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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung Wong Hoi She Siu Lun Ho Albert Chi Yan Chan Chung Mau Lo Tan To Cheung department of Surgery The University of Hong KongHong KongChina department of pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anatomical and Cellular pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

Quantization and Event-Triggered Policy Design for Encrypted Networked Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia Shi Ehsan Nekouei the department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

Integrated bound-state-in-the-continuum photon-pair source

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Photonics Research 2024年第6期12卷 1322-1327页

作者： FAN YE YUE QIN CHENFEI CUI XIANKAI SUN HON KI TSANG department of Electronic Engineering The Chinese University of Hong KongHong KongChina

Integrated photon-pair sources based on spontaneous parametric down conversion(SPDC)in novel high-χ^((2))materials are used in quantum photonic systems for quantum information processing,quantum metrology,and quantum ***,the need for extensive fabrication process development and optimization of dry-etching processes significantly impedes the rapid exploration of different material platforms for low-loss quantum photonic ***,bound states in the continuum(BICs)have emerged as a promising approach for realizing ultralow-loss integrated photonic circuits without requiring an etching *** realizations of BIC photonic circuits have,however,been limited primarily to the classical ***,we explore the BIC phenomena in the quantum regime and show that the etchless BIC platform is suitable for use in integrated entangled photon-pair sources based on the SPDC process in high-χ^((2))*** lithium niobate as an example,we demonstrate photon-pair generation at telecommunication wavelengths,attaining a maximum internal generation rate of 3.46 MHz,a coincidence-to-accidental ratio of 5773,and an experimental two‐photon interference visibility of 94%.Our results demonstrate that the BIC platform can be used for quantum photonic circuits,and this will enable the rapid exploration of different emergingχ^((2))materials for possible use in integrated quantum photonics in the future.

关键词： process. quantum continuum

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai Lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To department of Anatomical and Cellular pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina department of pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina department of Pediatrics The Chinese University of Hong KongHong KongChina department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

Cooperative Target Fencing of Multiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of Systems Science & Complexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben M department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem for n-dimensional systems and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull formed by the ***,the dynamics of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the communication network and collision avoidance among the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a numerical example.

关键词： Multi-agent systems networked systems target fencing

Soft,body conformable electronics for thermoregulation enabled by kirigami

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Bio-Design and Manufacturing 2024年第4期7卷 453-462页

作者： Lung Chow Guangyao Zhao Pengcheng Wu Xingcan Huang Jiyu Li Jian Li Wanying Wang Guihuan Guo Zhiyuan Li Jiachen Wang Jingkun Zhou Yawen Yang Yuyu Gao Binbin Zhang Qiang Zhang Dengfeng Li Ya Huang Kuanming Yao Jian Lu Xinge Yu department of Biomedical Engineering City University of Hong KongHong Kong 999077China hong kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong 999077China department of Biomedical Sciences City University of Hong KongHong Kong 999077China department of Mechanical Engineering City University of Hong KongHong Kong 999077China

The application of thermoelectric devices(TEDs)for personalized thermoregulation is attractive for saving energy while balancing the quality of *** that directly attach to human skin remarkably minimized the energy wasted for cooling the entire ***,facing the extreme dynamic geometry change and strain of human skin,conventional TEDs cannot align with the contour of our bodies for the best thermoregulation ***,we designed a kirigami-based wearable TED with excellent water vapor permeability,flexibility,and *** analysis and experimental results reveal that our product can withstand various types of large mechanical deformation without circuit *** stated outcome and proposed facile approach not only reinforce the development of wearable TEDs but also offer an innovative opportunity for different electronics that require high conformability.

关键词： Thermoregulation Thermoelectric Kirigami Body conformable Wearable

Data-driven Static Equivalence with Physics-informed Koopman Operators

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 432-438页

作者： Wei Lin Changhong Zhao Maosheng Gao C.Y.Chung department of Electrical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina department of Information Engineering The Chinese University of Hong KongHong Kong SARChina School of Electrical Engineering Chongqing UniversityChongqing 400044China

With deployment of measurement units,fitting static equivalent models of distribution networks(DNs)by linear regression has been recognized as an effective method in power flow analysis of a transmission *** volatility of measurements caused by variable distributed renewable energy sources makes it more difficult to accurately fit such equivalent *** tackle this challenge,this letter proposes a novel data-driven method to improve equivalency accuracy of DNs with distributed energy *** letter provides a new perspective that an equivalent model can be regarded as a mapping from internal conditions and border voltages to border power *** mapping can be established through 1)Koopman operator theory,and 2)physical features of power flow equations at the root node of a *** of the proposed method is demonstrated on the IEEE 33-bus and IEEE 136-bus test systems connected to a 661-bus utility system.

关键词： Data-driven distribution network Koopman operator theory static equivalent model

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang Meng Wang Kin Fai Ho Tao Wang Shuncheng Lee department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

Extended wet sieving method for determination of complete particle size distribution of general soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 242-257页

作者： Shengnan Ma Yi Song Jiawei Liu Xingyu Kang Zhongqi Quentin Yue department of Civil Engineering The University of Hong KongHong KongChina

The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general *** paper extends the traditional method and presents an extended wet sieving *** extended method uses both the steel sieves and the nylon filter cloth *** apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,*** extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size *** complete PSD of the general soil is then calculated from the dry masses of the individual material *** extended method is demonstrated with a general soil of completely decomposed granite(CDG)in hong kong,*** silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property *** results further confirm the correctness of the extended wet sieving method.

关键词： Particle size distribution(PSD) General soil Silt Clay Wet sieving Physical and chemical properties