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Regulation of the protein stability of POSH and MLK family

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Protein & Cell 2010年第9期1卷 871-878页

作者： Chunyan Wang Yang Tao Yaqing Wang Zhiheng Xu Key Laboratory of Molecular and developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Sequential activation of the JNK pathway components,including Rac1/Cdc42,MLKs(mixed-lineage kinases),MKK4/7 and JNKs,plays a required role in many cell death *** components are organized by a scaffold protein,POSH(Plenty of SH3’s),to ensure the effective activation of the JNK pathway and cell death upon apoptotic *** have shown recently that the expression of POSH and MLK family proteins are regulated through protein *** generating a variety of mutants,we provide evidence here that the Nterminal half of POSH is accountable for its stability regulation and its over-expression-induced cell *** addition,POSH’s ability to induce apoptosis is correlated with its stability as well as its MLK binding *** family’s stability,like that of POSH,requires activation of ***,we were surprised to find out that the widely used dominant negative(d/n)form of c-Jun could down-regulate MLK’s stability,indicating that peptide from d/n c-Jun can be potentially developed into a therapeutical drug.

关键词： the JNK pathway protein stability POSH MLK family and poptosis

Whole genome sequencing of cotton—a new chapter in cotton genomics

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Science China(Life Sciences) 2015年第5期58卷 515-516页

作者： CAO XiaoFeng Institute of genetics and developmental biology Chinese Academy of Sciences

A Cotton Genome Consortium led by the Cotton Research Institute, Chinese Academy of Agricultural Sciences, with scientists from Peking University, Wuhan University, BGI and US department of Agriculture Southern Plains Research Center has completed the genome sequence of the allotetraploid G. hirsutum （AtDt） by using the second-generation high-throughput sequencing technology assisted by 5-fold traditional BAC-to-BAC sequences.

关键词：全基因组测序棉花研究所基因组学中国农业科学院基因组序列异源四倍体北京大学武汉大学

Genome editing in crops: from bench to field

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National Science Review 2015年第1期2卷 13-15页

作者： Caixia Gao Institute of genetics and developmental biology Chinese Academy of Sciences

Conventional plant breeding can accelerate crop improvement by crossing superior plants with other compatible plants,or randomly induced variants generated by chemical-or radiation-induced ***,its contribution to crop... 详细信息

关键词： NHEJ DNA Genome editing in crops from bench to field SSN

ECRG4: a new potential target in precision medicine

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Frontiers of Medicine 2019年第5期13卷 540-546页

作者： Xin Qin Ping Zhang medical College Hubei University of Arts and ScienceXiangyartg 441053China State Key Laboratory of Cancer biology Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi'an 710032China

Given the rapid development in precision medicine, tremendous efforts have been devoted to discovering new biomarkers for disease diagnosis and treatment. Esophageal cancer-related gene-4 (ECRG4),which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis. ECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expression pattern. The gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precision medicine. This review provides an updated summary on the biology of ECRG4, with emphasis on its important roles in cancer diagnosis and therapy. The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed in detail.

关键词： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

Emerging role of ER quality control in plant cell signal perception

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Protein & Cell 2012年第1期3卷 10-16页

作者： Hong-Ju Li Wei-Cai Yang State Key Laboratory of Molecular developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The endoplasmic reticulum quality control(ER-QC)is a conserved mechanism in surveillance of secreted signaling factors during cell-to-cell communication in *** data show that the ER-QC plays important roles in diverse cell-to-cell signaling processes during immune response,vegetative and reproductive development in *** tube guidance is a precisely guided cell-cell communication process between the male and female gametophytes during plant ***,the female signal has been identified as small secreted peptides,but how the pollen tube responds to this signal is still *** this review,we intend to summarize the role of ER-QC in plants and discuss the recent advances regarding our understanding of the mechanism of pollen tube response to the female signals.

关键词： cell-to-cell communication pollen tube guidance gametophyte ER quality control

ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression

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Protein & Cell 2013年第9期4卷 711-721页

作者： Yuangang Zhu Chunyan Wang Mei Yu Jie Cui Liang Liu Zhiheng Xu The National Key Laboratory of Molecular developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Mutations in LR RK2(Leucine rich repeat kinase 2)are a major cause of Parkinson’s disease(PD).We and others reported recently that expression of the pathogenic gain-of-function mutant form of LRRK2,LRRK2 G2019S,induc-es mitochondrial fi ssion in neurons through *** we provide evidence that expression of LRRK2 G2019S stimulates mitochondria loss or *** have char-acterized several LRRK2 interacting proteins and found that LRRK2 interacts with ULK1 which plays an essential role in *** of either ULK1 or DLP1 expression with shRNAs suppresses LRRK2 G2019S expression-induced mitochondrial clearance,suggesting that LRRK2 G2019S expression induces mitochondrial fi ssion through DLP1 followed by mitophagy via an ULK1 dependent *** addition to ULK1,we found that LRRK2 interacts with the endogenous MKK4/7,JIP3 and coordinates with them in the activation of JNK ***,LRRK2 G2019S-induced loss of mitochon-dria can also be suppressed by 3 different JNK inhibitors,implying the involvement of the JNK pathway in the path-ogenic mechanism of mutated *** our fi ndings may provide an insight into the complicated pathogenesis of PD as well as some clues to the development of novel therapeutic strategies.

