed(a)the frequency of repeatable behaviors of each experiment,(b)the behavioral means among populations,and(c)the behavioral repeatability,*** found that(a)boldness and exploring were most repeatable and represent a good experimental setup,(b)the aggressive population was bolder and more explorative and risk-prone than the peaceful population,(c)boldness and exploring behaviors were highly repeatable in both populations,thus corroborating our *** results suggest that boldness,exploring,and risk-taking but not foraging are presumably coupled with aggression and indicate the presence of behavioral syndromes in this *** specific ecological conditions,aggression may be coupled with other behaviors and important for finding *** is probably adaptive in ***,possibly indicating that selection favors aggression at least partially,which may counteract the complete loss of intraspecific aggression.

关键词： adaptive value behavioral syndromes boldness exploration repeatability trade-off

Glucokinase regulatory protein rs780094 polymorphism is associated with type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease, and nephropathy

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World Journal of Diabetes 2024年第5期15卷 814-817页

作者： Ashraf Al Madhoun department of genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Liu et al published in the recent issue of the World Journal of Diabetes(Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria).Type 2 diabetes mellitus(T2DM)is a chronic disorder characterized by dysregulated glucose *** persistent elevated blood glucose level in T2DM significantly increases the risk of developing severe complications,including cardiovascular disease,re-tinopathy,neuropathy,and nephropathy.T2DM arises from a complex interplay between genetic,epigenetic,and environmental *** genomic studies have identified numerous genetic variations associated with an increased risk of ***,variations within the glucokinase regulatory protein(GCKR)gene have been linked to heightened susceptibility to T2DM and its associated *** clinical trial by Liu et al further elucidates the role of the GCKR rs780094 polymorphism in T2DM and nephropathy *** findings demonstrate that individuals carrying the CT or TT genotype at the GCKR rs780094 locus are at a higher risk of developing T2DM with albuminuria compared to those with the CC *** findings highlight the importance of genetic testing and risk assessment in T2DM to develop effective preventive strategies and personalized treatment plans.

关键词： Glucokinase regulatory protein rs780094 Type 2 diabetes mellitus Dyslipidemia Non-alcoholic fatty liver disease Nephropathy

Teneligliptin:A potential therapeutic approach for diabetic cardiomyopathy

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World Journal of Diabetes 2024年第8期15卷 1654-1658页

作者： Ashraf Al Madhoun department of genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Zhang et *** mellitus is a chronic disorder associated with several complications like cardiomyopathy,neuropathy,and *** prevalence is increasing *** diabetes medications are prescribed based on individual patients’***,the exact mechanisms by which many of these drugs exert their protective effects remain *** et al elucidates molecular mechanisms undelaying cardioprotective effect of the dipeptidyl peptidase-IV inhibitor,***,teneligliptin alleviates the activation of NOD-like receptor protein 3 inflammasome,a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory *** of NOD-like receptor protein 3 inflammasome activity reduces the expression of cytokines,oxygen radicals and *** findings highlight teneligliptin as an anti-diabetic cardioprotective reagent.

关键词： Teneligliptin Diabetes mellitus NOD-like receptor protein 3 inflammasome Inflammation Cardiomyopathy

MicroRNA-630:A potential guardian against inflammation in diabetic kidney disease

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World Journal of Diabetes 2024年第9期15卷 1837-1841页

作者： Ashraf Al Madhoun department of genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Wu et al published“MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4”.Diabetic kidney disease(DKD)stands as a significant complication occurring from diabetes mellitus,which contributes substantially to the morbidity and mortality rates *** tubular epithelial cell damage,often accompanied by inflammatory responses and mesenchymal transdifferentiation,plays a pivotal role in the progression of *** extensive research,the intricate molecular mechanisms underlying these processes remain to be *** et al remarkable work identifies microRNA-630(miR-630)as an emerging potential regulator of cell migration,apoptosis,and autophagy,prompting investigation into its association with DKD *** study endeavors to elucidate the impact of miR-630 on TEC injury and the inflammatory response in DKD *** role of miR-630 in human DKD will be of interest for future studies.

关键词： Diabetic kidney disease MicroRNA MicroRNA-630 Toll-like receptor 4 Inflammation

Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration

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Neural Regeneration Research 2024年第7期19卷 1411-1413页

作者： Caleb A.Wood Nicholas M.Tran department of Neuroscience Baylor College of MedicineHoustonTXUSA department of Molecular and Human genetics Baylor College of MedicineHoustonTXUSA

A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may possess unique features that support their survival.U nderstanding the basis of neuronal resilience or vulnerability would provide a logical strategy to identify factors that could be targeted therapeutically.

关键词： selective targeted

A new species of Discostella guiyangensis ***.(Bacillariophyta,Stephanodiscales)from Guiyang,China:morphology and phylogeny

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Journal of Oceanology and Limnology 2024年第4期42卷 1312-1324页

作者： Yandan XIANG Fangru NAN Xudong LIU Shulian XIE John Patrick KOCIOLEK Qi LIU School of Life Science Shanxi UniversityTaiyuan 030006China department of Ecology and evolutionary Biology and Museum of Natural History University of ColoradoBoulder CO 80309USA

We describe a new species of Discostella from Guiyang based on light and scanning electron microscopic observations,as well as molecular *** species is morphologically distinguished from other species by a relatively smooth and slightly recessed central area with marginal striae of unequal lengths forked near the *** fultoportulae and a single rimoportula are situated between every two costae or on the *** morphological characters and the concatenated data of rbc L and SSU rDNA indicate that Discostella guiyangensis is a unique and new *** to divergence time estimation analysis,Discostella guiyangensis is the oldest species among the Discostella species sequenced *** addition,we complement molecular data of Discostella asterocostata and Discostella stelligera.

关键词： Discostella morphology molecular analysis divergence time estimation new species