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Imaging characteristics of hypervascular focal nodular hyperplasialike lesions in patients with chronic alcoholic liver disease

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World Journal of Gastroenterology 2025年第2期31卷 61-70页

作者： Atsushi Urase Masakatsu Tsurusaki Ryohei Kozuki Atsushi Kono Keitaro Sofue Kazunari Ishii department of Radiology Kindai UniversityFaculty of MedicineOsakasayama 589-8511OsakaJapan department of Radiology Kansai Medical University Medical CenterMoriguchi 570-8507OsakaJapan department of Radiology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Focal nodular hyperplasia(FNH)-like lesions are hyperplastic formations in patients with micronodular cirrhosis and a history of alcohol *** pathologically similar to hepatocellular carcinoma(HCC)lesions,they are *** such,it is important to develop methods to distinguish between FNH-like lesions and *** To evaluate diagnostically differential radiological findings between FNH-like lesions and *** We studied pathologically confirmed FNH-like lesions in 13 patients with alco-holic cirrhosis[10 men and 3 women;mean age:54.5±12.5(33-72)years]who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography(CT)and magnetic resonance imaging(MRI),including superparamagnetic iron oxide(SPIO)and/or gadoxetic acid-enhanced *** patients also underwent angiography-assisted *** The evaluated lesion features included arterial enhancement pattern,washout appearance(low density compared with that of surrounding liver parenchyma),signal intensity on T1-weighted image(T1WI)and T2-weighted image(T2WI),central scar presence,chemical shift on in-and out-of-phase images,and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and SPIO-enhanced *** patients had multiple small lesions(<1.5 cm).Radiological features of FNH-like lesions included hypervascularity despite small lesions,lack of“corona-like”enhancement in the late phase on CT during hepatic angiography(CTHA),high-intensity on T1WI,slightly high-or iso-intensity on T2WI,no signal decrease in out-of-phase images,and complete SPIO uptake or incomplete/partial uptake of gadoxetic ***,similar to HCC,FNH-like lesions showed many unpaired arteries and sinusoidal *** Overall,the present study showed that FNH-like lesions have unique radiological findings useful for differential ***,SPIO-and/or gadoxetic acid-enhanced MRI and CTHA features might facili

关键词： Focal nodular hyperplasia Alcoholic liver disease Hepatocellular carcinoma Magnetic resonance imaging Liver

Nonalcoholic Fatty Liver Disease and the Intestinal Microbiome:An Inseparable Link

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1498-1507页

作者： Maria Effenberger Christoph Grander Felix Grabherr Herbert Tilg department of Internal Medicine I GastroenterologyHepatologyEndocrinology and MetabolismMedical University of InnsbruckInnsbruckAustria

Nonalcoholic fatty liver disease(NAFLD)particularly affects patients with type 2 diabetes and *** incidence of NAFLD has increased significantly over the last decades and is now pandemically across the *** is a complex systemic disease comprising hepatic lipid accumulation,inflammation,lipotoxicity,gut dysbiosis,and insulin resistance as main features and with the potential to progress to cirrhosis and hepatocellular carcinoma(HCC).In numerous animal and human studies the gut microbiota plays a key role in the pathogenesis of NAFLD,NAFLD-cirrhosis and NAFLD-associated *** is the driver of inflammation,insulin resistance,and liver ***,western diet,obesity,and metabolic disorders may alter the gut microbiota,which activates innate and adaptive immune responses and fuels hereby hepatic and systemic *** carbohydrates are fermented by the gut microbiota to produce important metabolites,such as short-chain fatty acids and *** animal and human studies suggested a pivotal role of these metabolites in the progression of NAFLD and its ***,modification of the gut microbiota and/or the metabolites could even be beneficial in patients with NAFLD,NAFLD-cirrhosis,and NAFLD-associated *** this review we collect the evidence that exogenous and endogenous hits drive liver injury in NAFLD and propel liver fibrosis and the progressing to advanced disease *** can be seen as the product of a complex interplay between gut microbiota,the immune response and ***,the challenge will be to understand its pathogenesis and to develop new therapeutic strategies.

