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Enhancing osteogenic bioactivities of coaxial electrospinning nanoscaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration

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nano Research 2024年第7期17卷 6430-6442页

作者： Peng Wang Qianjin Wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai Wang Jiayu Gu Hao Wu Zhihong Xu Qing Jiang School of Biomedical engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Center of Modem Analysis Nanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China Co-Innovation Center for Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Jiangsu Institute of Metrology Nanjing 210023China

Bone tissue engineering provides a promising strategy for the treatment of bone ***,the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical strength and absence of osteo-inductive ***,we proposed to endow nano-scaffold(NS)constructed by coaxial electrospinning technique with enhanced osteogenic bioactivities and mechanical properties by incorporating biocompatible magnetic iron oxide nanoparticles(IONPs)and icaritin(ICA).Four types of nano-scaffolds(NS,ICA@NS,NS-IONPs and ICA@NS-IONPs)were *** incorporation of ICA and IONPs minimally impact their surface morphological and chemical *** enhanced the mechanical properties of NS scaffolds,including hardness,tensile strength,and elastic *** vitro assessments demonstrated that ICA@NS-IONPs exhibited enhanced osteogenic bioactivities towards mouse calvarial pre-osteoblast cell line MC3T3-E1 as evidenced by detecting the alkaline phosphatase(ALP)activity level,expressions of osteogenesis-related genes and proteins as well as mineralized nodule *** investigations revealed that MEK/ERK(MAP kinase-ERK kinase(MEK)/extracellularsignal-regulated kinase(ERK))signaling pathway could offer a plausible explanation for the osteogenic differentiation of MC3T3-E1 cells induced by ICA@***,the implantation of nano-scaffolds in rat skull defects exhibited a substantial improvement in in vivo bone ***,IONPs and ICA incorporated coaxial electrospinning nano-scaffolds present a novel strategy for the optimization of scaffolds for bone tissue engineering.

关键词： iron oxide nanoparticles icaritin coaxial electrospinning nano-scaffolds MEK/ERK signaling pathway bone regeneration

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Zinc(Ⅱ)metal-organic framework eluting titanium implant as propulsive agent to boost the endothelium regeneration

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Frontiers of Chemical science and engineering 2024年第6期18卷 123-131页

作者： Wen Liu Xiaoyu Wang Ying Li Shihai Xia Wencheng Zhang Yakai Feng School of Chemical engineering and Technology Tianjin UniversityTianjin 300350China College of Materials science and engineering Qingdao UniversityQingdao 266071China department of Hepatopancreatobiliary and Splenic Medicine Affiliated HospitalLogistics University of People’s Armed Police ForceTianjin 300162China department of Physiology and Pathophysiology Logistics University of Chinese People’s Armed Police ForceTianjin 300309China Frontiers science Center for Synthetic Biology Tianjin UniversityTianjin 300072China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China

The advent of antiproliferative drug-eluting vascular stents can dramatically reduce in-stent restenosis via inhibiting the hyperproliferation of vascular smooth muscle ***,the antiproliferative drugs also restrain the repair of the injured endothelial layer,which in turn leads to the very later in-stent *** points that competent endothelium plays a critical role in guaranteeing the long-term patency via maintaining vascular *** the regeneration of endothelium on the implanted vascular stents could be rendered as a promising strategy to reduce stent implantation *** this regard,bioactive zinc(II)metal-organic framework modified with endothelial cell-targeting Arg-Glu-Asp-Val peptide was embedded in poly(lactide-co-caprolactone)to serve as a functional coating on the surface of titanium substrate,which can promote the proliferation and migration of endothelial *** in vitro cell experiments revealed that the zinc(II)metal-organic framework embedded in the polymer coating was able to modulate the behaviors of endothelial cells owing to the bioactive effects of zinc ion and *** results confirmed that zinc(II)metal-organic framework eluting coating represented a new possibility for promoting the repair of the damaged endothelium with potential clinical implications in vascular-related biomaterials and tissue engineering applications.

