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Application of Trichoderma harzianum (T22) and Trichoderma atroviride (P1) as plant growth promoters, and their compatibility with copper oxychloride

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 425-425页

作者： Francesco Vinale Gaetano D'Ambrosio Khalid Abadi Felice Scala Roberta Marra David Turrà Sheridan L Woo Matteo Lorito department ar.bo.pa.ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) ItalyDepartment Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) ItalyDepartment Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy

Trichoderma strains are used in agriculture because they provide to the plants the following benefits: i) are rhizosphere competence and establish stable rhizosphere microbial communities; ii) control plant disease caused by pathogenic and competitive microflora, by using a variety of mechanisms; iii) improve vegetative growth, root development and yield; iv) make nutrients more available to the plant. In this work we have investigated the ability of T. harzianum T22 and T. atroviride P1 to improve plant growth of locally important horticultural crops: lettuce, tomatoes and peppers and to prevent disease in the greenhouse and field. The effect of the Trichoderma treatment was evaluated by determining the weight of fresh and dry roots and above ground plant biomass, measuring plants height, counting the number of emerged leaves (lettuce, tomatoes and peppers) and quantifying production (tomatoes and peppers). No disease symptoms were found during production, although Fusarium sp. strains pathogenic to tomato were detected in the soil. Compounds containing copper oxychloride are frequently used for fungal disease control in agriculture. In order to investigate the compatibility of T. harzianum T22 and T. atroviride P1 with copper oxychloride applications, the effect on mycelia growth was monitored in both liquid and solid medium. In general, the tests indicated a high level of tolerance of the Trichoderma strains to concentrations of copper oxychloride varying from 0.1 to 5 mmol/L.

关键词：园艺作物真菌病害防治木霉属植物生长促进剂氯化铜

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Extracellular proteome of Trichoderma harzianum to identify proteins with biotechnological value

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 452-452页

作者： Ambrosino P Scala V Marra R Vinale F Soriente I Ferraioli S Carbone V Ruocco M Woo S L Lorito M Dep. ar.bo.pa.ve.-Plant pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyISA-CNR Avellino ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples Italy

Trichoderma harzianum strain T22 parasitizes and controls many phytopatogenic fungi and is applied commercially as biological control agent. The production of hydrolitic enzymes appears to be a key factor in the parasitic process. We tested the endo-esochitinolitic and glucanolitic activities of culture filtrates of T22 grown under carbon and nitrogen starvation or in presence of biomass or cell walls of the phytopathogenic fungi botrytis cinerea, Rhizoctonia solani and Pythium ultimum. The highest level of enzimatic activities was found in culture where the mycoparasite interacted with a phytopathogenic fungus. Therefore we used a proteomic approach to investigate changes in the complex mixture of extracellular proteins secreted by T. harzianum strain T22 in order to identify proteins of potential biotechnology value for commercial and industrial *** technology has greatly enhanced our ability to conduct functional genomics studies. Nevertheless only a few studies have been published so far on the fungal extracellular proteome. Sample preparation remains the most critical step in analyses based on two-dimensional gel electrophoresis (2-DE), and it requires to be optimized for each specific application. In this study, our first aim was to set up the extraction protocol of the extracellular proteins secreted by T . harzianum strain T22 when it was grown in vitro .The secreted proteins were analysed by two-dimensional electrophoresis (2-DE) and substantial changes in the extracellular proteome of the mycoparasite have been observed. Comparing the 2D maps of the fungus grown in minimal medium with glycerol as carbon source (used as control condition) with those obtained in inducing conditions, a lot of novel proteins appeared. The higher number of novel and up-regulated spots was obtained in the presence of Rhizoctonia solani biomass. Other spots were specifically up-regulated by the interaction with different plant pathogens. Differentially expressed proteins

关键词：木霉属真菌蛋白质鉴定生物技术植物病原体水解酶

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Novel understanding of Trichoderma interaction mechanisms

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 387-387页

作者： Matteo Lorito department of ar.bo.pa.ve. Plant Pathology Section University of Naple and CNR IPP-Institute for Plants Protection Portici Section Via Università 100 Portici (Napoli) 80055 Italy

