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Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 1-14页

作者： Mengzhu Li Xiude Fan Jiajun Zhao Dawei Wang department of Endocrinology Shandong Provincial HospitalShandong UniversityJinanShandongChina Key Laboratory of Endocrine Glucose&lipids Metabolism and Brain Aging Ministry of EducationDepartment of EndocrinologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of Endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina

Background and Aims:Stress granules(SGs)as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile *** carcinoma(HCC)is prone to be highly aggressive once diagnosed,which markedly reduces patient survival ***,it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis,which promotes individualized precision therapeutics in *** the pro-tumorigenic activity of SGs,it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes(SGGs).Methods:Bioinformatic analysis was employed to establish an SGG-based prognostic *** blotting and realtime polymerase chain reaction assays were used to assess the expression patterns of the related ***-of-function experiments were performed to analyze the effect of the SGGs on SG formation and cell ***:A four-SGG signature(KPNA2,MEX3A,WDR62,and SFN)targeting HCC was established and validated to exhibit a robust performance in predicting HCC ***,all four genes were further found to be highly expressed in human HCC *** important,we demonstrated that individually knocking down the four SGGs significantly reduced HCC cell proliferation and metastasis by compromising the SG formation ***:We developed an SGG-based predictive signature that can be used as an independent prognostic tool for *** strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2,MEX3A,WDR62,and SFN in HCC cells by regulating SG formation.

关键词： Hepatocellular carcinoma Stress granules Prognostic factor G3BP1

Plant-based milk alleviates antibiotics-induced intestinal barrier damage associated with modulation of gut microbiome and metabolome

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Food Science and Human Wellness 2024年

作者： Xiaoyan Ma Yashu Chen Zhenxia Xu Chao Wang Xu Wang Zhitao Chen Shufang Xu Chen Yang Qianchun Deng Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences， Oil Crops and lipids Process Technology National & Local Joint Engineering Laboratory， Hubei Key Laboratory of Lipid Chemistry and Nutrition， Key Laboratory of Oilseeds Processing， Ministry of Agriculture and Rural affairs Key Laboratory of Fermentation Engineering (Ministry of Education)， Hubei Key Laboratory of Industrial Microbiology， Hubei Provincial Cooperative Innovation Center of Industrial Fermentation， Hubei University of Technology Huazhong Agricultural University department of Gastroenterology， The Central Hospital of Wuhan， Tongji Medical College， Huazhong University of Science and Technology Clinical Nutrition department， The Central Hospital of Wuhan， Tongji Medical College， Huazhong University of Science and Technology

Plant-based milk is rich in polyunsaturated fatty acids， polyphenols and other bioactive compounds. This study investigated the effect of three plant-based milk (flaxseed milk， oat milk and soy milk) on the ceftriaxone-induced intestinal disorders， and compared the regulation patterns associated with gut microbiome and metabolome. The results showed plant-based milk alleviated the ceftriaxone caused cecum swelling， colonic tissue damage and intestinal microecological disorders. Meanwhile， administered plant-based milk decreased levels of pro-inflammatory cytokine (tumor necrosis factor (TNF-α)， interleukin (IL-6)， interleukin (IL-1β) and oxidative stresses (malondialdehyde (MDA) and myeloperoxidase (MPO) in the colon， as well as increasing the levels of tight junction proteins (Occludin， Claudin-1， and ZO-1) in the colon. Moreover， administration of plant-based milk modulated the intestinal microbiota by promoting the relative levels of beneficial bacteria (Bifidobacterium)， and inhibiting the harmful bacteria genus (Enterococcus). Furthermore， plant-based milk treatment significantly modulated glycerophospholipids metabolism (e.g. glycerophosphocholine) and arachidonic acid metabolism (e.g. prostaglandin G2 and arachidonic acid) in the serum. In conclusion， plant-based milk could alleviate antibiotic-related imbalance of barrier function damage， gut microbiota disorders and the reduction of metabolic disorders， which lays a foundation for exploring anti-inflammatory and intestinal micro-ecological approach to plant-based milk.

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Cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies

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Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean M.Riordan Matthew C.Gernon Peter Koulen department of Ophthalmology School of MedicineUniversity of Missouri department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human *** have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human *** of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS *** review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS *** addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS *** and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-Mai Jacob M.Samuel Boone M.Prentice department of Neurology University of FloridaGainesvilleFLUSA department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice

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World Journal of Hepatology 2024年第10期16卷 1188-1198页

作者： Chun-Mei Li Tian Sun Mou-Jie Yang Zhi Yang Qing Li Jia-Lin Shi Chong Zhang Jun-Fei Jin Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Guangxi Health Commission Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina China-United States lipids in Health and Disease Research Center Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Laboratory of Hepatobiliary and Pancreatic Surgery the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina

BACKGROUND Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen(APAP).However,the role of the complement inhibitor C2-FH in APAP-induced liver injury remains *** To explore C2-FH in protecting against APAP-induced liver injury by inhibiting complement *** A model of APAP-induced liver injury was used to study the protective effect of C2-FH on liver injury.C2-FH was administered through intraperitoneal injection 30 minutes after APAP *** detected the effects of C2-FH on liver function,inflammatory response and complement ***,RNA-sequencing(RNA-Seq)analysis was conducted to understand the mechanism through which C2-FH provides protection against APAP-induced liver *** C2-FH inhibited the increase in serum alanine aminotransferase activity,aspartate aminotransferase activity and lactate dehydrogenase,and reduced liver tissue necrosis caused by ***,it attenuated the inflammatory response and inhibited complement activation in APAP-induced liver ***-Seq analysis provided additional explanations for the protective role of C2-FH against APAP-induced liver *** C2-FH attenuates APAP-induced liver injury by inhibiting complement activation.

