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Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang Jiayu Xu Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Guang Jia department of occupational and Environmental health Sciences School of Public HealthPeking UniversityBeijing 100191China School of engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for occupational Safety and health Beijing 102308China department of occupational health and Radiological health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for occupational Medicine Zhengzhou 450052China department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis

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Biochar regulates biogeochemical cycling of iron and chromium in a soil-rice system by stimulating Geobacter and Clostridium

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Pedosphere 2024年第5期34卷 929-940页

作者： Min XU Yang LIN Jing MA Lulu LONG Chao CHEN Gang YANG Chun SONG Jun WU Xiaohong ZHANG Peng GAO College of Environmental Science Sichuan Agricultural University Soil Water and Ecosystem Sciences Department University of Florida College of Water Conservancy and Hydropower engineering Sichuan Agricultural University department of Environmental and occupational health University of Pittsburgh School of Public Health

In soil-rice systems,microbial reduction of iron （Fe） has been recognized as a crucial biogeochemical process that regulates Fe and chromium （Cr）translocation;however,the underlying processes are *** investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%（weight/weight） to a paddy soil spiked with 300 mg kg-1Cr under two phosphorus （P） levels (0 or 90 mg kg-1) in a pot *** key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were *** inhibited root Cr uptake by 36%,owing to the promoted iron plaque （IP） formation on the rice root *** analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter （r=0.81–0.94,P<0.05） and Clostridium （r=0.83–0.95,P<0.05）,indicating that Geobacter and Clostridium played essential roles in Fe *** analysis showed that labile carbon and pore water P concentrations were the key determinants influencing Fe-reducing bacterial abundances,accounting for 42%and 32%of the variation in community composition,***,biochar increased Fe and P concentrations in root cell walls,which retained more ***,Cr stress in rice under biochar treatment was relieved through increasing IP formation and altering subcellular *** mechanistic insights had important implications for reducing Cr uptake by rice.

关键词： chromium translocation iron plaque iron reduction maize straw biochar microbial reduction paddy soil phosphorus fertilization subcellular distribution

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Effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of Coal Science & Technology 2024年第3期11卷 86-101页

作者： F.Animah C.Keles W.R.Reed E.Sarver department of Mining and Minerals engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of occupational Safety and health(NIOSH) PittsburghPAUSA

Control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of occupational Safety and health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(CACs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter CAC on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and CAC appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SEM–EDX Scrubber Canopy air curtain Silica

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Development of a Proof-of-Concept Multi-Method Computer Simulation to Support Rural healthcare Disaster Preparedness Planning

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International Journal of Disaster Risk Science 2024年第3期15卷 346-358页

作者： Thomas A.Berg Kristina W.Kintziger Julie Suzuki Crumly Scott A.Lawson Carole R.Myers Tracey T.Stansberry College of Nursing University of Tennessee Knoxville department of Environmental Agricultural and Occupational Health University of Nebraska Medical Center Public health and healthcare Oak Ridge Associated Universities

Due to a lack of resources, rural communities often face challenges when planning catastrophic events. This project involved applying systems thinking and model-based systems engineering to develop a proof-of-concept, multi-method computer simulation and then determining whether the simulation could be used to assess the efficacy of disaster planning approaches on health outcomes in rural communities, as a function of primary healthcare. The project focus was a rural or non-urban healthcare system experiencing a natural hazard. Both system dynamics and discrete event models were incorporated to represent subsystem operations, crucial disaster responses, as well as three key response systems: public health, emergency management, and healthcare. The subsystem models included several components: policies/procedures, communications,resources, exercises/drills/training, healthcare space and staff, and the flow of affected people into and through the *** combined simulation can serve as a first step to a more comprehensive approach to helping rural communities achieve more efficient and effective healthcare planning for disaster responses.

关键词： Computer simulation Disaster preparedness Model-based systems engineering Rural healthcare System dynamics model Systems thinking

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Dynamic Forecasting of Traffic Event Duration in Istanbul:A Classification Approach with Real-Time Data Integration

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Computers, Materials & Continua 2024年第8期80卷 2259-2281页

作者： Mesut Ulu Yusuf Sait Türkan Kenan Menguc Ersin Namlı Tarık Kucukdeniz occupational health and Safety department Bandirma Onyedi Eylul UniversityBalikesir10200Türkiye department of Industrial engineering Istanbul University-CerrahpasaIstanbul34320Türkiye department of Industrial engineering Istanbul Technical UniversityIstanbul34467Türkiye

Today,urban traffic,growing populations,and dense transportation networks are contributing to an increase in traffic *** incidents include traffic accidents,vehicle breakdowns,fires,and traffic disputes,resulting in long waiting times,high carbon emissions,and other undesirable *** is vital to estimate incident response times quickly and accurately after traffic incidents occur for the success of incident-related planning and response *** study presents a model for forecasting the traffic incident duration of traffic events with high *** proposed model goes through a 4-stage process using various features to predict the duration of four different traffic events and presents a feature reduction approach to enable real-time data collection and *** the first stage,the dataset consisting of 24,431 data points and 75 variables is prepared by data collection,merging,missing data processing and data *** the second stage,models such as Decision Trees(DT),K-Nearest Neighbour(KNN),Random Forest(RF)and Support Vector Machines(SVM)are used and hyperparameter optimisation is performed with *** the third stage,feature selection and reduction are performed and real-time data are *** the last stage,model performance with 14 variables is evaluated with metrics such as accuracy,precision,recall,F1-score,MCC,confusion matrix and *** RF model outperforms other models with an accuracy of 98.5%.The study’s prediction results demonstrate that the proposed dynamic prediction model can achieve a high level of success.