Trichoderma- based biofungicides are a reality in commercial agriculture, with more than 50 formulations registered worldwide as biopesticides or biofertilizers. Several research strategies have been applied to identify the main genes and compounds involved in the complex, three-way interactions between fungal antagonists, plants and microbial pathogens. Proteome and genome analyses have greatly enhanced our ability to conduct targeted and genome-based functional studies. We have obtained reproducible 2-D maps of the entire fungal proteome in various conditions of interaction, which permitted the isolation of many proteins related to specific functions. Many differential proteins from several biocontrol strains of Trichoderma spp. during the in vivo interaction with different plants and/or several phytopathogenic fungi have been isolated and analyzed by MALDI-TOF. Relevant genes have been cloned and specifically inactivated, to demonstrate their function in biocontrol and induction of disease resistance. GFP-based reporter systems with interaction-inducible promoters allowed the characterization of regulatory sequences activated by the presence of the pathogen or the plant. From extensive cDNA. and EST libraries of genes expressed during Trichoderma-pathogen-plant interactions, we are identified and determined the role of a variety of novel genes and gene-products, including ABC transporters specifically induced during antagonism with other microbes; enzymes and other proteins that produce or act as novel elicitors of Induced Resistance in plant and promote root growth and crop yield; proteins possibly responsible of a gene-for-gene avirulent interaction between Trichoderma and plants; mycoparasitism-related inducers released from fungal pathogens and that activate biocontrol in Trichoderma; fungal promoters specifically induced during mycoparasitism and plant colonization; plant proteins and a novel phytoalexin induced by the presence of the fungal antagonist; etc.

关键词：木霉素相互作用机制拮抗真菌无毒力 ISR 抗性

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G protein signalling involved in host recognition and mycoparasitism-related chitinase expression in Trichoderma atroviride

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 448-448页

作者： Susanne Zeilinger Barbara Reithner Kurt Brunner Valeria Scala Isabel Peiβl Matteo Lorito Robert L Mach Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 ItalyVienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 ItalyVienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 ItalyVienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 Italy

Mycoparasitic species of Trichoderma are commercially applied as biological control agents against various fungal pathogens. The mycoparasitic interaction is host specific and includes recognition, attack and subsequent penetration and killing of the host. Investigations on the underlying events revealed that Trichoderma responds to multiple signals from the host (e.g. lectins or other ligands such as low molecular weight components released from the host’s cell wall) and host attack is accompanied by morphological changes and the secretion of hydrolytic enzymes and antibiotics. Degradation of the cell wall of the host fungus is-besides glucanases and proteases-mainly achieved by chitinases. In vivo studies showed that the ech42 gene (encoding endochitinase 42) is expressed before physical contact of Trichoderma with its host, probably representing one of the earliest events in mycoparasitism, whereas Nag1 (N-acetylglucosaminidase) plays a key role in the general induction of the chitinolytic enzyme system of T. atroviride . Investigations on the responsible signal transduction pathways of T. atroviride led to the isolation of several genes encoding key components of the cAMP and MAP kinase signaling pathways, as alpha and β subunits of heterotrimeric G proteins, the regulatory subunit of cAMP-dependent protein kinase, adenylate cyclase, and three MAP kinases. Analysis of knockout mutants, generated by Agrobacterium-mediated transformation, revealed that at least two alpha-subunits of heterotrimeric G proteins are participating in mycoparasitism-related signal transduction. The Tga1 G alpha subunit was shown to be involved in mycoparasitism-related processes such as chitinase expression and overproduction of toxic secondary metabolites, whereas Tga3 was found to be completely avirulent showing defects in chitinase formation and host recognition.

