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颅内动脉瘤管状栓塞装置的中期效果评价——对143例病人的178个动脉瘤的前瞻性研究

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国际医学放射学杂志 2013年第1期 78-79页

作者： S.C.Yu C.Kwok P.Cheng K.Chan S.S.Lau W.Lui 范文骏 department of Imaging and Interventional Radiology the Chinese University of Hong KongPrince of Wales Hospital30-32 Ngan Shing StreetRoom 2A0612/FNew Extension BlockShatinNew TerritoriesHong Kong

目的通过临床观察和血管造影评价颅内动脉瘤采用管状栓塞装置(ped)治疗后的中期效果。材料与方法本研究为多中心非随机前瞻性研究,获得所有参与单位伦理委员会的批准,所有病人均签署知情同意书。具有未破裂的囊状或梭形动脉瘤或治疗后... 详细信息

目的通过临床观察和血管造影评价颅内动脉瘤采用管状栓塞装置(ped)治疗后的中期效果。材料与方法本研究为多中心非随机前瞻性研究,获得所有参与单位伦理委员会的批准,所有病人均签署知情同意书。具有未破裂的囊状或梭形动脉瘤或治疗后动脉瘤复发的病人(143例病人的178个动脉瘤)纳入本研究,ped治疗后血管造影随访18个月以上,临床随访3年以上。研究终止条件包括:动脉瘤完全闭塞、术后30d至3年内出现神经系统并发症、ped治疗术后出现颅神经麻痹,术后6、12和18个月血管造影检查显示上游动脉狭窄或闭塞或覆盖分支血管闭塞、临床或CT检查提示出现穿支动脉梗死。结果 5例(3.5%)病人在围手术期出现死亡或严重的脑卒中[改良Rankin评分(mRS)>3分](95%CI:1.3%～8.4%),包括2例治疗后动脉瘤延迟破裂、2例颅内出血和1例血栓栓塞。5例(3.5%)病人于术后30d内出现轻微神经系统并发症(mRS=1),包括短暂性脑缺血发作(n=2)、小面积脑梗死(n=2)和颅神经麻痹(n=1)。术后30d后,1例病人出现致死性的颅内出血,1例病人出现短暂性脑缺血发作。13例颅神经麻痹病人中有10例(95%CI:46%～93.8%)在平均3.5个月内症状完全缓解。术后18个月血管造影显示,动脉瘤完全闭塞的比例为84%(49/58;95%CI:72.1%～92.2%),无病人出现上游动脉闭塞,3例出现上游动脉的狭窄(狭窄程度ped治疗是一种安全、有效的颅内动脉瘤治疗方法。这种方法对于形态不良的动脉瘤,如宽颈、大尺寸、梭形、分支和治疗后血管再通者非常有价值,应成为未破裂动脉瘤或复发动脉瘤的首选治疗。

关键词：动脉瘤前瞻性研究中期效果病人管状栓塞病理装置

Whole‑genome transcriptome and DNA methylation dynamics of pre‑implantation embryos reveal progression of embryonic genome activation in buffaloes

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2411-2427页

作者： Penghui Fu Du Zhang Chunyan Yang Xiang Yuan Xier Luo Haiying Zheng Yanfei Deng Qingyou Liu Kuiqing Cui Fei Gao Deshun Shi State Key Laboratory for Conservation and Utilization of Subtropical Agro‑Bioresources&Guangxi Key Laboratory of Animal Breeding and Disease Control Guangxi UniversityNanning 530004China. College of Animal Science and Technology Southwest UniversityChongqing 402460China. Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China. Guangxi Key Laboratory of Buffalo Genetics Reproduction and BreedingGuangxi Buffalo Research InstituteChinese Academy of Agricultural ScienceNanning 530001China Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region Nanning 530016China. Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and Engineering Foshan UniversityFoshan 528225China. Comparative pediatrics and Nutrition Department of Veterinary and Animal SciencesFaculty of Health and Medical SciencesUniversity of CopenhagenDK 1870 C FrederiksbergDenmark.

