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Adherence to 24-hour movement guidelines in children with mental,behavioral,and developmental disorders:Data from the 2016-2020 National Survey of Children's Health

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Journal of Sport and Health science 2023年第3期12卷 304-311页

作者： Ning Pan Li-Zi Lin George P.Nassis Xin Wang Xiao-Xuan Ou Li Cai Jin Jing Qiang Feng Guang-Hui Dong Xiu-Hong Li department of Maternal and Child Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Physical Education department College of Education(CEDU)United Arab Emirates UniversityAl Ain 15551United Arab Emirates department of sports science and clinical biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdense 5230Denmark department of Fitness Surveillance Centre China Institute of Sport ScienceBeijing 100061China

Background:Adopting a healthy lifestyle during childhood could improve physical and mental health outcomes in adulthood and reduce relevant disease ***,the lifestyles of children with mental,behavioral,and developmental disorders(MBDDs)remains under-described within the literature of public health *** study aimed to examine adherence to 24-hour movement guidelines among children with MBDDs compared to population norms and whether these differences are affected by demographic ***:Data were from the 2016-2020 National Survey of Children’s Health—A national,population-based,cross-sectional *** used the data of 119,406 children aged 6-17 years,which included 38,571 participants with at least 1 MBDD and 80,835 *** to the 24-hour movement guidelines was measured using parent-reported physical activity,screen time,and sleep ***:Among children with MBDDs,20.3%,37.0%,60.7%,and 77.3%met the physical activity,screen time,sleep,and at least 1 of the 24-hour movement *** rates were lower than those in children without MBDDs(22.8%,46.2%,66.7%,and 83.4%,respectively;all p<0.001).Children with MBDDs were less likely to meet these guidelines(odds ratio(OR)=1.21,95%confidence interval(95%CI):1.13-1.30;OR=1.37,95%CI:1.29-1.45;OR=1.29,95%CI:1.21-1.37;OR=1.45,95%CI:1.35-1.56)than children without *** with emotional disorders had the highest odds of not meeting these guidelines(OR=1.43,95%CI:1.29-1.57;OR=1.48,95%CI:1.37-1.60;OR=1.49,95%CI:1.39-1.61;OR=1.72,95%CI:1.57-1.88)in comparison to children with other *** children aged12-17 years,the difference in proportion of meeting physical activity and screen time guidelines for children with *** without MBDD was larger than that among children aged 6-11 ***,the above difference of meeting physical activity guidelines in ethnic minority children was smaller than that in white ***:Children with MBDDs were

关键词： Mental disorders Physical activity Sedentary behavior Sleep

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Loss of C-terminal α-helix decreased SDF-1α-mediated signaling and chemotaxis without influencing CXCR4 internalization

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Acta Pharmacologica Sinica 2004年第2期25卷 26-34页

作者： Shao-hui CAI, Yi TAN2, Xian-da REN, Xiao-hong LI, Shao-xi CAI2, Jun DU3,4 department of clinical Pharmacology, Pharmacy School of Ji-nan University, Guangzhou 510612 2College of Bioengineering, Key Laboratory for biomechanics & Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing 400044 School of Pharmaceutical science, Sun Yat-Sen University, Guangzhou 510612, China 3 4department of Medical Technology, Nagoya University School of Health sciences, Aichi 461-8673, Japan department of clinical Pharmacology Pharmacy School of Jinan University GD Guangzhou 510612 College of Bioengineering Chongqing University Key Laboratory for Biomechanics & Tissue Engineering of the State Ministry of Education 重庆 400044 department of Medical Technology Nagoya University School of Health Sciences Aichi 461-8673 日本

AIM: To investigate the possibility that a novel α-helix-defective mutant of stromal cell-derived factor-1α (SDF- 1α) (SDF-1/54R) acts as an antagonist of CXC chemokine receptor 4 (CXCR4). METHODS: According to the genetic sequence of natural SDF-1α, a recombinant α-helix-defective mutant of SDF-1α was designed and some biologic characteristics of this mutant were demonstrated. The migration of Jurkat cells was assessed with chemo- tactic assay. ERK phosphorylation was analyzed by Western blot with a specific anti-phospho-ERK1/2 antibody. Intracellular calcium influx was examined by flow cytometer with a calcium indicator dye Fluo-3AM. The CXCR4 on the cell surface was detected by flow cytometer with a PE conjoined anti-human CXCR4 antibody. RESULTS: Compared with native SDF-1α, SDF-1/54R displayed apparent decrease in chemotactic ability, ERK1/2 activation, and intracellular calcium influx in Jurkat cells. However, the binding to CXCR4 and inducing CXCR4 internalization of SDF-1/54R did not change outstandingly. Moreover, a competitive inhibitory effect of SDF-1/54R on the migration of Jurkat cells induced by native SDF-1α was confirmed. CONCLUSION: α-helix-defective mutant of SDF-1α, SDF-1/54R that remained both the N-terminus and the central β-sheet region, decreased SDF-1α-medi- ated signaling and chemotaxis but did not influence CXCR4 internalization, which suggested that SDF-1/54R might be developed as an anti-CHIV inhibitor with high biological potency and low side-effect.