关键词：真菌寄生现象 G蛋白信号识别宿主几丁质酶表达真菌

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G protein signalling involved in host recognition and mycoparasitism-related chitinase expression in Trichoderma atroviride

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浙江大学学报(农业与生命科学版) 2004年第4期 98-98页

作者： Susanne Zeilinger,Barbara Reithner,Kurt Brunner,Valeria Scala,Isabel Peiβl,Matteo Lorito,Robert L Mach Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy Vienna University of Technology Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Naples Dep. ar.bo.pa.ve. Plamt pathology Via Università 100 Portici 80055 Italy

Mycoparasitic species of Trichoderma are commercially applied as biological control agents against various fungal pathogens. The mycoparasitic interaction is host specific and includes recognition, attack and subsequent penetration and killing of the host. Investigations on the underlying events revealed that Trichoderma responds to multiple signals from the host (e.g. lectins or other ligands such as low molecular weight components released from the host's cell wall) and host attack is accompanied by morphological changes and the secretion of hydrolytic enzymes and antibiotics. Degradation of the cell wall of the host fungus is-besides glucanases and proteases-mainly achieved by chitinases. In vivo studies showed that the ech42 gene (encoding endochitinase 42) is expressed before physical contact of Trichoderma with its host, probably representing one of the earliest events in mycoparasitism, whereas Nag1 (N-acetylglucosaminidase) plays a key role in the general induction of the chitinolytic enzyme system of T. atroviride . Investigations on the responsible signal transduction pathways of T. atroviride led to the isolation of several genes encoding key components of the cAMP and MAP kinase signaling pathways, as alpha and β subunits of heterotrimeric G proteins, the regulatory subunit of cAMP-dependent protein kinase, adenylate cyclase, and three MAP kinases. Analysis of knockout mutants, generated by Agrobacterium-mediated transformation, revealed that at least two alpha-subunits of heterotrimeric G proteins are participating in mycoparasitism-related signal transduction. The Tga1 G alpha subunit was shown to be involved in mycoparasitism-related processes such as chitinase expression and overproduction of toxic secondary metabolites, whereas Tga3 was found to be completely avirulent showing defects in chitinase formation and host recognition.

关键词： Trichoderma G proteins . signal transduction . biocontrol . host recognition.

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Identification and characterization of chondrogenic progenitor cells in the fascia of postnatal skeletal muscle

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分子细胞生物学报:英文版 2011年第6期3卷 369-377页

作者： Guangheng Li bo Zheng Laura B.Meszaros Joseph B.vella arvydas Usas Tomoyuki Matsumoto Johnny Huard Stem Cell Research Center Department of Orthopaedic SurgeryUniversity of Pittsburgh450 Technology Drive Suite 206PittsburghPA 15219USA Pediatric Cancer Biological Program Department of PediatricsOregon Health and Science UniversityPortlandOR 97239USA department of Bioengineering University of PittsburghPittsburghPA 15219USA department of Molecular Genetics and Biochemistry University of PittsburghPittsburghPA 15219USA

Intramuscular injection of bone morphogenetic proteins(BMPs)has been shown to induce ectopic bone formation.A chondrogenic phase is typically observed in this process,which suggests that there may exist a chondrogenic subpopulation of cells residing in skeletal *** prospective cell populations were isolated from rat skeletal muscle:fascia-derived cells(FDCs),extracted from gluteus maximus muscle fascia(epimysium)and muscle-derived cells(MDCs)isolated from the muscle *** populations were investigated for their cell surface marker profiles(flowcytometry analysis),proliferation rates as well as their myogenic and chondrogenic *** majority of FDCs expressed mesenchymal stromal cell markers but not endothelial cell *** underwent chondrogenic differentiation after BMP4 treatment in vitro,but not myogenic *** MDCs showed chondrogenic potential,they expressed the myogenic cell marker desmin and readily underwent myogenic differentiation in vitro;however,the chondrogenic potential of the MDCs is confounded by the presence of FDC-like cells residing in the muscle perimysium and *** clarify the role of the muscle-derived myogenic cells in chondrogenesis,mixed pellets with varying ratios of FDCs and L6 myoblasts were formed and studied for chondrogenic *** results indicated that the chondrogenic potential of the mixed pellets decreased with the increased ratio of myogenic cells to FDCs supporting the role of FDCs in chondro*** together,our results suggest that non-myogenic cells residing in the fascia of skeletal muscle have a strong chondrogenic potential and may represent a novel donor cell source for cartilage regeneration and repair.