Background During mammalian pre-implantation embryonic development(ped),the process of maternal-to-zygote transition(MZT)is well orchestrated by epigenetic modification and gene sequential expression,and it is related to the embryonic genome activation(EGA).During MZT,the embryos are sensitive to the environment and easy to arrest at this stage in ***,the timing and regulation mechanism of EGA in buffaloes remain *** Buffalo pre-implantation embryos were subjected to trace cell based RNA-seq and whole-genome bisulfite sequencing(WGBS)to draw landscapes of transcription and *** typical developmental steps were classified during buffalo *** major EGA was identified at the 16-cell stage by the comprehensive analy-sis of gene expression and DNA methylation *** weighted gene co-expression network analysis,stage-spe-cific modules were identified during buffalo maternal-to-zygotic transition,and key signaling pathways and biological process events were further *** and continuous activation of these pathways was necessary for success of buffalo *** addition,the hub gene,CDK1,was identified to play a critical role in buffalo *** Our study provides a landscape of transcription and DNA methylation in buffalo ped and reveals deeply the molecular mechanism of the buffalo EGA and genetic programming during buffalo *** will lay a foundation for improving the in vitro development of buffalo embryos.

关键词： Buffalo DNA methylome Embryonic genome activation Maternal-to-zygote transition Transcriptome

带血管蒂肋软骨移植治疗声门下及高位气管狭窄

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 51-51页

作者： Hashizume K. Kanamori Y. Sugiyama M. 宁亮 department of pediatric Surgery The University of Tokyo Hospital Tokyo JapanDr.

Background/purpose Free costal cartilage graft for the treatment of subglottic and tracheal stenosis is widely used, but postoperative granulation formation i s a problem. To reduce the risk of granulation formation after free costal graft , a new operation of costal cartilage graft with vascular pedicle was introduced . Methods A vascular pedicled fifth costal cartilage graft is prepared using int ernal thoracic artery and vein and intercostal artery and vein as a vascular ped icle. The prepared graft is brought to the upper trachea. The anterior wall of c ricoid is split, and the costal cartilage graft is implanted to the split part a nd tracheostomy. Extubation on the next day is possible if the general condition of the patient permits. Results In 3 cases of subglottic or upper tracheal sten osis, this operation was performed. All the patients had tracheostomy made durin g early infancy. The postoperative course was uneventful, and all the patients w ere extubated soon after the operation. No granulation tissue was obserbed by po stoperative bronchoscopic examinations. Conclusions Costal cartilage graft with vascular pedicle is a safe and useful new operation for the treatment of subglot tic and upper tracheal stenosis. There also is a possibility of using this proce dure for the treatment of long segment tracheal stenosis.

关键词：气管狭窄带血管蒂肋软骨移植物气管造口术颗粒形成动静脉带蒂移植拔管支气管镜检查

通过攻毒模型对比免疫反应、断奶前死亡率来评估pedV疫苗在阴性和感染过pedV母猪群的免疫效果

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猪业科学 2016年第8期33卷 24-25页

作者：于俊勇(译) 孙龙(译) 吴志诚(译) t.j.schwartz c.j.rademacher l.g.gimenez-lirola y.sun j.j.zimmerman 广西农垦永新畜牧集团有限公司良圻原种猪场广西横县530317 suidae health and production AlgonaIowa department of veterinary diagnostic and production animal medicine college of veterinary medicineiowa state universityAmesIwoa

猪流行性腹泻病毒（pedV）属于冠状病毒，在美国于2013年4月首次发现。造成猪群100％的发病率、哺乳仔猪50％～100％的死亡率。已证实，猪流行性腹泻病（ped）是一个很难处理及控制的疾病，没有一个单一的干预措施能100％成功。通过仔... 详细信息

猪流行性腹泻病毒（pedV）属于冠状病毒，在美国于2013年4月首次发现。造成猪群100％的发病率、哺乳仔猪50％～100％的死亡率。已证实，猪流行性腹泻病（ped）是一个很难处理及控制的疾病，没有一个单一的干预措施能100％成功。通过仔猪的攻毒试验发现，来自免疫母猪的初乳能提高仔猪的成活率。已有其他的研究报道指出，

关键词：免疫反应攻毒试验母猪群 pedV 死亡率模型对比免疫效果猪流行性腹泻病毒

伴有睫状体视网膜动脉吻合现象的视网膜血管瘤增生症:1例罕见的病例报道

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 48-48页

作者： Ghazi N.G. Conway B.P. 王文军 department of Ophthalmology University of Virginia Health System Charlottesville VA United States

