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World Journal of gastroenterology 2023年第1期29卷 144-156页

作者： Ming Luo Rui-Juan Xin Fang-Rui Hu Li Yao sheng-Juan Hu Fei-Hu Bai department of gastroenterology People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750021Ningxia Hui Autonomous RegionChina

Minimal hepatic encephalopathy(MHE) is a frequent neurological and psychiatric complication of liver cirrhosis. The precise pathogenesis of MHE is complicated and has yet to be fully elucidated. studies in cirrhotic patients and experimental animals with MHE have indicated that gut microbiota dysbiosis induces systemic inflammation, hyperammonemia, and endotoxemia, subsequently leading to neuroinflammation in the brain via the gut-liver-brain axis. Related mechanisms initiated by gut microbiota dysbiosis have significant roles in MHE pathogenesis. The currently available therapeutic strategies for MHE in clinical practice, including lactulose, rifaximin, probiotics, synbiotics, and fecal microbiota transplantation, exert their effects mainly by modulating gut microbiota dysbiosis. Microbiome therapies for MHE have shown promised efficacy and safety;however, several controversies and challenges regarding their clinical use deserve to be intensively discussed. We have summarized the latest research findings concerning the roles of gut microbiota dysbiosis in the pathogenesis of MHE via the gut-liver-brain axis as well as the potential mechanisms by which microbiome therapies regulate gut microbiota dysbiosis in MHE patients.

关键词： Gut microbiota Minimal hepatic encephalopathy Gut-liver-brain axis Pathogenesis Therapeutics

Novel computerized psychometric tests as primary screening tools for the diagnosis of minimal hepatic encephalopathy

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World Journal of Clinical Cases 2020年第16期8卷 3377-3389页

作者： Ming Luo Rui Mu Jian-Fang Liu Fei-Hu Bai department of gastroenterology People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750021Ningxia Hui Autonomous RegionChina

Minimal hepatic encephalopathy(MHE)is a critical neurocognitive complication of decompensated liver cirrhosis and portosystemic shunting,which results in a wide range of cognitive deficits including impairments in working attention,psychomotor speed,and executive *** guidelines have recommended paper-and-pencil psychometric tests for the diagnosis of *** high-risk cirrhotic patients are required to be examined;however,paperand-pencil psychometric tests are neither convenient nor rapid to perform in the ***,novel computerized psychometric tests,including the inhibitory control test,EncephalApp stroop App,and critical flicker frequency,have been proven to be rapid,effective,and convenient methods for screening MHE in clinical practice and for identifying high-risk cirrhotic patients for further validation using rigid neuropsychometric ***,diagnostic accuracy of these tests is influenced by educational background,age,and cultural *** review summarizes clinical evidence of the application of novel computerized psychometric tests for screening MHE.

关键词： Minimal hepatic encephalopathy Diagnosis Psychometric test Inhibitory control test EncephalApp stroop App Critical flicker frequency

Prevalence of malnutrition among adult inpatients in China:a nationwide cross-sectional study

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science China Life sciences 2025年

作者： Yan Liu Chunhua song Xue Wang Xianghua Ma Pianhong Zhang Gaiyun Chen Zhenqian Cheng Juying Liu Ying Yao Wenjun Ma Zengning Li Ping sun Fan Lin Weilian Hou Ting Han Ying Zhang Min Weng Wanying shi Dagang Yang Ji Feng Junqiang Chen Li Li Hua Jiang Hongxia Xu Ruifang Guo Ying Liu Xiaopan Chen Qian Zhao Yumei Qi Qiang Chi Rong Liu Rui Xiong Tiantian Wu shangfeng Tang shuyan Guo Wei Chen department of Clinical Nutrition The First Hospital of Hebei Medical University department of Clinical Nutrition The First Affiliated Hospital of Shanxi Medical University department of Clinical Nutrition Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial Hospital department of Clinical Nutrition The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China department of Clinical Nutrition Shanghai Tenth People’s HospitalTongji University School of Medicine department of Clinical Nutrition Shaanxi Provincial People’s Hospital department of Clinical Nutrition The First Affiliated Hospital of Kunming Medical University department of Clinical Nutrition The First Affiliated Hospital of China Medical University The Affiliated hospital of Guizhou Medical University The second Affiliated hospital of Nanchang University department of Clinical Nutrition Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College The First Affiliated hospital of Guangxi Medical University department of Clinical Nutrition The First Affiliated Hospital of Xinjiang Medical University Institute for Emergency and Disaster Medicine Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China department of Clinical Nutrition Daping HospitalArmy Medical University (Third Military Medical University) Inner Mongolia people’s hospital Jilin people’s hospital (Jilin) The First Affiliated hospital of Hainan Medical University department of Clinical Nutrition Ningxia Hui Autonomous Region People’s Hospital department of Clinical Nutrition Tianjin Third Central Hospital The second Affiliated hospital of Harbin Medical University department of Epidemiology and statistics College of Public HealthZhengzhou University The First hospital of Lanzhou University Qinghai Provincial people’s hospital school of Medicine and Health Management Tongji Medical CollegeHuazhong Uni