关键词： Zinc(II)metal-organic framework vascular stent REDV peptide endothelium regeneration coating

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酸性电解水催化剂的催化活性和稳定性展望

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science China Materials 2024年第4期67卷 1124-1128页

作者：王振斌 department of Materials science and engineering City University of Hong KongHong Kong SAR999077China School of Energy and Environment City University of Hong KongHong Kong SAR999077China

在全球追求可持续清洁能源的背景下,电解水被视为一种高效生产氢气的方法,其效能极大依赖于催化剂的表现.设计实用催化剂时,活性和稳定性是至关重要的因素.尽管传统研究倾向于使用热力学活性来解释实验结果并指导新型催化材料的开发,研... 详细信息

在全球追求可持续清洁能源的背景下,电解水被视为一种高效生产氢气的方法,其效能极大依赖于催化剂的表现.设计实用催化剂时,活性和稳定性是至关重要的因素.尽管传统研究倾向于使用热力学活性来解释实验结果并指导新型催化材料的开发,研究催化剂的动力学活性和稳定性却未受到足够关注.本文分析了酸性条件下非贵金属催化剂在动力学活性和稳定性方面的局限,并提出了计算评估催化剂稳定性的标准化方法,同时探讨设计低成本、高效能催化剂面临的挑战.

关键词：活性和稳定性新型催化材料催化剂稳定性非贵金属催化剂标准化方法酸性电解水计算评估清洁能源

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Convolution-Transformer for Image Feature Extraction

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Computer Modeling in engineering & sciences 2024年第10期141卷 87-106页

作者： Lirong Yin Lei Wang Siyu Lu Ruiyang Wang Youshuai Yang Bo Yang Shan Liu Ahmed AlSanad Salman A.AlQahtani Zhengtong Yin Xiaolu Li Xiaobing Chen Wenfeng Zheng department of Geography and Anthropology Louisiana State UniversityBaton RougeLA70803USA School of Automation University of Electronic Science and Technology of ChinaChengdu610054China College of Computer and Information sciences King Saud UniversityRiyadh11574Saudi Arabia College of Resources and Environmental engineering Key Laboratory of Karst Georesources and Environment(Guizhou University)Ministry of EducationGuiyang550025China School of Geographical sciences Southwest UniversityChongqing400715China School of Electrical and Computer engineering Louisiana State UniversityBaton RougeLA70803USA

This study addresses the limitations of Transformer models in image feature extraction,particularly their lack of inductive bias for visual *** to Convolutional Neural Networks(CNNs),the Transformers are more sensitive to different hyperparameters of optimizers,which leads to a lack of stability and slow *** tackle these challenges,we propose the Convolution-based Efficient Transformer Image Feature Extraction Network(CEFormer)as an enhancement of the Transformer *** model incorporates E-Attention,depthwise separable convolution,and dilated convolution to introduce crucial inductive biases,such as translation invariance,locality,and scale invariance,into the Transformer ***,we implement a lightweight convolution module to process the input images,resulting in faster convergence and improved *** results in an efficient convolution combined Transformer image feature extraction *** results on the ImageNet1k Top-1 dataset demonstrate that the proposed network achieves better accuracy while maintaining high computational *** achieves up to 85.0%accuracy across various model sizes on image classification,outperforming various baseline *** integrated into the Mask Region-ConvolutionalNeuralNetwork(R-CNN)framework as a backbone network,CEFormer outperforms other models and achieves the highest mean Average Precision(mAP)*** research presents a significant advancement in Transformer-based image feature extraction,balancing performance and computational efficiency.

关键词： Transformer E-Attention depth convolution dilated convolution CEFormer

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Some results on probabilities of moderate deviations

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Acta Mathematica Sinica,English Series 2024年

作者： Deli LI Yu MIAO Yongcheng QI department of Mathematical sciences Lakehead University College of Mathematics and Information science Henan Normal University department of Mathematics and Statistics University of Minnesota Duluth

Let{X,X_n;n≥1}be a sequence of ***-degenerate real-valued random variables with EX2<∞.Let ■ be a nondecreasing regularly varying function with indexρ≥0 and lim2t→∞g（t）=∞.Letμ=EX andσ=E（X-μ）*** this paper,on the scale g（log n）,we obtain precise asymptotic estimates for the probabilities of moderate deviations of the form ■.Unlike those known results in the literature,the moderate deviation results established in this paper depend on both the variance and the asymptotic behavior of the tail distribution of X.

