检索结果-南通市图书馆

World Journal of Clinical Cases 2024年第11期12卷 1909-1917页

作者： Maja Milickovic Petar Rasic Sofija Cvejic Dejana Bozic Djordje Savic Tanja Mijovic Sava Cvetinovic Slavisa M Djuricic department of Abdominal surgery Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia department of Radiology The Children’s University HospitalBelgrade 11000Serbia department of Clinical Pathology Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of Banja LukaBanja Luka 78000Bosnia and Herzegovina

Splenic hamartomas(SHs)are uncommon,benign vascular lesions of unclear etiology and are mostly found incidentally on abdominal images,at surgery,or at *** the first case description,in 1861,less than 50 pediatric SH cases have been reported in the *** this article,we have performed an analysis of all SH cases in children published in the literature to date and presented our case of an 8-year-old male with *** lesions in children were shown to cause symptoms more often than in the adult *** observed SH sizes in children ranged from a few millimeters to 18 cm,and the symptomatic lesions were mostly larger or *** most common clinical finding was *** of hypersplenism were present in children with a single SH larger than 4.5 cm(diameter range:4.5-18.0 cm)and in those with multiple hamartomas,ranging from a few millimeters to 5 *** percent of patients with available laboratory findings had hematological abnormalities such as anemia,thrombocytopenia,or *** symptoms and signs included abdominal pain,recurrent infections,fever,night sweats,lethargy,growth retardation,and weight *** use of multiple imaging modalities may suggest the preoperative diagnosis of a splenic mass in children and determine the therapeutic ***,the final diagnosis of SH relies on histopathological ***,including total or partial splenectomy(PS),is the mainstay of SH *** M et *** in children WJCC https://*** 1910 April 16,2024 Volume 12 Issue 11 Although total splenectomy carries a greater risk of overwhelming post-splenectomy infection than PS it has remained the most performed surgical procedure in children with *** the majority of pediatric patients with symptomatic SH,resolution of symptoms and resolution or improvement of cytopenias occurred after surgical treatment.

关键词： Splenic hamartoma Pediatric Splenoma Clinical features Radiological features Histopathology Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeted therapies in cholangiocarcinoma:light at the end of the tunnel?

引用

Hepatobiliary surgery and Nutrition 2023年第4期12卷 631-633页

作者： Iakovos Amygdalos Ulf Peter Neumann Sven Arke Lang department of General Visceral and Transplantation SurgeryUniversity Hospital RWTH AachenAachenGermany

The genetic landscape of cholangiocarcinoma(CCA)remains largely *** is one of the deadliest cancers(1),with the gold standard treatment for all anatomical forms(intrahepatic-iCCA,perihilar-pCCA and distal-dCCA)being surgical resection(with adjuvant capecitabine also recommended in the newest guidelines)(2,3).The importance of genetic markers in terms of postoperative and oncological outcomes is being increasingly recognized,but few actionable mutations have been identified so far(2,4).This is particularly pertinent for patients with advanced/irresectable disease,who rely on systemic *** outcomes are poor in these patients[5-year survival up to 10%-(5)]and they would profit the most from novel,targeted therapies.

关键词： Cholangiocarcinoma(CCA) targeted therapy biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as well as Complex Blood and vascular Pathologies in Alzheimer’s Disease

引用

Neuroscience Bulletin 2024年第8期40卷 1115-1126页

作者： Hualin Fu Jilong Li Chunlei Zhang Peng Du Guo Gao Qiqi Ge Xinping Guan Daxiang Cui Institute of Nano Biomedicine and Engineering School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Shanghai Jiao Tong UniversityShanghai 200240China department of Colorectal surgery School of MedicineXinhua HospitalShanghai Jiao Tong UniversityShanghai 200092China department of Automation Shanghai Jiao Tong UniversityShanghai 200240China The Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China

Senile plaque blue autofluorescence was discovered around 40 years ago,however,its impact on Alzheimer’s disease(AD)pathology has not been fully *** analyzed senile plaques with immunohistochemistry and fluorescence imaging on AD brain sections and also Aβ aggregation in *** DAPI or Hoechst staining,the nuclear blue fluorescence could only be correctly assigned after subtracting the blue plaque *** flower-like structures wrapping dense-core blue fluorescence formed by cathepsin D staining could not be considered central-nucleated neurons with defective lysosomes since there was no nuclear staining in the plaque core when the blue autofluorescence was *** Aβ self-oligomers and Aβ/hemoglobin heterocomplexes generated blue *** Aβ amyloid blue autofluorescence not only labels senile plaques but also illustrates red cell aggregation,hemolysis,cerebral amyloid angiopathy,vascular plaques,vascular adhesions,and *** summary,we conclude that Aβ-aggregation-generated blue autofluorescence is an excellent multi-amyloidosis marker in Alzheimer’s disease.