关键词： stromal cell-derived factor-1 alpha CXC chemokine receptor 4 chemotaxis

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Liposomalα-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis

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Nano Research 2024年第4期17卷 2949-2959页

作者： Lin Yang Xueying An Wang Gong Wenshu Wu Bin Liu Xiaoyan Shao Yansi Xian Rui Peng Baosheng Guo Qing Jiang Division of sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical University321 Zhongshan RoadNanjing 210008China Branch of National clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolNanjing University&Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women,and the hyperfunction of osteoclasts is the primary contributor to postmenopausal ***,the development of effective therapeutic drugs and precise delivery systems remains a challenge in the field of anti-absorption ***,we reported theα-cyperone(α-CYP)for anti-osteoporosis and developed a liposome-based nano-drug delivery system ofα-CYP,that specifically targets the bone resorption ***,we found that theα-CYP,one of the major sesquiterpenes of Cyperus rotundus L.,attenuated the progression of osteoporosis in ovariectomized(OVX)mice and down-regulated the expression of phosphorylated proteins of phosphoinositide 3-kinase(PI3K)and protein kinase B(Akt),causing down-regulation of osteoclast-related genes/proteins and curbing osteoclast ***,α-CYP reversed the activation of osteoclastic differentiation and enhanced osteoporosis-related proteins expression caused by PI3K/Akt agonist(YS-49).More importantly,we adopted the osteoclastic resorption surface targeting peptide Asp8 and constructed the liposome(lipαC@Asp8)to deliverα-CYP to osteoclasts and confirmed its anti-osteoporosis effect and enhanced osteoclast inhibition by blocking PI3K/Akt *** conclusion,this study demonstrated thatα-CYP inhibits osteoclast differentiation and osteoporosis development by silencing PI3K/Akt pathway,and the liposome targeting delivery systems loaded withα-CYP might provide a novel and effective strategy to treat osteoporosis.

关键词： osteoporosis α-cyperone osteoclast phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) liposome

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A comparison of lower limb stiffness and mechanical muscle function in ACL-reconstructed,elite,and adolescent alpine ski racers/ski cross athletes

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Journal of Sport and Health science 2018年第4期7卷 416-424页

作者： Matthew J.Jordan Per Aagaard Walter Herzog Canadian Sport Institute Calgary Calgary AB T2N IN4Canada department of sports science and clinical biomechanics SDU Muscle Research ClusterUniversity of Southern DenmarkOdense DK-5230Denmark Human Performance Laboratory University of CalgaryCalgaryAB T2N IN4Canada Corresponding author.E-mail address： mjordan@ucalgary.ca

Purpose： The aim of this study was to compare mechanical muscle function in the eccentric/concentric phases of vertical bilateral jumping in anterior cruciate ligament-reconstructed （ACLR）, elite （ELITE）, and adolescent （ADOL） alpine ski racers and ski cross athletes. Methods： Alpine ski racers/ski crossers （ACLR： n = 12, age = 26.7 ± 3.8 years; ELITE： n = 12, age = 23.9 ± 3.0 years; ADOL： n = 12, age = 17.8 ± 0.7 years; females： n = 6 per group, males： n = 6 per group） performed 5 maximal countermovement jumps （CMJs） and 5 squat jumps. The ground reaction forces for each limb were analyzed using dual force plate recording to obtain body center of mass （BCM） velocity, displacement, and power. The eccentric deceleration （ECC） and concentric phases were determined from BCM velocity. CMJ net concentric and ECC impulses were calculated （body mass normalized） along with the peak and mean BCM power and maximal vertical jump height. CMJ lower limb stiffness （LLS） was determined by the slope of the ground reaction forces vs. the BCM displacement curve over the ECC phase. Concentric and ECC asymmetry indices were calculated for each leg, and the left vs. right LLS was compared. Outcome measures （reported as mean ± SD） calculated as a 5-jump mean were normalized to body mass and compared using an analysis of variance. Results： No between-group differences were found for peak and mean power or jump heights. There were no group differences for LLS or net concentric phase impulse, but the net ECC impulse was lower in the ADOL group compared with ELITE skiers （ADOL： 1.33 ± 0.32 Ns/kg; ELITE： 1.59 ± 0.16 Ns/kg; p 〈 0.05）. Although no group differences were found for ECC asymmetry indices, a group × limb interaction was found for LLS （p 〈 0.01）, which was systematically higher in the right vs. the left limb of ADOL skiers （right： 54.1 ± 17.9 N/m/kg; left： 48.7 ± 15.7 N/m/kg;p 〈 0.01）. Conclusion： ADOL skiers demonstrated decreased ECC impulse and systematic right limb dominance in