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Role of cancer stem cell ecosystem on breast cancer metastasis and related mouse models

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Zoological Research 2024年第3期45卷 506-517页

作者： Xilei Peng Haonan Dong Lixing Zhang Suling Liu Fudan University Shanghai Cancer Center&Institutes of Biomedical sciences/State Key Laboratory of Genetic engineering/Cancer Institutes/department of Oncology/Key Laboratory of Breast Cancer in Shanghai/Shanghai Key Laboratory of Medical Epigenetics/Shanghai Key Laboratory of Radiation Oncology/International Co-laboratory of Medical Epigenetics and Metabolism Ministry of Science and Technology/Shanghai Medical College/Fudan UniversityShanghai 200032China

Breast cancer metastasis is responsible for most breast cancer-related deaths and is influenced by many factors within the tumor ecosystem,including tumor cells and *** cancer stem cells(BCSCs)constitute a small population of cancer cells with unique characteristics,including their capacity for self-renewal and *** have shown that BCSCs not only drive tumorigenesis but also play a crucial role in promoting metastasis in breast *** tumor microenvironment(TME),composed of stromal cells,immune cells,blood vessel cells,fibroblasts,and microbes in proximity to cancer cells,is increasingly recognized for its crosstalk with BCSCs and role in BCSC survival,growth,and dissemination,thereby influencing metastatic ***,a thorough understanding of BCSCs and the TME is critical for unraveling the mechanisms underlying breast cancer *** this review,we summarize current knowledge on the roles of BCSCs and the TME in breast cancer metastasis,as well as the underlying regulatory ***,we provide an overview of relevant mouse models used to study breast cancer metastasis,as well as treatment strategies and clinical trials addressing BCSC-TME interactions during ***,this study provides valuable insights for the development of effective therapeutic strategies to reduce breast cancer metastasis.

关键词： Breast cancer Metastasis Cancer stem cell Ecosystem Tumor microenvironment Mouse model

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Glycerol Electrooxidation over Precision-Synthesized Gold nanocrystals with Different Surface Facets

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Precision Chemistry 2024年第3期2卷 103-111页

作者： Hansen Mou Fang Lu Zechao Zhuang Qiaowan Chang Lihua Zhang Xiaobo Chen Yugang Zhang Jingguang G.Chen department of Chemical engineering Columbia UniversityNew YorkNew York 10027United States School of Chemical engineering and Bioengineering Washington State UniversityPullmanWashington 99164United States Center for Functional nanomaterials Brookhaven National LaboratoryUptonNew York 11973United States Materials science and engineering Program State University of New York at BinghamtonBinghamtonNew York 13902United States Chemistry Division Brookhaven National LaboratoryUptonNew York 11973United States

Electrochemical glycerol oxidation(EGO)emerges as a promising route to valorize glycerol,an underutilized byproduct from biodiesel production,into value-added *** study employed three types of gold(Au)nanocrystals with controlled shapes to elucidate the facet-dependent electrocatalytic behavior in ***,rhombic dodecahedral,and cubic Au nanocrystals with{111},{110},and{100}facets,respectively,were precisely synthesized with uniform size and *** dodecahedra exhibited the lowest onset potential for EGO due to facile AuOH formation,while octahedra showed enhanced electrochemical activity for glycerol oxidation and resistance to ***-situ FTIR analysis revealed that Au{111}surfaces selectively favored C_(2) products,whereas Au{100}surfaces promoted C_(3) product formation,highlighting the significant effect of facet orientation on EGO performance and informing catalyst design.