关键词： Senile plaque Blue autofluorescence Aβ Amyloid aggregation Hemoglobin Cathepsin D.Microaneurysm Alzheimer's disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于压印细胞片组装的仿生肝小叶

引用

Science Bulletin 2024年第10期69卷 1448-1457页

作者：王经琳黄丹青陈涵旭赵远锦 department of Hepatobiliary surgery Hepatobiliary InstituteNanjing Drum Tower HospitalMedical SchoolNanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Liver-tissue engineering has proven valuable in treating liver diseases,but the construction of liver tissues with high fidelity remains ***,we present a novel three-dimensional(3D)-imprinted cell-sheet strategy for the synchronous construction of biomimetic hepatic microtissues with high accuracy in terms of cell type,density,and *** achieve this,the specific composition of hepatic cells in a normal human liver was determined using a spatial proteogenomics *** data and biomimetic hepatic micro-tissues with hexagonal hollow cross-sections indicate that cell information was successfully generated using a homemade 3D-imprinted device for layer-by-layer imprinting and assembling the hepatic cell *** infiltrating vascular endothelial cells into the hollow section of the assembly,biomimetic hepatic microtissues with vascularized channels for nutrient diffusion and drug perfusion can be *** demonstrate that the resultant vascularized biomimetic hepatic micro-tissues can not only be integrated into a microfluidic drug-screening liver-on-a-chip but also assembled into an enlarged physiological structure to promote liver *** believe that our 3D-imprinted cell sheets strategy will open new avenues for biomimetic microtissue construction.

关键词： Biomimetic Hepatic lobules Cell sheets 3D imprinting Tissue engineering Artificial liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heterotopic pancreas in the gallbladder:A case report

引用

World Journal of Clinical Cases 2024年第22期12卷 5140-5144页

作者： Ting Wang Jing Jiang Ling-Ling Guo Xu Chen Er-Bao Chen department of Hepatobiliary and Pancreatic surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina department of Pathology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina department of Radiation Oncology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND Heterotopic pancreas(HP)refers to pancreatic tissue located in areas with no vascular or anatomical connection to the *** occurs mostly in the stomach,duodenum,and colon,and rarely in the *** SUMMARY A 57-year-old woman was referred to our hospital complaining of right upper quadrant discomfort for 3 *** abdominal computed tomography scan revealed adenomyomatosis with a thickened fundus of the *** patient underwent a laparoscopic cholecystectomy,and pathological examination unexpectedly showed heterotopic pancreatic tissue in the *** patient had a favorable recovery and was discharged on postoperative day *** did not report any symptoms or complications at the 6-mo postoperative *** should pay close attention to such pancreatic tissue and carefully examine it for dysplasia or *** This case provides more information about HP in the gallbladder,a rare occurrence.

关键词： Adenomyomatosis Diagnosis Heterotopic pancreas Gallbladder Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

