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Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

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World Journal of Stem Cells 2024年第1期16卷 33-53页

作者： Hong-Shuo Shi Xin Yuan Fang-Fang Wu Xiao-Yu Li Wei-Jing Fan Xiao Yang Xiao-Ming Hu Guo-Bin Liu department of Peripheral vascular surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 250021China

BACKGROUND Stem cell therapy has shown great potential for treating diabetic foot(DF).AIM To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades,with the aim of depicting the current global research landscape,identifying the most influential research hotspots,and providing insights for future research *** We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in *** analysis was carried out using CiteSpace,VOSviewer,and R(4.3.1)to identify the most notable *** A search was conducted to identify publications related to the use of stem cells for DF treatment.A total of 542 articles published from 2000 to 2023 were *** United States had published the most papers on this *** this field,Iran’s Shahid Beheshti university Medical Sciences demonstrated the highest ***,*** from the same university has been an outstanding researcher in this *** Cell Research&Therapy is the journal with the highest number of publications in this *** main keywords were“diabetic foot ulcers,”“wound healing,”and“angiogenesis.”CONCLUSION This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 *** research findings suggested that the hotspots in this field include stem cell dressings,exosomes,wound healing,and adipose-derived stem *** research should also focus on the clinical translation of stem cell therapies for DF.

关键词： Stem cells Diabetic foot Bibliometric CiteSpace VOSviewer R-bibliometrix

Clinical efficacy of endovascular revascularization combined with vacuum-assisted closure for the treatment of diabetic foot

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World Journal of Diabetes 2024年第7期15卷 1499-1508页

作者： Feng-Rui Lei Xiao-Fei Shen Chuang Zhang Xin-Qing Li Hao Zhuang Hong-Fei Sang department of vascular surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND The diabetic foot is a common cause of disability and death,and comorbid foot infections usually lead to prolonged hospitalization,high healthcare costs,and a significant increase in amputation *** most diabetic foot trauma is complicated by lower extremity arteriopathy,which becomes an independent risk factor for major amputation in diabetic foot *** To establish the efficacy and safety of endovascular revascularization(ER)combined with vacuum-assisted closure(VAC)for the treatment of diabetic *** Clinical data were collected from 40 patients with diabetic foot admitted to the Second Affiliated hospital of Soochow university from April 2018 to April *** foot lesions were graded according to Wagner’s classification,and blood flow to the lower extremity was evaluated using the ankle-brachial index test and computerized tomography angiography of the lower extremity *** subcutaneous insulin infusion pumps were used to achieve glycemic *** limb revascularization was facilitated by percutaneous transluminal balloon angioplasty(BA)or *** were cleaned by nibbling *** granulation tissue growth was induced by VAC,and wound repair was performed by skin grafting or skin flap *** Of the 35 cases treated with lower limb revascularization,34 were successful with a revascularization success rate of 97%.Of these,6 cases underwent stenting after BA of the superficial femoral artery,and 1 received popliteal artery stent *** the 25 cases treated with infrapopliteal artery revascularization,39 arteries were reconstructed,7 of which were treated by drug-coated BA and the remaining 32 with plain old *** was performed in 32 ***-four cases of skin grafting and 2 cases of skin flap transplantation were *** patients underwent major amputations,whereas 17 had minor amputations,accounting for a success limb salvage rate of 95%.CONCLUSION ER in

关键词： Diabetic foot Revascularization Vacuum-assisted closure Balloon angioplasty Wound repair

HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells

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World Journal of Gastroenterology 2024年第19期30卷 2553-2563页

作者： Yang Gao Li Li Sheng-Ning Zhang Yuan-Yi Mang Xi-Bing Zhang Shi-Ming Feng department of Hepatobiliary Pancreatic and vascular surgery The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of KunmingKunming 650011Yunnan ProvinceChina

BACKGROUND The role of exosomes derived from HepG2.2.15 cells,which express hepatitis B virus(HBV)-related proteins,in triggering the activation of LX2 liver stellate cells and promoting liver fibrosis and cell proliferation remains *** focus was on comprehending the relationship and influence of differentially expressed microRNAs(DE-miRNAs)within these *** To elucidate the effect of exosomes derived from HepG2.2.15 cells on the activation of hepatic stellate cell(HSC)LX2 and the progression of liver *** Exosomes from HepG2.2.15 cells,which express HBV-related proteins,were isolated from parental HepG2 and WRL68 *** blotting was used to confirm the presence of the exosomal marker protein *** activation of HSCs was assessed using oil red staining,whereas DiI staining facilitated the observation of exosomal uptake by LX2 ***,we evaluated LX2 cell proliferation and fibrosis marker expression using 5-ethynyl-2′-deoxyuracil staining and western blotting,***-miRNAs were analyzed using *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways were used to annotate the target genes of *** Exosomes from HepG2.2.15 cells were found to induced activation and enhanced proliferation and fibrosis in LX2 cells.A total of 27 miRNAs were differentially expressed in exosomes from HepG2.2.15 *** analysis indicated that these DE-miRNA target genes were associated with cell differentiation,intracellular signal transduction,negative regulation of apoptosis,extracellular exosomes,and RNA *** pathway analysis highlighted ubiquitin-mediated proteolysis,the MAPK signaling pathway,viral carcinogenesis,and the toll-like receptor signaling pathway,among others,as enriched in these *** These findings suggest that exosomes from HepG2.2.15 cells play a substantial role in the activation,proliferation,and fibrosis of LX2 cells and that DE-miRNAs within these exos

关键词： Hepatic stellate cells Liver fibrosis Exosomes Small RNA sequencing HepG2.2.15

The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice

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Animal Models and Experimental Medicine 2024年第3期7卷 388-395页