Malnutrition substantially contributes to adverse clinical ***,no national survey has been conducted to characterize its epidemiology in hospital settings in *** conducted the China Nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces,autonomous regions and municipalities(except for Hong Kong,Macao,Taiwan Province,and the Xizang autonomous region,please see MATERIALs AND METHODs for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk *** collected information on participants' sociodemographic characteristics,physical examinations,and laboratory test *** was defined according to the Global Leadership Initiative on Malnutrition(GLIM) *** standardized prevalence of malnutrition was calculated,and factors associated with malnutrition were examined using logistic regression *** included 54,652 individuals with seven systemic diseases who completed all the survey documents in the final *** overall prevalence of malnutrition was 12.5%,representing 7.6 million adult inpatients in *** prevalence of malnutrition was higher in men,individuals aged≥60 years,residents of central and western regions,people from lower economic areas,and those with lower education levels than in women,individuals ageds,residents of eastern regions,individuals from higher economic areas,and those with higher education *** with higher disease severity scores,infectious diseases,and neoplasms had a higher tendency for malnutrition than those without such ***,age,region,economic level,education level,disease severity score,infectious diseases,and neoplasms were independently associated with *** conclusion,malnutrition is prevalent among Chinese adult inpatients,necessitating national-and hospital-level *** surv

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Identification of a novel p.R1443W mutation in RP1 gene associated with retinitis pigmentosa sine pigmento

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 430-435页

作者： Li Ma Xun-Lun sheng hui-Ping Li Fang-Xia Zhang Ya-Ni Liu Wei-Ning Rong Jian-Ling Zhang ningxia Eye hospital people's hospital of ningxia hui autonomous region

AIM:To screen mutations in the retinitis pigmentosa 1(RP1) gene and the rhodopsin(RHO) gene in Chinese patients with retinitis pigmentosa sine pigmento(RPsP)and describe the genotype-phenotype relationship of the mutations.·METHODs:Twenty affected,unrelated Chinese individuals with RPsP(4 autosomal dominant RPsP,12autosomal recessive RPsP and 4 unknown inheritance pattern) were recruited between 2009 and *** clinical features were determined by complete ophthalmologic *** chain reaction(PCR) and direct DNA sequencing were used to screen the entire coding region and splice junctions of the RP1gene and the RHO *** cosegregation analysis and population frequency studies were performed for patients with identified mutations.·REsULTs:Five variants in the RP1 gene and one in the RHO gene were detected in 20 *** missense changes(rs444772,rs446227,rs414352,rs441800) and one non-coding variant(rs56340615) were common sNPs and none of them showed a significant relationship with RPsP.A missense mutation p.R1443W was identified in the RP1 gene in three affected individuals from a family with autosomal dominant RPsP and was found to cosegregate with the phenotype in this family,suggestive of *** addition,population frequency analysis showed the p.R1443W mutation was absent in 300 healthy controls.·CONCLUsION:The identification of p.R1443W mutationcosegregating in a family with autosomal dominant RPsP highlights an atypical phenotype of the RP1 gene mutation,while RHO gene is not associated with the pathogenesis of RPsP in this *** our knowledge,this is the fist mutation identified to associate with RPsP.