关键词： Electrochemical glycerol oxidation Precision synthesis Shaped nanocrystals Au nanocrystals SAXS In-situ FTIR

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Analysis and Key Parameter Optimization Design of Leningrader Seal Performance

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Wuhan University Journal of Natural sciences 2024年第2期29卷 177-192页

作者： YANG Dongya WANG Xuelin WANG Feng ZHANG Hailong GAO Gui College of mechanical and Electrical engineering Lanzhou University of TechnologyLanzhou 730050Gansu China Wenzhou Pump and Valve engineering Research Institute Lanzhou University of TechnologyWenzhou 325000ZhejiangChina State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000GansuChina

In order to improve the performance and service life of the Leningrader seal of the Stirling engine piston rod,interference,pre-load and friction coefficient were taken as influencing factors,and the curved surface response method was adopted to reduce the contact stress of sealing surface and von Mises stress of the sealing sleeve as the response index,with the optimization goal of reducing wear and extending *** above three key parameters are analyzed and optimized,the influence of each parameter on the sealing performance and service life is obtained,and the best combination scheme of the three is *** results show that the interaction between pre-tightening force and interference fit has the greatest impact on contact *** interaction between interference fit and friction coeffi-cient has the most significant effect on von Mises *** optimized parameters can reduce the maximum contact stress and maximum von Mises stress of the sealing sleeve by 26.3%and 20.6%,respectively,under a media pressure of 5-9 *** bench verification shows that the leakage of the optimized sealing device in 12 h is reduced by 0.44 cc·min^(-1)(1 cc=1 cm^(3)).The wear rate of the sealing sleeve is 1.08%before optimization and 0.45%after optimization,indicating that the optimized parameters in this paper are effective.

关键词： Leningrader seal Stirling engine performance analysis optimized design parameter configuration

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Free-standing MXene/chitosan/Cu2O electrode:an enzyme-free and efficient biosensor for simultaneous determination of glucose and cholesterol

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Journal of Zhejiang University-science A(Applied Physics & engineering) 2022年第7期23卷 579-586页

作者： Tao HU Man ZHANG Hui DONG Tong LI Xiao-bei ZANG Xiao LI Zhong-hua NI School of mechanical engineering Southeast UniversityNanjing211189China Jiangsu Key Laboratory for Design and Manufacture of micro-nano Biomedical Instruments Southeast UniversityNanjing211189China School of Materials science and engineering China University of Petroleum(East China)Qingdao266580China

1 Introduction The incidence of"three highs",referring to hy-perglycemia,hypertension,and hyperlipidemia,has been increasing rapidly all over the world(Dey and Raj,2013;Gao et al.,2019).These illnesses may be attributed to the perturbations of blood metabolites which are small molecules within biofluids(Patil et al.,2018).Among them,the presence of cholesterol and glucose in blood at abnormal levels highly increases the risk of cardiac and brain vascular diseases,and diabetes(Li et al.,2019).

关键词： cholesterol diseases

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Mathematical Modelling and Design of Helical Coil Heat Exchanger for Production of Hot Air for Fluidized Bed Dryer

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Advances in Chemical engineering and science 2024年第3期14卷 125-136页

作者： Iniubong James Uwa Uwem Ekwere Inyang Innocent Oseribho Oboh department of Chemical engineering Faculty of Engineering University of Uyo Uyo Nigeria

In global industrialization, efforts have been made to increase the rate of heat transfer in heat exchanger, minimizing the size of heat exchanger to reduce cost as well as increasing the effectiveness. Helical coil heat exchanger (HCHE) has been proven to be effective in improving heat transfer due to its large surface area. In this study, HCHE was designed to provide hot air needed for fluidized bed drying processes. The HCHE design model was fabricated and evaluated to study the efficiency of the hot air output for a laboratory fluidized bed dryer. The mathematical model for estimation of the final (output) temperature of air, Taf, passing through the HCHE was developed and validated experimentally. The drying of bitter kola particulates was carried out with a drying temperature of 50C 3C and a bed height-to-bed diameter ratio (H/D) of 1.5. The time taken to dry bitter kola particulates to 0.4% moisture content was 1 hour 45 minutes. Hence, HCHE is recommended for use in the production of hot for laboratory-scale fluidized bed dryers.

关键词： Helical Coil Heat Exchanger Fluidized Bed Dryer Heat Transfer Output Air Temperature

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