关键词： C2-FH Complement Complement activation Acetaminophen-induced liver injury Inflammation

Non-Carbohydrate Components on the Surface of Starch Granules According to the Hardness of Wheat

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Food and Nutrition Sciences 2015年第1期6卷 112-123页

作者： Izabella Kwasniewska-Karolak Justyna Rosicka-Kaczmarek Ewa Nebesny Maria Stasiuk Institute of Chemical Technology of Food Technical University of LodzLodzPoland Laboratory of lipids and liposomes Faculty of BiotechnologyUniversity of WroclawWroclawPoland

An attempt was made to demonstrate the usefulness of pre-knowledge of the quality and quantity analysis of non-carbohydrate components of starch surface, such as proteins and lipids, in starch isolated from wheat with varying degrees of hardness, for receiving glucose hydrolysates. The chemical composition of starches isolated from wheat grains of different hardness was examined. The amount of protein fraction (surface proteins, puroindolins and internal proteins), total and surface lipids, apparent amylose, phosphorous and pentosans contents were evaluated. It was found that starches, depending on the hardness of wheat grain, have a different chemical composition. A clear influence of wheat hardness on lipid and proteins content on the surface of starch grains and on apparent amylose was proved. It was showed that the presence of polar lipids (glyco and phospholipids) on the surface of starch was connected with their role in binding of surface proteins fraction (friabilins) to starch grains. There was a clear positive correlation between the amount of lipid fraction on starch surface and the amount of protein fraction, depending on wheat hardness. Starches from soft wheat varieties were characterized by higher amounts of proteins and lipids on their surface. In addition, it was determined that basing on the knowledge of mechanical properties of wheat grains, namely its hardness and initial starch chemical content analysis, one may predict its further directions of processing, including evaluation, whether the starch from a given wheat variety would be appropriate for obtaining hydrolysates with good physicochemical properties.

关键词： Hardness of Wheat Wheat Starch Surface Puroindolines lipids Glucose Hydrolysates

Exploring the functional roles of small-molecule metabolites in disease research:Recent advancements in metabolomics

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Chinese Chemical Letters 2024年第8期35卷 93-100页

作者： Aolei Tan Xiaoxiao Ma department of Precision Instrument Tsinghua UniversityBeijing 100084China

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in ***,an essential scientific discipline,is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during *** the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and *** comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic *** scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

关键词： Metabolites Small molecules Biological functions Physiological processes Diseases

Carboxylesterases in lipid metabolism： From mouse to human

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Protein & Cell 2018年第2期9卷 178-195页

作者： Jihong Lian Randal Nelson Richard Lehner Group on Molecular and Cell Biology of lipids University of Alberta Edmonton Alberta Canada department of Pediatrics University of Alberta Edmonton Alberta Canada department of Cell Biology University of Alberta Edmonton Alberta Canada

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through （over）expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, dif- ferences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human car- boxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.

关键词： carboxylesterase lipase lipid lipoprotein iver adipose intestine

Preparation of microparticles and nanoparticles using membrane-assisted dispersion,micromixing,and evaporation processes

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Particuology 2024年第1期84卷 30-44页

作者： Goran T.Vladisavljevic Chemical Engineering department Loughborough UniversityLoughboroughLeicestershire LE113TUUnited Kingdom

Synthetic microporous membranes are increasingly used for energy-efficient and controlled production of micro-and nanoparticles and micro-and nanoemulsions with tuneable morphology and physico-chemical properties through various micromixing,emulsification,and evaporation *** emul-sification processes,the membrane pores are used for dispersed phase injection and size-controlled generation of droplets and droplet-templated *** micromixing processes,membrane is utilised as a micromixer for mixing two miscible liquids,usually solvent and antisolvent-rich solutions,which leads to the creation of supersaturation and subsequent nanoprecipitation or *** mem-brane evaporation processes,membrane is used to prevent phase dispersion while allowing efficient molecular diffusion of solvent and/or antisolvent vapour through gas-filled *** dispersion processes can be operated continuously by decoupling shear stress on the membrane surface from cross flow using tube insets,flow pulsations,swirling flow,membrane oscillations or membrane *** generation and solidification can be performed continuously in a single pass by connecting membrane module with a downstream *** dispersion processes can be used for pro-duction of nanoparticles such as nanovesicles(liposomes,micelles,ethosomes,and niosomes),nanogels,polymeric,lipid and metallic nanoparticles,and *** main advantages of membrane-assisted particle generation are in low energy consumption,controlled geometry and hydrodynamic conditions at the microscale level,flexible throughput due to modular and scalable design of membrane devices,and a wide choice of available microporous membranes with various wall porosities,wetta-bilities,pore sizes,and pore morphologies to suit different applications.

关键词： Nanoparticles Microparticles Nanoemulsions Microemulsions Microporous membrane Crystallisation Flash nanoprecipitation Emulsification Zero liquid discharge