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giant cavernous liver hemangiomas： is it the time to change the size categories？

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 21-29页

作者： isidoro di carlo renol koshy saif al mudares annalisa ardiri gaetano bertino adriana toro departments of general surgery hamad general hospitalDohaQatar department of surgical sciences and advanced technologies"g.f.ingrassia" university of cataniaCataniaItaly hepatology unit department of medical and pediatric scienceuniversity of cataniaCataniaItaly department of surgery patti hospitalMessinaItaly

BACKgROUND： four different sizes （4, 5, 8 and 10 cm in diameter） can be found in the literature to categorize a liver hemangioma as giant. The present review aims to clarify the appropriateness of the size category ＂giant＂ for liver heman- gioma. DATA SOURCES： We reviewed the reports on the categoriza- tion of hemangioma published between 1970 and 2014. The number of hemangiomas, size criteria, mean and range of hemangioma sizes, and number of asymptomatic and symp- tomatic patients were investigated in patients aged over 18 years. Liver hemangiomas were divided into four groups：〈5.0 cm, 5.0-9.9 cm, 10.0-14.9 cm and 〉15.0 cm in diameter. Inclu- sion criteria were noted in 34 articles involving 1972 （43.0%） hemangiomas （〉4.0 cm）. RESULTS： The patients were divided into the following groups： 154 patients （30.0%） with hemangiomas less than 5.0 cm in diameter （small）, 182 （35.5%） between 5.0 cm and 9.9 cm （large）, 75 （14.6%） between 10.0 and 14.9 cm （giant）, and 102 （19.9%） more than 15.0 cm （enormous）. There were 786 （39.9%） asymptomatic patients and 791 （40.1%） symptomatic patients. Indications for surgery related to symptoms were reported in only 75 （3.8%） patients. Operations including 137 non-anatomical resection （12.9%） and 469 enudeation （44.1%） were undearly related to size and ***： The term ＂giant＂ seems to be justified for liver hemangiomas with a diameter of 10 cm. Hemangiomas categorized as ＂giant＂ are not indicated for surgery. Surgery should be performed only when other symptoms are apparent.

关键词： giant hemangioma cavernous hemangioma liver hemangioma

Repetitive transcranial magnetic stimulation for post-traumatic stress disorder:Lights and shadows

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World Journal of Clinical Cases 2022年第17期10卷 5929-5933页

作者： Carmen Concerto giuseppe Lanza francesco fisicaro Manuela Pennisi Alessandro Rodolico giulia Torrisi Rita Bella Eugenio Aguglia department of Clinical and Experimental Medicine Psychiatry UnitUniversity of CataniaCatania 95124Italy department of Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Clinical Neurophysiology Research Unit Oasi Research Institute-IRCCSTroina 94018Italy department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy department of Medical and Surgical Sciences and Advanced Technologies“g.f.ingrassia” University of CataniaCatania 95123Italy

We have read with interest the publication that describes the available data related to the use of neuromodulation strategies for the treatment of posttraumatic stress disorder(PTSD).Despite treatment advances,however,a substantial proportion of PTSD patients receiving psychological and/or pharmacological treatment do not reach an adequate clinical *** their paper,the authors draw attention to the current understanding of the use of repetitive transcranial magnetic stimulation(rTMS)as a potential treatment for *** of the previous studies indeed applied both inhibitory(1 Hz)and excitatory(>1 Hz,up to 20 Hz)rTMS to the right and/or left dorsolateral prefrontal *** larger therapeutic effects observed when high-frequency stimulation was applied,the question of which side and frequency of stimulation is the most successful is still *** authors also reported on the after-effect of rTMS related to neuroplasticity and identified the intermittent theta burst stimulation as a technique of particular interest because of it showed the most effective improvement on PTSD ***,although numerous studies have highlighted the possible beneficial use of rTMS protocols for PTSD,the exact mechanism of action remains *** their conclusions,the authors stated that rTMS has been demonstrated to be effective for the treatment of PTSD ***,we believe that further research with homogeneous samples,standardized protocols,and objective outcome measures is needed to identify specific therapeutic targets and to better define significant changes when active and sham stimulation procedures are compared.