关键词： retinitis pigmentosa sine pigmento RP1 and RHO gene gene mutation

Video-assisted bystander cardiopulmonary resuscitation improves the quality of chest compressions during simulated cardiac arrests: A systemic review and meta-analysis

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World Journal of Clinical Cases 2022年第31期10卷 11442-11453页

作者： Dong-Feng Pan Zheng-Jun Li Xin-Zhong Ji Li-Ting Yang Pei-Feng Liang department of Emergency Medicine The First Affiliated Hospital of Northwest Minzu UniversityPeople’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750002Ningxia Hui Autonomous RegionChina department of Emergency Medicine People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750002Ningxia Hui Autonomous RegionChina department of Emergency Medicine The Third Clinical Medical College of Ningxia Medical UniversityYinchuan 750002Ningxia Hui Autonomous RegionChina department of Medicine statistics People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750002Ningxia Hui Autonomous RegionChina

BACKGROUND It remains unclear whether video aids can improve the quality of bystander cardiopulmonary resuscitation(CPR).AIM To summarize simulation-based studies aiming at improving bystander CPR associated with the quality of chest compression and time-related quality *** The systematic review was conducted according to the PRIsMA *** relevant studies were searched through PubMed,EMBAsE,Medline and Cochrane Library *** risk of bias was evaluated using the Cochrane collaboration *** A total of 259 studies were eligible for inclusion,and 6 randomised controlled trial studies were ultimately *** results of meta-analysis indicated that video-assisted CPR(V-CPR)was significantly associated with the improved mean chest compression rate[OR=0.66(0.49-0.82),Pst compression with correct hand positioning[OR=1.63(0.71-2.55),Pst compression depth was not statistically significant[OR=0.18(-0.07-0.42),P=0.15],and V-CPR was not associated with the time to first chest compression compared to telecommunicator CPR[OR=-0.12(-0.88-0.63),P=0.75].CONCLUsION Video real-time guidance by the dispatcher can improve the quality of bystander CPR to a certain ***,the quality is still not ideal,and there is a lack of guidance caused by poor video signal or inadequate interaction.

关键词： Dispatcher-assisted cardiopulmonary resuscitation Video Quality of chest compressions simulated cardiac arrests

Outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of the Toric implantable collamer lens for high myopic astigmatism

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 459-465页

作者： Xun-Lun sheng, De-Jun Zhu department of Ophthalmology People's Hospital of Ningxia Hui Autonomous Region Yinchuan 750001 Ningxia Hui Autonomous Region China department of Ophthalmology the Affiliated Hospital of Ningxia Medical University Yinchuan 750004 Ningxia Hui Autonomous Region China

AIM: To assess the visual outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of Toric implantable collamer lens (TICL) for the correction of high myopic astigmatism. METHODs: In this prospective, nonrandomized clinical study, 54 consecutive eyes of 29 patients with high myopic astigmatism received TICL implantation. To evaluate postoperative axis deviation from the intended axis, a digital anterior segment photograph was taken. The ultrasound biomicroscopy(UBM) was used to observe footplate-position. REsULTs: After mean follow-up of 8.6 months, mean manifest refractive cylinder (MRC) decreased 79.3% from (-1.88 +/- 1.49)D preoperatively to (0.39 +/- 0.61)D postoperatively. MRC within 1.00D occurred in 68.5% (37/54) of eyes, whereas 48.1% (26/54) had MRC within 0.50D. Mean manifest refraction spherical equivalent (MRsE) changed from (-1208 +/- 422)D preoperatively to (-0.41 +/- 0.61)D postoperatively. Uncorrected binocular vision of 20/20 or better occurred in 72.2% (39/54) of patients compared with binocular best-corrected visual acuity (BCVA) of 20/20 or better in 44.4% (24/54) preoperatively. The mean difference between intended and achieved TICL axes was (6.96 +/- 8.37)degrees. Footplates of TICLs were in the ciliary sulcus in 22 eyes (46.3%), below the ciliary sulcus in 32 eyes (53.7%). The angle of TICL rotation had significant correlation with the footplates-position (t = 2.127; P=0.045) and the postoperative TICL vaulting (r=-0.516; P=0.000). CONCLUsION: The results of our study further support the safety, efficacy and predictability of TICL for the correct high myopic astigmatism. The footplate-position of TICL and vault value should be taken into consideration as two possible risks factors for TICL rotation.