关键词： LRRK2 Parkinson’s disease mitophagy ULK1 JNK DLP1

Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation

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Journal of genetics and Genomics 2019年第1期46卷 5-17页

作者： Mingyue Jia Danqing Meng Mo Chen Tingting Li Yong Q.Zhang Aiyu Yao State Key Laboratory of Molecular developmental biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of Sciences

Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the Drosophila ortholog of human ACSL3 and ACSL4, result in developmental defects of the mushroom body (MB), the center of olfactory learning and memory. Specifically, Acsl mutants show fewer MB neuroblasts (Nbs) due to reduced proliferation activity and premature differentiation. Consistently, these surviving Nbs show reduced expression of cyclin E, a key regulator of the G1-to S-phase cell cycle transition, and nuclear mislocalization of the transcriptional factor Prospero, which is known to repress self-renewal genes and activate differentiating genes. Furthermore, RNA-seq analysis reveals downregulated Nb-and cell-cyclerelated genes and upregulated neuronal differentiation genes in Acsl mutant Nbs. As Drosophila Acsl and human ACSL4 are functionally conserved, our findings provide novel insights into a critical and previously unappreciated role of Acsl in neurogenesis and the pathogenesis of ACSL4-related ID.

关键词： ACSL4 Drosophila Mushroom body Neuroblast Neural stem cell Premature differentiation

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

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Regenerative Biomaterials 2023年第1期10卷 205-217页

作者： Ziqiang Wang Ya Li Chenxuan Sun Pukong Cui Yuanyuan Han Tong Wu Bai Xu Can Zhang Liyang Shi Jianwu Dai College of biology Hunan UniversityChangsha 410000China State Key Laboratory of Molecular Developmental BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Transplantation of adult spinal cord tissue(aSCT)is a promising treatment for spinal cord injury(SCI)basing on various types of neural cells and matrix components inside ***,long-term systemic administration of immunosuppressors(***,TAC)is required for the survival of allogeneic tissue,which often associated with severe side effects such as infection,liver damageand renal *** this study,a triglycerol monostearate(TGM)-based TAC delivery system(***@TGM)with high drug loading concentration was developed,which possessed injectable properties as well as sustainable and immune-responsive drug release *** complete transected SCI model,locally injected TAC@TGM could reduce the infiltration of inflammation cells,enhance the survival of transplanted aSCT(***-1^(+)and NF^(+)neurons)and promote the recovery of locomotor ***,controlled release of TAC by TAC@TGM attenuated side effects of TAC on liver and kidneys compared with traditional systemic *** importantly,the developed TAC@TGM system provided a facile single dose of long-term immunosuppressive effect not just for aSCT transplantation,but also for other tissue/organ and cell transplantations.

关键词： spinal cord injury adult spinal cord tissue transplantation immune rejection controlled release tacrolimus

Multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans

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Journal of Environmental Sciences 2007年第11期19卷 1367-1372页

作者： WANG Da-yong YANG Peng department of genetics and developmental biology Southeast University Nanjing 210009 China Key Laboratory of developmental Genes and Human Disease Ministry of Education of China Nanjing 210009 China

Whether the multi-biological toxicity from lead exposure could be transferred to progeny has not been clarified. In the present study, we explored the Caenorhabditis elegans to analyze the multiple toxicities from lead exposure and their possibly transferable properties. The lead exposure could cause series of severe multi-biological defects with a concentration-dependent manner by affecting the endpoints of life span, development, reproduction and locomotion behaviors in nematodes. Moreover, most of these toxicities could be transferred to progeny from lead exposed animals and some of the defects in progeny appeared even more severe than in their parents, such as the body sizes and mean life spans. We summarized the defects caused by lead exposure into three groups according to their transferable properties or rescue patterns. That is, the defects caused by lead exposure could be largely, or partially, or became even more severe in progeny animals. Therefore, our results suggest that lead exposure can cause severely multi-biological defects, and most of these multiple toxicities can be considered as transferable for exposed animals in C. elegans.

关键词： lead exposure toxicity transferable phenotype behavior Caenorhabditis elegans