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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 110-118页

作者： Sevgi Aslan Tuncay Gulsen Akkoc Seyhan Yilmaz Burcu Parlak Pinar Canizci Erdemli Aylin Dizi Isik Didem Buyuktas Aytac Meryem Cagla Abaci Capar Eda Kepenekli Kadayifci Marmara University Faculty of Medicine Department of Pediatric Infectious DiseaseIstanbulTurkey

Objective:To investigate the importance of immunization in preventing measles infection and to determine the most useful laboratory tests for confirmation of ***:This study included pediatric cases evaluated with a presumed diagnosis of measles between December 2022 and June 2023,at Marmara University Pendik Training and Research *** effects of vaccination status and underlying disease on the clinical course,treatments,and complications were ***:In total,117 patients were enrolled in the study with a median age of 80 months(IQR:32.5-125.0).Twelve patients with contact history were asymptomatic and had an underlying disorder,and intravenous immunoglobulin was given to them for post-exposure ***-one patients had confirmed measles *** treatment was given to three patients(a newborn,a girl with rhabdomyosarcoma,and a healthy boy)with respiratory ***-eight percent of confirmed measles cases were unvaccinated,and all hospitalized cases were unvaccinated or *** full-vaccinated children had confirmed measles *** PCR from nasopharyngeal swabs was negative in all of them,and their diagnosis was established with anti-measles IgM ***:The measles vaccine is the most effective way to protect from measles and measles-related *** measles can also occur in fully vaccinated patients,the disease is milder than in unvaccinated *** ELISA and RT-PCR tests together may be beneficial in patients with high clinical suspicion for early diagnosis.

关键词： Measles Outbreak Vaccination Vitamin A Ribavirin

Treatment of Post-traumatic pediatric Ankle Varus Deformity with Physeal Bar Resection and Hemi-Epiphysiodesis

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Current Medical Science 2019年第4期39卷 604-608页

作者： Gang FU Wang WANG Yi-fei DONG Xue-min LV Zheng YANG department of pediatric Orthopedics Beijing Jishuitan HospitalBeijing 100035China

Children presenting with partial physeal arrest and significant remaining growth may benefit from physeal bar resection,although the operation is a technique demanding *** study evaluates the treatment of post-traumatic pediatric ankle varus deformity using physeal bar resection and hemi-epiphysiodesis with the assistance of two operative ***-five patients presenting with a distal tibial medial physeal bridge as well as ankle varus deformity following traumatic ankle physeal injury between 2009 and 2017 were *** patients were treated w让h physeal bar resection and hemi-epiphysiodesis,with the assistance of either fluoroscopy (10 cases) or intraoperative three-dimensional navigation (35 cases).Of the 45 cases,the median age was 9.0 years (range:3-14 years) with 28 male and 17 female *** median of pre-operation ankle varus angle was 20 degrees (IQR 15-25) and 5 degrees (IQR 0-20) at the time of final follow up,representing a statistically significant difference (P0.05).The median of pre-operative ankle varus angles of the navigation and fluoroscopy groups were both 20 degrees (P>0.05).The median correction angle of the navigation and fluoroscopy groups was 10 and 15 degrees,respectively (P>0.05).Our results indicate that physeal bar resection and hemiepiphysiodesis are effective treatments for correcting ankle varus deformity due to traumatic medial physeal arrest of the distal *** observe no difference in outcome between fluoroscopy group and three-dimensional navigation group during the procedures.

关键词： ankle varus physeal bar resection navigation

Analysis of trends in testicular atrophy index values with age in patients with unilateral palpable cryptorchidism

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Asian Journal of Andrology 2022年第5期24卷 500-502页

作者： Pei-Qiang Li Yan Huang Fu-Yun Liu department of pediatric Urology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Cryptorchidism affects the growth of testicular *** volume is associated with reproductive *** testicular atrophy index evaluates the degree of damage caused by cryptorchidism,but it remains unclear whether changes in testicular atrophy index are related to *** selected patients who underwent surgery for unilateral palpable *** volume was measured using *** testicular atrophy indices of the undescended testes were then reviewed,and their correlation with age was *** studied 228 cases(age range:6–53 months).Scatter plots were constructed,and Loess curves were fitted,revealing a turning point at 24 months of *** patients were divided into age groups of 6–24 months and 25–53 *** testicular volume of the cryptorchid side was smaller than that of the normal side in both groups(both P<0.001).In the 6–24-month group,the testicular atrophy index was positively correlated with age,testicular volume on the cryptorchid side was not correlated with age,and testicular volume was positively correlated with age on the normal *** the 25–53-month group,testicular atrophy index and testicular volumes on either side were not correlated with age.A palpable unilateral cryptorchid testis is smaller than the contralateral *** testicular atrophy index increases with age between 6 months and 24 months,but not between 25 months and 53 *** volume increased with age on the normal side between 6 months and 24 months,but not on the cryptorchid *** in testicular atrophy index with age contribute to the decision of operation time.