Purpose: To report an unusual phenotype of retinal angiomatous proliferation ( RAP) in age-related macular degeneration (AMD) and its short-term response to laser photocoagulation. Methods: Case report. Results: An 85-year-old woman wa s found to have an unusual RAP with a major feeder vessel originating from a cil ioretinal artery and associated with a cilioretinal-retinal anastomosis (C-RRA ). Diffuse cystoid macular edema (CME), intraretinal hard exudates in a circinat e pattern, and a fibrovascular pigment epithelial detachment (ped) were present. Laser photocoagulation was performed and led to occlusion of the cilioretinal f eeder vessel and angiomatous lesion, with less CME. The other (retinal) arm of t he C-RRA became more engorged and a new cilioretinal feeder developed, and both were associated with intraretinal hemorrhages. Visual acuity was stable and the ped persisted throughout follow-up. Conclusions: We report an unusual phenotyp e of RAP that is associated with a major cilioretinal feeder vessel and comment on the possible effect of such an association on the response to laser treatment .

关键词：视网膜血管瘤视网膜动脉激光凝固疗法视网膜硬性渗出色素上皮黄斑囊样水肿老年性黄斑变性纤维血管视网膜内出血吻合支

老年性黄斑变性脉络膜及视网膜色素上皮细胞的自体易位研究

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 54-54页

作者： Joussen A.M. Heussen F.M.A. Joeres S. 王文军 department of Vitreoretinal Surgery Center for OphthalmologyUniversity of CologneCologneGermany Dr.

Purpose:To evaluate the autologous translocation of peripheral choroid and retinal pigment epithelium(RPE)in 45 eyes of 43 patients with age-related macular degeneration(AMD).Design:Prospective nonrandomized ***:All patients had visual loss due to AMD(n=5 classic membranes,n=14 occult,n=2 mixed,n=16 pigment epithelial detachment(ped),n=5 subretinal hemorrhage,n=3 geographic atrophy).After extraction of the neovascular complex,an autologous peripheral full-thickness explant of RPE,Bruch membrane,and choroid was translocated from the midperiphery to ***:Preoperative distant visual acuity ranged from 20/800 to 20/*** vision ranged from 1.4 logarithm of reading acuity determination(logRAD)to 0.5 logRAD(0.04 to 0.32 Snellen equivalent).Revision surgery was required in 22 eyes as a result of proliferative vitreoretinopathy(PVR),retinal detachment,macular pucker,or vitreous *** eight patients,the patch was *** six months,distant visual acuity ranged from light perception to 20/50(increase of 15 letters in four eyes).Reading vision ranged from 1.4 to 0.4 *** outcome was unrelated to the type of *** of the transplant was visible on indocyanine green(ICG)angiography in 40 of 42 *** most patients,autofluorescence of the pigment epithelium was coincident with revascularization of the *** on the patch was positively related to visual ***:Autologous translocation of a full thickness transplant of choroid and RPE usually results in a vascularized and functioning *** was even achieved in patients with geographic *** stability and microperimetry before the patch translocation may be helpful in selecting patients who will profit from surgery.

关键词：老年性黄斑变性色素上皮视网膜下出血黄斑部植片视力测定萎缩型远视力黄斑皱褶膜性病变

用Visudyne光动力疗法治疗老年性黄斑变性有较好疗效

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 10-10页

作者： Frennesson C.I. Nilsson S.E.G. 陈立军 department of Ophthalmolo gy Linkping University SE-581 85 Linkping Sweden Dr.

Purpose: To investigate the effects of photodynamic therapy (PDT) on subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD) i n a Swedish patient material with smaller lesions than those investigated in the TAP (Treatment of Age-related Macular Degeneration with Photodynamic Therapy) and VIP (Verteporfin in Photodynamic Therapy) Studies. Methods: Photodynamic the rapy with verteporfin was performed according to the results and recommendations of the TAP and VIP Studies. The patients were followed up for 12 months and ret reatment was performed every 12 weeks when leakage from CNV was present. Of the 100 eyes in the first 100 patients with a follow-up period of 12 months, 59%ha d a predominantly classic lesion, 36%had an occult-only lesion and 5%had a mi nimally classic lesion. The greatest linear dimension (GLD) was ≤3 NIPS (Macula r Photocoagulation Study) disc diameters (DD) in 73%, 39%and 20%of lesions, r espectively, for the three groups. The actual lesion area was ≤3 MPS disc areas (DA) in 85%, 50%and 40%of lesions, respectively. There was a positive correl ation (P ped after 2.9 ±0.9 treatments in 77%of the total group of patients. Conclusion: T he visual outcome was comparable to those of the TAP and VIP Studies (P > 0.3). Regarding the effect on leakage, however, our results are far better than those of the TAP and VIP Studies. The proportion of patients in which leakage had stop ped was almost three times that of the TAP (27%) and VIP (26%) Studies. It see ms likely that this difference was caused by the fact that the lesions in our st udy were m