关键词： Traffic event duration forecasting machine learning feature reduction shapley additive explanations(SHAP)

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Advances and perspectives in environmental health research in China

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Frontiers of Environmental Science & engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun Liu Shunqing Xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen Chen Jicheng Gong Guohua Qin Xinghua Qiu Jing Shang Haobo Wang Pengpeng Wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for Environment and health Peking UniversityBeijing 100871China School of Life and health Sciences Huainan UniversityHaikou 570228China Joint International Research Laboratory of Environment and health(Ministry of Education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke School of Public health Tsinghua UniversityBeijing 100084China Research Center of Environment and health College of Environment and ResourceShanxi UniversityTaiyuan 030006China department of Environmental health School of Public HealthFudan UniversityShanghai 200032China School of Environmental and Biological engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Industrial Ecology and Environmental engineering(Ministry of Education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China department of occupational and Environmental health College of Public HealthZhengzhou UniversityZhengzhou 450001China

Environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： Environmental pollution Emerging pollutants Climate change Exposure Mechanism

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Investigating the future study area on VR technology implementation in safety training: A systematic literature review

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Journal of Safety Science and Resilience 2024年第2期5卷 235-248页

作者： Adithya Sudiarno Ratna Sari Dewi Retno Widyaningrum Ahmad Murtaja Dzaky Ma'arij Aldi Yustisia Supriatna Industrial and Systems engineering department Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia occupational Safety and health Councilof East Java Province(Dewan K3 Provinsi Jawa Timur) Surabaya60234Indonesia

Safety training is the exercise normally conducted for all the current and future employees of a company to identify and recognize occupational hazards and diseases as well as determine the appropriate controlling ***,virtual reality(VR)is a technology developed to virtually simulate the surrounding envi-ronment to ensure immersive experience and interaction through artificial three-dimensional(3D)*** devices have been developed to be more compact,easy to use,and affordable to enable people to enjoy immersive virtual experiences and provide interactive and realistic *** has made technology one of the most popular forms of media for different kinds of training,such as safety-related ***,this study aimed to review the use of VR in safety training through the systematic literature review(SLR)*** process focused on developing 4 primary questions(PQs)classified into 11 systematic research questions(SRQs)for discussion points concerning current developments in VR technology *** were further combined with the preferred reporting items for systematic reviews and meta-analyses(PRISMA)flow diagrams in selecting the relevant *** questions were also used to investigate the scenarios,methods,objectives,and outcomes of previous *** results showed the need for further studies on the application of VR technology in safety training in other fields such as firefighting,chemical industry,maritime,***,several scenarios such as construction design,disaster response,rescue procedures,and others need to be *** study also provides information on the gaps for future study,including the exploration of a broader range of industries and VR scenarios.

关键词： Virtual reality Safety training VRfuture development Systematic literaturereview

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Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale

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Research 2024年第3期2023卷 401-415页

作者： Mingxing Ouyang Yanling Hu Weihui Chen Hui Li Yingbo Ji Linshuo Qiu Linlin Zhu Baohua Ji Bing Bu Linhong Deng Institute of Biomedical engineering and health Sciences School of Medical and Health Engineering and School of PharmacyChangzhou UniversityChangzhou213164China Institute of Biomechanics and Applications Department of Engineering MechanicsZhejang UniversityHangzhou310027China.

Living tissues often have anisotropic and heterogeneous organizations, in which developmental processes are coordinated by cells and extracellular matrix modeling. Cells have the capability of modeling matrix in long distance;however, the biophysical mechanism is largely unknown. We investigated the dynamic remodeling of collagen I (COL) fibril matrix by cell contraction with designed patterns of cell clusters. By considering cell dynamic contractions, our molecular dynamics simulations predicted the anisotropic patterns of the observed COL bundling in experiments with various geometrical patterns without spatial limitation. The pattern of COL bundling was closely related to the dynamic remodeling of fibril under cell active contraction. We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.

关键词： contraction Dynamic Matrix

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A novel low-cost visual ear tag based identification system for precision beef cattle livestock farming

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Information Processing in Agriculture 2024年第1期11卷 117-126页

作者： Andrea Pretto Gianpaolo Savio Flaviana Gottardo Francesca Uccheddu Gianmaria Concheri department of Civil Environmental and Architectural EngineeringUniversity of PaduaItaly department of Animal Medicine Production and HealthUniversity of PadovaItaly department of Industrial engineering University of PadovaItaly

The precision livestock farming(PLF)has the objective to maximize each animal's performance while reducing the environmental impact and maintaining the quality and safety of meat *** the PLF techniques,the personalised management of each individual animal based on sensors systems,represents a viable *** is worth noting that the implementation of an effective PLF approach can be still expensive,especially for small and medium-sized farms;for this reason,to guarantee the sustainability of a customized livestock management system and encourage its use,plug and play and cost-effective systems are *** this context,we present a novel low-cost method for identifying beef cattle and recognizing their basic activities by a single surveillance *** leveraging the current state-of-the-art methods for real-time object detection,(i.e.,YOLOv3)cattle's face areas,we propose a novel mechanism able to detect the ear tag as well as the water ingestion state when the cattle is close to the *** cow IDs are read by an Optical Character Recognition(OCR)algorithm for which,an ad hoc error correction algorithm is here presented to avoid numbers misreading and correctly match the IDs to only actually present *** to the detection of the tag position,the OCR algorithm can be applied only to a specific region of interest reducing the computational cost and the time *** times for the areas are outputted as cattle activity recognition *** results demonstrate the effectiveness of our proposed method,showing a mAP@0.50 of 89%.

关键词： Precision livestock farming Deep learning Cattlei dentification Low-cost sensors Computer vision

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei HUANG Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU Yuan Jie DU Yuan Zhen ZHANG Ya Jun HUI Zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of occupational Safety and health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of occupational Medicine and health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina department of occupational&Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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