关键词： cryptorchidism testicular atrophy index testicular volume

RESULTS OF DEBRIDEMENT TREATMENT FOR SPINAL PARALYSIS DUE TO TUBERCULOSIS IN CHILDREN

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中华医学杂志(英文版) 1965年第3期84卷 161-165+160页

作者：邸建德戴祥祺方先之 pediatric Section Department of Orthopedics and Traumatology Tientsin People's Hospital Tientsin

The results of 49 cases of tuber-culosis of the spine complicated withspinal paralysis in children were *** cases were all treated by thedebridement method,and 96.8% of thecases treated by the anterolateral routehad complete recovery from *** paralysis in the majority ofchildren patients was *** was the first to become disturbedor *** was the next to beinvolved and to a less ***-ter function was usually normal or onlymildly *** on the cord was inmost cases due to necrotic disc tissue orsequestra which had been displaced intothe vertebral *** debride-ment operation the operator should ex-cise only the necessary portions of theribs and preserve the transverse pro-cesses,laminae and articular facets inorder to avoid postoperative scoliosisand lateral displacement of the spine.

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How to evaluate diagnosis and management of biliary atresia in the era of liver Transplantation in China

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World Journal of pediatric Surgery 2018年第1期1卷 3-8页

作者： Jianghua Zhan Yajun Chen Kenneth K Y Wong department of pediatric Surgery Tianjin Children’s HospitalTianjinChina department of pediatric Surgery Beijing Children’s HospitalBeijingChina department of pediatric Surgery Queen Mary HospitalHong KongChina

background Biliary atresia(BA)is one of the most challenging hepatobiliary diseases in *** the reasonable outcome of liver transplantation(LT),portoenteral anastomosis(Kasai operation)is still the first choice of treatment for patients with *** to improve the survival rate of the patients with BA in the era of LT is a new *** sources Based on recent original publications and the experience with the BA in China,we review many factors that influence BA survival situation,including early diagnosis and screen plan,defects of early treatment,Kasai operation,and LT and indicate present questions about BA diagnosis and treatment in *** BA diagnosis may also be delayed due to insufficient understanding of BA and lack of jaundice monitoring methods at different levels of the hospitals in *** education of the physicians at smaller city hospitals about BA,neonatal jaundice and cholestasis would be helpful in improving early diagnosis of *** surgical intervention is still the only guarantee to improve the survival rate of BA with native *** In the era of LT,especially in China,Kasai operation can provide waiting time for living donor LT and improve the success rate of LT and minimize the rapid deterioration of liver function of the children with BA and decrease the mortality in patients with BA.

关键词： diagnosis treatment guarantee

Supermicroscopy and arterio-venolization for digit replantation in young children after traumatic amputation: Two case reports

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World Journal of Clinical Cases 2020年第21期8卷 5394-5400页

作者： Yun Chen Ze-Min Wang Jing-Hui Yao department of pediatric Orthopedics The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina department of pediatric Orthopedics Loudi Central HospitalLoudi 417000Hunan ProvinceChina department of pediatric Orthopedics The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND To report the application of supermicroscopy combined with arterio-venolization without venous anastomosis for replantation of digits following traumatic amputation in young *** SUMMARY In March 2016,we treated two children aged 2 years and 7 years with traumatic digit amputation,no venous anastomosis,and bilateral digital inherent arteries on the palmar *** combined with an arteriovenous technique was adopted to improve the replantation *** management involved auxiliary treatments such as anticoagulation,composure,antiinflammatory drugs,and *** treatment,the amputated fingers survived completely without major complications,with good *** Supermicroscopy combined with arterio-venolization is a safe and effective approach to treat traumatic digit amputation in young children without venous anastomosis.

关键词： Digit replantation Traumatic digit amputation Children Supermicroscopy Arterio-venolization Case report

Late-onset Leigh syndrome without delayed development in China:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7133-7138页

作者： Jian-Min Liang Cui-Juan Xin Guang-Liang Wang Xue-Mei Wu department of pediatric Neurology 1st Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of pediatric Neurology Jilin Provincial Key Laboratory of Pediatric NeurologyChangchun 130021Jilin ProvinceChina department of Cardiology Dalinghe Hospital of Far Eastern HorizonDalinghe 121200Liaoning ProvinceChina

BACKGROUND Leigh syndrome(LS)is one of the most common mitochondrial diseases in infants and *** often manifests as early-onset with delayed phenotypic ***,late-onset LS with normal development and white matter lesions in the brain is rarely reported,thereby highlighting the phenotypic variability of LS *** SUMMARY We report a 12-year-old boy who presented with an unusual late-onset and fulminant form of LS that is maternally inherited without developmental *** patient was admitted to the hospital with symptoms of ptosis and somnolence,and died within 2 *** of peripheral blood leukocytes showed a homoplasmic m.9176T>C mutation in the *** resonance imaging also revealed lesions in bilateral white matter as well as symmetrical lesions in the basal ganglia and brain *** patient was diagnosed with *** patient was treated with vitamin C,vitamin D,and *** patient died within 2 mo of hospital *** LS can present in both infants and older children with different phenotypes.