关键词： skeletal muscle fascia chondrocytes cartilage

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Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions

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Bioactive Materials 2022年第8期7卷 61-75页

作者： bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan Sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan Mary&Dick Holland Regenerative Medicine Program and Division of Cardiology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNEUSA department of Pharmacology and Experimental Neuroscience University of Nebraska Medical CenterOmahaNEUSA department of Genetics Cell Biology&AnatomyCollege of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA department of Pharmacology&Experimental Neuroscience College of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA department of Biomedical Engineering Huck Institutes of the Life SciencesSartorius Mammalian Cell Culture FacilityPennsylvania State UniversityUniversity ParkPAUSA department of Surgery College of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNEUSA

Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health ***,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural *** this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related *** results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without *** dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUveC migration and *** to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem ***,microRNA(miRNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA *** more miRNAs were identified in dExo than in *** upregulated miRNAs,like miRNA-132-3p and miRNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and *** dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration.

关键词： Anti-oxidation Anti-inflammatory Axon growth Neural regeneration microRNA

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GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive patients with Schizophrenia

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Neuroscience Bulletin 2020年第2期36卷 97-109页

作者： Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li Mental Health Center and Psychiatric Laboratory State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA Analytic and Translational Genetics Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Broad Institute of MIT and Harvard CambridgeMA 02141USA

The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with *** used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched *** real-time PCR was used to assess the differential levels of GABA-related transcripts in brain ***,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of *** correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout ***,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic *** psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in *** study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia.

关键词： ErbB4 Schizophrenia MRI Gene pathway Mouse

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Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma

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Hepatobiliary & pancreatic Diseases International 2020年第3期19卷 244-251页

作者： Gil Chun Park Sung Gyu Lee Young In Yoon Kyu bo Sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(Pve)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with Pve *** present study aimed to clarify whether preoperative sequential TACE and Pve before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall ***:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November *** were divided into four groups according to the procedure performed before the surgery:sequential TACE and Pve(TACE-Pve),Pve-only,TACE-only,or na?ve control *** baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were ***:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and Pve were well *** TACE-Pve group had a higher mean increase in percentage FLR volume compared with that of the Pve-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-Pve group had significantly better overall and disease-free survival rates compared with the other groups(both Pve prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic *** active application of preoperative sequential TACE and Pve for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression.

关键词： Sequential selective transcatheter arterial chemoembolization Portal vein embolization Hepatocellular carcinoma Future liver remnant

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Early enteral and parenteral nutritional support in patients with cirrhotic portal hypertension after pericardial devascularization

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Hepatobiliary & pancreatic Diseases International 2005年第1期4卷 55-59页

作者： Ke Zhang, Weng-Bing Sun, Hui-Feng Wang, Zhi-Wei Li, Xiao-Dong Zhang, Hong-bo Wang and Xu Ji Beijing, China department of Hepatobiliary Surgery, The 302nd Hospital of PLA, Beijing 100039, China department of Hepatobiliary Surgery The 302nd Hospital of PLA Beijing 100039 China. zhangke@***

BACKGROUND: The abnormal metabolism caused by cir- rhosis always results in a complex problem about nutritional support, which will be more intricate while patients with portal hypertension are treated with pericardial devasculari- zation. Comparing the effects of early enteral and parente- ral nutritional support in patients with cirrhotic portal hy- pertension after pericardial devascularization, we try to rea lize the advantages and disadvantages of the two nutritional therapies and to guide our clinical practice. METHODS: After pericardial devascularization,40 patients with cirrhotic portal hypertension were divided randomly into 2 groups; enteral and parenteral nutritional support, respectively. The general nutritional condition, capability of producing protein, liver function, blood velocity of the portal vein, gut function, bowel bacterial translocation, mortality, complication rate, stay in ICU, duration of hos- pitalization and costs of treatment were determined in all the patients and compared between the 2 groups. RESULTS; both enteral and parenteral nutritional supports could improve the general nutrition condition of the pa- tients; but patients receiving enteral nutritional support had fewer complications. Enteral nutrition was more ef- fective than parenteral nutrition in increasing the blood ve- locity of the portal vein, stimulating gut motion, preven- ting bowel bacterial translocation, shortening the stay in ICU and the duration of hospitalization, and saving costs of treatment. CONCLUSION: After pericardial devascularization, pa- tients with cirrhotic portal hypertension should be treated with enteral nutritional support as early as possible.

关键词： hypertension, portal liver cirrhosis

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