引用

World Journal of Gastrointestinal surgery 2024年第7期16卷 2054-2064页

作者： Chun-Juan Zhao Chao Ren Zhen Yuan Guo-Hui Bai Jin-Yu Li Long Gao Jin-Hui Li Ze-Qi Duan Dui-Ping Feng Hui Zhang College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina department of Radiology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina department of Occupational Health School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionNHC Key Laboratory of PneumoconiosisMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina department of Oncological and vascular Intervention The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Provincial Clinical Research Center for Interventional Medicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina First Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Intelligent Imaging Big Data and Functional Nano-imaging Engineering Research Center of Shanxi Province The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Portal shunt and immune status related to the spleen are related to the occurrence of hepatic encephalopathy(HE).It is unknown whether spleen volume before transjugular intrahepatic portosystemic shunt(TIPS)is related to postoperative *** To investigate the relationship between spleen volume and the occurrence of *** This study included 135 patients with liver cirrhosis who underwent TIPS,and liver and spleen volumes were elevated upon computed tomography *** Kaplan-Meier curve was used to compare the difference in the incidence rate of HE among patients with different spleen *** and multivariate Cox regression analyses were performed to identify the factors affecting overt HE(OHE).Restricted cubic spline was used to examine the shapes of the dose-response association between spleen volumes and OHE *** The results showed that 37(27.2%)of 135 patients experienced OHE during a 1-year follow-up *** with preoperative spleen volume(901.30±471.90 cm3),there was a significant decrease in spleen volume after TIPS(697.60±281.0 cm^(3))in OHE *** the severity of OHE increased,the spleen volume significantly decreased(P<0.05).Compared with patients with a spleen volume≥782.4 cm^(3),those with a spleen volume<782.4 cm^(3) had a higher incidence of HE(P<0.05).Cox regression analysis showed that spleen volume was an independent risk factor for post-TIPS OHE(hazard ratio=0.494,P<0.05).Restricted cubic spline model showed that with an increasing spleen volume,OHE risk showed an initial increase and then decrease(P<0.05).CONCLUSION Spleen volume is related to the occurrence of OHE after *** spleen volume is an independent risk factor for post-TIPS OHE.

关键词： Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Spleen volume Portal hypertension Cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and validation of a preoperative prediction model for all-cause mortality in patients following abdominal aortic aneurysm repair

引用

Chinese Medical Journal 2024年第10期137卷 1255-1257页

作者： Tan Li Guangxiao Li Yijun Wu Chao Yang Jun Yang Liping Sun Chunyan Ma department of Cardiovascular Ultrasound The First Hospital of China Medical UniversityShenyangLiaoning 110001China Clinical Medical Research Center of Imaging in Liaoning Province The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Medical Record Management Center The First Hospital of China Medical UniversityShenyangLiaoning 110001China Tumor Etiology and Screening department of Cancer Institute and General surgery The First Hospital of China Medical UniversityShenyangLiaoning 110001China Trauma Center and department of Burns The First Hospital of China Medical UniversityShenyangLiaoning 110001China

To the Editor:Abdominal aortic aneurysm(AAA)is a life-threatening vascular *** intervention is typically recommended when the maximum AAA diameter reaches a threshold of 5.5cm for men and 5.0cm for women,or when an AAA experiences a rapid expansion of greater than 1.0cm/year.[1]Survival after AAA repair is inuenced by various factors,and the identication of independent prognostic factors and the development of accurate prediction models are crucial for optimal treatment planning,counseling,and postoperative *** several scoring systems with varying degrees of accuracy have been developed to predict the risk of mortality after intervention for patients with ruptured AAA.

关键词： patients mortality aneurysm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of alkaline phosphatase and γ-glutamyltransferase after radiofrequency ablation of primary liver cancer: A retrospective study

引用

World Journal of Gastrointestinal surgery 2024年第9期16卷 2860-2869页

作者： Wen-Yu Huang Sheng Zheng Dan Zhu Ying-Lang Zeng Juan Yang Xue-Li Zeng Pei Liu Shun-Ling Zhang Ming Yuan Zhi-Xia Wang department of Tumor and vascular Interventional Therapy Xiamen Humanity HospitalXiamen 361000Fujian ProvinceChina department of Gastroenterology The Third People's Hospital of Yunnan ProvinceKunming 650011Yunnan ProvinceChina Medical Imaging Center Qian Wei Hospital of Jilin ProvinceChangchun 130000Jilin ProvinceChina department of Science and Education The Third People's Hospital of Yunnan ProvinceKunming 650011Yunnan ProvinceChina Graduate School of Clinical Medicine Dali UniversityDali 671000Yunnan ProvinceChina department of Hepatobiliary surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina department of Oncology The Affiliated Shuyang Hospital of Xuzhou Medical UniversitySuqian 223600Jiangsu ProvinceChina