关键词： Leigh syndrome 9176 mutation Late-onset Case report

Emerging role of regulated cell death in intestinal failure-associated liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 228-233页

作者： Si-Yang Cheng Lu Jiang Ying Wang Wei Cai department of pediatric Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Shanghai Key Laboratory of pediatric Gastroenterology and Nutrition Shanghai 200092China Shanghai Institute for pediatric Research Shanghai 200092China Division of pediatric Gastroenterology and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and *** is mainly characterized by cholestasis in children and steatohepatitis in ***,there is no effective approach to prevent or reverse the *** cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver *** cell death is reclassified into several types,based on the mechanisms and morphological *** evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver *** studies have shown that different modes of RCD are present in animal models and patients with *** the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in *** this review,we discuss the current knowledge on how RCD may link to the pathogenesis of *** highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.

关键词： Parenteral nutrition Apoptosis Necroptosis Cholestasis Steatosis

Magnetic resonance imaging in children and adolescents with chronic inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1180-1191页

作者： Hans-Joachim Mentzel Steffen Reinsch Monika Kurzai Martin Stenzel Section of pediatric Radiology Department of Radiology University Hospital Jena- Friedrich-Schiller-University Jena Section of pediatric Gastro-enterology Department of Pediatrics University Hospital Jena Friedrich-Schiller-University Jena

Inflammatory bowel diseases(IBD) represent challenges, both from a diagnostic, and therapeutic point of view. Deep-seated anatomic structures are difficult to assess by ultrasound technique alone. As radiation-free alternative cross-sectional imaging method, magnetic resonance imaging of the intestinal structures is costly and time-consuming. Examination of pediatric patients imply additional considerations: reduction of body motions in younger children and consideration of the most appropriate preparation, and examination technique. The demanding Sellink technique is the only means for appropriately distending the lesser intestine in order to detect small bowel strictures. Oral intake of contrast medium(CM) alone shows its limitations regarding distensibility. The need for intravenous contrast media application needs to be considered, too. Active inflammation of both intestinal wall, and mesentery can be demonstrated accurately. Nevertheless, viable alternatives to CM application is desirable, considering non-negligible adverse reactions. Recent data suggest diffusion weighted imaging might fill this diagnostic gap. Irrespective of sequence technique chosen, bowel movement remains a major obstacle. Antispasmolytics in their function as smooth muscle relaxants help in improving image quality, however, their use in children might be off-label. Optimal preparation for the examination and appropriate imaging technique allow for diagnosing typical patterns of changes in IBD, such as bowel wall thickening, ulcers, mural stratification, strictures, creeping fat, and comb sign, and lymphadenopathy. The article gives a detailed overview of current significance of magnetic resonance imaging pediatric patients suffering from IBD, considering indications, limitations, and safety aspects.

关键词： Children, Adolescents, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Magnetic resonance imaging, Enterography

Atypical pathogens in community acquired pneumonia of Egyptian children

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 1-8页

作者： Deraz TE El Sahriggy SA Shaheen MA Motawea AA Gomaa HE Fawzy SH Mohamed AA pediatric department Ain Shams Faculty of Medicine pediatric department National Research Center Clinical Pathology department National Research Center Microbiology department Ain Shams Faculty of Medicine Cairo 11371 Egypt

Objective:Diagnosis of atypical pathogens as an aetiology for community-acquired pneumonia(CAP) in children is a challenge world *** aim of this study was to detect the frequency of atypical pathogens as a cause of community-acquired pneumonia(CAP) in Egyptian ***:From 50 children(with age ranged from 2 months to 12 years) hospitalized for community-acquired pneumonia;respiratory sputum samples were collected by induction or *** samples were subjected to conventional cultures and Polymerase Chain Reaction(PCR) technique DNA extraction for identification of Mycoplasma,Chlamydia pneumoniae and Legionella ***;A definite pathogen was identified in 78%of the studied children;30% typical bacteria,8%Candida albicans and atypical bacteria in 40%of the pneumonic *** pneumoniae was isolated from 26%of the children while Mycoplasma pneumoniae was isolated from 14%, whereas Legionella pneumophilla was not isolated at ***;Atypical pathogens are evident as a potential aetiology for community-acquired pneumonia in(13.3%) of young and(80%) of older Egyptian children.

关键词： Atypical pathogens Community-acquired pneumonia Children Egypt