作者： Meng Li Panpan Wei Kexin Li Haole Liu Naqash Alam Haiwen Hou Jie Deng Baohui Xu Enqi Liu Sihai Zhao Yankui Li Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina department of vascular surgery The Second Hospital of Tianjin Medical UniversityTianjinChina department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina department of vascular surgery Stanford University School of MedicineStanfordCaliforniaUSA

Intimal hyperplasia(IH)is a negative vascular remodeling after arterial *** occasionally occurs in elastase-induced abdominal aortic aneurysm(AAA)mouse *** study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastaseinduced mouse AAA *** IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were *** 42 elastase-induced AAA mouse models,10 mice developed mild IH(24%)and severe IH was found in only 2 mice(5%).The outer diameters of the AAA segments in mice with and without IH did not show significant *** mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH *** was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe ***,only a lower numbers of T cells and B cells were found in the IH *** cell-secreted matrix metalloproteinases(MMP)2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe *** conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastaseinduced mouse AAA *** will help researchers better understand this model,and optimize it for use in AAA-related research.

关键词： abdominal aortic aneurysms animal model histology intimal hyperplasia

Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes

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Transactions of Tianjin university 2024年第1期30卷 63-73页

作者： Yu-Long Men Ning Dou Yiyi Zhao Yan Huang Lei Zhang Peng Liu department of Chemical Engineering School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China department of Thyroid Breast and vascular surgery Shanghai Fourth People’s Hospital Affi liated to Tongji University School of MedicineShanghai 200081China department of vascular surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell ***,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)*** the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 ***,MC-60 has superior stability and anti-interference ability to impurities in the *** better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C *** Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the ***,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.

关键词： Interface eff ect Electrocatalysis Molybdenum oxide Glucose Oxidation reaction

Intra-thyroid esophageal duplication cyst:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2231-2236页

作者： Hong-Guo Lin Ming Liu Xue-Yang Huang Da-Sheng Liu department of vascular Thyroid surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Esophageal cysts are relatively rare in clinical practice,with most of the literature comprising case *** cysts protruding into the thyroid gland are easily misdiagnosed as thyroid *** such cases have been reported so *** SUMMARY This article reports the case of a 31-year-old adult male diagnosed with thyroid nodules before *** patient underwent left thyroidectomy and *** the surgery,esophageal cysts were identified in the esophageal muscle and thyroid *** pathology results confirmed a nodular goiter combined with esophageal ***,the patient developed a neck infection and underwent another operation and broad-spectrum antibiotic treatment for *** We report the first clinical case of an esophageal cyst located within the thyroid gland that was successfully treated *** cyst located within the thyroid gland cause difficulties in *** the present study,the contents of the esophageal cysts were calcified foci,and a small amount of fluid mixture,which were easily misdiagnosed as thyroid nodules and misled the surgical methods.

关键词： Esophageal cysts Thyroid Diagnosed surgery Case report

Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

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Chinese Medical Journal 2024年第9期137卷 1105-1114页

作者： Xinsheng Xie Ye Yuan Yulong Huang Xiang Hong Shichai Hong Gang Chen Yihui Chen Yue Lin Weifeng Lu Weiguo Fu Lixin Wang department of vascular surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China department of vascular surgery Zhongshan HospitalFudan UniversityShanghai 200032China vascular surgery Institute of Fudan university Fudan UniversityShanghai 200032China

Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been *** study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this ***:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)*** expressed genes(DEGs)were identified using the"limma"package in *** absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker ***-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in ***:A total of 16 DEGs were *** enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related *** type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for *** expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall ***,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall ***-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T *** addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall ***:COL1A1 and SYTL2 may serve as diagnostic marker genes for *** upregulation of SYTL2 and COL1A1 may be involved in the inflammat

关键词： Bioinformatics Thoracic aortic aneurysm Immune response Single cell analysis Machine learning

Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 127-136,I0006-I0009页

作者： Zhen-Zhen Li Min Liu Xiong-Hui He Zhen-Dong Liu Zhan-Xiang Xiao Hao Qian You-Fei Qi Cun-Chuan Wang department of Metabolic and Bariatric surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong Province510632China department of vascular surgery Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouHainan Province570311China department of Physical Examination Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouHainan Province570311China department of Gastrointestinal surgery Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouHainan Province570311China

Objective:To explore the balance of peripheral blood T helper 17 cells/regulatory T cell(Th17/Treg)ratio and the polarization ratio of M1 and M2 macrophages in lower extremity arteriosclerosis obliterans(ASO).Methods:A rat model of lower extremity ASO was established,and blood samples from patients with lower extremity ASO before and after surgery were *** was used to detect interleukin 6(IL-6),IL-10,and ***-time RCR and Western blot analyses were used to detect Foxp3,IL-6,IL-10,and IL-17 ***,flow cytometry was applied to detect the Th17/Treg ratio and M1/M2 ***:Compared with the control group,the iliac artery wall of ASO rats showed significant hyperplasia,and the concentrations of cholesterol and triglyceride were significantly increased(Pvascular surgery(such as percutaneous transluminal angioplasty and arterial stenting),all these changes were significantly improved(Psurgery can effectively improve the balance of Th17/Treg,and reduce the ratio of M1/M2,and the expression of inflammatory factors.

关键词： Lower extremity arteriosclerosis Regulatory T cells Regulatory B cells Inflammatory factors M1 macrophages M2 macrophages

Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying Shao Xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng Jing Jing Ting Luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor *** that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired ***,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing ***,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive *** determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice *** may be attributed to enhanced autophagy induced by endoplasmic reticulum ***,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of ***,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with *** of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive ***,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together