关键词： Post-traumatic stress disorder Neuromodulation Repetitive transcranial magnetic stimulation Translational neuroscience Neuroplasticity Metaplasticity

Utility of fluorescent cholangiography during laparoscopic cholecystectomy: A systematic review

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World Journal of gastroenterology 2015年第25期21卷 7877-7883页

作者： Antonio Pesce gaetano Piccolo gaetano La greca Stefano Puleo department of Medical and Surgical Sciences and Advanced Technologies "g.f. ingrassia" University of Catania department of Surgery University of Catania

AIM: To verify the utility of fluorescent cholangiography for more rigorous identification of the extrahepatic biliary ***: MEDLINE and Pub Med searches were performed using the key words "fluorescent cholangiography", "fluorescent angiography", "intraoperative fluorescent imaging", and "laparoscopic cholecystectomy" in order to identify relevant articles published in English, french, german, and Italian during the years of 2009 to 2014. Reference lists from the articles were reviewed to identify additional pertinent articles. for studies published in languages other than those mentioned above, all available information was collected from their English abstracts. Retrieved manuscripts(case reports, reviews, and abstracts) concerning the application of fluorescent cholangiography were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. In contrast to classic meta-analyses, statistical analysis was performed where the outcome was calculated as the percentages of an event(without comparison) in pseudo-cohorts of observed ***: A total of 16 studies were found that involved fluorescent cholangiography during standard laparoscopic cholecystectomies(n = 11), singleincision robotic cholecystectomies(n = 3), multiport robotic cholecystectomy(n = 1), and single-incision laparoscopic cholecystectomy(n = 1). Overall, these preliminary studies indicated that this novel technique was highly sensitive for the detection of important biliary anatomy and could facilitate the prevention of bile duct injuries. The structures effectively identified before dissection of Calot's triangle included the cystic duct(CD), the common hepatic duct(CHD), the common bile duct(CBD), and the CD-CHD junction. A review of the literature revealed that the frequenciesof detection of the extrahepatic biliary system ranged from 71.4% to 100% for the CD, 33.3% to 100% for the CHD, 50%

关键词： Extrahepatic biliary system Laparoscopiccholecystectomy Bile duct injury Biliary anomalies fluorescent cholangiography

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song Raymond g.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience graduate group University of PennsylvaniaPhiladelphiaPAUSA department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Worldwide epidemiology of liver hydatidosis including the Mediterranean area

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World Journal of gastroenterology 2012年第13期18卷 1425-1437页

作者： giuseppe grosso Salvatore gruttadauria Antonio Biondi Stefano Marventano Antonio Mistretta department"g.f.ingrassia"Section of Hygiene and Public Health University of Catania95123 CataniaItaly Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione-University of Pittsburgh Medical Center in Italy 90127 PalermoItaly Section of general Surgery and Oncology Department of General SurgeryUniversity of Catania95123 CataniaItaly

The worldwide incidence and prevalence of cystic echinococcosis have fallen dramatically over the past several ***,infection with Echinococcus granulosus(***)remains a major public health issue in several countries and regions,even in places where it was previously at low levels,as a result of a reduction of control programmes due to economic problems and lack of *** distribution differs by country and region depending on the presence in that country of large numbers of nomadic or semi-nomadic sheep and goat flocks that represent the intermediate host of the parasite,and their close contact with the final host,the dog,which mostly provides the transmission of infection to *** greatest prevalence of cystic echinococcosis in human and animal hosts is found in countries of the temperate zones,including several parts of Eurasia(the Mediterranean regions,southern and central parts of Russia,central Asia,China),Australia,some parts of America(especially South America)and north and east *** is currently considered an endemic zoonotic disease in the Mediterranean *** most frequent strain associated with human cystic echinococcosis appears to be the common sheep strain(g1).This strain appears to be widely distributed in all *** purpose of this review is to examine the distribution of *** and the epidemiology of a re-emerging disease such as cystic echinococcosis.

关键词： Epidemiology, Echinococcus granu/osus Cystic echinococcosis

Course of Atypical Manifestations of a Case of Charcot-Marie-Tooth Disease over 35 Years of Clinical Observation

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Neuroscience & Medicine 2013年第3期4卷 145-149页

作者： giuseppe Lanza Luisa Vinciguerra Valentina Puglisi Daniela Modica Alfio Catalano giuseppe Zelante Riccardo Ricceri Lorenzo Lupo Salvatore giuffrida Manuela Pennisi department “g. f. ingrassia” MED 01 University of Catania Catania Italy department “g. f. ingrassia” Section of Neurosciences University of Catania Catania Italy department of Chemistry University of Catania Catania Italy.

