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Quantitative assessment of the impact of a triage physician on the Accreditation council for Graduate Medical Education resident milestones in the emergency department

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World Journal of Emergency Medicine 2024年第3期15卷 220-222页

作者： Julie Cueva Duncan Grossman Vishnu Muppala Arlene Chung Mahlaqa Butt Jefferson Drapkin Antonios Likourezos Errel Khordipour department of Emergency Medicine Maimonides Medical CenterNew York 11219USA

The “door-to-doctor” time for patients to be seen by a physician is an increasingly studied *** may shorten this time by implementing a triage physician (TP).The exact role of a TP may vary across *** put in preliminary orders for lab work,imaging,and treatment,and decide treatment location for further *** the prevalence of TPs grows,its effect on resident education in academic emergency departments (EDs) remains *** implemented a TP in the spring of 2016 and assessed resident physicians before and after implementation.

关键词： physician doctor treatment

Nitrite,a novel method to decrease ischemia/reperfusion injury in the rat liver

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World Journal of Gastroenterology 2015年第6期21卷 1775-1783页

作者： Bergthor Bjrnsson Linda Bojmar Hans Olsson Tommy Sundqvist Per Sandstrm department of Surgery County Council of ?sterg?tland department of Clinical and Experimental Medicine Faculty of Health Sciences Link?ping University department of Pathology County Council of ?sterg?tland

AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver ***:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmental ischemia of the left liver lobe(IR,n=14)and ischemia/reperfusion(I/R)preceded by the administration of 480 nmol of nitrite(n=14).Serum transaminases were measured after 4 h of *** microdialysate(MD)was sampled in 30-min intervals and analyzed for glucose,lactate,pyruvate and glycerol as well as the total nitrite and nitrate(NOx).The NOx was measured in ***:Aspartate aminotransferase(AST)at the end of reperfusion was higher in the IR group than in the nitrite group(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similarly,alanine aminotransferase(ALT)was also higher in the I/R group than in the nitrite group(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher in the nitrite group than in the I/R group(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after the administration of *** ischemia,the levels decreased in both groups and then increased again during *** the end of reperfusion,there was a tendency towards a higher NOx in the I/R group than in the nitrite group(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher in the IR group than in the nitrite group(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)during ischemia and the first 30 min of *** the same period,glycerol was also higher in the IRI group than in the nitrite group(464±38μmol/L vs 367±31μmol/L,P=0.049).With respect to histology,there were more signs of tissue damage in the I/R group than in the nitrite group,and29%of the animals in the I/R group exhibited necrosis compared with none in the nitrite *** nitric oxide synthase transcription increased between early ischemia(t=15)and the end of reperfusion in both ***:Nitrite administered before liver ischemia in the rat liver redu

关键词： Ischemia-reperfusion injury Nitrite Liver ischemia

Determination of inclusions in liquid steel after calcium treatment

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International Journal of Minerals,Metallurgy and Materials 2010年第1期17卷 28-31页

作者： Kabamba Tshilombo department of Material Science and Manufacturing Council for Scientific and Industrial ResearchPretoria South Africa

Nozzle blocking was eliminated by calcium-treated liquid steel through changing the chemical and phase composition of alumina inclusions in aluminium-killed steel. Three different methods were applied to determine the composition of inclusions in liquid steel： total oxygen content samples, sampling spoon samples, and ＂lollipop＂ steel samples. The results show that calcium modification of liquid steel influences the inclusion composition varying from 2wt% to 14wt% depending on the method used. The composition of inclusions contains mainly Al2O3-CaO only, or is associated with SiO2 or MgO depending on the initial input. The methods used in this study are indicators of the inclusion composition but can be improved to quantify the inclusion size.

关键词： inclusion modification castability deoxidation

Extreme wave loads on submerged water intakes in shallow water

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Journal of Hydrodynamics 2015年第1期27卷 38-51页

作者： CORNETT Andrew HECIMOVICH Mark NISTOR Ioan Ocean Coastal and River Engineering National Research Council department of Civil Engineering University of Ottawa

This paper provides new guidance concerning the hydrodynamic loads on submerged intake structures located in shallow water under breaking and non-breaking waves. Results from a series of experiments conducted in a large wave flume at 1 ： 15 scale to study the hydrodynamic forces exerted on a generic intake structure located on a sloping seabed in shallow water below breaking and non-breaking irregular waves are presented. Based on analysis of the experimental data, empirical relationships are developed to describe the peak loads in terms of characteristic wave parameters such as significant wave height and peak wave period. The distribution of the peak loads across different parts of the intake structure is also described. Drag and inertia force coefficients for the horizontal forcing on the intake structure and for the main structural sub-components are derived and presented. It is shown that the well-known Morison equation, with appropriate drag and inertia force coefficients, can provide reasonable estimates of the moderate horizontal loads, but the peak loads are less well predicted.