关键词： Between-limb asymmetry Injury prevention Knee injuries Muscle power Vertical jump

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Recreational team sports: The motivational medicine

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Journal of Sport and Health science 2018年第2期7卷 129-131页

作者： Carlo Castagna Maysa de Sousa Peter Krustrup Donald T.Kirkendall School of Sport and Exercise sciences Faculty of Medicine and SurgeryUniversity of Rome Tor Vergata Fitness Training and biomechanics Laboratory Technical DepartmentItalian Football Association Laboratory of Medical Investigation LIM-18Endocrinology DivisionSchool of MedicineUniversity of S?o Paulo department of sports science and clinical biomechanics Sport and Health Sciences Cluster (SHSC)University of Southern Denmark Sport and Health sciences Faculty of Life and Environmental SciencesUniversity of Exeter James R.Urbaniak MDSport Sciences InstituteDuke University Medical Center

Remember way back when?When we were kids?We played games like soccer,basketball,rugby,and volleyball because they were *** we stayed with it long enough(and became good enough)we might have played competitively,where ... 详细信息

关键词：激发性运动娱乐橄榄球

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Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

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Genes & Diseases 2024年第3期11卷 351-367页

作者： Xinzhu Quiu Hongbo He Hao Zeng Xiaopeng Tongg Can Zhang Yupeng Liu Zhan Liao Qing Liu department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China department of sports Medicine Research Center of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

MYBL2(MYB proto-oncogene like 2)is an emerging prognostic marker for malignant tumors,and its potential role in osteosarcoma and its relationship with immune infiltration in pan-cancer is yet to be *** constructed a transcription factor activity profile of os-teosarcoma using the single-cell regulatory network inference algorithm based on single-cell RNA sequencing data obtained from the Gene Expression ***,we calcu-lated the extent of MYBL2 activation in malignant proliferative *** also explored the association between MYBL2 and chemotherapy resistance in ***,we systematically correlated MYBL2 with immunological signatures in the tumor microenviron-ment in pan-cancer,including immune cell infiltration,immune checkpoints,and tumor immu-notherapy ***,we developed and validated a risk score(MRGS),derived an osteosarcoma risk score nomogram based on MRGS,and tested its ability to predict ***2 and gene enrichment analyses in osteosarcoma and pan-cancer revealed that MYBL2 was positively correlated with cell proliferation and tumor immune ***2 expres-sion positively correlated with SLC19A1 in pan-cancer and osteosarcoma cell ***-cancer immune infiltration analysis revealed that MYBL2 was correlated with myeloid-derived sup-pressor cells,Th2 cell infiltration,CD276,RELT gene expression,and tumor mutation burden.

关键词： Biomarker Immunecheckpoint MYBL2 Osteosarcoma Pan-cancer

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Children＇s exercise capacity at high altitude in Tibet

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中国应用生理学杂志 2014年第6期30卷 481-488页

作者： Bianba Lars Bo Andersen Hein Stigum Ouzhuluobu Espen Bjertness Research Center for High Altitude Medicine Tibet University Medical College Lhasa 850002 China department of Community Medicine Institute of Health and-Society University of Oslo Osio 0316 Norway. department of sports Medicine Norwegian School of Sport Sciences Oslo 4014 Norway department of ExerciseEpidemiology Institute of Sport Science and Clinical Biomechanics University of Southern Denmark Odense 5230Denmark Division of Epidemiology Norwegian Institute of Public Health Oslo 4404 Norway

Maximal oxygen uptake(exercise capacity) is a vital parameter in the evaluation of adaptation to high altitude,providing an index of the integrated function of the oxygen transport *** studies of maximal oxygen uptake in population at high altitude have mainly focused on adults and adolescents,though data on children are *** oxygen uptake can be measured directly,using an oxygen analyser,or indirectly through the development of equations for estimation from the maximal power output(W_(max)).Such estimations and studies of the physiological aspects of children's capacity to work and live at different altitudes in Tibet ancestry were not reported previously,although differences similar to those seen in adults may be expected to *** present paper summarized the findings of studies on exercise capacity among children living at high altitude in Tibet.