关键词：老年性黄斑变性光动力疗法 Visudyne 视盘面积经典型眼底病变隐匿型维替泊芬光敏剂

经颅磁刺激引起的运动后运动诱发电位易化及抑制:关于多发性硬化症的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 7-7页

作者： Perretti A. Balbi P. OreficeG. 张勇 department of Neurological Sciences Servizio di Neurofisiopatologia Univ. Naples ’Federico II’ Via S. Naples Italy

Objective: To evaluate motor cortex excitability changes by transcranial magnetic stimulation (TMS) following repetitive muscle contractionsE in patients with multiple sclerosis (MS); to state whether a typical pattern of post exercise motor evoked potentials (MEPs) is related to clinical fatigue in ***: In 41 patients with definite MS (32 with fatigue and 9 without fatigue according to Fatigue Severity Scale) and 13 controls, MEPs were recorded at rest: at baseline condition, following repetitive contractions until fatigue, and after fatigue, to evaluate post exerciseMEP facilitation (PEF) and depression (ped). Results: After exercise,MEP amplitude significantly increased both in patients and controls (PEF). When fatigue set in, MEP amplitude was significantly reduced in normal subjects (ped), but not in patients. Post exercise MEP findings were similar both in patients with and without fatigue. Conclusions: Our findings suggest an intracortical motor dysfunction following a voluntary contraction in MS patients, possibly due to failure of depression of facilitatory cortical circuits, or alternatively of inhibitory mechanisms.

关键词：多发性硬化症运动诱发电位经颅磁刺激肌无力严重程度评分肌肉收缩功能失调变化结果抑制作用抑制机制

利用组织培养的人羊膜上皮细胞的非外科移植术进行眼表重建

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 12-12页

作者： Parmar D.N. Alizadeh H. Awwad S.T. J.P. McCulley 潘佳鸿 department of Ophthalmology University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas TX 75390-9057United States Dr.

PURPOSE: To assess the effect of tissue-cultured human amniotic epithelial cells (AECs) in restoring the ocular surface, transplanted using a collagen shield seeded with AECs supported by a soft contact lens. DESIGN: Prospective interventional single-institutional case series with crossover controls. METHODS: Three eyes in three patients were identified with persistent corneal epithelial defects (peds) refractory to medical therapy. Two cases were secondary to neurotrophic keratopathy, while one case was attributable to longstanding alkali injury. AECs were isolated from serologically screened donor human placenta, seeded onto collagen corneal shields, and incubated in tissue culture medium for 7 days. These collagen shields were placed over the ped and supported by an overlying soft contact lens. The collagen shields dissolved by 72 hours, and the contact lenses were removed after this time. This cycle was repeated every week until healing was achieved. As a crossover control, collagen shields without AECs were placed in the same eye 1 week before placing collagen shields containing AECs. The ped was assessed by vital staining and slit-lamp color photography. RESULTS: The peds had a mean duration of 4 months and involved 20%to 37%of the corneal surface area, one case secondary to longstanding alkali injury and two cases attributable to neurotrophic keratopathy. No change in ped size was observed in those control eyes receiving collagen shields without AECs. Complete resolution of the ped was seen after two cycles of AEC-seeded collagen shield in one case, and four cycles in two cases, from 7 to 12 weeks following treatment in all patients. No loss of visual acuity was seen and clinical improvement was maintained in all cases, with a mean follow-up of 6.3 months. CONCLUSIONS: Nonsurgical transplantation of tissue-cultured AECs on a collagen shield provides a promising approach to restoring the ocular surface in cases of ped.

关键词：羊膜上皮细胞组织培养液眼表重建移植术软性接触镜角膜胶原外科角膜上皮神经营养性临床研究