关键词： wave force water intake drag force inertia force coastal engineering

High-quality reference genes for quantifying the transcriptional responses of Oryza sativa L. (ssp. indica and japonica) to abiotic stress conditions

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Chinese Science Bulletin 2013年第16期58卷 1919-1930页

作者： MAKSUP Sarunyaporn SUPAIBULWATANA Kanyaratt SELVARAJ Gopalan department of Biotechnology Faculty of Science Mahidol University Plant Biotechnology Institute National Research Council of Canada

Rice (Oryza sativa L.) is important to food security and is also an excellent model plant for numerous cereal crops. A functional genomics study in rice includes characterization of the expression dynamics of genes by quantitative real-time PCR (qPCR) analysis; this is a significant key for developing rice varieties that perform well in the face of adverse climate change. The qPCR analysis requires the use of appropriate reference genes in order to make any quantitative interpretations meaningful. Here, the new potential reference genes were selected from a huge public database of rice microarray experiments. The expression stability of 14 candidates and 4 conventional reference genes was validated by geNorm PLUS and NormFinder software. Seven candidates are superior to the conventionally used reference genes in qPCR and three genes can be used reliably for quantitating the expression of genes involved in abiotic stress responses. These high-quality references EP (LOC_Os05g08980), HNR (LOC_Os01g71770), and TBC (LOC_Os09g34040) worked very well in three indica genotypes and one japonica genotype. One of indica genotypes including the Jasmine rice, KDML105 developed in Thailand for which no reference genes have been reported until now.

关键词：功能基因组学胁迫反应非生物水稻胁迫条件籼稻品质实时定量PCR

The Flight Dynamics of Tapejara,a Pterosaur From the Early Cretaceous of Brazil with a Large Cranial Crest

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Acta Geologica Sinica(English Edition) 2012年第6期86卷 1377-1388页

作者： Sankar CHATTERJEE R.Jack TEMPLIN department of Geosciences Museum of Texas Tech University Aerodynamic Laboratory National Research Council

Tapejara wellnhoferi, a small azhdarchoid pterodactyloid from the Early Cretaceous Santana Formation of Brazil, provides critical information about the aerodynamic function of its spectacular head crest. The cranial crests in pterodactyloids were sexually dimorphic and are thought to have evolved in adult males in response to female mate choice. However, the location of cranial crests in front of the center of gravity would create instability in the yaw axis during flight and may seem like a handicap. Vertically aligned webbed feet probably suppressed the yawing rotations and instability from the crest. Here we show that the crest functioned as a front rudder to make agile turn and mediate flight control. A computer simulation model suggests that Tapejara had a large excess of muscle power available above the power required for continuous flapping flight. It could easily takeoff from a perch, ground, or water surface and land safely on the ground. It was an excellent glider with a gliding angle close to 4~ and a cruising speed of 27 km/h. Tapejara could soar efficiently on the windward side of cliffs or circle on rising thermals over tropical waters for efficient long-distance flight. Various control surfaces in the wings of Tapejara analogous to the slat, aileron, elevator, fin, rudder, and horizontal stabilizer of an aircraft made pterodactyloids versatile flyers.

关键词： Tapejara Cretaceous pterodactyloids cranial crest flight Brazil

Measurement of Anomalous Radon Gas Emanation Across the Yammouneh Fault in Southern Lebanon: A Possible Approach to Earthquake Prediction

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International Journal of Disaster Risk Science 2015年第3期6卷 250-266页

作者： Mohammed A.Kobeissi Francisco Gomez Charles Tabet Lebanese Atomic Energy Commission Lebanese National Council for Scientific Research department of Geological Sciences University of Missouri Lebanese National council for Scientific Research BeirutLebanon

The eastern Mediterranean region is an active tectonic setting that includes the Dead Sea Transform Fault, which forms the boundary between the African and the Arabian Plates and crosses Lebanon from south to north, striking in a restraining bend around 25–30°NE. The major structural feature in Lebanon is the Yammouneh Fault, which reaches to Syria and southern Turkey in a north–south direction. Measurements of radon gas concentration and exhalation rates in two locations along the southern segment of the Yammouneh Fault in south Lebanon were performed. Two profiles in the El-Khiam basin and Blat pull-apart basin and perpendicular to the Yammouneh Fault trace were analyzed. An approximate fault width 25–30 m wide was determined in the El-Khiam study area. Temporal increase of radon concentration was measured and correlated with stress/strain tectonic activity and stress drops along the studied fault segment *** variable radon concentrations were detected during one of the measurements where an earthquake occurred in the region of Tiberias Lake in northern Palestine along the Yammouneh Fault in the study area. Measurements of radon concentration along a station’s profile in Blat village did not show any radon anomalous variation due to the discontinuity along the fault(pull-apart), and possible absence of stress and energy accumulation along the Yammouneh Fault line in that location.

关键词： CR-39 Detector Earthquake prediction Exhalation rate Lebanon Radon Stress/strain

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

CTP Synthase Is Required for Optic Lobe Homeostasis in Drosophila

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Journal of Genetics and Genomics 2015年第5期42卷 261-274页

作者： Ömür Y.Tastan Ji-Long Liu Medical Research council Functional Genomics Unit Department of PhysiologyAnatomy and GeneticsUniversity of Oxford

CTP synthase （CTPsyn） is a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTE Several recent studies have shown that CTPsyn forms filamentous subcellular structures known as cytoophidia in bacteria, yeast, fruit flies and humans. However, it remains elusive whether and how CTPsyn and cytoophidia play a role during development. Here, we show that cytoophidia are abundant in the neuroepithelial stem cells in Drosophila optic lobes. Optic lobes are underdeveloped in CTPsyn mutants as well as in CTPsyn RNAi. Moreover, overexpressing CTPsyn impairs the development of optic lobes, specifically by blocking the transition from neuro- epithelium to neuroblast. Taken together, our results indicate that CTPsyn is critical for optic lobe homeostasis in Drosophila.

关键词： CTP synthase Cytoophidium Drosophila Central nervous system Neuroepithelial stem cell