关键词：高海拔地区运动能力儿童西藏最大摄氧量集成功能输送系统直接测量

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Unlocking the potential of transdermal drug delivery

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International Journal of Smart and Nano Materials 2024年第3期15卷 432-468页

作者： Shuang Li Jianhao Wu Xiangjun Peng Xi-Qiao Feng Institute of biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijingChina

Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device *** notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery *** maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research *** begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible ***,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative *** on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关键词： Transdermal drug delivery biomechanics nanomedicine flexible electronics

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A novel non-invasive method for predicting bone mineral density and fracture risk using demographic and anthropometric measures

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sports Medicine and Health science 2023年第4期5卷 308-313页

作者： Justin Aflatooni Steven Martin Adib Edilbi Pranav Gadangi William Singer Robert Loving Shreya Domakonda Nandini Solanki Patrick C.McCulloch Bradley Lambert Orthopedic biomechanics Research Laboratory Department of Orthopedics and Sports MedicineHouston Methodist HospitalHoustonTXUSA Sydney&J.L.Huffines Institute for sports Medicine&Human Performance Department of Health and KinesiologyTexas A&M UniversityCollege StationTXUSA

Fractures are costly to treat and can significantly increase *** dual-energy x-ray absorptiometry(DEXA)is used to screen at risk people with low bone mineral density(BMD),not all areas have access to *** sought to create a readily accessible,inexpensive,high-throughput prediction tool for BMD that may identify people at risk of fracture for further *** and demographic data were collected from 492 volunteers(♂275,♀217;[44-20]years;Body Mass Index(BMI)=[27.6-6.0]kg/m^(2))in addition to total body bone mineral content(BMC,kg)and BMD measurements of the spine,pelvis,arms,legs and total ***-linear-regression with step-wise removal was used to develop a two-step prediction model for BMC followed by *** selection was determined by the highest adjusted R2,lowest error of estimate,and lowest level of variance inflation(α=0.05).Height(HTcm),age(years),sex^(m=1,f=0),%body fat(%fat),fat free mass(FFMkg),fat mass(FMkg),leg length(LLcm),shoulder width(SHWDTHcm),trunk length(TRNKLcm),and pelvis width(PWDTHcm)were observed to be significant predictors in the following two-step model(p<0.05).Step1:BMC(kg)=(0.0063×HT)+(-0.0024×AGE)+(0.1712×SEX^(m=1,f=0))+(0.0314×FFM)+(0.001×FM)+(0.0089×SHWDTH)+(-0.0145×TRNKL)+(-0.0278×PWDTH)-0.5073;R^(2)=0.819,***2:Total body BMD(g/cm^(2))=(-0.0028×HT)+(-0.0437×SEX^(m=1,f=0))+(0.0008×%FAT)+(0.2970×BMC)+(-0.0023×LL)+(0.0023×SHWDTH)+(-0.0025×TRNKL)+(-0.0113×PWDTH)+1.379;R^(2)=0.89,*** models were also developed to predict leg,arm,spine,and pelvis BMD(R^(2)=0.796-0.864,p<0.05).The equations developed here represent promising tools for identifying individuals with low BMD at risk of fracture who would benefit from further evaluation,especially in the resource or time restricted setting.

关键词： Bone Bone density Fracture Fracture risk Assessment Osteoporosis

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Biomimetic delivery of signals for bone tissue engineering

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Bone Research 2018年第3期6卷 205-216页

作者： Ming Dang Laura Saunders Xufeng Niu Yubo Fan Peter X.Ma Macromolecular science and Engineering Center University of Michigan Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing Advanced Innovation Center for Biomedical Engineering Beihang University department of Biologic and Materials sciences University of Michigan department of Biomedical Engineering University of Michigan department of Materials science and Engineering University of Michigan

Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for *** play a pivotal role in providing a template and extracellular environment to support regenerative cells and promote tissue regeneration. A variety of signaling cues have been identified to regulate cellular activity, tissue development, and the healing process. Numerous studies and trials have shown the promise of tissue engineering, but successful translations of bone tissue engineering research into clinical applications have been limited, due in part to a lack of optimal delivery systems for these signals. Biomedical engineers are therefore highly motivated to develop biomimetic drug delivery systems, which benefit from mimicking signaling molecule release or presentation by the native extracellular matrix during development or the natural healing process. Engineered biomimetic drug delivery systems aim to provide control over the location, timing, and release kinetics of the signal molecules according to the drug's physiochemical properties and specific biological mechanisms. This article reviews biomimetic strategies in signaling delivery for bone tissue engineering, with a focus on delivery systems rather than specific molecules. Both fundamental considerations and specific design strategies are discussed with examples of recent research progress, demonstrating the significance and potential of biomimetic delivery systems for bone tissue engineering.

关键词： exciting approach therefore highly motivated

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