关键词： Nonalcoholic fatty liver disease NAFLD Microbiome Metabolome

Interactions of zinc and cadmium toxicity in their effects on growth and in antioxidative systems in tomato plants (Solanum lycopersicum)

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Journal of Environmental Sciences 2011年第5期23卷 837-844页

作者： Jaouhra Cherif Chamseddine Mediouni Wided Ben Ammar Fatma Jemal Unit of Research "Nitrogenized Nutrition and metabolism and Stress Proteins" UR 99/09-20 Department of BiologyFaculty of Science University of Tunis Tunis 2092 Tunisia Unit of Research "Nitrogenized Nutrition and metabolism and Stress Proteins" UR 99/09-20 Department of BiologyFaculty of ScienceUniversity of Tunis Tunis 2092 Tunisia

The interaction between zinc and cadmium was investigated in tomato plants （Solanum lycopersicum）. Ten-day-old seedlings were treated with 10 μmol/L CdC12 associated to different concentrations of ZnC12 （10, 50, 100, and 150 μmol/L）. Zn supply clearly reduced Cd accumulation in leaves and simultaneously increased Zn concentration. Cd induced oxidative stress in leaves as indicated by an increase in thiobarbituric acid-reactive substances （TBARS） level and chlorophyll breakdown. Furthermore, compared with control, Cd- treated plants had significantly higher activities of superoxide dismutase （SOD, EC 1.***.1.1）, whereas, catalase （CAT, EC 1.***.1.6）, ascorbate peroxidase （APX, EC 1.***.1.11）, and glutathione reductase （GR, EC 1.***.4.2） activities were significantly suppressed by Cd addition. Zn supplementation, at low level, restored and enhanced the functional activity of these enzymes （SOD, CAT, APX and GR） as compared to Cd-alone-treated plants. The beneficial effect of adequate Zn level on Cd toxicity was confirmed by a significant decrease in TBARS level and restoration of chlorophyll content. However, when Zn was added at high level in combination with Cd there was an accumulation of oxidative stress, which was higher than that for Cd or excess Zn alone treatments. These results suggested that higher Zn concentrations and Cd are synergistic in their effect on plant growth parameters and oxidative stress.

关键词： Solanum lycopersicum cadmium zinc oxidative stress antagonism synergism.

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： Ying-Jin Wang Ze-Chuan Liu Jian Wang Yin-Mo Yang department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Effects of Tai Chi in diabetes patients: Insights from recent research

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World Journal of Diabetes 2024年第1期15卷 1-10页

作者： Hidetaka Hamasaki department of Endocrinology and metabolism Internal MedicineHamasaki ClinicKagoshima 890-0046Japan

Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health *** body of evidence concerning the impact of Tai Chi on diabetes has recently been *** editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes(T2D).The review includes 3 randomized controlled trials(RCTs)and 5 systematic reviews and meta-analyses,all of which investigate the effectiveness of Tai Chi on various health outcomes in individuals with *** Chi demonstrates a significant effect to enhance glycemic control,lower blood pressure,improve serum lipid profiles,reduce insulin resistance,positively influence obesity-related indices,and improve overall quality of life in individuals with ***,it is noteworthy that recent RCTs have reported inconsistent findings regarding the effects of Tai Chi on glycemic control and insulin *** author also delves into potential mechanisms by which Tai Chi may exert its influence on the human ***,the editorial highlights the critical issues that warrant further exploration in the future.

关键词： Type 2 diabetes Tai Chi Exercise Mind-body exercise Chinese traditional exercise Randomized controlled trial Systematic review and meta-analysis

Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes:A meta-analysis

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World Journal of Diabetes 2023年第10期14卷 1573-1584页

作者： Chu Lin Zong-Lin Li Xiao-Ling Cai Sui-Yuan Hu Fang Lv Wen-Jia Yang Li-Nong Ji department of Endocrinology and metabolism Peking University People's HospitalBeijing 100044China

BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-analyses have compared the efficacy and safety of chiglitazar and traditional PPAR-γagonist thiazolidinediones(TZDs).A meta-analysis concerning this topic is therefore *** To compare the efficacy and safety of chiglitazar and TZD in patients with *** PubMed,Medline,Embase,the Cochrane Central Register of Controlled Trials,Reference Citation Analysis and *** websites were searched from August 1994 to March *** controlled trials(RCTs)of chiglitazar or TZD vs placebo in patients with T2D were *** comparisons and sensitivity analyses were implemented to evaluate multiple efficacy and safety endpoints of *** We included 93 RCTs that compared TZD with placebo and one that compared chiglitazar with *** efficacy endpoints,the augmented dose of chiglitazar resulted in greater reductions in hemoglobin(Hb)A1c[weighted mean difference(WMD)=-0.15%,95%confidence interval(CI):-0.27 to-0.04%],triglycerides(WMD=-0.17 mmol/L,95%CI:-0.24 to-0.11 mmol/L)and alanine aminotransferase(WMD=-5.25 U/L,95%CI:-8.50 to-1.99 U/L),and a greater increase in homeostasis model assessment-β(HOMA-β)(WMD=17.75,95%CI:10.73-24.77)when compared with TZD *** safety endpoints,the risks of hypoglycemia,edema,bone fractures,upper respiratory tract infection,urinary tract infection,and weight gain were all comparable between the augmented dose of chiglitazar and *** patients with baseline HbA1c≥8.5%,body mass index≥30 kg/m^(2)or diabetes duration<10 years,the HbA1c reduction and HOMA-βincrease were more conspicuous for the augmented dose of chiglitazar compared with *** Augmented dose of chiglitazar,a pan-activator of PPARs,may serve as an antidiabetic agent with preferable glycemic and lipid control