关键词： astigmatism myopia Toric

Development of a machine learning-based model for predicting risk of early postoperative recurrence of hepatocellular carcinoma

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World Journal of gastroenterology 2023年第43期29卷 5804-5817页

作者： Yu-Bo Zhang Gang Yang Yang Bu Peng Lei Wei Zhang Dan-Yang Zhang department of Hepatobiliary surgery General Hospital of Ningxia Medical UniversityYinchuan 750003Ningxia Hui Autonomous RegionChina department of Hepatobiliary surgery People's Hospital of Ningxia Hui Autonomous RegionYinchuan 750003Ningxia Hui Autonomous RegionChina

BACKGROUND surgical resection is the primary treatment for hepatocellular carcinoma(HCC).However,studies indicate that nearly 70%of patients experience HCC recurrence within five years following *** earlier the recurrence,the worse the *** studies on postoperative recurrence primarily rely on postoperative pathology and patient clinical data,which are ***,developing a new pre-operative prediction model for postoperative recurrence is crucial for guiding individualized treatment of HCC patients and enhancing their *** To identify key variables in pre-operative clinical and imaging data using machine learning algorithms to construct multiple risk prediction models for early postoperative recurrence of *** The demographic and clinical data of 371 HCC patients were collected for this retrospective *** data were randomly divided into training and test sets at a ratio of 8:*** training set was analyzed,and key feature variables with predictive value for early HCC recurrence were selected to construct six different machine learning prediction *** model was evaluated,and the bestperforming model was selected for interpreting the importance of each ***,an online calculator based on the model was generated for daily clinical *** Following machine learning analysis,eight key feature variables(age,intratumoral arteries,alpha-fetoprotein,preoperative blood glucose,number of tumors,glucose-to-lymphocyte ratio,liver cirrhosis,and pre-operative platelets)were selected to construct six different prediction *** XGBoost model outperformed other models,with the area under the receiver operating characteristic curve in the training,validation,and test datasets being 0.993(95%confidence interval:0.982-1.000),0.734(0.601-0.867),and 0.706(0.585-0.827),*** curve and decision curve analysis indicated that the XGBoost model also had good predictive performance and clin

关键词： Machine learning Hepatocellular carcinoma Early recurrence Risk prediction models Imaging features Clinical features

Deep sylvian fissure meningiomas:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7438-7444页

作者： Anni Wang Xu Zhang Kun-Kun sun Can Li Zi-Mu song Tao sun Feng Wang department of Neurosurgery General Hospital of Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina department of Pathology Peking University People's HospitalBeijing 100000China department of Neurosurgery People's Hospital of Ningxia Hui Autonomous RegionYinchuan 750001Ningxia Hui Autonomous RegionChina

BACKGROUND Deep sylvian meningiomas are rare and difficult to diagnose when small tumours lead to various *** difficulty associated with surgery is *** case involved a mass(11 mm×12 mm×12 mm in size)in the right sylvian *** is the smallest deep sylvian meningioma known and might be more easily misdiagnosed than previous *** sUMMARY A well-enhanced mass in the right sylvian fissure of a 26-year-old male with a three-month history of seizure was identified via magnetic resonance *** patient underwent operations twice for seizure *** the first operation,the tumour was surrounded by the second segment of the middle cerebral artery and its numerous *** resection had to be selected due to mild arterial *** the first operation,the patient presented with simple partial *** reoperation,we isolated the anatomical structure near the tumour and the tumour over and removed it from its dorsal side by piecemeal *** This case reported the smallest deep sylvian meningioma according to a literature *** diagnosis is a crucial step due to deep sylvian meningioma firmly adhering to the middle cerebral artery and its *** preparation is crucial to ensure the success of surgery.