BACKGROUND Changes in alkaline phosphatase(ALP)andγ-glutamyltransferase(GGT)levels in patients with primary liver cancer(PLC)after radiofrequency ablation(RFA).Hepatocellular carcinoma is a malignant tumor with high incidence *** a common local treatment,RFA has attracted much attention for its efficacy and influence on liver *** To investigate the effect of serum ALP and GGT levels on the prognosis of patients with PLC treated by *** The preoperative clinical data of 165 patients who were pathologically or clinically diagnosed with PLC and who received RFA in our hospital between October 2018 and June 2023 were *** chi-square test was used to compare the data between *** Kaplan-Meier method and Cox regression were used to analyze the associ-ations between serum ALP and GGT levels and overall survival,progression-free survival(PFS)and clinical characteristics of patients before *** The 1-year survival rates of patients with normal(≤135 U/L)and abnormal(>135 U/L)serum ALP before treatment were 91%and 79%,respectively;the 2-year survival rates were 90%and 68%,respectively;and the 5-year survival rates were 35%and 18%,*** difference between the two groups was statistically significant(P=0.01).Before treatment,the 1-year survival rates of patients with normal serum GGT levels(≤45 U/L)and abnormal serum GGT levels(>45 U/L)were 95%and 87%,the 2-year survival rates were 85%and 71%,and the 5-year survival rates were 37%and 21%,*** difference between the two groups was statist-ically significant(P<0.001).Serum ALP[hazard ratio(HR)=1.766,95%confidence interval(95%CI):1.068-2.921,P=0.027]and GGT(HR=2.312,95%CI:1.367-3.912,P=0.002)is closely related to the overall survival of PLC patients after RF ablation and is an independent prognostic *** 1-year PFS rates were 72%and 50%,the 2-year PFS rates were 52%and 21%,and the 5-year PFS rates were 14%and 3%,*** difference between the

关键词： Alkaline phosphatase γ-glutamyltransferase Radiofrequency ablation Primary liver cancer Retrospective study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three cases of uncommon medication-associated osteonecrosis of temporal bone

引用

World Journal of Otorhinolaryngology-Head and Neck surgery 2024年第3期10卷 237-240页

作者： Hunter VanDolah Jason R.Crossley H.Jeffrey Kim Georgetown university School of Medicine Washington DCUSA department of Otolaryngology–Head and Neck surgery MedStar Georgetown University HospitalWashington DCUSA

Introduction:Medication-related osteonecrosis of the temporal bone is rare and has been reported to be associated with the use of anti-resorptive and biologic ***,we present the first case of tyrosine-kinase inhibitor-related external auditory canal(EAC)osteonecrosis as well as two cases related to anti-resorptive ***:A retrospective case ***:Case one:an 84-year-old female presented with chronic otitis externa and osteonecrosis of EACs *** had a history of osteoporosis treated with denosumab and risedronic *** successfully underwent left EAC reconstruction using an inferiorly-based pedicle periosteal flap while the right ear canal was managed *** two:a 69-year-old male presented with osteonecrosis of the right *** had a history of osteoporosis treated with alendronic acid and zoledronic *** osteonecrosis is conservatively managed with local debridement and antibiotic *** three:a 60-year-old male presented with osteonecrosis of the right inferior *** had a history of chronic myelogenous leukemia treated with a tyrosine-kinase inhibitor,*** failing conservative therapy,he underwent right ear canal reconstruction using a periosteal vascular pedicle flap without complication and experienced complete resolution to his ***:Anti-resorptive agents and/or tyrosine kinase inhibitors may lead to dysregulation of bone remodeling and result in rare cases of temporal bone *** a local debridement and antibiotic therapy fail,definitive surgical excision of necrotic bone with subsequent reconstruction of the EAC may offer patients a possible resolution in symptoms.

关键词： bisphosphonates denosumab external auditory canal imatinib medication-related osteonecrosis osteonecrosis temporal bone tyrosine-kinase Inhibitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

引用

Acta Pharmaceutica Sinica B 2024年第5期14卷 2077-2096页

作者： Cheng Qian Yueke Zhou Teng Zhang Guanglu Dong Mengyao Song Yu Tang Zhonghong Wei Suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.Choi Juming Yan Chongjin Zhong Li Wan Jia Li Aiyun Wang Yin Lu Yang Zhao Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Centre for Inflammation Faculty of ScienceCentenary InstituteSchool of Life SciencesUniversity of Technology SydneySydney NSW 2050Australia Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Experimental Demonstration Center for Basic Medicine EducationXuzhou Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004China department of General surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Macquarie Medical School Faculty of MedicineHuman Health SciencesMacquarie UniversitySydney NSW 2109Australia

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor ***,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic *** was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to ***,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial *** importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent *** findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.

关键词： Salvianic acid A Tumor vascular normalization PKM2 β-Catenin Claudin-5 Endothelial glycolysis Tight junctions Doxorubicin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：