关键词： Chiglitazar Thiazolidinedione Glycemic control β-cell function Drug safety

25-Hydroxyvitamin D Is Associated with Islet Homeostasis in Type-2 Diabetic Patients with Abdominal Obesity

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Current Medical Science 2023年第5期43卷 919-926页

作者： Qing LI Wen ZHANG Bing HAN Yu-ying WANG Heng WAN Min ZHANG Ning-jian WANG Ying-li LU Institute and department of Endocrinology and metabolism Shanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Institute and department of Endocrinology and metabolism Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China

Objective Isletαcells input is essential for insulin secretion fromβ*** present study aims to investigate the association between 25-hydroxyvitamin D[25(OH)D]and islet function homeostasis in type-2 diabetes(T2D)*** A total of 4670 T2D patients from seven communities in Shanghai,China were *** anthropometric indices,biochemical parameters,serum 25(OH)D,and islet function[including C-peptide(C-p)and glucagon]were *** The fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),glucagon,and C-p levels exhibited a significantly decreasing trend in T2D patients as the 25(OH)D levels ***,the population was divided into two groups:abdominal obesity and non-abdominal obesity *** adjustment,the 25(OH)D level was found to be associated with HbA1c,glucagon,and homeostasis model assessment ofβ(HOMA-β)in the non-abdominal obesity *** was a significant relationship between 25(OH)D and HbA1c,glucagon,HOMA-IR,baseline insulin or C-p in the abdominal obesity *** the abdominal obesity group,the ordinary least squares(OLS)regression and quantile regression revealed that 25(OH)D was obviously associated with glucagon and fasting C-p *** the abdominal obesity group,the moderate analysis revealed a significant interaction effect of 25(OH)D and glucagon on C-p(P=0.0124).Furthermore,the conditional indirect effect of 25(OH)D on the glucagon/C-p ratio was significantly lower at 1 standard deviation(SD)below the mean(P=0.0002),and lower at the mean of the course of diabetes(P=0.0007).Conclusion 25(OH)D was found to be negatively correlated to glucagon and C-p in T2D patients with abdominal *** 25(OH)D influenced C-p in part by influencing *** effect of 25(OH)D on the glucagon/C-p ratio in T2D patients with abdominal obesity,in terms of islet homeostasis,is influenced by the course of diabetes.

关键词： 25-hydroxyvitamin D glucagon C-peptide isletαcells isletβcells type-2 diabetes

Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

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World Journal of Clinical Cases 2024年第4期12卷 787-794页

作者： Hui Li Yun Chai Wei-Hong Guo Yu-Meng Huang Xiao-Na Zhang Wen-Li Feng Qing He Jin Cui Ming Liu department of Endocrinology and metabolism Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose ***,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed *** patients were diagnosed with GDM during the second trimester and were *** blood glucose level elevated suddenly during the third trimester and then were diagnosed with *** patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before *** patient developed ketoacidosis,and three developed *** patients had cesarean section deliveries,and two had vaginal *** growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet *** frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present *** In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less *** pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA *** speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

关键词： Fulminant type 1 diabetes mellitus Gestational diabetes mellitus Pregnancy-related fulminant type 1 diabetes mellitus Double diabetes Case report

Genomics revolution on andrology： genetic testing for male infertility

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Asian Journal of Andrology 2010年第3期12卷 449-450页

作者： Marumudi Eunice Ariachery Chinnama Ammini department of Endocrinology and metabolism All lndia Institute of Medical Sciences New Delhi 110029 lndia

Dear Editor, We would like to write to you on the era of＇omics-- genomics revolution on andrology, the way that has taken into a new dimension for tackling the emerging pressure on male infertility and for normal successful fertility outcome. In the Special Issue on Semen Analysis of Asian Journal ofAndrology, Aitken [1] has extensively discussed the causes of male infertility,

关键词： Genomics genetic infertility