Introduction: Atypical manifestations of peripheral neuropathy are not rare, challenging the differential diagnosis. In the past, the diagnosis of hereditary neuropathy was mainly based on the clinical and electromyographic (EMg) findings and, occasionally, biopsy. Nowadays, the genetic tests allow us to identify more than 40 different genes/loci associated with Charcot-Marie-Tooth (CMT) disease, although some subtypes are clinically indistinguishable. We have followed a patient with a clinical diagnosis of apparent sporadic and atypical CMT and recently diagnosed genetically as distal hereditary motor neuropathy, type V (dHMN-V). Case Report: Thirty-five years ago, a 16 years old patient complained muscular weakness and wasting at the hands small muscles. Sporadic fasciculations were observed whereas deep tendon reflexes and sensation were normal. EMg examination revealed neurogenic muscular denervation in the distribution of C7, C8 and T1 segments bilaterally. Muscular biopsy of the left Biceps Brachii showed rare atrophic fibers and some cellular atypia. The disease has undergone a clinical and EMg progression and diffusion over the years, involving the lower limbs and leading to a bilateral steppage. A more slight diffuse axonal motor neuropathy was also identified in the proband’s son and second cousin. The genetic study found a known missense mutation in BSCL2 gene related to a dHMN-V. Interestingly, there was a remarkable intra-familiar phenotypic variability, especially in the clinical onset and severity. Discussion: Atypical manifestations of hereditary neuropathies often overlap with other conditions. The present case highlights how a comprehensive clinical evaluation and a careful follow-up have led to a correct diagnosis even 35 years later and have allowed to identify other affected family members. The apparent lack of familiarity was probably due to the very soft presentation in the proband’s relatives. Although the genetic study was not available at t

关键词： Hereditary Neuropathies Clinical Overlap genetic Analysis Phenotypic Variability

Modeling and Comprehensive Review of Signaling Storms in 3gPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 123-153页

作者： Muhammad Qasim Khan fazal Malik fahad Alturise Noor Rahman department of Computer Science Iqra National UniversityPeshawar25000Pakistan department of Cybersecurity College of ComputerQassim UniversityBuraydah52555Saudi Arabia department of Computer Science and Engineering Al-Fayha CollegeAl Jubayl31961Saudi Arabia

Control signaling is mandatory for the operation and management of all types of communication networks,including the Third generation Partnership Project(3gPP)mobile broadband ***,they consume important and scarce network resources such as bandwidth and processing *** have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial *** paper draws its motivation from such real network disaster incidents attributed to signaling *** this paper,we present a thorough survey of the causes,of the signaling storm problems in 3gPP-based mobile broadband networks and discuss in detail their possible solutions and *** provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding *** important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a *** paper presents an update and an extension of our earlier conference *** our knowledge,no similar survey study exists on the subject.

关键词： Signaling storm problems control signaling load analytical modeling 3gPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5g mobile communication

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar Pradhan Rainer Rupprecht gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Evaluation of the Effectiveness of a 4-Months Continuous Injection of a gas Mixture (CO<sub>2</sub>and Inert gases) on <i>Legionella</i>Contamination of a Hot Water Distribution System

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Health 2015年第7期7卷 819-823页

作者： Maria Anna Coniglio Legionella Reference Laboratory Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” University of Catania Catania Italy

Within the biofilm and scales Legionella is less far susceptible to the effects of the most frequently used biocides. The objective of this study was to evaluate the effect of a 4-months continuous injection of a gas mixture (CO2 and inert gas) in the hot water distribution system of a large hotel colonized by L. pneumophila sg3 on limiting biofilm formation and scales and in turn Legionella growth. Before the continuous injection of the gas mixture, out of the 15 sampling points examined every month 60% were colonized by Legionella (mean concentrations of 102 cfu/L in the boilers and the return loop, and 104 cfu/L in taps and showers). One week after the injection of the gas mixture and daily fluxing of the distal outlets, the level of colonization decreased (3 cfu/L). When it was decided to flux all the distal outlets only 1 day per week the mean concentration of Legionella increased again (>104 cfu/L) in all the sampling points. Thus, cleaning of the boilers was performed and distal outlets were again fluxed daily. One week after the level of contamination decreased again (2 cfu/L). Nonetheless, the colonization was not eliminated and when fluxing of the distal outlets was not performed every day the mean concentrations of Legionella raised up to >104 cfu/L. Results indicate that the gas mixture was able to reduce the level of colonization by Legionella only because associated to the fluxing of the distal outlets.

关键词： Legionella gas Mixture fluxing Water Distribution Systems