关键词： Meningioma Deep sylvian fissure Atypical Neurosurgery Imaging characteristics Case report

Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3

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World Journal of Diabetes 2025年第4期16卷 205-219页

作者： Guang-Yong Li shuai Ren Bin-Cheng Huang Jia-Jin Feng Qiang-Qiang Wang Qing-Jie Peng Hai-Fu Tian Le-Yi Yu Cun-Ling Ma shu-Zhe Fan Xiao-Jiang Chen Mohammed Abdulkarem Al-Qaisi Rui He department of Urology General Hospital of Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina Peking University First hospital ningxia Women's and Children's hospital Yinchuan 750000Ningxia Hui Autonomous RegionChina Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetes mellitus(DM)is linked to an earlier onset and heightened severity of urinary complications,particularly bladder dysfunction,which profoundly impacts patient quality of *** bladder(OAB)is a common storage disorder of the lower urinary tract and is characterized by urgency,frequency,and *** factors contribute to bladder dysfunction in diabetic individuals,including changes in urothelial signaling,detrusor morphology,and central nervous system *** transient receptor potential vanilloid type 1 channel,expressed by bladder urothelial cells,is upregulated in OAB and plays a crucial role in ATP release during bladder *** ATP release subsequently activates purinergic receptor P2X3,further exacerbating OAB *** To clarify the mechanism of Roux-en-Y gastric bypass(RYGB)metabolic surgery to improve OAB in type 2 DM(T2DM).METHODs The model of T2DM was induced by feeding a high-fat diet to mice for 16 *** 16 weeks,sham operation and RYGB operation were *** related indexes of glucose metabolism were also detected to evaluate the therapeutic effect,and the recovery degree of bladder function and micturition behavior of mice was assessed by urodynamics and micturition spot *** Compared with the normal mice in the sham group,T2DM mice had increased urine spot count,uncontrolled urination behavior,shortened urination interval,and reduced bladder *** and immunofluorescence costaining showed that Transient receptor potential vanilloid type 1(TRPV1)and purinergic receptor P2X3 were both expressed in mouse bladder epithelial layer,and they had the same *** the bladder of T2DM mice,the mRNA and protein expression of TRPV1 and P2X3 were significantly *** ATP content in urine of T2DM mice was significantly higher than that of the sham *** RYGB operation,the glucose metabolism index of the RYGB group was significantly improved compare

关键词： Roux-en-Y gastric bypass Diabetes Bladder Transient receptor potential vanilloid type 1 P2X3

Identification of a novel FOXL2 mutation in a fourth-generation Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 504-509页

作者： Wei-Ning Rong Mei-Jiao Ma Wei Yang shi-Qin Yuan Xun-Lun sheng department of Ophthalmology Ningxia Eye HospitalPeople’s Hospital of Ningxia Hui Autonomous Region(First Affiliated Hospital of Northwest University for Nationalities)Yinchuan 750002the Ningxia Hui Autonomous RegionChina

AIM:To characterize the genetic causes and clinical features in a four-generation Chinese family with blepharophimosisptosis-epicanthus inversus syndrome(BPEs).METHODs:Thirteen patients with BPEs and eight healthy family members were included in this *** participants received routine ophthalmic *** target next-generation sequencing(NGs)was performed to determine the causative mutation for this *** silico analysis was also applied to predict the pathogenesis of identified ***:All patients had severe ptosis,normal intelligence,female patients have normal *** assessments revealed a heterozygous insertion variation in FOXL2 gene,c.672_701 ins GCGGCTGCCGC CGCAGCTGCTG CAGGCGCT(***234_Gly235 lins AAAAAAAAGA),carried by 13 patient but absent in all unaffected *** silico analysis supported the pathogenic nature of this highly conserved *** mutation resulted in the insertion of 10 amino acids into the encoded polyala nine chain,which increased the number of original polyalanine chains from 14 to 24,resulting in an extended ***:A novel FOXL2 mutation c.672_701 ins GCGGCTGCCGCCGCAGCTGCTGC AGGCGCT(***234_Gly235 lins AAAAAAAAGA)was identified in a large Chinese family with *** study amplified the genotypic spectrum of FOXL2-BPEs and better illustrates its genotype-phenotypecorrelations,which provided a basis for elucidating the pathogenesis of BPEs and genetic counseling.

关键词： blepharophimosis-ptosis-epicanthus inversus syndrome FOXL2 mutation Chinese